Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure

Journal of Neuroscience

Volumn 16, Issue 18, 1996, Pages 5688-5697

  White, R James ^a   Reynolds, Ian J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

CGP 37157; excitotoxicity; forebrain neurons; intracellular calcium; NMDA; permeability transition pore

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; CALCIUM; CARBOCYANINE; CYCLOSPORIN A; DIZOCILPINE; EXCITOTOXIN; GLUTAMATE RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; EMBRYO; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SODIUM CALCIUM EXCHANGE;

EID: 0029788243     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-18-05688.1996     Document Type: Article

References (52)

1. Andreeva L, Crompton M (1994) An ADP-sensitive cyclosporin-A-binding protein in rat liver mitochondria. Eur J Biochem 221:261-268.
2. Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119-130.
3. Bernardi P, Broekemeier KM, Pfeiffer DR (1994) Recent progress on regulation of the mitochondrial permeability transition pore: a cyclosporin-sensitive pore in the inner mitochondrial membrane. J Bioenerg Biomembr 26:509-517.
4. 2+ in cultured cortical neurons. Neuron 11: 751-757.
5. 2+ exchanger. Biochem Pharmacol 37:4399-4403.
6. Choi DW (1995) Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 18:58-60.
7. Connern CP, Halestrap AP (1994) Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem J 302:321-324.
8. 2+ exchange. Trends Pharmacol Sci 14:408-413.
9. 2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J Cardiovasc Pharmacol 21:595-599.
10. Czyz A, Szewczyk A, Nalecz MJ, Wojtczak L (1995) The role of mitochondrial potassium fluxes in controlling the proton motive force in energized mitochondria. Biochem Biophys Res Commun 210:98-104.
11. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661.
12. 2+ as a second messenger within mitochondria of the heart and other tissues. Annu Rev Physiol 52: 451-466.
13. Griffiths EJ, Halestrap AP (1995) Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem J 307:93-98.
14. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
15. Gunter KK, Gunter TE (1994) Transport of calcium by mitochondria. J Bioenerg Biomembr 26:471-485.
16. Gunter TE, Gunter KK, Sheu SS, Gavin CE (1994) Mitochondrial calcium transport: physiological and pathological relevance. Am J Physiol 267:C313-C339.
17. 2+ transport. J Bioenerg Biomembr 26:495-508.
18. Hartley DM, Choi DW (1989) Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture. J Pharmacol Exp Ther 250:752-758.
19. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci 13:1993-2000.
20. 1H NMR spectroscopy. Neurology 43:2689-2695.
21. Jung DW, Baysal K, Brierley GP (1995) The sodium-calcium antiport of heart mitochondria is not electroneutral. J Biol Chem 270:672-678.
22. Kiedrowski L, Costa E (1995) Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering. Mol Pharmacol 47:140-147.
23. Kiedrowski L, Brooker G, Costa E, Wroblewski JT (1994) Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron 12:295-300.
24. Koch RA, Barish ME (1994) Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. J Neurusci 14:2585-2593.
25. Lynch DR, Dawson TM (1994) Secondary mechanisms in neuronal trauma. Curr Opin Neurol 7:510-516.
26. 2+ in the regulation of energy metabolism. Dev Neurosci 15:165-173.
27. Michaels RL, Rothman SM (1990) Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J Neurosci 10:283-292.
28. Minezaki KK, Suleiman MS, Chapman RA (1994) Changes in mitochondrial function induced in isolated guinea-pig ventricular myocytes by calcium overload. J Physiol (Lond) 476:459-471.
29. Moudy AM, Handran SD, Goldberg MP, Ruffin N, Karl I, Kranz-Eble P, DeVivo DC, Rothman SM (1995) Abnormal calcium homeostasis and mitochondrial polarization in a human encephalomyopathy. Proc Natl Acad Sci USA 92:729-733.
30. Nguyen PV, Atwood HL (1994) Altered impulse activity modifies synaptic physiology and mitochondria in crayfish phasic motor neurons. J Neurophysiol 72:2944-2955.
31. Nicholls DG (1985) A role for the mitochondrion in the protection of cells against calcium overload? Prog Brain Res 63:97-106.
32. Nieminen AL, Saylor AK, Tesfai SA, Herman B, Lemasters JJ (1995) Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem J 307:99-106.
33. Novgorodov SA, Gudz TI, Brierley GP, Pfeifer DR (1994) Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP. Arch Biochem Biophys 311: 219-228.
34. Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, Bernardi P (1994) The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols: increase of the gating potential by oxidants and its reversal by reducing agents. J Biol Chem 269:16638-16642.
35. Rajdev S, Reynolds IJ (1994) Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia. Neuroscience 62:667-679.
36. Randall RD, Thayer SA (1992) Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci 12:1882-1895.
37. Reers M, Smith TW, Chen LB (1991) J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 30:4480-4486.
38. Reynolds IJ, Hastings TG (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 15:3318-3327.
39. Rothman SM, Thurston JH, Hauhart RE (1987) Delayed neurotoxicity of excitatory amino acids in vitro. Neuroscience 22:471-480.
40. Rothman SM, Yamada KA, Lancaster N (1993) Nordihydroguaiaretic acid attenuates NMDA neurotoxicity: action beyond the receptor. Neuropharmacology 32:1279-1288.
41. Satrustegui J, Richter C (1984) The role of hydroperoxides as calcium release agents in rat brain mitochondria. Arch Biochem Biophys 233:736-740.
42. Schweizer M, Richter C (1994) Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension. Biochem Biophys Res Commun 204:169-175.
43. Siesjo BK, Bengtsson F (1989) Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab 9:127-140.
44. Smiley ST, Reers M, Mottola-Hartshorn C, Lin M, Chen A, Smith TW, Steele Jr GD, Chen LB (1991) Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 88:3671-3675.
45. 2+ efflux in rat forebrain neurones in culture. J Physiol (Lond) 492:641-657.
46. 2+ overload indicates early neuronal injury which precedes staining with viability indicators. Brain Res 607:319-323.
47. Wainio WW (1970) The mammalian mitochondrial respiratory chain. New York: Academic.
48. 2+-loads by mitochondria in cultured rat hippocampal neurons. J Neurophysiol, in press.
49. 2+ loads. J Neurophysiol 72:2563-2569.
50. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. J Neurosci 15:1318-1328.
51. Zhang J, Dawson VL, Dawson TM, Snyder SH (1994) Nitric oxide activation of poly(ADP-rihose) synthetase in neurotoxicity. Science 263:687-689.
52. Zhang Y, Marcillat O, Giulivi C, Ernster L, Davies KJ (1990) The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem 265:16330-16336.