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Volumn 14, Issue 6, 2006, Pages 290-302

The role of opioid receptor phosphorylation and trafficking in adaptations to persistent opioid treatment

Author keywords

G Protein coupled receptor kinase; Morphine, chronic; Opioid receptor trafficking; Phosphorylation

Indexed keywords

MORPHINE; OPIATE; OPIATE RECEPTOR; PHOSPHOPROTEIN;

EID: 33745018099     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093044     Document Type: Review
Times cited : (44)

References (96)
  • 1
    • 0042572492 scopus 로고    scopus 로고
    • Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro
    • Hack SP, Vaughan CW, Christie MJ: Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology 2003;45:575-584.
    • (2003) Neuropharmacology , vol.45 , pp. 575-584
    • Hack, S.P.1    Vaughan, C.W.2    Christie, M.J.3
  • 3
    • 12344316960 scopus 로고    scopus 로고
    • GABA transporter currents activated by protein kinase a excite midbrain neurons during opioid withdrawal
    • Bagley EE, Gerke MB, Vaughan CW, Hack SP, Christie MJ: GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron 2005;45:433-445.
    • (2005) Neuron , vol.45 , pp. 433-445
    • Bagley, E.E.1    Gerke, M.B.2    Vaughan, C.W.3    Hack, S.P.4    Christie, M.J.5
  • 4
    • 33646026212 scopus 로고    scopus 로고
    • Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
    • doi:10.1 186/1744-8069-1-7
    • Bie B, Pan ZZ: Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats. Mol Pain 2005;1:7. doi:10.1 186/1744-8069-1-7.
    • (2005) Mol Pain , vol.1 , pp. 7
    • Bie, B.1    Pan, Z.Z.2
  • 5
    • 0037456565 scopus 로고    scopus 로고
    • Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons
    • Saal D, Dong Y, Bonci A, Malenka RC: Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 2003;37:577-582.
    • (2003) Neuron , vol.37 , pp. 577-582
    • Saal, D.1    Dong, Y.2    Bonci, A.3    Malenka, R.C.4
  • 6
    • 0035138995 scopus 로고    scopus 로고
    • Cellular and synaptic adaptations mediating opioid dependence
    • Williams JT, Christie MJ, Manzoni O: Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev 2001;81:299-343.
    • (2001) Physiol Rev , vol.81 , pp. 299-343
    • Williams, J.T.1    Christie, M.J.2    Manzoni, O.3
  • 7
    • 12344271040 scopus 로고    scopus 로고
    • Opioids: Cellular mechanisms of tolerance and physical dependence
    • Bailey CP, Connor M: Opioids: cellular mechanisms of tolerance and physical dependence. Curr Opin Pharmacol 2005;5:60-68.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 60-68
    • Bailey, C.P.1    Connor, M.2
  • 8
    • 2442678807 scopus 로고    scopus 로고
    • Agonist-induced regulation and trafficking of κ opioid receptors
    • Liu-Chen L-Y: Agonist-induced regulation and trafficking of κ opioid receptors. Life Sci 2004;75:511-536.
    • (2004) Life Sci , vol.75 , pp. 511-536
    • Liu-Chen, L.-Y.1
  • 10
    • 7444249478 scopus 로고    scopus 로고
    • Chronic morphine-induced plasticity among signalling molecules
    • Gintzler AR, Chakrabarti S: Chronic morphine-induced plasticity among signalling molecules. Novartis Found Symp 2004;261:167-176.
    • (2004) Novartis Found Symp , vol.261 , pp. 167-176
    • Gintzler, A.R.1    Chakrabarti, S.2
  • 12
    • 22944452140 scopus 로고    scopus 로고
    • The origins of diversity and specificity in G protein-coupled receptor signaling
    • Maudsley S, Martin B, Luttrell LM: The origins of diversity and specificity in G protein-coupled receptor signaling. J Pharmacol Exp Ther 2005;314:485-494.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 485-494
    • Maudsley, S.1    Martin, B.2    Luttrell, L.M.3
  • 13
    • 0030953290 scopus 로고    scopus 로고
    • A constitutively internalizing and recycling mutant of the μ-opioid receptor
    • Segredo V, Burford NT, Lameh J, Sadee W: A constitutively internalizing and recycling mutant of the μ-opioid receptor. J Neurochem 1997;68:2395-2404.
