-
1
-
-
0026319007
-
The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion
-
doi:10.1016/0022-2828(91)90183-M
-
Ambrosio, G., Zweier, J. L. & Flaherty, J. T. 1991 The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion. J. Mol. Cell Cardiol. 23, 1359-1374. (doi:10.1016/0022-2828(91)90183-M.)
-
(1991)
J. Mol. Cell Cardiol
, vol.23
, pp. 1359-1374
-
-
Ambrosio, G.1
Zweier, J.L.2
Flaherty, J.T.3
-
2
-
-
0027181186
-
Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow
-
Ambrosio, G. et al. 1993 Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. J. Biol. Chem. 268, 18 532-18 541.
-
(1993)
J. Biol. Chem
, vol.268
-
-
Ambrosio, G.1
-
3
-
-
0032547309
-
Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide
-
doi:10.1006/bbrc. 1998.9171
-
Andersson, U., Leighton, B., Young, M. E., Blomstrand, E. & Newsholme, E. A. 1998 Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Biochem. Biophys. Res. Commun. 249, 512-516. (doi:10.1006/bbrc. 1998.9171.)
-
(1998)
Biochem. Biophys. Res. Commun
, vol.249
, pp. 512-516
-
-
Andersson, U.1
Leighton, B.2
Young, M.E.3
Blomstrand, E.4
Newsholme, E.A.5
-
4
-
-
0014670576
-
Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein
-
doi:10.1016/0006-291X(69)90288-5
-
Ballou, D., Palmer, G. & Massey, V. 1969 Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein. Biochem. Biophys. Res. Commun. 36, 898-904. (doi:10.1016/0006-291X(69)90288-5.)
-
(1969)
Biochem. Biophys. Res. Commun
, vol.36
, pp. 898-904
-
-
Ballou, D.1
Palmer, G.2
Massey, V.3
-
5
-
-
0026083374
-
Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase
-
Bando, Y. & Aki, K. 1991 Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase. J. Biochem. (Tokyo) 109, 450-454.
-
(1991)
J. Biochem. (Tokyo)
, vol.109
, pp. 450-454
-
-
Bando, Y.1
Aki, K.2
-
6
-
-
0030273295
-
Mitochondria, free radicals, and neurodegeneration
-
doi:10.1016/S0959-4388(96) 80100-0
-
Beal, M. F. 1996 Mitochondria, free radicals, and neurodegeneration. Curr. Opin. Neurobiol. 6, 661-666. (doi:10.1016/S0959-4388(96) 80100-0.)
-
(1996)
Curr. Opin. Neurobiol
, vol.6
, pp. 661-666
-
-
Beal, M.F.1
-
7
-
-
0035344211
-
Experimental models of Parkinson's disease
-
doi:10.1038/35072550
-
Beal, M. F. 2001 Experimental models of Parkinson's disease. Nat. Rev. Neurosci. 2, 325-334. (doi:10.1038/35072550.)
-
(2001)
Nat. Rev. Neurosci
, vol.2
, pp. 325-334
-
-
Beal, M.F.1
-
8
-
-
0029092913
-
4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium
-
Blasig, I. E., Grune, T., Schonheit, K., Rohde, E., Jakstadt, M., Haseloff, R. F. & Siems, W. G. 1995 4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium. Am. J. Physiol. 269, H14-H22.
-
(1995)
Am. J. Physiol
, vol.269
-
-
Blasig, I.E.1
Grune, T.2
Schonheit, K.3
Rohde, E.4
Jakstadt, M.5
Haseloff, R.F.6
Siems, W.G.7
-
9
-
-
0023785749
-
Demonstration of free radical generation in 'stunned' myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone
-
Bolli, R., Patel, B. S., Jeroudi, M. O., Lai, E. K. & McCay, P. B. 1988 Demonstration of free radical generation in 'stunned' myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone. J. Clin. Invest. 82, 476-485.
-
(1988)
J. Clin. Invest
, vol.82
, pp. 476-485
-
-
Bolli, R.1
Patel, B.S.2
Jeroudi, M.O.3
Lai, E.K.4
McCay, P.B.5
-
10
-
-
0015882341
-
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
-
Boveris, A. & Chance, B. 1973 The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 134, 707-716.
-
(1973)
Biochem. J
, vol.134
, pp. 707-716
-
-
Boveris, A.1
Chance, B.2
-
11
-
-
0015363173
-
The cellular production of hydrogen peroxide
-
Boveris, A., Oshino, N. & Chance, B. 1972 The cellular production of hydrogen peroxide. Biochem. J. 128, 617-630.
-
(1972)
Biochem. J
, vol.128
, pp. 617-630
-
-
Boveris, A.1
Oshino, N.2
Chance, B.3
-
12
-
-
0017154414
-
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
-
Boveris, A., Cadenas, E. & Stoppani, A. O. 1976 Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem. J. 156, 435-444.
-
(1976)
Biochem. J
, vol.156
, pp. 435-444
-
-
Boveris, A.1
Cadenas, E.2
Stoppani, A.O.3
-
13
-
-
0034607467
-
2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex
-
doi:10.1074/jbc.275.18.13441
-
2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex. J. Biol. Chem. 275, 13 441-13 447. (doi:10.1074/jbc.275.18.13441.)
-
(2000)
J. Biol. Chem
, vol.275
-
-
Brown, A.M.1
Kristal, B.S.2
Effron, M.S.3
Shestopalov, A.I.4
Ullucci, P.A.5
Sheu, K.F.6
Blass, J.P.7
Cooper, A.J.8
-
14
-
-
0021253074
-
Calcium inhibition of the NAD+-linked isocitrate dehydrogenase from blowfly flight muscle mitochondria
-
Bulos, B. A., Thomas, B. J. & Sacktor, B. 1984 Calcium inhibition of the NAD+-linked isocitrate dehydrogenase from blowfly flight muscle mitochondria. J. Biol. Chem. 259, 10 232-10 237.
-
(1984)
J. Biol. Chem
, vol.259
-
-
Bulos, B.A.1
Thomas, B.J.2
Sacktor, B.3
-
15
-
-
0037352050
-
2-Oxo acid dehydrogenase complexes in redox regulation
-
doi:10.1046/j.1432-1033.2003. 03470.x
-
Bunik, V. I. 2003 2-Oxo acid dehydrogenase complexes in redox regulation. Eur. J. Biochem. 270, 1036-1042. (doi:10.1046/j.1432-1033.2003. 03470.x.)
-
(2003)
Eur. J. Biochem
, vol.270
, pp. 1036-1042
-
-
Bunik, V.I.1
-
16
-
-
0036408866
-
Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species
-
doi:10.1046/j.1432-1033.2002.03204.x
-
Bunik, V. I. & Sievers, C. 2002 Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species. Eur. J. Biochem. 269, 5004-5015. (doi:10.1046/j.1432-1033.2002.03204.x.)
-
(2002)
Eur. J. Biochem
, vol.269
, pp. 5004-5015
-
-
Bunik, V.I.1
Sievers, C.2
-
17
-
-
0025650037
-
Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease
-
doi:10.1007/BF00997071
-
Butterworth, R. F. & Besnard, A. M. 1990 Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab. Brain Dis. 5, 179-184. (doi:10.1007/BF00997071.)
-
(1990)
Metab. Brain Dis
, vol.5
, pp. 179-184
-
-
Butterworth, R.F.1
Besnard, A.M.2
-
18
-
-
0027131501
-
Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome
-
Butterworth, R. F., Kril, J. J. & Harper, C. G. 1993 Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. Alcohol Clin. Exp. Res. 17, 1084-1088.
-
(1993)
Alcohol Clin. Exp. Res
, vol.17
, pp. 1084-1088
-
-
Butterworth, R.F.1
Kril, J.J.2
Harper, C.G.3
-
19
-
-
0017406503
-
Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria
-
doi:10.1016/0003-9861(77)90035-2
-
Cadenas, E., Boveris, A., Ragan, C. I. & Stoppani, A. O. 1977 Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch. Biochem. Biophys. 180, 248-257. (doi:10.1016/0003-9861(77)90035-2.)
-
(1977)
Arch. Biochem. Biophys
, vol.180
, pp. 248-257
-
-
Cadenas, E.1
Boveris, A.2
Ragan, C.I.3
Stoppani, A.O.4
-
20
-
-
0023887866
-
Oxygen free radical involvement in ischemia and reperfusion injury to brain
-
doi:10.1016/0304-3940(88)90132-2
-
Cao, W., Carney, J. M., Duchon, A., Floyd, R. A. & Chevion, M. 1988 Oxygen free radical involvement in ischemia and reperfusion injury to brain. Neurosci. Lett. 88, 233-238. (doi:10.1016/0304-3940(88)90132-2.)
-
(1988)
Neurosci. Lett
, vol.88
, pp. 233-238
-
-
Cao, W.1
Carney, J.M.2
Duchon, A.3
Floyd, R.A.4
Chevion, M.5
-
21
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
doi:10.1046/j.0022- 3042.2001.00681.x
-
Casley, C. S., Canevari, L., Land, J. M., Clark, J. B. & Sharpe, M. A. 2002 Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J. Neurochem. 80, 91-100. (doi:10.1046/j.0022- 3042.2001.00681.x.)
-
(2002)
J. Neurochem
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
22
-
-
0019320740
-
Glyceraldehyde-3-phosphate dehydrogenase-catalyzed chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals
-
Chan, P. C. & Bielski, B. H. 1980 Glyceraldehyde-3-phosphate dehydrogenase-catalyzed chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals. J. Biol. Chem. 255, 874-876.
-
(1980)
J. Biol. Chem
, vol.255
, pp. 874-876
-
-
Chan, P.C.1
Bielski, B.H.2
-
23
-
-
0023879595
-
Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes
-
Cheeseman, A. J. & Clark, J. B. 1988 Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes. J. Neurochem. 50, 1559-1565.
-
(1988)
J. Neurochem
, vol.50
, pp. 1559-1565
-
-
Cheeseman, A.J.1
Clark, J.B.2
-
24
-
-
0035162338
-
Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: Relevance to Parkinson's disease
-
doi:10.1046/j.1471-4159.2001.00060.x
-
Chinopoulos, C. & Adam-Vizi, V. 2001 Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J. Neurochem. 76, 302-306. (doi:10.1046/j.1471-4159.2001.00060.x.)
-
(2001)
J. Neurochem
, vol.76
, pp. 302-306
-
-
Chinopoulos, C.1
Adam-Vizi, V.2
-
25
-
-
0033000269
-
Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: Inhibition of alpha-ketoglutarate dehydrogenase
-
doi:10.1046/j.1471-4159.1999.0730220.x
-
Chinopoulos, C., Tretter, L. & Adam-Vizi, V. 1999 Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase. J. Neurochem. 73, 220-228. (doi:10.1046/j.1471-4159.1999.0730220.x.)
-
(1999)
J. Neurochem
, vol.73
, pp. 220-228
-
-
Chinopoulos, C.1
Tretter, L.2
Adam-Vizi, V.3
-
26
-
-
0034653388
-
Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: The role of ATP depletion & rise of [Ca(2+)](i)
-
Chinopoulos, C., Tretter, L., Rozsa, A. & Adam-Vizi, V. 2000 Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: the role of ATP depletion & rise of [Ca(2+)](i). J. Neurosci. 20, 2094-2103.
-
(2000)
J. Neurosci
, vol.20
, pp. 2094-2103
-
-
Chinopoulos, C.1
Tretter, L.2
Rozsa, A.3
Adam-Vizi, V.4
-
27
-
-
0019769085
-
Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart
-
Cooney, G. J., Taegtmeyer, H. & Newsholme, E. A. 1981 Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart. Biochem. J. 200, 701-703.
-
(1981)
Biochem. J
, vol.200
, pp. 701-703
-
-
Cooney, G.J.1
Taegtmeyer, H.2
Newsholme, E.A.3
-
28
-
-
0027686249
-
Oxidative stress, glutamate and neurodegenerative disorders
-
Coyle, J. T. & Puttfarcken, P. 1993 Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689-695.
-
(1993)
Science
, vol.262
, pp. 689-695
-
-
Coyle, J.T.1
Puttfarcken, P.2
-
29
-
-
0019170947
-
On the role of the calcium transport cycle in heart and other mammalian mitochondria
-
doi:10.1016/0014-5793(80)80986-0
-
Denton, R. M. & McCormack, J. G. 1980 On the role of the calcium transport cycle in heart and other mammalian mitochondria. FEBS Lett. 119, 1-8. (doi:10.1016/0014-5793(80)80986-0.)
-
(1980)
FEBS Lett
, vol.119
, pp. 1-8
-
-
Denton, R.M.1
McCormack, J.G.2
-
30
-
-
0015347784
-
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase
-
Denton, R. M., Randle, P. J. & Martin, B. R. 1972 Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase. Biochem. J. 128, 161-163.
-
(1972)
Biochem. J
, vol.128
, pp. 161-163
-
-
Denton, R.M.1
Randle, P.J.2
Martin, B.R.3
-
31
-
-
0018252101
-
Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues
-
Denton, R. M., Richards, D. A. & Chin, J. G. 1978 Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues. Biochem. J. 176, 899-906.
-
(1978)
Biochem. J
, vol.176
, pp. 899-906
-
-
Denton, R.M.1
Richards, D.A.2
Chin, J.G.3
-
32
-
-
0038637993
-
Zinc inhibition of cellular energy production: Implications for mitochondria and neurodegeneration
-
Dineley, K. E., Votyakova, T. V. & Reynolds, I. J. 2003 Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. J. Neurochem. 85, 563-570.
-
(2003)
J. Neurochem
, vol.85
, pp. 563-570
-
-
Dineley, K.E.1
Votyakova, T.V.2
Reynolds, I.J.3
-
33
-
-
0026555280
-
Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons
-
Duchen, M. R. 1992 Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochem. J. 283, 41-50.
-
(1992)
Biochem. J
, vol.283
, pp. 41-50
-
-
Duchen, M.R.1
-
34
-
-
0030575298
-
Limitation of glycolysis by hexokinase in rat brain synaptosomes during intense ion pumping
-
doi:10.1016/0006-8993(96)00324- 1
-
Erecinska, M., Nelson, D., Deas, J. & Silver, I. A. 1996 Limitation of glycolysis by hexokinase in rat brain synaptosomes during intense ion pumping. Brain Res. 726, 153-159. (doi:10.1016/0006-8993(96)00324- 1.)
