Chronic heroin self-administration desensitizes μ opioid receptor- activated G-proteins in specific regions of rat brain

Journal of Neuroscience

Volumn 20, Issue 12, 2000, Pages 4555-4562

  Sim Selley, Laura J ^a   Selley, Dana E ^a   Vogt, Leslie J ^b   Childers, Steven R ^b   Martin, Thomas J ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Desensitization; G protein; Heroin; Nociceptin orphanin FQ receptor; opioid receptor; opioid receptor

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE A1 RECEPTOR; CANNABINOID RECEPTOR; DELTA OPIATE RECEPTOR; DIAMORPHINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MORPHINE; MU OPIATE RECEPTOR; NALOXONE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN; CONTROLLED STUDY; DESENSITIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

EID: 0034660289     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-12-04555.2000     Document Type: Article

References (52)

1. 35S]thio)triphosphate binding by endogenous opioids acting at a cloned mu receptor. J Pharmacol Exp Ther 286:282-288.
2. Blasig J, Hollt V, Hengstenberg J, Dum J, Herz A (1979) Non-competitive nature of the antagonistic mechanism responsible for tolerance to opiate-induced analgesia. Neuropharmacology 18:473-481.
3. Bozarth MA, Wise RA (1984) Anatomically distinct opiate receptor fields mediate reward and physical dependence. Science 224:516-517.
4. Brady LS, Herkenham M, Long JB, Rothman RB (1989) Chronic morphine increases μ-opiate receptor binding in rat brain: a quantitative autoradiographic study. Brain Res 477:382-386.
5. Breivogel CS, Selley DE, Childers SR (1997) Acute and chronic effects of opioids on delta and mu receptor activation of G-proteins in NG108-15 and SK-N-SH cell membranes. J Neurochem 68:1462-1472.
6. Chakrabarti S, Yang W, Law PY, Loh HH (1997) The mu-opioid receptor down-regulates differently from the delta-opioid receptor: requirement of a high affinity receptor/G protein complex formation. Mol Pharmacol 52:105-113.
7. Chen Y, Mestek A, Liu J, Hurley JA, Yu L (1993) Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol Pharmacol 44:8-12.
8. Childers SR, Snyder SH (1980) Differential regulation by guanine nucleotides of opiate agonist and antagonist receptor interactions. J Neurochem 34:583-593.
9. Christie MJ, Williams JT, North RA (1987) Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol Pharmacol 32:633-638.
10. Clark MJ, Emmerson PJ, Mansour A, Akil H, Woods JH, Portoghese PS, Remmers AE, Medzihradsky F (1997) Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. J Pharmacol Exp Ther 283:501-510.
11. Colpaert FC (1995) Drug discrimination: no evidence for tolerance to opiates. Pharmacol Rev 47:605-629.
12. Contarino A, Zanotti A, Drago F, Natolino F, Lipartiti M, Giusti P (1997) Conditioned place preference: no tolerance to the rewarding properties of morphine. Naunyn Schmiedebergs Arch Pharmacol 355:589-594.
13. Evans CJ, Keith Jr DE, Morrison H, Magendzo K, Edwards RH (1992) Cloning of a delta opioid receptor by functional expression. Science 258:1952-1955.
14. Goldstein A, Herrera J (1995) Heroin addicts and methadone treatment in Albuquerque: a 22-year follow-up. Drug Alcohol Dep 40:139-150.
15. Herkenham M, Pert CB (1982) Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality. J Neurosci 2:1129-1149.
16. Inturrisi CE, Schultz M, Shin S, Umans JG, Angel L, Simon EJ (1983) Evidence from opiate binding studies that heroin acts through its metabolites. Life Sci 33:773-776.
17. Jordan BA, Devi LA (1999) G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399:697-700.
18. Keith DE, Anton B, Murray SR, Zaki PA, Chu PC, Lissin DV, Monteillet-Agius G, Stewart PL, Evans CJ, von Zastrow M (1998) mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain. Mol Pharmacol 53:377-384.
19. Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG (1992) The δ-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci USA 89:12048-12052.
20. Klee WA, Streaty RA (1974) Narcotic receptor sites in morphine-dependent rats. Nature 248:61-63.
21. Kogan JH, Nestler EJ, Aghajanian GK (1992) Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus in brain slices from opiate-dependent rats. Eur J Pharmacol 211:47-53.
22. Law PY, Hom DS, Loh HH (1983) Opiate receptor down-regulation and desensitization in neuroblastoma x glioma NG108-15 hybrid cells are two separate cellular adaptation processes. Mol Pharmacol 24:413-424.
23. Lefkowitz RJ, Inglese J, Koch WJ, Pitcher J, Attramadal H, Caron MG (1992) G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. Cold Spring Harbor Symp Quant Biol 57:127-133.
24. Maher C, Selley D, Childers S (2000) Relationship of mu opioid receptor binding to activation of G-proteins in specific rat brain regions. Biochem Pharmacol 59:1395-1401.
25. Martin TJ, Dworkin SI, Smith JE (1995) Alkylation of mu opioid receptors by β-funaltrexamine in vivo: comparison of the effects on in situ binding and heroin self-administration in rats. J Pharmacol Exp Ther 272:1135-1140.
26. Nestler EJ (1992) Molecular mechanisms of drug addiction. J Neurosci 12:2439-2450.
27. Noble F, Cox BM (1996) Differential desensitization of mu-and delta-opioid receptors in selected neural pathways following chronic morphine treatment. Br J Pharmacol 117:161-169.
28. Noble F, Cox BM (1997) The role of dopaminergic systems in opioid receptor desensitization in nucleus accumbens and caudate putamen of rat after chronic morphine treatment. J Pharmacol Exp Ther 283:557-565.
29. Puttfarcken PS, Cox BM (1989) Morphine-induced desensitization and downregulation at mu-receptors in 7315C pituitary tumor cells. Life Sci 45:1937-1942.
30. Puttfarcken PS, Werling LL, Cox BM (1988) Effects of chronic morphine exposure on opioid inhibition of adenylyl cylcase in 7315c cell membranes: a useful model for the study of tolerance at mu opioid receptors. Mol Pharmacol 33:520-527.
31. Rossi CG, Leventhal L, Pan YX, Cole J, Su W, Bodnar RJ, Pasternak GW (1997) Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6β-glucuronide antinociception. J Pharmacol Exp Ther 281:109-114.
32. Schuller AG, King MA, Zhang J, Bolan E, Pan YX, Morgan DJ, Chang A. Czick ME, Unterwald EM, Pasternak GW, Pintar JE (1999) Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci 2:151-156.
33. Schulteis G, Koob GF (1996) Reinforcement processes in opiate addiction: a homeostatic model. Neurochem Res 21:1437-1454.
34. Selley DE, Nestler EJ, Breivogel CS, Childers SR (1997a) Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: decrease in activity after chronic morphine treatment. Brain Res 746:10-18.
35. 35S]GTPγS binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy. Mol Pharmacol 51:87-96.
36. 35S]GTPγS binding in mMOR-CHO cells and rat thalamus. J Pharmacol Exp Ther 285:496-505.
37. 35S]thio]-triphosphate binding. Proc Natl Acad Sci USA 92:7242-7246.
38. 35S]GTPγS autoradiography in rat brain. J Neurosci 16:2684-2692.
39. Sim LJ, Selley DE, Xiao R, Childers SR (1996b) Differences in G-protein activation by mu and delta opioid, and cannabinoid, receptors in rat striatum. Eur J Pharmacol 307:95-107.
40. 35S]GTPγS binding in rat brain. NeuroReport 7:729-733.
41. 35S]GTPγS binding. In: Methods in molecular biology: receptor signal transduction protocols (Challiss RS, ed), pp 117-132. Totowa, NI: Humana.
42. Smith J, Co C, Freeman M, Sands M, Lane J (1980) Neurotransmitter turnover in rat striatum is correlated with morphine self-administration. Nature 287:152-154.
43. Tao P-L, Law P-Y, Loh HH (1987) Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment. J Pharmacol Exp Ther 240:809-816.
44. Tao P-L, Chang L-R, Chou Y-P, Law P-Y, Loh HH (1993) Chronic opioid treatment may uncouple opioid receptors and G-proteins: evidence from irradiation inactivation analysis. Eur J Pharmacol 246:233-238.
45. Thompson RC, Mansour A, Akil H, Watson SJ (1993) Cloning and pharmacological characterization of a rat μ opioid receptor. Neuron 11:903-913.
46. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol Pharmacol 47:848-854.
47. Umans JG, Inturrisi CE (1981) Pharmacodynamics of subcutaneously administered diacetylmorphine. 6-acetylmorphine and morphine in mice. J Pharmacol Exp Ther 218:409-415.
48. Vaccarino FJ, Bloom FE, Koob GF (1985) Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat. Psychopharmacology 86:37-42.
49. Way EL, Young JM, Kemp JW (1965) Metabolism of heroin and its pharmacologic implications. Bull Narcotics 17:25-33.
50. Way EL, Loh HH, Shen FH (1969) Simultaneous quantitative assessment of morphine tolerance and physical dependence. J Pharmacol Exp Ther 167:1-8.
51. Yoburn BC, Billings B, Duttaroy A (1993) Opioid receptor regulation in mice. J Pharmacol Exp Ther 265:314-320.
52. 3H]opioid receptors in rat brain. Brain Res 179:255-270.