    • (1997) J Neurochem , vol.68 , pp. 2395-2404
    • Segredo, V.1    Burford, N.T.2    Lameh, J.3    Sadee, W.4
  • 15
    • 0030797055 scopus 로고    scopus 로고
    • Efficacy and kinetics of opioid action on acutely dissociated neurons
    • Ingram S, Wilding TJ, McCleskey EW, Williams JT: Efficacy and kinetics of opioid action on acutely dissociated neurons. Mol Pharmacol 1997;52:136-143.
    • (1997) Mol Pharmacol , vol.52 , pp. 136-143
    • Ingram, S.1    Wilding, T.J.2    McCleskey, E.W.3    Williams, J.T.4
  • 16
    • 10044280635 scopus 로고    scopus 로고
    • μ-Opioid receptor desensitization: Is morphine different?
    • Connor M, Osborne P, Christie MJ: μ-Opioid receptor desensitization: is morphine different? Br J Pharmacol 2004;143:685-696.
    • (2004) Br J Pharmacol , vol.143 , pp. 685-696
    • Connor, M.1    Osborne, P.2    Christie, M.J.3
  • 18
    • 0027998413 scopus 로고
    • Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons
    • Nomura K, Reuveny E, Narahashi T: Opioid inhibition and desensitization of calcium channel currents in rat dorsal root ganglion neurons. J Pharmacol Exp Ther 1994;270:466-474.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 466-474
    • Nomura, K.1    Reuveny, E.2    Narahashi, T.3
  • 19
    • 0038383458 scopus 로고    scopus 로고
    • Regulated endocytosis of opioid receptors: Cellular mechanisms and proposed roles in physiological adaptation to opioid drugs
    • Von Zastrow M, Svingos A, Haberstock-Debic, Evans C: Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opioid drugs. Curr Opin Neurobiol 2003;13:348-353.
    • (2003) Curr Opin Neurobiol , vol.13 , pp. 348-353
    • Von Zastrow, M.1    Svingos, A.2    Haberstock-Debic3    Evans, C.4
  • 20
    • 21244499733 scopus 로고    scopus 로고
    • Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS
    • Garzon J, Rodriguez-Munoz M, de la Torre-Madrid E, Sanchez-Blazquez P: Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS. Psychopharmacology 2005;180:1-11.
    • (2005) Psychopharmacology , vol.180 , pp. 1-11
    • Garzon, J.1    Rodriguez-Munoz, M.2    De La Torre-Madrid, E.3    Sanchez-Blazquez, P.4
  • 21
    • 15544367084 scopus 로고    scopus 로고
    • RGS proteins: New players in the filed of opioid signaling and tolerance mechanisms
    • Xie G-X, Palmer PP: RGS proteins: new players in the filed of opioid signaling and tolerance mechanisms. Anesth Analg 2005;100:1034-1042.
    • (2005) Anesth Analg , vol.100 , pp. 1034-1042
    • Xie, G.-X.1    Palmer, P.P.2
  • 22
    • 15744387869 scopus 로고    scopus 로고
    • Activation of μ-opioid receptors transfers control of Gα subunits to regulator of G-protein signalling RGS9-2
    • Garzon J, Rodriguez-Munoz M, Lopez-Fernando A, Sanchez-Blazquez P: Activation of μ-opioid receptors transfers control of Gα subunits to regulator of G-protein signalling RGS9-2. J Biol Chem 2005;280:8951-8960.
    • (2005) J Biol Chem , vol.280 , pp. 8951-8960
    • Garzon, J.1    Rodriguez-Munoz, M.2    Lopez-Fernando, A.3    Sanchez-Blazquez, P.4
  • 24
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitisation and signaling
    • Ferguson SSG: Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitisation and signaling. Pharmacol Rev 2001;53:1-24.