-
(1996)
Brain Res
, vol.726
, pp. 153-159
-
-
Erecinska, M.1
Nelson, D.2
Deas, J.3
Silver, I.A.4
-
35
-
-
0025814980
-
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
-
doi:10.1016/0891-5849(91)90192-6
-
Esterbauer, H., Schaur, R. J. & Zollner, H. 1991 Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11, 81-128. (doi:10.1016/0891-5849(91)90192-6.)
-
(1991)
Free Radic. Biol. Med
, vol.11
, pp. 81-128
-
-
Esterbauer, H.1
Schaur, R.J.2
Zollner, H.3
-
36
-
-
1642498212
-
Zinc and excitotoxic brain injury: A new model
-
doi:10.1177/1073858403255840
-
Frederickson, C. J., Maret, W. & Cuajungco, M. P. 2004 Zinc and excitotoxic brain injury: a new model. Neuroscientist 10, 18-25. (doi:10.1177/1073858403255840.)
-
(2004)
Neuroscientist
, vol.10
, pp. 18-25
-
-
Frederickson, C.J.1
Maret, W.2
Cuajungco, M.P.3
-
37
-
-
0026806913
-
Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical
-
Gardner, P. R. & Fridovich, I. 1992 Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical. J. Biol. Chem. 267, 8757-8763.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 8757-8763
-
-
Gardner, P.R.1
Fridovich, I.2
-
38
-
-
0029064257
-
Superoxide radical and iron modulate aconitase activity in mammalian cells
-
doi:10.1074/jbc.270.16.9137
-
Gardner, P. R., Raineri, I., Epstein, L. B. & White, C. W. 1995 Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270, 13 399-13 405. (doi:10.1074/jbc.270.16.9137.)
-
(1995)
J. Biol. Chem
, vol.270
-
-
Gardner, P.R.1
Raineri, I.2
Epstein, L.B.3
White, C.W.4
-
39
-
-
0013770658
-
Some kinetic properties of pig-heart oxoglutarate dehydrogenase that provide a basis for metabolic control of the enzyme activity and also a stoicheiometric assay for coenzyme A in tissue extracts
-
Garland, P. B. 1964 Some kinetic properties of pig-heart oxoglutarate dehydrogenase that provide a basis for metabolic control of the enzyme activity and also a stoicheiometric assay for coenzyme A in tissue extracts. Biochem. J. 92, 10C-12C.
-
(1964)
Biochem. J
, vol.92
-
-
Garland, P.B.1
-
40
-
-
0037155880
-
Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase
-
doi:10.1074/jbc.M108264200
-
Gazaryan, I. G., Krasnikov, B. F., Ashby, G. A., Thorneley, R. N., Kristal, B. S. & Brown, A. M. 2002 Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. J. Biol. Chem. 277, 10 064-10 072. (doi:10.1074/jbc.M108264200.)
-
(2002)
J. Biol. Chem
, vol.277
-
-
Gazaryan, I.G.1
Krasnikov, B.F.2
Ashby, G.A.3
Thorneley, R.N.4
Kristal, B.S.5
Brown, A.M.6
-
41
-
-
0023732664
-
Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease
-
Gibson, G. E., Sheu, K. F., Blass, J. P., Baker, A., Carlson, K. C., Harding, B. & Perrino, P. 1988 Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch. Neurol. 45, 836-840.
-
(1988)
Arch. Neurol
, vol.45
, pp. 836-840
-
-
Gibson, G.E.1
Sheu, K.F.2
Blass, J.P.3
Baker, A.4
Carlson, K.C.5
Harding, B.6
Perrino, P.7
-
42
-
-
0031754275
-
Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation
-
doi:10.1002/ana.410440414
-
Gibson, G. E., Zhang, H., Sheu, K. F., Bogdanovich, N., Lindsay, J. G., Lannfelt, L., Vestling, M. & Cowburn, R. F. 1998 Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation. Ann. Neurol. 44, 676-681. (doi:10.1002/ana.410440414.)
-
(1998)
Ann. Neurol
, vol.44
, pp. 676-681
-
-
Gibson, G.E.1
Zhang, H.2
Sheu, K.F.3
Bogdanovich, N.4
Lindsay, J.G.5
Lannfelt, L.6
Vestling, M.7
Cowburn, R.F.8
-
43
-
-
0033382224
-
Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits
-
Gibson, G. E., Park, L. C., Zhang, H., Sorbi, S. & Calingasan, N. Y. 1999 Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits. Ann. NY Acad. Sci. 893, 79-94.
-
(1999)
Ann. NY Acad. Sci
, vol.893
, pp. 79-94
-
-
Gibson, G.E.1
Park, L.C.2
Zhang, H.3
Sorbi, S.4
Calingasan, N.Y.5
-
44
-
-
0033990449
-
The alpha-ketoglutarate dehydrogenase complex in neurodegeneration
-
doi:10.1016/S0197-0186(99)00114-X
-
Gibson, G. E., Park, L. C., Sheu, K. F., Blass, J. P. & Calingasan, N. Y. 2000 The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochem. Int. 36, 97-112. (doi:10.1016/S0197-0186(99)00114-X.)
-
(2000)
Neurochem. Int
, vol.36
, pp. 97-112
-
-
Gibson, G.E.1
Park, L.C.2
Sheu, K.F.3
Blass, J.P.4
Calingasan, N.Y.5
-
45
-
-
0027400110
-
Brain hydroxyl radical generation in acute experimental head injury
-
Hall, E. D., Andrus, P. K. & Yonkers, P. A. 1993 Brain hydroxyl radical generation in acute experimental head injury. J. Neurochem. 60, 588-594.
-
(1993)
J. Neurochem
, vol.60
, pp. 588-594
-
-
Hall, E.D.1
Andrus, P.K.2
Yonkers, P.A.3
-
46
-
-
0026754574
-
Reactive oxygen species and the central nervous system
-
Halliwell, B. 1992 Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
-
(1992)
J. Neurochem
, vol.59
, pp. 1609-1623
-
-
Halliwell, B.1
-
47
-
-
0021759809
-
Free radicals, lipid peroxidation & cell damage
-
doi:10.1016/S0140-6736(84)91530-7
-
Halliwell, B. & Gutteridge, J. M. 1984 Free radicals, lipid peroxidation & cell damage. Lancet 2, 1095. (doi:10.1016/S0140-6736(84)91530-7.)
-
(1984)
Lancet
, vol.2
, pp. 1095
-
-
Halliwell, B.1
Gutteridge, J.M.2
-
48
-
-
0022394280
-
The importance of free radicals and catalytic metal ions in human diseases
-
doi:10.1016/0098-2997(85)90001-9
-
Halliwell, B. & Gutteridge, J. M. 1985 The importance of free radicals and catalytic metal ions in human diseases. Mol. Aspects Med. 8, 89-193. (doi:10.1016/0098-2997(85)90001-9.)
