What does cell death have to do with aging?

Journal of the American Geriatrics Society

Volumn 45, Issue 9, 1997, Pages 1140-1146

  Warner, Huber R ^b   Hodes, Richard J ^b   Pocinki, Karen ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; DEGENERATIVE DISEASE; FIBROBLAST; HUMAN; HUMAN CELL; PARKINSON DISEASE; SEQUENCE HOMOLOGY;

EID: 0030765215     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1997.tb05981.x     Document Type: Article

References (104)

1. Campisi J. Replicative senescence: An old lives tale? Cell 1996;84:497-500.
2. Campisi J, Dimri G, Hara E. Control of replicative senescence. In: Handbook of the Biology of Aging, 4th Ed. E Schneider, J Rowe, eds. New York: Academic Press, 1996, pp. 121-149.
3. Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-9367.
4. Columbano A. Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J Cell Biochem 1995;58:181-190.
5. Kerr JFR, Wyllie AH, Currie AR. Apoptosis. A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
6. Nagata S, Golstein P. The Fas death factor. Science 1995;1995:1449-1456.
7. Ogawa N, Dang H, Talal N. Apoptosis and autoimmunity. J Autoimmun 1995;8:1-19.
8. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-1462.
9. Vaux DL, Cory S, Adams J. bcl-2 gene promotes hacmopoietic cell survial and cooperates with c-myc to immortalize pre-B cells. Nature 1988;335:440-442.
10. Williams GT. Programmed cell death: Apoptosis and oncogenesis. Cell 1991;65:1097-1098.
11. Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell 1997;88:347-354.
12. Franceschi C, Monti D, Scarfi MR et al. Genomic instability and aging. Ann NY Acad Sci 1992;663:4-16.
13. Bonfoco E, Krainc D, Ankarcrona M et al. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 1995;92:7162-7165.
14. Kastan MB, Zhan Q, El-Deiry WS et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992;71:587-597.
15. Paulovich AG, Toczyski DP, Hartwell LH. When checkpoints fail. Cell 1997;88:315-321.
16. Pellegata NS, Antomono RJ, Redpath JL, Stanbridge EJ. DNA damage and p53-mediated cell cycle arrest: A reevaluation. Proc Nat Acad Sci USA. 1997;93:15209-15214.
17. Ellis RE, Yuan J, Horvitz HR. Mechanisms and functions of cell death. Annu Rev Cell Biol 1991;7:663-698.
18. Yuan J, Horvitz HR. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol 1990;138:33-41.
19. Hengartner MO, Horvitz HR. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994;76:665-676.
20. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365.
21. Yuan J, Shaham S, Ledoux S et al. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 1993;75:641-652.
22. Miura M, Zhu H, Rotello R et al. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of C. elegans cell death gene ced-3. Cell 1993;75:653-660.
23. Tewari M, Quan LT, O'Rourke K et al. Yama/CPP32β, a mammalian homolog of ced-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 1995;81:801-809.
24. Chen-Levy Z, Nourse J, Cleary ML. The bcl-2 candidate protooncogene product is a 24-kd integral membrane protein highly expressed in lymphoid lines and lymphomas carrying the 5 (14; 18) translocation. Mol Cell Biol 1989;9:701-710.
25. White E. Life, death and the pursuit of apoptosis. Genes Dev 1996;10:1-15.
26. Oltvai Z, Milliman C, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-619.
27. Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death. Science 1997;275:1122-1126.
28. Hevelone J, Hartman PS. An endonuclease from Caenorhaditis elegans: Partial purification and characterization. Biochem Genet 1988;26:447-461.
29. Wyllie AH. Glucocorticord-induced thymocyte apoptosis is associated with endogenous nuclease activation. Nature 1980;284:555-556.
30. Kayalar C, Ord T, Testa MP et al. Cleavage of actin by interleukin 1β-converting enzyme to reserve DNase I inhibition. Proc Natl Acad Sci USA 1995;93:2234-2238.
31. Hanawalt PC. Transcription-coupled repair and human disease. Science 1994;266:1957-1958.
32. Sancar A. Mechanisms of DNA excision repair. Science 1994;266:1954-1956.
33. Wang E. Senescent human fibroblasts resist programmed cell death and failure to suppress bcl-2 is involved. Cancer Res 1995;55:2284-2292.
34. Wang E, Lee MJ, Pandey S. Control of fibroblast senescence and activation of programmed cell death. J Cell Biochem 1994;54:432-439.
35. Warner HR, Fernandes G, Wang E. A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction. J Gerontol 1995;50A:B107-109.
36. Grasl-Kraupp B, Bursh W, Ruttkay-Nedecky B et al. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc Natl Acad Sci USA 1994;91:9995-9999.