    • (2001) Pharmacol Rev , vol.53 , pp. 1-24
    • Ferguson, S.S.G.1
  • 25
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
    • Daaka Y, Luttrell LM, Lefkowitz RJ: Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997;390:88-91.
    • (1997) Nature , vol.390 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 26
    • 0034954517 scopus 로고    scopus 로고
    • Regulation of opioid receptor function by chronic agonist exposure: Constitutive activity and desensitization
    • Chavkin C, McLaughlin JP, Celver JP: Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization. Mol Pharmacol 2001;60:20-25.
    • (2001) Mol Pharmacol , vol.60 , pp. 20-25
    • Chavkin, C.1    McLaughlin, J.P.2    Celver, J.P.3
  • 28
    • 4444311166 scopus 로고    scopus 로고
    • Morphine induces terminal μ-opioid receptor desensitization by sustained phosphorylation of serine-375
    • Schulz S, Mayer D, Pfeiffer M, Stumm R, Koch T, Hollt V: Morphine induces terminal μ-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J 2004;23:3282-3289.
    • (2004) EMBO J , vol.23 , pp. 3282-3289
    • Schulz, S.1    Mayer, D.2    Pfeiffer, M.3    Stumm, R.4    Koch, T.5    Hollt, V.6
  • 30
    • 17644390240 scopus 로고    scopus 로고
    • Mass spectrophotometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells
    • Trester-Zedlitz M, Burlingame A, Kobilka B, von Zastrow M: Mass spectrophotometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry 2005;44:6133-6143.
    • (2005) Biochemistry , vol.44 , pp. 6133-6143
    • Trester-Zedlitz, M.1    Burlingame, A.2    Kobilka, B.3    Von Zastrow, M.4
  • 31
    • 0035917750 scopus 로고    scopus 로고
    • Agonist-induced μ opioid receptor phosphorylation and functional desensitization in rat thalamus
    • Deng HB, Yu Y, Wang H, Guang W, Wang JB: Agonist-induced μ opioid receptor phosphorylation and functional desensitization in rat thalamus. Brain Res 2001;898:204-214.
    • (2001) Brain Res , vol.898 , pp. 204-214
    • Deng, H.B.1    Yu, Y.2    Wang, H.3    Guang, W.4    Wang, J.B.5
  • 32
    • 0029130047 scopus 로고
    • Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK 293 cells
    • Arden JR, Segredo V, Wang Z, Lameh J, Sadee W: Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK 293 cells. J Neurochem 1995;65:1636-1645.
    • (1995) J Neurochem , vol.65 , pp. 1636-1645
    • Arden, J.R.1    Segredo, V.2    Wang, Z.3    Lameh, J.4    Sadee, W.5
  • 33
    • 15844416295 scopus 로고    scopus 로고
    • Differential μ opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters
    • Zhang L, Yu Y, Mackin S, Weight FF, Uhl GR, Wang JB: Differential μ opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. J Biol Chem 1996;271:11449-11454.
    • (1996) J Biol Chem , vol.271 , pp. 11449-11454
    • Zhang, L.1    Yu, Y.2    Mackin, S.3    Weight, F.F.4    Uhl, G.R.5    Wang, J.B.6
  • 35
    • 0030691760 scopus 로고    scopus 로고
    • μ-Opioid receptor phosphorylation, desensitization and ligand efficacy
    • Yu Y, Zhang L, Yin X, Sun H, Uhl GR, Wang JB: μ-Opioid receptor phosphorylation, desensitization and ligand efficacy. J Biol Chem 1997;272:28869-28874.
    • (1997) J Biol Chem , vol.272 , pp. 28869-28874
    • Yu, Y.1    Zhang, L.2    Yin, X.3    Sun, H.4    Uhl, G.R.5    Wang, J.B.6
  • 37
    • 0033179904 scopus 로고    scopus 로고
    • Functional dissociation of μ-opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
    • Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M: Functional dissociation of μ-opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 1999;23:737-746.