-
(1985)
Mol. Aspects Med
, vol.8
, pp. 89-193
-
-
Halliwell, B.1
Gutteridge, J.M.2
-
49
-
-
84875738637
-
Control of mitochondrial substrate oxidation
-
Hansford, R. G. 1980 Control of mitochondrial substrate oxidation. Curr. Top. Bioenerg. 10, 217-278.
-
(1980)
Curr. Top. Bioenerg
, vol.10
, pp. 217-278
-
-
Hansford, R.G.1
-
50
-
-
0019881760
-
Effects of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate
-
Hansford, R. G. & Castro, F. 1981 Effects of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate. Biochem. J. 198, 525-533.
-
(1981)
Biochem. J
, vol.198
, pp. 525-533
-
-
Hansford, R.G.1
Castro, F.2
-
51
-
-
0028908516
-
Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons
-
doi:10.1016/0014-4886(95)90041-1
-
Harris, M. E., Hensley, K., Butterfield, D. A., Leedle, R. A. & Carney, J. M. 1995 Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Exp. Neurol. 131, 193-202. (doi:10.1016/0014-4886(95)90041-1.)
-
(1995)
Exp. Neurol
, vol.131
, pp. 193-202
-
-
Harris, M.E.1
Hensley, K.2
Butterfield, D.A.3
Leedle, R.A.4
Carney, J.M.5
-
52
-
-
0028840097
-
Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy
-
doi:10.1007/BF00995157
-
Heroux, M. & Butterworth, R. F. 1995 Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy. Neurochem. Res. 20, 87-93. (doi:10.1007/BF00995157.)
-
(1995)
Neurochem. Res
, vol.20
, pp. 87-93
-
-
Heroux, M.1
Butterworth, R.F.2
-
53
-
-
0034467677
-
Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria
-
doi:10.1023/A:1005626712319
-
Herrero, A. & Barja, G. 2000 Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria. J. Bioenerg. Biomembr. 32, 609-615. (doi:10.1023/A:1005626712319.)
-
(2000)
J. Bioenerg. Biomembr
, vol.32
, pp. 609-615
-
-
Herrero, A.1
Barja, G.2
-
54
-
-
2142782325
-
An oxidase for reduced diphosphopyridine nucleotide
-
Huennekens, F. M., Basford, R. E. & Gabrio, B. W. 1955 An oxidase for reduced diphosphopyridine nucleotide. J. Biol. Chem. 213, 951-967.
-
(1955)
J. Biol. Chem
, vol.213
, pp. 951-967
-
-
Huennekens, F.M.1
Basford, R.E.2
Gabrio, B.W.3
-
55
-
-
0032506040
-
Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: Reaction of lipoic acid with 4-hydroxy-2-nonenal
-
doi:10.1021/bi981512h
-
Humphries, K. M. & Szweda, L. I. 1998 Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry 37, 15 835-15 841. (doi:10.1021/bi981512h.)
-
(1998)
Biochemistry
, vol.37
-
-
Humphries, K.M.1
Szweda, L.I.2
-
56
-
-
0032512411
-
Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal
-
doi:10.1021/bi971958i
-
Humphries, K. M., Yoo, Y. & Szweda, L. I. 1998 Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry 37, 552-557. (doi:10.1021/bi971958i.)
-
(1998)
Biochemistry
, vol.37
, pp. 552-557
-
-
Humphries, K.M.1
Yoo, Y.2
Szweda, L.I.3
-
58
-
-
0032563567
-
Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP
-
Joffe, G. T., Parks, J. K. & Parker Jr, W. D. 1998 Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP. Neuroreport 9, 2781-2783.
-
(1998)
Neuroreport
, vol.9
, pp. 2781-2783
-
-
Joffe, G.T.1
Parks, J.K.2
Parker Jr, W.D.3
-
59
-
-
0023645471
-
The respiratory burst oxidase of neutrophils. Separation of an FAD enzyme and its characterization
-
Kakinuma, K., Fukuhara, Y. & Kaneda, M. 1987 The respiratory burst oxidase of neutrophils. Separation of an FAD enzyme and its characterization. J. Biol. Chem. 262, 12 316-12 322.
-
(1987)
J. Biol. Chem
, vol.262
-
-
Kakinuma, K.1
Fukuhara, Y.2
Kaneda, M.3
-
60
-
-
0035704857
-
Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: Does mitochondrial variation contribute to selective vulnerability?
-
doi:10.1385/JMN:17:3:361
-
Ko, L. W., Sheu, K. F., Thaler, H. T., Markesbery, W. R. & Blass, J. P. 2001 Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability? J. Mol. Neurosci. 17, 361-369. (doi:10.1385/JMN:17:3:361.)
-
(2001)
J. Mol. Neurosci
, vol.17
, pp. 361-369
-
-
Ko, L.W.1
Sheu, K.F.2
Thaler, H.T.3
Markesbery, W.R.4
Blass, J.P.5
-
61
-
-
0029777299
-
The role of zinc in selective neuronal death after transient global cerebral ischemia
-
Koh, J. Y., Suh, S. W., Gwag, B. J., He, Y. Y., Hsu, C. Y. & Choi, D. W. 1996 The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013-1016.
-
(1996)
Science
, vol.272
, pp. 1013-1016
-
-
Koh, J.Y.1
Suh, S.W.2
Gwag, B.J.3
He, Y.Y.4
Hsu, C.Y.5
Choi, D.W.6
-
62
-
-
0020080427
-
A familial progressive neurodegenerative disease with 2-oxoglutaric aciduria
-
Kohlschutter, A., Behbehani, A., Langenbeck, U., Albani, M., Heidemann, P., Hoffmann, G., Kleineke, J., Lehnert, W. & Wendel, U. 1982 A familial progressive neurodegenerative disease with 2-oxoglutaric aciduria. Eur. J. Pediatr. 138, 32-37.
-
(1982)
Eur. J. Pediatr
, vol.138
, pp. 32-37
-
-
Kohlschutter, A.1
Behbehani, A.2
Langenbeck, U.3
Albani, M.4
Heidemann, P.5
Hoffmann, G.6
Kleineke, J.7
Lehnert, W.8
Wendel, U.9
-
63
-
-
0017223847
-
Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes
-
Koike, M. & Koike, K. 1976 Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes. Adv. Biophys. 9, 182-227.
-
(1976)
Adv. Biophys
, vol.9
, pp. 182-227
-
-
Koike, M.1
Koike, K.2
-
64
-
-
0016254851
-
Properties and subunit composition of the pig heart 2-oxoglutarate dehydrogenase
-
Koike, K., Hamada, M., Tanaka, N., Otsuka, K. I., Ogasahara, K. & Koike, M. 1974 Properties and subunit composition of the pig heart 2-oxoglutarate dehydrogenase. J. Biol. Chem. 249, 3836-3842.
-
(1974)
J. Biol. Chem
, vol.249
, pp. 3836-3842
-
-
Koike, K.1
Hamada, M.2
Tanaka, N.3
Otsuka, K.I.4
Ogasahara, K.5
Koike, M.6
-
65
-
-
0030729851
-
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria
-
doi:10.1016/S0014- 5793(97)01159-9
-
Korshunov, S. S., Skulachev, V. P. & Starkov, A. A. 1997 High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416, 15-18. (doi:10.1016/S0014- 5793(97)01159-9.)
