Cell therapy of α-sarcoglycan null dystrophic mice through intra-arterial delivery of mesoangioblasts

Science

Volumn 301, Issue 5632, 2003, Pages 487-492

  Sampaolesi, Maurilio ^a   Torrente, Yvan ^b   Innocenzi, Anna ^a   Tonlorenzi, Rossana ^a   D'Antona, Giuseppe ^c   Pellegrino, M Antonietta ^c   Barresi, Rita ^d   Bresolin, Nereo ^b,e   De Angelis, M Gabriella Cusella ^a,c   Campbell, Kevin P ^d   Bottinelli, Roberto ^c   Cossu, Giulio ^a,f,g  

^a Stem Cell Research Institute   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY OF IOWA   (United States)

^e SCIENTIFIC INSTITUTE   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g Institute of Cell Biology and Tissue Engineering   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; CELLS; MEDICINE; MUSCLE;

STEM CELLS;

CYTOLOGY;

ALPHA SARCOGLYCAN; LENTIVIRUS VECTOR; SARCOGLYCAN; UNCLASSIFIED DRUG; VIRUS VECTOR;

MICROBIOLOGY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; GENE TRANSFER; LIMB GIRDLE MUSCULAR DYSTROPHY; MESOANGIOBLAST; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; TRANSGENIC MOUSE;

ANIMALS; BLOOD VESSELS; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DYSTROPHIN; ENDOTHELIUM, VASCULAR; FEMALE; FEMORAL ARTERY; GENETIC VECTORS; LENTIVIRUS; LOCOMOTION; MALE; MEMBRANE GLYCOPROTEINS; MESODERM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUSCLE CONTRACTION; MUSCLE FIBERS; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; REGENERATION; SARCOGLYCANS; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSFECTION;

ANIMALIA; LENTIVIRUS; MUS MUSCULUS;

EID: 0042344907     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082254     Document Type: Article

References (38)

1. D. Skuk, J. T. Vilquin, J. P. Tremblay, Curr. Opin. Neurol. 15, 563 (2002).
2. G. Cossu, F. Mavilio, J. Clin. Invest. 105, 1669 (2000).
3. M. G. Minasi et al., Development 129, 2773 (2002).
4. M. Sampaolesi et al., unpublished data.
5. M. Ramalho-Santos, S. Yoon, Y. Matsuzaki, R. C. Mulligan, D. A. Melton, Science 298, 597 (2002).
6. N. B. Ivanova et al., Science 298, 601 (2002).
7. E. Tagliafico et al., unpublished data.
8. R. Palumbo et al., in preparation.
9. P. Scaffidi, T. Misteli, M. E. Bianchi, Nature 418, 191 (2002).
10. J. R. Beauchamps et al., J. Cell Biol. 144, 1113 (1999).
11. Y. Torrente et al., J. Cell Biol. 152, 335 (2001).
12. P. Duclos et al., J. Cell Biol. 142, 1461 (1998).
13. T. Takada et al., Nature Biotechnol. 5, 458 (1997).
14. G. Condorelli et al., Proc. Natl. Acad. Sci. U.S.A. 98, 10733 (2001).
15. FISH analysis was performed using the kit from Vysis, following manufacturer instructions.
16. M. Sampaolesi et al., data not shown.
17. P. Seale, A. Asakura, M. A. Rudnicki, Dev. Cell 1, 333 (2001).
18. M. Durbey, K. P. Campbell, Curr. Opin. Genet. Dev. 12, 349 (2002).
19. R. Bottinelli, R. Betto, S. Schiaffino, C. Reggiani, J. Physiol. 478, 341 (1994).
20. M. A. Pellegrino et al., J. Physiol. 546, 677 (2003).
21. R. Bottinelli, C. Reggriani, Prog. Biophys. Mol. Biol. 73, 195 (2000).
22. S. Weiss, R. Rossi, M. A. Pellegrino, R. Bottinelli, M. A. Geeves, J. Biol. Chem. 276, 45902 (2001).
23. O. Pansarasa et al., Eur. J. Appl. Physiol. 87, 550 (2002).
24. D. Dressman et al., Hum. Gene Ther. 13, 1631 (2002).
25. G. Ferrari et al., Science 279, 1528 (1998).
26. E. Gussoni et al., Nature 401, 390 (1999).
27. A. Asakura, P. Seale, A. Girgis-Gabardo, M. A. Rudnicki, J. Cell Biol. 159, 123 (2002).
28. M. A. LaBarge, H. M. Blau, Cell 111, 589 (2002).
29. G. Ferrari, A. Stomaiuolo, F. Mavilio, Nature 411, 1014 (2001).
30. C. Dello Russo et al., Proc. Natl. Acad. Sci. U.S.A. 99, 12979 (2002).
31. K. Yuasa et al., Gene Ther. 9, 1576 (2002).
32. E. R. Barton et al., J. Cell Biol. 157, 137 (2002).
33. S. Bogdanovic et al., Nature 420, 418 (2002).
34. Y. Jiang et al., Nature 418, 41 (2002).
35. R. R. MacGregor, Hum. Gene Ther. 12, 2028 (2001).
36. S. Q. Harper et al., Nature Med. 8, 253 (2002).
37. F. De Angelis et al., Proc. Natl. Acad. Sci. U.S.A. 99, 9456 (2002).
38. We thank C. Bordignon, M. Buckingham, and N. Rosenthal for critical reading of the manuscript and helpful suggestions. G.C. dedicates this paper to the late Franco Tatò, whose scientific insights and subtle sense of humor are still sadly missed. Supported by grants from Telethon/Fondazione Zegna, the European Community, Duchenne Parent Project Italia/Compagnia di San Paolo, Muscular Dystrophy Association (USA), Fondazione Istituto Pasteur-Cenci Bolognetti, Associazione Italiana Ricerca sul Cancro, Agenzia Spaziale Italiana, the Association Francoise contra les Myopathies, and the Italian Ministry of Health. K.P.C. is an investigator of the Howard Hughes Medical Institute.