Morphine-induced μ-opioid receptor desensitization

Molecular Pharmacology

Volumn 68, Issue 4, 2005, Pages 1127-1130

  Dang, Vu C ^a   Williams, John T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METENKEPHALIN; MORPHINE; MU OPIATE RECEPTOR;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LOCUS CERULEUS; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; WHOLE CELL;

ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; MALE; MORPHINE; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 25144435574     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.013185     Document Type: Article

References (29)

1. Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, and Williams JT (2002) mu-Opioid receptors: ligand-dependent activation of potassium conductance, desensitization and internalization. J Neurosci 22:5769-5776.
2. Bailey CP, Couch D, Johnson E, Griffiths K, Kelly E, and Henderson G (2003) mu-Opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine. J Neurosci 23:10515-10520.
3. Bailey CP, Kelly E, and Henderson G (2004) Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons. Mol Pharmacol 66:1592-1598.
4. Blanchet C and Luscher C (2002) Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector. Proc Natl Acad Sci USA 99:4674-4679.
5. Blanchet C, Sollini M, and Luscher C (2003) Two distinct forms of desensitization of G-protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide mu-opioid receptor agonists. Mol Cell Neurosci 24:517-523.
6. Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, and Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature (Lond) 408:720-723.
7. Borgland SL, Connor M, Osborne PB, Furness JB, and Christie MJ (2003) Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization and endocytosis of mu-opioid receptors. J Biol Chem 278:18776-18784.
8. Bradaia A, Berton F, Ferrari S, and Luscher C (2005) beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids. Proc Natl Acad Sci USA 102:3034-3039.
9. Celver J, Xu M, Jin W, Lowe J, and Chavkin C (2004) Distinct domains of the μ-opioid receptor control uncoupling and internalization. Mol Pharmacol 65:528-537.
10. Christie MJ, Williams JT, and North RA (1987) Cellular mechanisms of opioid tolerance: studies in single brain neurons. Mol Pharmacol 32:633-638.
11. Connor M, Borgland SL, and Christie MJ (1999) Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons form morphine-dependent rats. Br J Pharmacol 128:1561-1569.
12. Dang VC and Williams JT (2004) Chronic morphine treatment reduces recovery from opioid desensitization. J Neurosci 24:7699-7706.
13. Finn AK and Whistler JL (2001) Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron 32:829-839.
14. Fiorillo CD and Williams JT (1996) Opioid desensitization: interactions with G protein-coupled receptors in the locus coeruleus. J Neurosci 15:1479-1485.
15. Haberstock-Debic H, Wein M, Barrot M, Colago EE, Rahman Z, Neve RL, Pickel VM, Nestler EJ, von Zastrow M, and Svingos AL (2003) Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons. J Neurosci 23:4324-4332.
16. Hack SP, Bagley EE, Chieng BCH, and Christie MJ (2005) Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. J Neurosci 25:3192-3198.
17. Harris GC and Williams JT (1991) Transient homologous μ-opioid receptor desensitization in rat locus coeruleus neurons. J Neurosci 11:2574-2581.
18. He L, Fong J, von Zastrow M, and Whistler JL (2002) Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell 108:271-282.
19. Ishimatsu M and Williams JT (1996) Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions. J Neurosci 16:5196-5204.
20. Kovoor A, Celver JP, Wu A, and Chavkin C (1998) Agonist induced homologous desensitization of μ-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Mol Pharmacol 54:704-711.
21. Minnis JG, Patierno S, Kohlmeier SE, Brecha NC, Tonini M, and Sternini C (2003) Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons. Neuroscience 119:33-42.
22. Sternini C, Spann M, Anton B, Keith DE Jr, Bunnett NW, von Zastrow M, Evans C, and Brecha NC (1996) Agonist-selective endocytosis of mu opioid receptor by neurons in vivo. Proc Natl Acad Sci USA 93:9241-9246.
23. Terwilliger RZ, Ortiz J, Guitart X, and Nestler EJ (1994) Chronic morphine administration increases beta-adrenergic receptor kinase (beta ARK) levels in the rat locus coeruleus. J Neurochem 63:1983-1986.
24. von Zastrow M (2001) Role of endocytosis in signalling and regulation of G-protein-coupled receptors. Biochem Soc Trans 29:500-504.
25. Whistler JL, Chuang HH, Chu P, Jan LY, and von Zastrow M (1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23:737-746.
26. Whistler JL and von Zastrow M (1998) Morphine-activated opioid receptors elude desensitization by beta-arrestin. Proc Natl Acad Sci USA 95:9914-9919.
27. Williams JT and North RA (1984) Opiate-receptor interactions on single locus coeruleus neurones. Mol Pharmacol 26:489-497.
28. Yu Y, Zhang L, Yin X, Sun H, Uhl GR, and Wang JB (1997) Mu opioid receptor phosphorylation, desensitization and ligand efficacy. Mol Pharmacol 272:28869-28874.
29. Zhang J, Ferguson SS, Barak LS, Bodduluri SR, Laporte SA, Law PY, and Caron MG (1998) Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. Proc Natl Acad Sci USA 95:7157-7162.