-
(1997)
FEBS Lett
, vol.416
, pp. 15-18
-
-
Korshunov, S.S.1
Skulachev, V.P.2
Starkov, A.A.3
-
66
-
-
0027380609
-
Nitric oxide, superoxide and peroxynitrite: Putative mediators of NMDA-induced cell death in cerebellar granule cells
-
doi:10.1016/0028-3908(93)90020-4
-
Lafon-Cazal, M., Culcasi, M., Gaven, F., Pietri, S. & Bockaert, J. 1993 Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells. Neuropharmacology 32, 1259-1266. (doi:10.1016/0028-3908(93)90020-4.)
-
(1993)
Neuropharmacology
, vol.32
, pp. 1259-1266
-
-
Lafon-Cazal, M.1
Culcasi, M.2
Gaven, F.3
Pietri, S.4
Bockaert, J.5
-
67
-
-
0022972426
-
Brain alpha-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution and effects of inhibitors
-
Lai, J. C. & Cooper, A. J. 1986 Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution and effects of inhibitors. J. Neurochem. 47, 1376-1386.
-
(1986)
J. Neurochem
, vol.47
, pp. 1376-1386
-
-
Lai, J.C.1
Cooper, A.J.2
-
68
-
-
0017344533
-
Synaptic and non-synaptic mitochondria from rat brain: Isolation and characterization
-
Lai, J. C., Walsh, J. M., Dennis, S. C. & Clark, J. B. 1977 Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization. J. Neurochem. 28, 625-631.
-
(1977)
J. Neurochem
, vol.28
, pp. 625-631
-
-
Lai, J.C.1
Walsh, J.M.2
Dennis, S.C.3
Clark, J.B.4
-
69
-
-
0021327317
-
Regional enzyme development in rat brain. Enzymes of energy metabolism
-
Leong, S. F. & Clark, J. B. 1984 Regional enzyme development in rat brain. Enzymes of energy metabolism. Biochem. J. 218, 139-145.
-
(1984)
Biochem. J
, vol.218
, pp. 139-145
-
-
Leong, S.F.1
Clark, J.B.2
-
70
-
-
0019731594
-
Energy-metabolizing enzymes in brain regions of adult and aging rats
-
Leong, S. F., Lai, J. C., Lim, L. & Clark, J. B. 1981 Energy-metabolizing enzymes in brain regions of adult and aging rats. J. Neurochem. 37, 1548-1556.
-
(1981)
J. Neurochem
, vol.37
, pp. 1548-1556
-
-
Leong, S.F.1
Lai, J.C.2
Lim, L.3
Clark, J.B.4
-
71
-
-
0036319021
-
Generation of reactive oxygen species by the mitochondrial electron transport chain
-
doi:10.1046/j.0022-3042.2002.00744.x
-
Liu, Y., Fiskum, G. & Schubert, D. 2002 Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80, 780-787. (doi:10.1046/j.0022-3042.2002.00744.x.)
-
(2002)
J. Neurochem
, vol.80
, pp. 780-787
-
-
Liu, Y.1
Fiskum, G.2
Schubert, D.3
-
72
-
-
0015694375
-
2 formation: Relationship with energy conservation
-
doi:10.1016/0014-5793(73)80165-6
-
2 formation: relationship with energy conservation. FEBS Lett. 33, 84-87. (doi:10.1016/0014-5793(73)80165-6.)
-
(1973)
FEBS Lett
, vol.33
, pp. 84-87
-
-
Loschen, G.1
Azzi, A.2
Flohe, L.3
-
73
-
-
0016148483
-
Superoxide radicals as precursors of mitochondrial hydrogen peroxide
-
doi:10.1016/0014-5793(74)80281-4
-
Loschen, G., Azzi, A., Richter, C. & Flohe, L. 1974 Superoxide radicals as precursors of mitochondrial hydrogen peroxide. FEBS Lett. 42, 68-72. (doi:10.1016/0014-5793(74)80281-4.)
-
(1974)
FEBS Lett
, vol.42
, pp. 68-72
-
-
Loschen, G.1
Azzi, A.2
Richter, C.3
Flohe, L.4
-
74
-
-
0033535948
-
Declines in mitochondrial respiration during cardiac reperfusion: Age-dependent inactivation of alpha-ketoglutarate dehydrogenase
-
doi:10.1073/pnas.96.12.6689
-
Lucas, D. T. & Szweda, L. I. 1999 Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase. Proc. Natl Acad. Sci. USA 96, 6689-6693. (doi:10.1073/pnas.96.12.6689.)
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 6689-6693
-
-
Lucas, D.T.1
Szweda, L.I.2
-
75
-
-
0031020476
-
A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide
-
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K. & Mattson, M. P. 1997 A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J. Neurochem. 68, 255-264.
-
(1997)
J. Neurochem
, vol.68
, pp. 255-264
-
-
Mark, R.J.1
Lovell, M.A.2
Markesbery, W.R.3
Uchida, K.4
Mattson, M.P.5
-
76
-
-
0028108347
-
Activation of molecular oxygen by flavins and flavoproteins
-
Massey, V. 1994 Activation of molecular oxygen by flavins and flavoproteins. J. Biol. Chem. 269, 22 459-22 462.
-
(1994)
J. Biol. Chem
, vol.269
-
-
Massey, V.1
-
77
-
-
0014670520
-
The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen
-
doi:10.1016/0006-291X(69)90287-3
-
Massey, V., Strickland, S., Mayhew, S. G., Howell, L. G., Engel, P. C., Matthews, R. G., Schuman, M. & Sullivan, P. A. 1969 The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen. Biochem. Biophys. Res. Commun. 36, 891-897. (doi:10.1016/0006-291X(69)90287-3.)
-
(1969)
Biochem. Biophys. Res. Commun
, vol.36
, pp. 891-897
-
-
Massey, V.1
Strickland, S.2
Mayhew, S.G.3
Howell, L.G.4
Engel, P.C.5
Matthews, R.G.6
Schuman, M.7
Sullivan, P.A.8
-
78
-
-
0027332651
-
Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
-
Mastrogiacomo, F., Bergeron, C. & Kish, S. J. 1993 Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J. Neurochem. 61, 2007-2014.
-
(1993)
J. Neurochem
, vol.61
, pp. 2007-2014
-
-
Mastrogiacomo, F.1
Bergeron, C.2
Kish, S.J.3
-
79
-
-
0029985851
-
Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1
-
doi:10.1006/neur.1996.0004
-
Mastrogiacomo, F., LaMarche, J., Dozic, S., Lindsay, G., Bettendorff, L., Robitaille, Y., Schut, L. & Kish, S. J. 1996 Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1. Neurodegeneration 5, 27-33. (doi:10.1006/neur.1996.0004.)
-
(1996)
Neurodegeneration
, vol.5
, pp. 27-33
-
-
Mastrogiacomo, F.1
LaMarche, J.2
Dozic, S.3
Lindsay, G.4
Bettendorff, L.5
Robitaille, Y.6
Schut, L.7
Kish, S.J.8
-
80
-
-
0018363365
-
The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex
-
McCormack, J. G. & Denton, R. M. 1979 The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. Biochem. J. 180, 533-544.