37. James SJ, Muskhelishvili L. Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57B/6 x C3HF1 mice. Cancer Res 1994;54:5508-5510.
38. Watanabe-Fukunaga R, Brannan CI, Copeland NG et al. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992;356:314-317.
39. Takahashi T, Tanaka M, Brannan CI et al. Generalized lymphoproliferative disease in mice caused by a point mutation in the fas ligand. Cell 1994;76:969-976.
40. Luan X, Zhao W, Chandrasekar B, Fernandes G. Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice. Immunol Lett 1995;47:181-186.
41. Zhou T, Edwards CK, Mountz JD. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J Exp Med 1995;182:129-137.
42. Rieux-Laucat F, Le Deist F, Hivroz C et al. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 1995;268:1347-1349.
43. Fisher GH, Rosenberg FJ, Straus SE et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative disease. Cell 1995;81:935-946.
44. Aringer M, Wintersberger W, Steiner CW et al. High levels of bcl-2 protein in circulating T-lymphocytes, but not β lymphocytes, of patients with systemic lupus erythematosus. Arthritis Rheum 1994;37:1423-1430.
45. Deckwerth TL, Johnson EM. Temporal analysis of early events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factors. J Cell Biol 1993;123:1207-1222.
46. Gagliardini V, Fernandez P-A, Lee RKK et al. Prevention of vertibrate neuronal death by the crmA gene. Science 1994;263:826-828.
47. Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell 1986;44:817-829.
48. Hong K, Driscoll M. A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature 1994;367:470-473.
49. Kane DJ, Ord T, Anton R, Bredesen DE. Expression of bcl-2 inhibits necrotic neural cell death. J. Neurosci Res 1995;40:269-275.
50. Zhong LT, Sarafian T, Kane DJ et al. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 1993;90:4533-4537.
51. Farlie PG, Dringen R, Rees SM et al. bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc Natl Acad Sci USA 1995;92:4397-4401.
52. Gonzalez-Garcia M, Garcia I, Ding L et al. bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death. Proc Natl Acad Sci USA 1995;92:4304-4308.
53. Smale G, Nichols NR, Brady DR et al. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995;133:225-230.
54. Dragunow M, Faull RL, Lawlor P et al. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport 1995;9:1053-1057.
55. Butterfield DA, Hensley K, Harris M, et al. β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease. Biochem Biophys Res Commun 1994;200:710-715.
56. Hensley K, Carney JM, Mattson MP et al. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimers disease. Proc Nat Acad Sci USA 1994;91:3270-3274.
57. Loo DT, Copani A, Pike CJ et al. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 1993;90:7951-7955.
58. Hsaio K, Chapman P, Nilsen S et al. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science 1996;274:99-102.
59. Wolozin B, Iwasaki K, Vito P et al. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 1996;274:1710-1713.
60. Kusiak JW, Izzo JA, Zhao B. Neurodegeneration in Alzheimer disease. Is apoptosis involved? Mol Chem Neuropathol 1996;28:153-162.
61. Rosen DR, Siddique T, Patterson D et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62.
62. Rabizadeh S, Gralla EB, Borchelt DR et al. Mutations associated with amyotrophic lateral sclerosis convert Superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci USA 1995;92:3024-3028.
63. Ripps ME, Huntley GW, Hof PR. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA. 1995;92:689-693.
64. Gurney ME, Pu H, Chiu AY. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation. Science 1994;264:1772-1775.
65. Thomas LB, Gates DJ, Richfield EK et al. DNA end labelling (TUNEL) in Huntington's disease and other neuropathological conditions. Exp Neurol 1995;133:265-272.
66. Protera-Cailliau C, Hedreen JC, Price DL, Koliatsos VE. Evidence for apoptotic cell death in Huntington's disease and excitotoxic animal models. J Neurosci 1995;15:3775-3787.
67. Goldberg YP, Nicholson DW, Rasper DM et al. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet 1996;13:442-449.
68. Nakao N, Frodl EM, Widner H et al. Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nature Med 1995;1:226-231.
69. Polymeropoulos MH, Higgins JJ, Golbe LI et al. Mapping of a gene for Parkinson's disease to chromosome 4q21-q23. Science 1996;274:1197-1199.
70. Lindsay RM. Neuron saving schemes. Nature 1995;373:289-290.