    • (1999) Neuron , vol.23 , pp. 737-746
    • Whistler, J.L.1    Chuang, H.H.2    Chu, P.3    Jan, L.Y.4    Von Zastrow, M.5
  • 38
    • 0033515531 scopus 로고    scopus 로고
    • 5-ol]enkephalin inhibition of adenylyl cyclase activity and agonist-induced μ-opioid receptor phosphorylation
    • 5-ol]enkephalin inhibition of adenylyl cyclase activity and agonist-induced μ-opioid receptor phosphorylation. J Biol Chem 1999;274:9207-9215.
    • (1999) J Biol Chem , vol.274 , pp. 9207-9215
    • El Kouhen, R.1    Maestri-El Kouhen, O.2    Law, P.-Y.3    Low, H.H.4
  • 40
    • 0035903152 scopus 로고    scopus 로고
    • C-terminal splice variants of the mouse μ-opioid receptor differ in morphine-induced internalization and receptor resensitization
    • Koch T, Schulz S, Pfeiffer M, Klutzny M, Schroder H, Kahl E, Hollt V: C-terminal splice variants of the mouse μ-opioid receptor differ in morphine-induced internalization and receptor resensitization. J Biol Chem 2001;276:31408-31414.
    • (2001) J Biol Chem , vol.276 , pp. 31408-31414
    • Koch, T.1    Schulz, S.2    Pfeiffer, M.3    Klutzny, M.4    Schroder, H.5    Kahl, E.6    Hollt, V.7
  • 41
    • 0031814749 scopus 로고    scopus 로고
    • 5-ol]enkephalin-μ-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation
    • 5-ol]enkephalin-μ-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation. J Neurochem 1998;71:231-239.
    • (1998) J Neurochem , vol.71 , pp. 231-239
    • Chakrabarti, S.1    Law, P.-Y.2    Low, H.H.3
  • 42
    • 0034985390 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the μ-opioid receptor regulates intrinsic agonist efficacy
    • McLaughlin JP, Chavkin C: Tyrosine phosphorylation of the μ-opioid receptor regulates intrinsic agonist efficacy. Mol Pharmacol 2001;59:1360-1368.
    • (2001) Mol Pharmacol , vol.59 , pp. 1360-1368
    • McLaughlin, J.P.1    Chavkin, C.2
  • 43
    • 27144541891 scopus 로고    scopus 로고
    • Chemical genetic engineering of G protein-coupled receptor kinase 2
    • Kenski DM, Zhang C, von Zastrow M, Shokat KM: Chemical genetic engineering of G protein-coupled receptor kinase 2. J Biol Chem 2005;280:35051-35061.
    • (2005) J Biol Chem , vol.280 , pp. 35051-35061
    • Kenski, D.M.1    Zhang, C.2    Von Zastrow, M.3    Shokat, K.M.4
  • 44
    • 0036154075 scopus 로고    scopus 로고
    • Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3
    • Schulz R, Wehmeyer A, Schulz K: Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3. J Pharmacol Exp Ther 2002;300:376-384.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 376-384
    • Schulz, R.1    Wehmeyer, A.2    Schulz, K.3
  • 45
    • 12844281159 scopus 로고    scopus 로고
    • Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities
    • Sadee W, Wang D, Bilsky EJ: Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sci 2005;76:1427-1437.
    • (2005) Life Sci , vol.76 , pp. 1427-1437
    • Sadee, W.1    Wang, D.2    Bilsky, E.J.3
  • 46
    • 0021200625 scopus 로고
    • Direct demonstration of impaired functionality of a purified desensitized β-adrenergic receptor in an reconstituted system
    • Strulovici B, Cerione R, Kilpatrick BF, Caron MG, Lefkowitz RJ: Direct demonstration of impaired functionality of a purified desensitized β-adrenergic receptor in an reconstituted system. Science 1984; 225: 837-840.