-
(1979)
Biochem. J
, vol.180
, pp. 533-544
-
-
McCormack, J.G.1
Denton, R.M.2
-
81
-
-
0025255460
-
Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets
-
McCormack, J. G., Longo, E. A. & Corkey, B. E. 1990 Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. Biochem. J. 267, 527-530.
-
(1990)
Biochem. J
, vol.267
, pp. 527-530
-
-
McCormack, J.G.1
Longo, E.A.2
Corkey, B.E.3
-
82
-
-
0028989810
-
Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
-
McNaught, K. S., Altomare, C., Cellamare, S., Carotti, A., Thull, U., Carrupt, P. A., Testa, B., Jenner, P. & Marsden, C. D. 1995 Inhibition of alpha-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuroreport 6, 1105-1108.
-
(1995)
Neuroreport
, vol.6
, pp. 1105-1108
-
-
McNaught, K.S.1
Altomare, C.2
Cellamare, S.3
Carotti, A.4
Thull, U.5
Carrupt, P.A.6
Testa, B.7
Jenner, P.8
Marsden, C.D.9
-
83
-
-
0025230826
-
Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease
-
doi:10.1016/0022-510X(90)90056-S
-
Mizuno, Y., Suzuki, K. & Ohta, S. 1990 Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease. J. Neurol. Sci. 96, 49-57. (doi:10.1016/0022-510X(90)90056-S.)
-
(1990)
J. Neurol. Sci
, vol.96
, pp. 49-57
-
-
Mizuno, Y.1
Suzuki, K.2
Ohta, S.3
-
84
-
-
0028176592
-
An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease
-
doi:10.1002/ana.410350212
-
Mizuno, Y., Matuda, S., Yoshino, H., Mori, H., Hattori, N. & Ikebe, S. 1994 An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35, 204-210. (doi:10.1002/ana.410350212.)
-
(1994)
Ann. Neurol
, vol.35
, pp. 204-210
-
-
Mizuno, Y.1
Matuda, S.2
Yoshino, H.3
Mori, H.4
Hattori, N.5
Ikebe, S.6
-
85
-
-
0031711713
-
Mitochondrial dysfunction in Parkinson's disease
-
doi:10.1002/ana.410440116
-
Mizuno, Y., Yoshino, H., Ikebe, S., Hattori, N., Kobayashi, T., Shimoda-Matsubayashi, S., Matsumine, H. & Kondo, T. 1998 Mitochondrial dysfunction in Parkinson's disease. Ann. Neurol. 44, S99-S109. (doi:10.1002/ana.410440116.)
-
(1998)
Ann. Neurol
, vol.44
-
-
Mizuno, Y.1
Yoshino, H.2
Ikebe, S.3
Hattori, N.4
Kobayashi, T.5
Shimoda-Matsubayashi, S.6
Matsumine, H.7
Kondo, T.8
-
86
-
-
0025336467
-
Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation
-
Moreno-Sanchez, R., Hogue, B. A. & Hansford, R. G. 1990 Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation. Biochem. J. 268, 421-428.
-
(1990)
Biochem. J
, vol.268
, pp. 421-428
-
-
Moreno-Sanchez, R.1
Hogue, B.A.2
Hansford, R.G.3
-
87
-
-
0035968183
-
Modulation of mitochondrial function by hydrogen peroxide
-
doi:10.1074/jbc.M100320200
-
Nulton-Persson, A. C. & Szweda, L. I. 2001 Modulation of mitochondrial function by hydrogen peroxide. J. Biol. Chem. 276, 23 357-23 361. (doi:10.1074/jbc.M100320200.)
-
(2001)
J. Biol. Chem
, vol.276
-
-
Nulton-Persson, A.C.1
Szweda, L.I.2
-
88
-
-
0027496238
-
A radical hypothesis for neurodegeneration
-
doi:10.1016/0166-2236(93)90070-3
-
Olanow, C. W. 1993 A radical hypothesis for neurodegeneration. Trends Neurosci. 16, 439-444. (doi:10.1016/0166-2236(93)90070-3.)
-
(1993)
Trends Neurosci
, vol.16
, pp. 439-444
-
-
Olanow, C.W.1
-
89
-
-
0033048258
-
Metabolic impairment induces oxidative stress, compromises inflammatory responses and inactivates a key mitochondrial enzyme in microglia
-
doi:10.1046/j.1471-4159.1999.0721948.x
-
Park, L. C., Zhang, H., Sheu, K. F., Calingasan, N. Y., Kristal, B. S., Lindsay, J. G. & Gibson, G. E. 1999 Metabolic impairment induces oxidative stress, compromises inflammatory responses and inactivates a key mitochondrial enzyme in microglia. J. Neurochem. 72, 1948-1958. (doi:10.1046/j.1471-4159.1999.0721948.x.)
-
(1999)
J. Neurochem
, vol.72
, pp. 1948-1958
-
-
Park, L.C.1
Zhang, H.2
Sheu, K.F.3
Calingasan, N.Y.4
Kristal, B.S.5
Lindsay, J.G.6
Gibson, G.E.7
-
90
-
-
0024848034
-
Abnormalities of the electron transport chain in idiopathic Parkinson's disease
-
doi:10.1002/ana.410260606
-
Parker Jr, W. D., Boyson, S. J. & Parks, J. K. 1989 Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26, 719-723. (doi:10.1002/ana.410260606.)
-
(1989)
Ann. Neurol
, vol.26
, pp. 719-723
-
-
Parker Jr, W.D.1
Boyson, S.J.2
Parks, J.K.3
-
91
-
-
0030052530
-
Requirement for superoxide in excitotoxic cell death
-
doi:10.1016/S0896-6273(00)80052-5
-
Patel, M., Day, B. J., Crapo, J. D., Fridovich, I. & McNamara, J. O. 1996 Requirement for superoxide in excitotoxic cell death. Neuron 16, 345-355. (doi:10.1016/S0896-6273(00)80052-5.)
-
(1996)
Neuron
, vol.16
, pp. 345-355
-
-
Patel, M.1
Day, B.J.2
Crapo, J.D.3
Fridovich, I.4
McNamara, J.O.5
-
92
-
-
0015514173
-
Function of calcium ions in pyruvate dehydrogenase phosphatase activity
-
doi:10.1016/0006-291X(72)90448-2
-
Pettit, F. H., Roche, T. E. & Reed, L. J. 1972 Function of calcium ions in pyruvate dehydrogenase phosphatase activity. Biochem. Biophys. Res. Commun. 49, 563-571. (doi:10.1016/0006-291X(72)90448-2.)
-
(1972)
Biochem. Biophys. Res. Commun
, vol.49
, pp. 563-571
-
-
Pettit, F.H.1
Roche, T.E.2
Reed, L.J.3
-
93
-
-
0026515760
-
Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells
-
Pralong, W. F., Hunyady, L., Varnai, P., Wollheim, C. B. & Spat, A. 1992 Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells. Proc. Natl Acad. Sci. USA 89, 132-136.
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 132-136
-
-
Pralong, W.F.1
Hunyady, L.2
Varnai, P.3
Wollheim, C.B.4
Spat, A.5
-
94
-
-
0029064518
-
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation
-
Reynolds, I. J. & Hastings, T. G. 1995 Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15, 3318-3327.