71. Choi-Lundberg DL, Lin Q, Chang Y-N et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 1997;275:838-841.
72. Gage FH, Ray J, Fisher LJ. Isolation, characterization and use of stem cells from the CNS. Annu Rev Neurosci 1995;18:159-192.
73. Hara H, Friedlander RM, Gagliardini V et al. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 1997;94:2007-2012.
74. Friedlander RM, Gagliardini V, Hara H et al. Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med 1997;185:933-940.
75. Selkoe DJ. Alzheimer's disease: Genotypes, phenotype, and treatments. Science 1997;275:630-631.
76. Chen DF, Schneider GE, Martinou J-C, Tonegawa S. bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 1997;385:434-439.
77. Broome HJ, Holtz J. Apoptosis in the heart: When and why? Mol Cell Biochem 1996;163-164:261-275.
78. Olivetti G, Abbi R, Quaini F et al. Apoptosis in the failing human heart. New Engl J Med 1997;336:1131-1141.
79. Saraste A, Pulkki K, Kallajoki M et al. Apoptosis in human acute myocardial infarction. Circulation 1997;95:320-323.
80. Bardales RH, Hailey LS, Xie SS et al. In situ apoptosis assay for the detection of early acute myocardial infarction. Am J Pathol 1996; 149:821-829.
81. Misao J, Hayakawa Y, Ohno M et al. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation 1996;94:1506-1512.
82. Narula J, Haider N, Virmani, et al. Apoptosis in end-stage heart failure. N Engl J Med 1996;335:1182-1189.
83. Cheng W, Kajstura J, Nitahara JA et al. Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res 1996;226:316-327.
84. Fliss H, Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res 1996;949-956.
85. Kajstura J, Cheng W, Reiss K, et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 1996;74:86-107.
86. Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atheroscleoris and restenosis. Circulation 1995;91:2703-2711.
87. Newby AC, George SJ. Proliferation, migration, matrix turnover, and death of smooth muscle cells in native coronary and vein graft atherosclerosis. Curr Opin Cardiol 1996;11:574-582.
88. Han DK, Haudenschild CC, Hong MK et al. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model. Am J Pathol 1995;147:267-277.
89. Hughes DE, Dai A, Tiffee JC et al. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β. Nature Med 1996;2:1132-1136.
90. Rogers MJ, Chilton KM, Coxon FP et al. Biphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism. J Bone Miner Res 1996;11:1482-1491.
91. Nikells RW. Retinal ganglion cell death in glaucoma: The how, the why, and the maybe. J Glaucoma 1996;5:345-356.
92. Didenko W, Wang X, Yang L, Hornsby PJ. Expression of p21 (WAF1/ CIP1/SDI1) and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury. J Clin Invest 1996;97:1723-1731.
93. Zenmyo M, Komiya S, Kawabata R et al. Morphological and biochemical evidence for apoptosis in the terminal hypertrophie chondrocytes of the growth plate. J Pathol 1996;180:430-433.
94. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995;96:1631-1638.
95. Nakajima T, Aono H, Hasunuma T et al. Apoptosis and functional fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 1995;38:485-491.
96. Hasunuma T, Hoa TT, Aono T et al. Induction of Fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthritis. Int Immunol 1996;8:1595-1602.
97. Ogawa N, Dang H, Kong L et al. Lymphocyte apoptosis and apoptosis-associated gene expression in Sjogren's syndrome. Arthritis Rheum 1996;39:1875-1885.
98. Iwata M, Myerson D, Torok-Storb B, Zager RA. An evaluation of renal tubular DNA laddering in response to oxygen deprivation and oxidant injury. J Am Soc Nephrol 1994;5:1307-1313.
99. Zager RA, Fuerstenberg SM, Baehr PH et al. An evaluation of antioxidant effects on recovery from postischemic acute renal failure. J Am Soc Nephrol 1994;4:1588-1597.
100. Lockshin RA, Zakeri ZF. Programmed cell death: New thoughts and relevance to aging. J Gerontol 1990;45:B135-140.
101. Barr PJ, Tomei LD. Apoptosis and its role in human disease. Biotechnology 1994;12:487-493.
102. Liu Y, Hernandez AM, Shibata D, Cortopassi GA. bcl-2 translocation frequency rises with age in humans. Proc Natl Acad Sci USA 1994;91:8910-8914.
103. Driscoll M. Genes controlling programmed cell death: Relationship to mechanisms of cell senescence and aging. In: Molecular Aspects of Aging. EsserK, Martin GM, eds. Chichester, England: John Wiley & Sons, 1995, pp 45-48.
104. Wang L, Miura M, Bergeron L et al. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death Cell 1994;78:739-750.