    • (1984) Science , vol.225 , pp. 837-840
    • Strulovici, B.1    Cerione, R.2    Kilpatrick, B.F.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 48
    • 0842331059 scopus 로고    scopus 로고
    • The molecular acrobatics of arrestin activation
    • Gurevich VV, Gurevich EV: The molecular acrobatics of arrestin activation. Trends Pharmacol Sci 2004;25:105-111.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 105-111
    • Gurevich, V.V.1    Gurevich, E.V.2
  • 49
    • 9444274109 scopus 로고    scopus 로고
    • Protein kinase C activation enhances morphine-induced rapid desensitization of μ-opioid receptors in mature rat locus ceruleus neurons
    • Bailey CP, Kelley EP, Henderson G: Protein kinase C activation enhances morphine-induced rapid desensitization of μ-opioid receptors in mature rat locus ceruleus neurons. Mol Pharmacol 2004;66:1592-1598.
    • (2004) Mol Pharmacol , vol.66 , pp. 1592-1598
    • Bailey, C.P.1    Kelley, E.P.2    Henderson, G.3
  • 51
    • 0034595860 scopus 로고    scopus 로고
    • Differential affinities of visual arrestin, βarrestin1 and βarrestin2 for G protein-coupled receptors delineate two major classes of receptors
    • Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS: Differential affinities of visual arrestin, βarrestin1 and βarrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 2000;275:17201-17210.
    • (2000) J Biol Chem , vol.275 , pp. 17201-17210
    • Oakley, R.H.1    Laporte, S.A.2    Holt, J.A.3    Caron, M.G.4    Barak, L.S.5
  • 53
    • 3042665659 scopus 로고    scopus 로고
    • Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery
    • Bohn LM, Dykstra LA, Lefkowitz RJ Caron MG, Barak LS: Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol Pharmacol 2004;66:106-112.
    • (2004) Mol Pharmacol , vol.66 , pp. 106-112
    • Bohn, L.M.1    Dykstra, L.A.2    Lefkowitz, R.J.3    Caron, M.G.4    Barak, L.S.5
  • 55
    • 0034619796 scopus 로고    scopus 로고
    • μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
    • Bohn LM, Gainetdinov RR, Lin F, Lefkowitz RJ, Caron, MG: μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence. Nature 2000;408:720-723.
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 56
    • 0036895747 scopus 로고    scopus 로고
    • Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knockout mice
    • Bohn LM, Lefkowitz RJ, Caron MG: Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knockout mice. J Neurosci 2002;22:10494-10500.
    • (2002) J Neurosci , vol.22 , pp. 10494-10500
    • Bohn, L.M.1    Lefkowitz, R.J.2    Caron, M.G.3
  • 58
    • 0034555126 scopus 로고    scopus 로고
    • Postsynaptic signaling via the μ-opioid receptor: Responses of dorsal horn neurons to exogenous opioids and noxious stimulation
    • Trafton JA, Abbadie C, Marek K, Basbaum AI: Postsynaptic signaling via the μ-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J Neurosci 2000;20:8578-8584.
    • (2000) J Neurosci , vol.20 , pp. 8578-8584
    • Trafton, J.A.1    Abbadie, C.2    Marek, K.3    Basbaum, A.I.4
  • 59
    • 0037169345 scopus 로고    scopus 로고
    • Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization
    • He L, Fong J, von Zastrow M, Whistler JL: Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell 2002;108:271-282.
    • (2002) Cell , vol.108 , pp. 271-282
    • He, L.1    Fong, J.2    Von Zastrow, M.3    Whistler, J.L.4
  • 60
    • 0036139464 scopus 로고    scopus 로고
    • Internalization and trafficking of opioid receptor ligands in rat cortical neurons
    • Lee M-C, Cahill CM, Vincent J-P, Beaudet A: Internalization and trafficking of opioid receptor ligands in rat cortical neurons. Synapse 2002;43:102-111.
    • (2002) Synapse , vol.43 , pp. 102-111
    • Lee, M.-C.1    Cahill, C.M.2    Vincent, J.-P.3    Beaudet, A.4
  • 63
    • 0037805628 scopus 로고    scopus 로고
    • Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of mu-opioid receptors
    • Borgland SL, Connor M, Osborne PB, Furness JB, Christie MJ: Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of mu-opioid receptors. J Biol Chem 2003;278:18776-18784.