-
(1995)
J. Neurosci
, vol.15
, pp. 3318-3327
-
-
Reynolds, I.J.1
Hastings, T.G.2
-
95
-
-
0036401499
-
Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion
-
doi:10.1016/S0003-9861(02)00446-0
-
Sadek, H. A., Humphries, K. M., Szweda, P. A. & Szweda, L. I. 2002 Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Arch. Biochem. Biophys. 406, 222-228. (doi:10.1016/S0003-9861(02)00446-0.)
-
(2002)
Arch. Biochem. Biophys
, vol.406
, pp. 222-228
-
-
Sadek, H.A.1
Humphries, K.M.2
Szweda, P.A.3
Szweda, L.I.4
-
96
-
-
0031797319
-
Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons
-
Scanlon, J. M. & Reynolds, I. J. 1998 Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons. J. Neurochem. 71, 2392-2400.
-
(1998)
J. Neurochem
, vol.71
, pp. 2392-2400
-
-
Scanlon, J.M.1
Reynolds, I.J.2
-
97
-
-
0033032999
-
Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia
-
Schapira, A. H. 1999 Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia. Biochim. Biophys. Acta 1410, 159-170.
-
(1999)
Biochim. Biophys. Acta
, vol.1410
, pp. 159-170
-
-
Schapira, A.H.1
-
98
-
-
0024390719
-
Mitochondrial complex I deficiency in Parkinson's disease
-
doi:10.1016/S0140-6736(89)92366-0
-
Schapira, A. H., Cooper, J. M., Dexter, D., Jenner, P., Clark, J. B. & Marsden, C. D. 1989 Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1, 1269. (doi:10.1016/S0140-6736(89)92366-0.)
-
(1989)
Lancet
, vol.1
, pp. 1269
-
-
Schapira, A.H.1
Cooper, J.M.2
Dexter, D.3
Jenner, P.4
Clark, J.B.5
Marsden, C.D.6
-
99
-
-
0025254401
-
Mitochondrial complex I deficiency in Parkinson's disease
-
Schapira, A. H., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P. & Marsden, C. D. 1990 Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54, 823-827.
-
(1990)
J. Neurochem
, vol.54
, pp. 823-827
-
-
Schapira, A.H.1
Cooper, J.M.2
Dexter, D.3
Clark, J.B.4
Jenner, P.5
Marsden, C.D.6
-
100
-
-
0025351232
-
Free radicals in central nervous system ischemia
-
Schmidley, J. W. 1990 Free radicals in central nervous system ischemia. Stroke 21, 1086-1090.
-
(1990)
Stroke
, vol.21
, pp. 1086-1090
-
-
Schmidley, J.W.1
-
102
-
-
0021332488
-
Alpha-ketoglutarate and malate uptake and metabolism by synaptosomes: Further evidence for an astrocyte-to-neuron metabolic shuttle
-
Shank, R. P. & Campbell, G. L. 1984 Alpha-ketoglutarate and malate uptake and metabolism by synaptosomes: further evidence for an astrocyte-to-neuron metabolic shuttle. J. Neurochem. 42, 1153-1161.
-
(1984)
J. Neurochem
, vol.42
, pp. 1153-1161
-
-
Shank, R.P.1
Campbell, G.L.2
-
103
-
-
0021813419
-
An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain
-
doi:10.1002/ana. 410170505
-
Sheu, K. F., Kim, Y. T., Blass, J. P. & Weksler, M. E. 1985 An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain. Ann. Neurol. 17, 444-449. (doi:10.1002/ana. 410170505.)
-
(1985)
Ann. Neurol
, vol.17
, pp. 444-449
-
-
Sheu, K.F.1
Kim, Y.T.2
Blass, J.P.3
Weksler, M.E.4
-
104
-
-
0028387219
-
Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease
-
doi:10.1002/ana.410350311
-
Sheu, K. F., Cooper, A. J., Koike, K., Koike, M., Lindsay, J. G. & Blass, J. P. 1994 Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease. Ann. Neurol. 35, 312-318. (doi:10.1002/ana.410350311.)
-
(1994)
Ann. Neurol
, vol.35
, pp. 312-318
-
-
Sheu, K.F.1
Cooper, A.J.2
Koike, K.3
Koike, M.4
Lindsay, J.G.5
Blass, J.P.6
-
105
-
-
0028932511
-
Glutamate, calcium and free radicals as mediators of ischemic brain damage
-
Siesjo, B. K., Zhao, Q., Pahlmark, K., Siesjo, P., Katsura, K. & Folbergrova, J. 1995 Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann. Thorac. Surg. 59, 1316-1320.
-
(1995)
Ann. Thorac. Surg
, vol.59
, pp. 1316-1320
-
-
Siesjo, B.K.1
Zhao, Q.2
Pahlmark, K.3
Siesjo, P.4
Katsura, K.5
Folbergrova, J.6
-
106
-
-
0037269343
-
Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals
-
doi:10.1046/j.1471-4159.2003.01513.x
-
Sipos, I., Tretter, L. & Adam-Vizi, V. 2003a Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals. J. Neurochem. 84, 112-118. (doi:10.1046/j.1471-4159.2003.01513.x.)
-
(2003)
J. Neurochem
, vol.84
, pp. 112-118
-
-
Sipos, I.1
Tretter, L.2
Adam-Vizi, V.3
-
107
-
-
0141482026
-
The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential
-
doi:10.1023/A:1025634728227
-
Sipos, I., Tretter, L. & Adam-Vizi, V. 2003b The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential. Neurochem. Res. 28, 1575-1581. (doi:10.1023/A:1025634728227.)
-
(2003)
Neurochem. Res
, vol.28
, pp. 1575-1581
-
-
Sipos, I.1
Tretter, L.2
Adam-Vizi, V.3
-
108
-
-
0015956014
-
Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase
-
Smith, C. M., Bryla, J. & Williamson, J. R. 1974 Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase. J. Biol. Chem. 249, 1497-1505.
-
(1974)
J. Biol. Chem
, vol.249
, pp. 1497-1505
-
-
Smith, C.M.1
Bryla, J.2
Williamson, J.R.3
-
109
-
-
0034811384
-
Myxothiazol induces H(2) 0(2) production from mitochondrial respiratory chain
-
doi:10.1006/bbrc.2001.4409
-
Starkov, A. A. & Fiskum, G. 2001 Myxothiazol induces H(2) 0(2) production from mitochondrial respiratory chain. Biochem. Biophys. Res. Commun. 281, 645-650. (doi:10.1006/bbrc.2001.4409.)
-
(2001)
Biochem. Biophys. Res. Commun
, vol.281
, pp. 645-650
-
-
Starkov, A.A.1
Fiskum, G.2
-
110
-
-
0042433242
-
2 production by membrane potential and NAD(P)H redox state
-
2 production by membrane potential and NAD(P)H redox state. J. Neurochem. 86, 1101-1107.
-
(2003)
J. Neurochem
, vol.86
, pp. 1101-1107
-
-
Starkov, A.A.1
Fiskum, G.2
-
111
-
-
4544359913
-
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species
-
doi:10.1523/JNEUROSCI.1899-04.2004
-
Starkov, A. A., Fiskum, G., Chinopoulos, C., Lorenzo, B. J., Browne, S. E., Patel, M. S. & Beal, M. F. 2004 Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J. Neurosci. 24, 7779-7788. (doi:10.1523/JNEUROSCI.1899-04.2004.)
-
(2004)
J. Neurosci
, vol.24
, pp. 7779-7788
-
-
Starkov, A.A.1
Fiskum, G.2
Chinopoulos, C.3
Lorenzo, B.J.4
Browne, S.E.5
Patel, M.S.6
Beal, M.F.7
-
112
-
-
0018393931
-
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation
-
Takeshige, K. & Minakami, S. 1979 NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem. J. 180, 129-135.
-
(1979)
Biochem. J
, vol.180
, pp. 129-135
-
-
Takeshige, K.1
Minakami, S.2
-
113
-
-
0032569826
-
Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia
-
doi:10.1016/S0022-510X(98) 00240-8
-
Terwel, D., Bothmer, J., Wolf, E., Meng, F. & Jolles, J. 1998 Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. J. Neurol. Sci. 161, 47-56. (doi:10.1016/S0022-510X(98) 00240-8.)
-
(1998)
J. Neurol. Sci
, vol.161
, pp. 47-56
-
-
Terwel, D.1
Bothmer, J.2
Wolf, E.3
Meng, F.4
Jolles, J.5
-
114
-
-
0025138527
-
Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat
-
doi:10.1016/0304-3940(90)90002-Q
-
Tonder, N., Johansen, F. F., Frederickson, C. J., Zimmer, J. & Diemer, N. H. 1990 Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat. Neurosci. Lett. 109, 247-252. (doi:10.1016/0304-3940(90)90002-Q.)
-
(1990)
Neurosci. Lett
, vol.109
, pp. 247-252
-
-
Tonder, N.1
Johansen, F.F.2
Frederickson, C.J.3
Zimmer, J.4
Diemer, N.H.5
-
115
-
-
0034671429
-
Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress
-
Tretter, L. & Adam-Vizi, V. 2000 Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20, 8972-8979.
-
(2000)
J. Neurosci
, vol.20
, pp. 8972-8979
-
-
Tretter, L.1
Adam-Vizi, V.2
-
116
-
-
4544226082
-
Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase
-
doi:10.1523/JNEUROSCI.1842-04.2004
-
Tretter, L. & Adam-Vizi, V. 2004 Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. J. Neurosci. 24, 7771-7778. (doi:10.1523/JNEUROSCI.1842-04.2004.)
-
(2004)
J. Neurosci
, vol.24
, pp. 7771-7778
-
-
Tretter, L.1
Adam-Vizi, V.2
-
117
-
-
0030658986
-
Enhanced depolarization-evoked calcium signal and reduced [ATP]/[ADP] ratio are unrelated events induced by oxidative stress in synaptosomes
-
Tretter, L., Chinopoulos, C. & Adam-Vizi, V. 1997 Enhanced depolarization-evoked calcium signal and reduced [ATP]/[ADP] ratio are unrelated events induced by oxidative stress in synaptosomes. J. Neurochem. 69, 2529-2537.
-
(1997)
J. Neurochem
, vol.69
, pp. 2529-2537
-
-
Tretter, L.1
Chinopoulos, C.2
Adam-Vizi, V.3
-
118
-
-
0142150051
-
Mitochondrial formation of reactive oxygen species
-
doi:10.1113/jphysiol.2003.049478
-
Turrens, J. F. 2003 Mitochondrial formation of reactive oxygen species. J. Physiol. 552, 335-344. (doi:10.1113/jphysiol.2003.049478.)
-
(2003)
J. Physiol
, vol.552
, pp. 335-344
-
-
Turrens, J.F.1
-
119
-
-
0019083215
-
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria
-
Turrens, J. F. & Boveris, A. 1980 Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem. J. 191, 421-427.
-
(1980)
Biochem. J
, vol.191
, pp. 421-427
-
-
Turrens, J.F.1
Boveris, A.2
-
120
-
-
0034740585
-
DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria
-
doi:10.1046/j.1471-4159.2001.00548.x
-
Votyakova, T. V. & Reynolds, I. J. 2001 DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem. 79, 266-277. (doi:10.1046/j.1471-4159.2001.00548.x.)
-
(2001)
J. Neurochem
, vol.79
, pp. 266-277
-
-
Votyakova, T.V.1
Reynolds, I.J.2
-
121
-
-
0000434165
-
Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons
-
Wang, G. J. & Thayer, S. A. 1996 Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons. J. Neurophysiol. 76, 1611-1621.
-
(1996)
J. Neurophysiol
, vol.76
, pp. 1611-1621
-
-
Wang, G.J.1
Thayer, S.A.2
-
122
-
-
0034306057
-
2+: A novel ionic mediator of neural injury in brain disease
-
doi:10.1016/S0165-6147(00)01541-8
-
2+: a novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 21, 395-401. (doi:10.1016/S0165-6147(00)01541-8.)
-
(2000)
Trends Pharmacol. Sci
, vol.21
, pp. 395-401
-
-
Weiss, J.H.1
Sensi, S.L.2
Koh, J.Y.3
-
123
-
-
0029788243
-
Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
-
White, R. J. & Reynolds, I. J. 1996 Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688-5697.
-
(1996)
J. Neurosci
, vol.16
, pp. 5688-5697
-
-
White, R.J.1
Reynolds, I.J.2
-
124
-
-
0024595834
-
2-Oxoglutarate: Oxidation and role as a potential precursor of cytosolic acetyl-CoA for the synthesis of acetylcholine in rat brain synaptosomes
-
Willoughby, J., Craig, F. E., Harvey, S. A. & Clark, J. B. 1989 2-Oxoglutarate: oxidation and role as a potential precursor of cytosolic acetyl-CoA for the synthesis of acetylcholine in rat brain synaptosomes. J. Neurochem. 52, 896-901.
-
(1989)
J. Neurochem
, vol.52
, pp. 896-901
-
-
Willoughby, J.1
Craig, F.E.2
Harvey, S.A.3
Clark, J.B.4
-
125
-
-
0028036798
-
Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle
-
Yudkoff, M., Nelson, D., Daikhin, Y. & Erecinska, M. 1994 Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle. J. Biol. Chem. 269, 27 414-27 420.
-
(1994)
J. Biol. Chem
, vol.269
-
-
Yudkoff, M.1
Nelson, D.2
Daikhin, Y.3
Erecinska, M.4
-
126
-
-
0024996681
-
The oxidative inactivation of mitochondrial electron transport chain components and ATPase
-
Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L. & Davies, K. J. 1990 The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265, 16 330-16 336.
-
(1990)
J. Biol. Chem
, vol.265
-
-
Zhang, Y.1
Marcillat, O.2
Giulivi, C.3
Ernster, L.4
Davies, K.J.5
-
127
-
-
0032545269
-
Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria
-
doi:10.1074/jbc.273.51.33972
-
Zhang, L., Yu, L. & Yu, C. A. 1998 Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria. J. Biol. Chem. 273, 33 972-33 976. (doi:10.1074/jbc.273.51.33972.)
-
(1998)
J. Biol. Chem
, vol.273
-
-
Zhang, L.1
Yu, L.2
Yu, C.A.3
|