Characterization of the CYP3A4 active site by homology modeling

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 7, 2004, Pages 830-835

  Tanaka, Toshimasa ^a   Okuda, Teruaki ^a   Yamamoto, Yoshio ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

CYP3A4; Cytochrome p450; Docking model; Drug drug interaction; Homology modeling; Ph4Dock

Indexed keywords

AMIODARONE; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; CANDESARTAN; COLCHICINE; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 2C5; CYTOCHROME P450 3A4; DEXAMETHASONE; EPROSARTAN; ERYTHROMYCIN; FENTANYL; INDINAVIR; IRBESARTAN; KETOCONAZOLE; LIGAND; LOSARTAN; MIDAZOLAM; NIFEDIPINE; PACLITAXEL; QUINIDINE; RITONAVIR; SAQUINAVIR; TAMOXIFEN; TERFENADINE; TESTOSTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSARTAN; VERAPAMIL; CYP2C5 PROTEIN, ORYCTOLAGUS CUNICULUS; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; STEROID 21 MONOOXYGENASE;

ARTICLE; CHEMICAL INTERACTION; CORRELATION ANALYSIS; CRYSTALLOGRAPHY; DRUG DETOXIFICATION; DRUG METABOLISM; LIGAND BINDING; MOLECULAR MODEL; PHARMACOPHORE; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HUMAN; MOLECULAR GENETICS; PHYSIOLOGY; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STEROID 21-HYDROXYLASE;

EID: 15744375035     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.830     Document Type: Article

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