    • (2003) J Biol Chem , vol.278 , pp. 18776-18784
    • Borgland, S.L.1    Connor, M.2    Osborne, P.B.3    Furness, J.B.4    Christie, M.J.5
  • 64
    • 1342265799 scopus 로고    scopus 로고
    • Distinct domains of the μ-opioid receptor control uncoupling and internalization
    • Celver J, Xu M, Jin W, Lowe J, Chavkin C: Distinct domains of the μ-opioid receptor control uncoupling and internalization. Mol Pharmacol 2004;65:528-537.
    • (2004) Mol Pharmacol , vol.65 , pp. 528-537
    • Celver, J.1    Xu, M.2    Jin, W.3    Lowe, J.4    Chavkin, C.5
  • 65
    • 23944437411 scopus 로고    scopus 로고
    • Morphine promotes rapid, arrestin-dependent endocytosis of μ-opioid receptors in striatal neurons
    • Haberstock-Debic H, Kim K-A, Yu YJ, von Zastrow M: Morphine promotes rapid, arrestin-dependent endocytosis of μ-opioid receptors in striatal neurons. J Neurosci 2005;25:7847-7857.
    • (2005) J Neurosci , vol.25 , pp. 7847-7857
    • Haberstock-Debic, H.1    Kim, K.-A.2    Yu, Y.J.3    Von Zastrow, M.4
  • 67
    • 0032577554 scopus 로고    scopus 로고
    • Carboxyl-terminal splicing of the rat μ-opioid receptor modulates agonist-mediated internalization and receptor resensitization
    • Koch T, Schulz S, Schroder H, Wolf R, Raulf E, Hollt V: Carboxyl-terminal splicing of the rat μ-opioid receptor modulates agonist-mediated internalization and receptor resensitization. J Biol Chem 1998;273:13652-13667.
    • (1998) J Biol Chem , vol.273 , pp. 13652-13667
    • Koch, T.1    Schulz, S.2    Schroder, H.3    Wolf, R.4    Raulf, E.5    Hollt, V.6
  • 68
    • 0242495833 scopus 로고    scopus 로고
    • A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors
    • Tanowitz M, von Zastrow M: A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors. J Biol Chem 2003;278:45978-45986.
    • (2003) J Biol Chem , vol.278 , pp. 45978-45986
    • Tanowitz, M.1    Von Zastrow, M.2
  • 70
    • 0035819078 scopus 로고    scopus 로고
    • Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of withdrawal
    • Finn AK, Whistler JL: Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of withdrawal. Neuron 2001;32:829-839.
    • (2001) Neuron , vol.32 , pp. 829-839
    • Finn, A.K.1    Whistler, J.L.2
  • 71
    • 25144435574 scopus 로고    scopus 로고
    • Morphine-induced μ-opioid receptor desensitization
    • Dang V, Williams JT: Morphine-induced μ-opioid receptor desensitization. Mol Pharmacol 2005;68:1127-1132.
    • (2005) Mol Pharmacol , vol.68 , pp. 1127-1132
    • Dang, V.1    Williams, J.T.2
  • 72
    • 0345305690 scopus 로고    scopus 로고
    • μ-Opioid receptor desensitization in mature rat neurons: Lack of interaction between DAMGO and morphine
    • Bailey CP, Couch D, Johnson E, Griffiths K, Kelly E, Henderson G: μ-Opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine. J Neurosci 2003;23:10515-10520.
    • (2003) J Neurosci , vol.23 , pp. 10515-10520
    • Bailey, C.P.1    Couch, D.2    Johnson, E.3    Griffiths, K.4    Kelly, E.5    Henderson, G.6
  • 73
    • 0142250830 scopus 로고    scopus 로고
    • Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide μ-opioid receptor agonists
    • Blanchet C, Sollini M, Luscher C: Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide μ-opioid receptor agonists. Mol Cell Neurosci 2003;24:517-523.
    • (2003) Mol Cell Neurosci , vol.24 , pp. 517-523
    • Blanchet, C.1    Sollini, M.2    Luscher, C.3
  • 74
    • 0023510867 scopus 로고
    • Cellular mechanisms of opioid tolerance: Studies in single brain neurons
    • Christie MJ, Williams JT, North RA: Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol Pharmacol 1987;32:633-638.
    • (1987) Mol Pharmacol , vol.32 , pp. 633-638
    • Christie, M.J.1    Williams, J.T.2    North, R.A.3
  • 75
    • 0032704860 scopus 로고    scopus 로고
    • Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats
    • Connor M, Borgland SL, Christie MJ: Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats. Br J Pharmacol 1999;128:1561-1569.
    • (1999) Br J Pharmacol , vol.128 , pp. 1561-1569
    • Connor, M.1    Borgland, S.L.2    Christie, M.J.3
  • 76
    • 4444236554 scopus 로고    scopus 로고
    • Chronic morphine treatment reduces recovery from desensitization
    • Dang V, Williams JT: Chronic morphine treatment reduces recovery from desensitization. J Neurosci 2004;24:7699-7706.
    • (2004) J Neurosci , vol.24 , pp. 7699-7706
    • Dang, V.1    Williams, J.T.2
  • 77
    • 30644458052 scopus 로고    scopus 로고
    • Opioid tolerance in periaqueductal gray mouse neurons isolated from mice chronically treated with morphine
    • Bagley EE, Chieng BCH, Christie MJ, Connor M: Opioid tolerance in periaqueductal gray mouse neurons isolated from mice chronically treated with morphine. Br J Pharmacol 2005;146:68-76.
    • (2005) Br J Pharmacol , vol.146 , pp. 68-76
    • Bagley, E.E.1    Chieng, B.C.H.2    Christie, M.J.3    Connor, M.4
  • 78
    • 4644231620 scopus 로고    scopus 로고
    • A inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area
    • A inhibition of bed nucleus of the stria terminalis neurons projecting to the ventral tegmental area. J Neurosci 2004;8198-8204.
    • (2004) J Neurosci , pp. 8198-8204
    • Dumont, E.1    Williams, J.T.2
  • 80
    • 0034660289 scopus 로고    scopus 로고
    • Chronic heroin self-administration desensitizes μ opioid receptor-activated G-proteins in specific regions of rat brain
    • Sim-Selley LJ, Selley DE, Vogt LJ, Childers SR, Martin TJ: Chronic heroin self-administration desensitizes μ opioid receptor-activated G-proteins in specific regions of rat brain. J Neurosci 2000;20:4555-4562.
    • (2000) J Neurosci , vol.20 , pp. 4555-4562
    • Sim-Selley, L.J.1    Selley, D.E.2    Vogt, L.J.3    Childers, S.R.4    Martin, T.J.5
  • 84
    • 0034955327 scopus 로고    scopus 로고
    • Chronic exposure μ-opioid agonists produces constitutive activation of μ-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment
    • Liu JG, Prather PL: Chronic exposure μ-opioid agonists produces constitutive activation of μ-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol 2001;60:53-62.
    • (2001) Mol Pharmacol , vol.60 , pp. 53-62
    • Liu, J.G.1    Prather, P.L.2
  • 86
    • 1942456664 scopus 로고    scopus 로고
    • 5]enkephalin- induced internalization of the μ-opioid receptor in the spinal cord of morphine tolerant rats
    • 5]enkephalin-induced internalization of the μ-opioid receptor in the spinal cord of morphine tolerant rats. Neuroscience 2004;125:541-543.
    • (2004) Neuroscience , vol.125 , pp. 541-543
    • Trafton, J.A.1    Basbaum, A.I.2
  • 87
    • 27744587829 scopus 로고    scopus 로고
    • Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine
    • Drake CT, Aicher SA, Montalmant FL, Milner TA: Redistribution of mu-opioid receptors in C1 adrenergic neurons following chronic administration of morphine. Exp Neurol 2005;196:365-372.
