The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential

Neurochemical Research

Volumn 28, Issue 10, 2003, Pages 1575-1581

  Sipos, Ildiko ^a   Tretter, Laszlo ^b   Adam Vizi, Vera ^b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Free radical generation; Membrane potential; Mitochondria; Synaptosomes

Indexed keywords

2,4 DINITROPHENOL; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CITRININ; FREE RADICAL; HYDROGEN PEROXIDE; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DEPOLARIZATION; ELECTRON TRANSPORT; GUINEA PIG; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION MEMBRANE POTENTIAL; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY CHAIN; SYNAPTOSOME;

ANIMALS; ANTIMYCIN A; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; GUINEA PIGS; HYDROGEN PEROXIDE; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; OLIGOMYCINS; REACTIVE OXYGEN SPECIES; ROTENONE; SYNAPTOSOMES;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0141482026     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025634728227     Document Type: Article

References (38)

1. Boveris, A., Oshino, N., and Chance, B. 1972. The cellular production of hydrogen peroxide. Biochem. J. 128:617-630.
2. Boveris, A. and Chance, B. 1973. The mitochondrial generation of hydrogen peroxide: General properties and effect of hyperbaric oxygen. Biochem. J. 134:707-716.
3. 2 formation: Relationship with energy conservation. FEBS Lett. 33:84-87.
4. Hyslop, P. A., Hinshaw, D. B., Halsey, W. A., Jr., Schraufstatter, I. U., Sauerheber, R. D., Spragg, R. G., Jackson, J. H., and Cochrane, C. G. 1988. Mechanisms of oxidant-mediated cell injury: The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J. Biol. Chem. 263:1665-1675.
5. Park, L. C., Zhang, H., Sheu, K. F., Calingasan, N. Y., Kristal, B. S. Lindsay, J. G., and Gibson, G. E. 1999. Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J. Neurochem. 72:1948-1958
6. Patel, M., Day, B. J., Crapo, J. D., Fridovich, I., and McNamara, J. O. 1996. Requirement for superoxide in excitotoxic cell death. Neuron 16:345-355.
7. Tretter, L. and Adam-Vizi, V. 2000. Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20:8972-8979.
8. Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L., and Davies, K. J. 1990. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265:16330-16336.
9. Starkov, A. A., Polster, B. M., and Fiskum, G. 2002. Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83:220-228.
10. Votyakova, T. V. and Reynolds, I. J. 2001. DeltaPsi(m)-dependent and-independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem, 79:266-277.
11. Sipos, I., Tretter, L., and Adam-Vizi, V. 2003. Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals. J. Neurochem. 84:112-118.
12. Beal, M. F. 1998. Mitochondrial dysfunction in neurodegenerative diseases. Biochim. Biophys. Acta 1366:211-223.
13. Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L. J., Wilson, J. M., Distefano, L. M., and Nobrega, J. N. 1992. Brain cytochrome oxidase in Alzheimer's disease. J. Neurochem. 59:776-779.
14. Schapira, A. H., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., and Marsden, C. D. 1990. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54:823-827.
15. Budd, S. L. and Nicholls, D. G. 1996. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurochem. 67:2282-2291.
16. Budd, S. L. and Nicholls, D. G. 1998. Mitochondria in the life and death of neurons. Essays Biochem. 33:43-52.
17. White, R. J. and Reynolds, I. J. 1996. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure. J. Neurosci. 16:5688-5697.
18. Dugan, L. L., Sensi, S. L., Canzoniero, L. M., Handran, S. D., Rothman, S. M., Lin, T. S., Goldberg, M. P., and Choi, D. W. 1995. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci. 15:6377-6388.
19. Lafon-Cazal, M., Pietri, S., Culcasi, M., and Bockaert, J. 1993 NMDA-dependent superoxide production and neurotoxicity. Nature 364:535-537.
20. Reynolds, I. J. and Hastings, T. G. 1995. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15:3318-3327.
21. Cadenas, E., Boveris, A., Ragan, C. I., and Stoppani, A. O. 1977. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch. Biochem. Biophys. 180:248-257.
22. Liu, Y., Fiskum, G., and Schubert, D. 2002. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80:780-787.
23. Turrens, J. F., Alexandre, A., and Lehninger, A. L. 1985. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch. Biochem. Biophys. 237:408-414.
24. Hansford, R. G., Hogue, B. A., and Mildaziene, V. 1997. Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. J. Bioenerg. Biomembr. 29:89-95.
25. Korshunov, S. S., Skulachev, V. P., and Starkov, A. A. 1997. High protonic potential actuates a mechanism of production of reative oxygen species in mitochondria. FEBS Lett. 416:15-18.
26. Gardner, P. R., Raineri, I., Epstein, L. B., and White, C. W. 1995. Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270:13399-13405.
27. Chinopoulos, C., Tretter, L., and Adam-Vizi, V. 1999. Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: Inhibition of alpha-ketoglutarate dehydrogenase. J. Neurochem. 73:220-228.
28. Kauppinen, R. A. and Nicholls, D. G. 1986. Failure to maintain glycolysis in anoxic nerve terminals. J. Neurochem. 47:1864-1869.
29. Chinopoulos, C. and Adam-Vizi, V. 2001. Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: Relevance to Parkinson's disease. J. Neurochem. 76:302-306.
30. Ragan, C. I., Wilson, M. T., Darley-Usmar, V.M., and and Lowe, P.N. 1987. Subfractionation of mitochondria, and isolation of the proteins of oxidative phosphorilation. Pages 79-112, in Darley-Usmar, V.M., Rickwood, D., and Wilson, M. T. (eds.), in Mitochondria: A Practiacal Approach, ed. IRL Press, London.
31. Rieske, J. S. 1967. Preparation and properties of reduced coenzyme Q-cytochrome c reductase., Pages 239-245, in Estabrook, R. W. and Pullmann, M. E. (eds.) in Methods in Enzymology, Academic Press, New York and London. X. ed.
32. 2 release from activated human leukocytes using a dihydroxyphenoxazine derivative. J. Immunol. Methods 202:133-141.
33. Scott, I. D. and Nicholls, D. G. 1980. Energy transduction in intact synaptosomes: Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ. Biochem. J. 186:21-33.
34. Nieminen, A. L., Petrie, T. G., Lemasters, J. J., and Selman, W. R. 1996. Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: Evidence of the mitochondrial permeability transition. Neuroscience 75:993-997
35. Kiedrowski, L. and Costa, E. 1995. Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: Role of mitochondria in calcium buffering. Mol. Pharmacol. 47:140-147.
36. Santos, A. E., Carvalho, A. L., Lopes, M. C., and Carvalho, A. P. 2001. Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal neurons. J. Neurosci. Res. 66:643-655.
37. Ambrosio, A. F., Silva, A. P., Malva, J. O., Mesquita, J. F., Carvalho, A. P., and Carvalho, C. M. 2000. Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]i changes in cultured rat hippocampal neurons. Eur. J. Neurosci. 12:2021-2031.
38. Boveris, A., Cadenas, E., and Stoppani, A. O. 1976. Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem. J. 156:435-444.