Molecular components of tolerance to opiates in single hippocampal neurons

Molecular Pharmacology

Volumn 61, Issue 1, 2002, Pages 55-64

  Bushell, T ^a,b   Endoh, T ^a   Simen, A A ^a   Ren, D ^a   Bindokas, V P ^a   Miller, R J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; BETA ARRESTIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; METHADONE; MORPHINE; OPIATE; OPIATE AGONIST; SIGMA OPIATE RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG TOLERANCE; ELECTROPHYSIOLOGY; ENDOCYTOSIS; FETUS; HIPPOCAMPUS; INTERNALIZATION; NERVE CELL CULTURE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC TRANSMISSION;

ANIMALS; ARRESTINS; BARIUM; CELLS, CULTURED; DRUG TOLERANCE; ELECTROPHYSIOLOGY; HIPPOCAMPUS; NARCOTICS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; RECEPTORS, OPIOID, MU; SYNAPTIC TRANSMISSION; TISSUE DISTRIBUTION;

EID: 0036140932     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.1.55     Document Type: Article

References (29)

1. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK 293 cells
2. Internal trafficking and surface mobility of a functionally intact 2-adrenergic receptor-green fluorescent protein conjugate
3. Enhanced morphine analgesia in mice lacking beta-arrestin 2
4. Modulation of synaptic transmission and differential localisation of mGlus in cultured hippocampal autapses
5. Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats
6. Opioid receptor signaling mechanisms
7. Autoradiographic mapping of mu-opioid receptors during opiate tolerance and supersensitivity in the rat central nervous system
8. Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence
9. Visualization of agonist-induced association and trafficking of green fluorescent protein-tagged forms of both beta-arrestin-1 and the thyrotropin-releasing hormone receptor-1
10. Opiate tolerance and dependence: Receptors, G-proteins, and antiopiates
11. Morphine activates opioid receptors without causing their rapid internalization
12. G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus
13. Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats
14. Augmentation of LTP induced by primed-bursts tetanic stimulation in hippocampal CA1 area of morphine dependent rats
15. Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal
16. Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions
17. A molecular basis for opiate action
18. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions
19. Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2
20. G protein-coupled receptor kinases
21. G protein-coupled receptor (GPCR) trafficking in the central nervous system: Relevance for drugs of abuse
22. Role of cAMP-dependent protein kinase (PKA) in opioid agonist-induced μ-opioid receptor downregulation and tolerance in mice
23. Endogenous opioid regulation of hippocampal function
24. Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors
25. Immunohistochemical study of opioid receptors after chronic morphine treatment in rats
26. From opiate pharmacology to opioid peptide physiology
27. Tolerance to morphine at the μ-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine
28. Functional dissociation of mu opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
29. Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness