-
1
-
-
13944278132
-
Mitochondria, oxidants and aging
-
Balaban RS, Nemoto S and Finkel T (2005) Mitochondria, oxidants and aging. Cell 120: 473-482
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
2
-
-
4544322045
-
Free radicals and aging
-
Barja G (2004) Free radicals and aging. Trends Neurosci 27: 595-600
-
(2004)
Trends Neurosci
, vol.27
, pp. 595-600
-
-
Barja, G.1
-
3
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM and DePinho RA et al. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
-
4
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Oullette M, Frolkis M, Holt SE, Chiu CP and Morin GB et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Oullette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
-
6
-
-
0037238101
-
Cellular senescence and apoptosis: How cellular responses might influence aging phenotypes
-
Campisi J (2002) Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol 38: 5-11
-
(2002)
Exp Gerontol
, vol.38
, pp. 5-11
-
-
Campisi, J.1
-
7
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120: 513-522
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
8
-
-
10744222737
-
Gene targeting in stem cells from individuals with osteogenesis imperfecta
-
Chamberlain JR, Schwarze U, Wang PR, Hirata RK, Hankenson KD and Pace JM et al. (2004) Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science 303: 1198-1201
-
(2004)
Science
, vol.303
, pp. 1198-1201
-
-
Chamberlain, J.R.1
Schwarze, U.2
Wang, P.R.3
Hirata, R.K.4
Hankenson, K.D.5
Pace, J.M.6
-
9
-
-
13944283022
-
Longevity and lineages: Toward the integrative biology of degenerative diseases in heart, muscle and bone
-
Chien KR and Karsenty G (2005) Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle and bone. Cell 120: 533-544
-
(2005)
Cell
, vol.120
, pp. 533-544
-
-
Chien, K.R.1
Karsenty, G.2
-
10
-
-
0035815414
-
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
-
Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H and Hafen E et al. (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-107
-
(2001)
Science
, vol.292
, pp. 104-107
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
-
11
-
-
0034455827
-
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
-
Coschigano KT, Clemmons D, Bellush LL and Kopchick JJ (2000) Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141: 2608-2613
-
(2000)
Endocrinology
, vol.141
, pp. 2608-2613
-
-
Coschigano, K.T.1
Clemmons, D.2
Bellush, L.L.3
Kopchick, J.J.4
-
12
-
-
21644484769
-
How much can human life span be extended
-
Couzin J (2005) How much can human life span be extended. Science 309: 83
-
(2005)
Science
, vol.309
, pp. 83
-
-
Couzin, J.1
-
13
-
-
0037123638
-
Premature ageing in mice deficient in DNA repair and transcription
-
De Boer J, Andressoo JO, de Wit J, Huikmans J, Beems RB and van Steeg H et al. (2002) Premature ageing in mice deficient in DNA repair and transcription. Science 296: 1276-1279
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
De Boer, J.1
Andressoo, J.O.2
De Wit, J.3
Huikmans, J.4
Beems, R.B.5
Van Steeg, H.6
-
14
-
-
0029047362
-
A novel biomarker identifies senescent human cells in culture and aging skin in vivo
-
USA
-
Dimri GP, Lee X, Basile G, Acosta M, Scott G and Roskelley C et al. (1995) A novel biomarker identifies senescent human cells in culture and aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367
-
(1995)
Proc Natl Acad Sci
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
-
15
-
-
0037673950
-
Recurrent de novo point mutations in Lamin a cause Hutchison-Gilford progeria syndrome
-
Eriksson M, Brown TW, Gordon LB, Glynn MW, Singer J and Scott L et al. (2003) Recurrent de novo point mutations in Lamin A cause Hutchison-Gilford progeria syndrome. Nature 423: 293-298
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, T.W.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
-
16
-
-
0023831256
-
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
-
Friedman DB and Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118: 75-86
-
(1988)
Genetics
, vol.118
, pp. 75-86
-
-
Friedman, D.B.1
Johnson, T.E.2
-
17
-
-
0030977793
-
Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein
-
Friguet B and Szweda LL (1997) Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein. FEBS Lett 405: 21-25
-
(1997)
FEBS Lett
, vol.405
, pp. 21-25
-
-
Friguet, B.1
Szweda, L.L.2
-
18
-
-
2942643923
-
Accumulation of mutant lamin a causes progressive changes in nuclear structure in Hutchinson-Gilford progeria syndrome
-
USA
-
Goldman RD, Shumaker DK, Erdos MR, Eriksson M, Goldman AE and Gordon LB et al. (2004) Accumulation of mutant lamin A causes progressive changes in nuclear structure in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 101: 8963-8968
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 8963-8968
-
-
Goldman, R.D.1
Shumaker, D.K.2
Erdos, M.R.3
Eriksson, M.4
Goldman, A.E.5
Gordon, L.B.6
-
19
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith JD, Comeau L, Rosenfeld S, Stansel RM, Bianchi A and Moss H et al. (1999) Mammalian telomeres end in a large duplex loop. Cell 97: 503-514
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfeld, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
-
20
-
-
13944253348
-
Calorie restriction - The SIR2 connection
-
Guarente L and Picard F (2005) Calorie restriction - the SIR2 connection. Cell 120: 473-482
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
21
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB and Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
22
-
-
77049308856
-
A theory based on free radical and radiation chemistry
-
Harman D (1956) A theory based on free radical and radiation chemistry. J Gerontol 11: 298-300
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
23
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1-cyclin dependent kinases
-
Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1-cyclin dependent kinases. Cell 75: 805-816
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
24
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
25
-
-
33745659506
-
Stochastic and genetic factors influence tissue decline in ageing C. elegans
-
Herndon LA, Schmeisser PJ, Dudaronek JM, Brown PA, Listner KM and Sakano Y et al. (2002) Stochastic and genetic factors influence tissue decline in ageing C. elegans. Nature 419: 788-794
-
(2002)
Nature
, vol.419
, pp. 788-794
-
-
Herndon, L.A.1
Schmeisser, P.J.2
Dudaronek, J.M.3
Brown, P.A.4
Listner, K.M.5
Sakano, Y.6
-
26
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KI, Bitterman KJ, Cohen HY, Lamming DW, Lavu S and Wood JG et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.I.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
-
27
-
-
0345237923
-
Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: Correlation to extended longevity
-
Ikeno Y, Bronson RT, Hubbard GB, Lee S and Bartke A (2002) Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity. J Gerontol 58: 291-296
-
(2002)
J Gerontol
, vol.58
, pp. 291-296
-
-
Ikeno, Y.1
Bronson, R.T.2
Hubbard, G.B.3
Lee, S.4
Bartke, A.5
-
28
-
-
0030813398
-
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura KD, Tissenbaum HA, Liu X and Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, X.3
Ruvkun, G.4
-
29
-
-
0036829090
-
Cancer and aging: A model for the cancer promoting effects of aging stroma
-
Krtolica A and Campisi J (2002) Cancer and aging: a model for the cancer promoting effects of aging stroma. Int J Biochem Cell Biol 34: 1401-1414
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 1401-1414
-
-
Krtolica, A.1
Campisi, J.2
-
30
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
USA
-
Krtolica A, Parrinello S, Lockett S, Desprez PY and Campisi J (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 98: 12072-12077
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
31
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K and Wohlgemuth SE et al. (2005) Mitochondrial DNA mutations, oxidative stress and apoptosis in mammalian aging. Science 309: 481-484
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
-
32
-
-
0037112338
-
Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury
-
LaBarge MA and Blau HM (2002) Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. Cell 111: 589-601
-
(2002)
Cell
, vol.111
, pp. 589-601
-
-
LaBarge, M.A.1
Blau, H.M.2
-
33
-
-
0027515616
-
Aging and resistance to oxidative stress in Caenorhabditis elegans
-
USA
-
Larsen P (1993) Aging and resistance to oxidative stress in Caenorhabditis elegans. Proc Natl Acad Sci USA 90: 8905-8909
-
(1993)
Proc Natl Acad Sci
, vol.90
, pp. 8905-8909
-
-
Larsen, P.1
-
34
-
-
0000977248
-
Selection for delayed senescence in Drosophila melanogaster
-
Luckinbill L, Arking R and Clare M (1984) Selection for delayed senescence in Drosophila melanogaster. Evolution 38: 996-1003
-
(1984)
Evolution
, vol.38
, pp. 996-1003
-
-
Luckinbill, L.1
Arking, R.2
Clare, M.3
-
36
-
-
0002458132
-
The effect of retarded growth upon the length of life span and upon ultimate body size
-
McCay CM, Crowell MF and Maynard LA (1935) The effect of retarded growth upon the length of life span and upon ultimate body size. J Nutr 10: 63-79
-
(1935)
J Nutr
, vol.10
, pp. 63-79
-
-
McCay, C.M.1
Crowell, M.F.2
Maynard, L.A.3
-
37
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Miggliaccio E, Giorgio M, Mele S, Pelicci G, Reholdi P and Pandolfi PP et al. (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402: 309-313
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Miggliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reholdi, P.5
Pandolfi, P.P.6
-
38
-
-
0031003513
-
Transgenic mice over-expressing urokinase-type plasminogen activator in brain exhibit reduced food consumption, body weight and increased longevity
-
Mishkin R and Masos T (1997) Transgenic mice over-expressing urokinase-type plasminogen activator in brain exhibit reduced food consumption, body weight and increased longevity. J Gerontol 52: B118-B124
-
(1997)
J Gerontol
, vol.52
-
-
Mishkin, R.1
Masos, T.2
-
39
-
-
0033518188
-
A telomerase component defective in the human disease dyskeratosis congenita
-
Mitchell JR, Wood E and Collins K (1999) A telomerase component defective in the human disease dyskeratosis congenita. Nature 402: 551-555
-
(1999)
Nature
, vol.402
, pp. 551-555
-
-
Mitchell, J.R.1
Wood, E.2
Collins, K.3
-
40
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
Morris J, Tissenbaum H and Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.1
Tissenbaum, H.2
Ruvkun, G.3
-
41
-
-
0037673940
-
A progeroid syndrome in mice is caused by defects in the A-type lamins
-
Mounkes LC, Kozlov S, Hernandez L, Sullivan T and Stewart CL (2003) A progeroid syndrome in mice is caused by defects in the A-type lamins. Nature 423: 298-301
-
(2003)
Nature
, vol.423
, pp. 298-301
-
-
Mounkes, L.C.1
Kozlov, S.2
Hernandez, L.3
Sullivan, T.4
Stewart, C.L.5
-
42
-
-
13244287677
-
Mechanisms of hair graying: Incomplete melanocyte stem cell maintenance in the niche
-
Nishimura EK, Granter SR and Fisher DE (2005) Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307: 720-724
-
(2005)
Science
, vol.307
, pp. 720-724
-
-
Nishimura, E.K.1
Granter, S.R.2
Fisher, D.E.3
-
43
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda A, Yi N, Venable SF, Pereira-Smith OM and Smith JR (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211: 90-98
-
(1994)
Exp Cell Res
, vol.211
, pp. 90-98
-
-
Noda, A.1
Yi, N.2
Venable, S.F.3
Pereira-Smith, O.M.4
Smith, J.R.5
-
44
-
-
17944371854
-
Mobilized bone marrow cells repair the infarcted heart, improving function and survival
-
USA
-
Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I and Quaini F et al. (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 98: 10344-10349
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 10344-10349
-
-
Orlic, D.1
Kajstura, J.2
Chimenti, S.3
Limana, F.4
Jakoniuk, I.5
Quaini, F.6
-
45
-
-
0000977247
-
Laboratory evolution of postponed senescence in Drosophila melanogaster
-
Rose MR (1984) Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution 38: 1004-1010
-
(1984)
Evolution
, vol.38
, pp. 1004-1010
-
-
Rose, M.R.1
-
46
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ and Greider C et al. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96: 701-712
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
-
47
-
-
0042344907
-
Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts
-
Sampaolesi M, Torrente Y, Innocenzi A, Tontorenzi R, D'Antona G and Pellogrino MA et al. (2003) Cell therapy of alpha-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts. Science 301: 487-491
-
(2003)
Science
, vol.301
, pp. 487-491
-
-
Sampaolesi, M.1
Torrente, Y.2
Innocenzi, A.3
Tontorenzi, R.4
D'Antona, G.5
Pellogrino, M.A.6
-
48
-
-
21144434217
-
Extension of life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE and Emond M et al. (2005) Extension of life span by overexpression of catalase targeted to mitochondria. Science 308: 1909-1911
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
-
49
-
-
0025052004
-
c-fos repression and an altered genetic program in senescent human fibroblasts
-
Seshadri T and Campisi J (1990) c-fos repression and an altered genetic program in senescent human fibroblasts. Science 247: 205-209
-
(1990)
Science
, vol.247
, pp. 205-209
-
-
Seshadri, T.1
Campisi, J.2
-
50
-
-
0033601746
-
Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases -2, -3, -6, -7, -8 and -10 in a caspase-9- Dependent manner
-
Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA and Newmeyer DD et al. (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases -2, -3, -6, -7, -8 and -10 in a caspase-9- dependent manner. J Cell Biol 144: 281-292
-
(1999)
J Cell Biol
, vol.144
, pp. 281-292
-
-
Slee, E.A.1
Harte, M.T.2
Kluck, R.M.3
Wolf, B.B.4
Casiano, C.A.5
Newmeyer, D.D.6
-
51
-
-
2342535103
-
Cord-blood transplants from unrelated donors in patients with Hurler's syndrome