    • (2005) Exp Neurol , vol.196 , pp. 365-372
    • Drake, C.T.1    Aicher, S.A.2    Montalmant, F.L.3    Milner, T.A.4
  • 89
    • 0027945014 scopus 로고
    • Chronic morphine administration increases β-adrenergic receptor kinase (βARK) levels in the rat locus coeruleus
    • Terwilliger RZ, Ortiz J, Guitart X, Nestler EJ: Chronic morphine administration increases β-adrenergic receptor kinase (βARK) levels in the rat locus coeruleus. J Neurochem 1994;63:1983-1986.
    • (1994) J Neurochem , vol.63 , pp. 1983-1986
    • Terwilliger, R.Z.1    Ortiz, J.2    Guitart, X.3    Nestler, E.J.4
  • 90
    • 0036892880 scopus 로고    scopus 로고
    • Opioid agonists differentially regulate μ-opioid receptor trafficking proteins in vivo
    • Patel MB, Patel CN, Rajashekara V, Yoburn BC: Opioid agonists differentially regulate μ-opioid receptor trafficking proteins in vivo. Mol Pharmacol 2002;62:1464-1470.
    • (2002) Mol Pharmacol , vol.62 , pp. 1464-1470
    • Patel, M.B.1    Patel, C.N.2    Rajashekara, V.3    Yoburn, B.C.4
  • 91
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by β-arrestins
    • Lefkowitz RJ, Shenoy SK: Transduction of receptor signals by β-arrestins. Science 2005;308:512-517.
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 92
    • 0013636518 scopus 로고
    • Selective changes in μ opioid receptor properties induced by chronic morphine exposure
    • USA
    • Werling LL, McMahon PN, Cox BM: Selective changes in μ opioid receptor properties induced by chronic morphine exposure. Proc Natl Acad Sci USA 1989;86:6393-6397.
    • (1989) Proc Natl Acad Sci , vol.86 , pp. 6393-6397
    • Werling, L.L.1    McMahon, P.N.2    Cox, B.M.3
  • 93
    • 0025185668 scopus 로고
    • Down-regulation of brain and spinal cord μ-opiate receptors in morphine tolerant-dependent rats
    • Bhargava HN, Gulati A: Down-regulation of brain and spinal cord μ-opiate receptors in morphine tolerant-dependent rats. Eur J Pharmacol 1990;190:305-311.
    • (1990) Eur J Pharmacol , vol.190 , pp. 305-311
    • Bhargava, H.N.1    Gulati, A.2
  • 94
    • 4444234066 scopus 로고    scopus 로고
    • Opioid agonist and antagonist treatment differentially regulates immunoreactive μ-opioid receptors and dynamin-2 in vivo
    • Yoburn BC, Purohit V, Patel K, Zhang Q: Opioid agonist and antagonist treatment differentially regulates immunoreactive μ-opioid receptors and dynamin-2 in vivo. Eur J Pharmacol 2004;498:87-96.
    • (2004) Eur J Pharmacol , vol.498 , pp. 87-96
    • Yoburn, B.C.1    Purohit, V.2    Patel, K.3    Zhang, Q.4
  • 95
    • 0023093925 scopus 로고
    • Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment
    • Tao PL, Law PY, Loh HH: Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment. J Pharmacol Exp Ther 1987;240:809-816.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 809-816
    • Tao, P.L.1    Law, P.Y.2    Loh, H.H.3
  • 96
    • 0029028841 scopus 로고
    • Mu-opioid receptor regulation during opioid tolerance and supersensitivity in rat central nervous system
    • Diaz A, Ruiz F, Florez J, Hurle MA, Pazos A: Mu-opioid receptor regulation during opioid tolerance and supersensitivity in rat central nervous system. J Pharmacol Exp Ther 1995;274:1545-1551.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1545-1551
    • Diaz, A.1    Ruiz, F.2    Florez, J.3    Hurle, M.A.4    Pazos, A.5


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