-
Staba SL, Escolar ML, Poe M, Kim Y, Martin PL and Szabolcs P et al. (2004) Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. N Eng J Med 350: 1960-1969
-
(2004)
N Eng J Med
, vol.350
, pp. 1960-1969
-
-
Staba, S.L.1
Escolar, M.L.2
Poe, M.3
Kim, Y.4
Martin, P.L.5
Szabolcs, P.6
-
52
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
Tatar M, Kopelmann A, Epstein D, Tu M-P, Yin C-M and Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-110
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelmann, A.2
Epstein, D.3
Tu, M.-P.4
Yin, C.-M.5
Garofalo, R.S.6
-
53
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA and Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
54
-
-
2642580016
-
Premature aging in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT and Bruder CE et al. (2004) Premature aging in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
-
55
-
-
0037011958
-
p53 mutant mice that display early age-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N and Igelmann H et al. (2002) p53 mutant mice that display early age-associated phenotypes. Nature 415: 45-53
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
-
56
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N and Thorpe SR et al. (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 16: 29-37
-
(2003)
Physiol Genomics
, vol.16
, pp. 29-37
-
-
Van Remmen, H.1
Ikeno, Y.2
Hamilton, M.3
Pahlavani, M.4
Wolf, N.5
Thorpe, S.R.6
-
57
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
van Steensel B, Smogorzewska A and de Lange T (1998) TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
58
-
-
0032827888
-
Deletion of ku86 causes early onset of senescence in mice
-
USA
-
Vogel H, Lim D-S, Karsenty G, Finegold M and Hasty P (1999) Deletion of ku86 causes early onset of senescence in mice. Proc Natl Acad Sci USA 96: 10770-10775
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.-S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
59
-
-
11144308949
-
Longevity genes: From primitive organisms to humans
-
Warner HR (2005) Longevity genes: from primitive organisms to humans. Mech Ageing Dev 126: 235-242
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 235-242
-
-
Warner, H.R.1
-
60
-
-
0037726549
-
Models of accelerated aging can be informative about the molecular mechanisms of ageing and/ or age-related pathology
-
Warner HR and Sierra F (2003) Models of accelerated aging can be informative about the molecular mechanisms of ageing and/ or age-related pathology. Mech Ageing Dev 124: 581-587
-
(2003)
Mech Ageing Dev
, vol.124
, pp. 581-587
-
-
Warner, H.R.1
Sierra, F.2
-
62
-
-
0343962628
-
Program for testing biological interventions to promote healthy aging
-
Warner HR, Ingram D, Miller RA, Nadon NA and Richardson AG (2000) Program for testing biological interventions to promote healthy aging. Mech Ageing Dev 115: 199-207
-
(2000)
Mech Ageing Dev
, vol.115
, pp. 199-207
-
-
Warner, H.R.1
Ingram, D.2
Miller, R.A.3
Nadon, N.A.4
Richardson, A.G.5
-
64
-
-
0032573066
-
Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
-
USA
-
Yan L-J and Sohal RS (1998) Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci USA 95: 12896-12901
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 12896-12901
-
-
Yan, L.-J.1
Sohal, R.S.2
-
65
-
-
0030881686
-
Oxidative damage during aging targets mitochondrial aconitase
-
USA
-
Yan L-J, Levine RL and Sohal RS (1997) Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci USA 94: 11168-11172
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 11168-11172
-
-
Yan, L.-J.1
Levine, R.L.2
Sohal, R.S.3
-
66
-
-
0029759443
-
Aging and oxidative stress: Modulation by dietary restriction
-
Yu BP (1996) Aging and oxidative stress: modulation by dietary restriction. Free Radic Biol Med 21: 651-668
-
(1996)
Free Radic Biol Med
, vol.21
, pp. 651-668
-
-
Yu, B.P.1
-
67
-
-
0025255636
-
The Caenorhabditis elegans genes ced-3 and ced-4 act autonomously to cause programmed cell death
-
Yuan J and Horvitz HR (1990) The Caenorhabditis elegans genes ced-3 and ced-4 act autonomously to cause programmed cell death. Dev Biol 138: 33-41
-
(1990)
Dev Biol
, vol.138
, pp. 33-41
-
-
Yuan, J.1
Horvitz, H.R.2
-
68
-
-
0027525104
-
The C. elegans cell death gene ced-3 gene codes for a protein similar to mammalian interleukin-1β-converting enzyme
-
Yuan J, Shaham S, Ledoux S, Ellis HM and Horvitz HR (1993) The C. elegans cell death gene ced-3 gene codes for a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75: 641-652
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan, J.1
Shaham, S.2
Ledoux, S.3
Ellis, H.M.4
Horvitz, H.R.5
|