-
1
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Tokyo
-
Sehgal, S.N., H. Baker, and C. Vezina, Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo), 28(10): 727-732, 1975.
-
(1975)
J Antibiot
, vol.28
, Issue.10
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
2
-
-
0031833563
-
Mammalian target of rapamycin: Immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
-
Abraham, R.T., Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol, 10(3): 330-336, 1998.
-
(1998)
Curr Opin Immunol
, vol.10
, Issue.3
, pp. 330-336
-
-
Abraham, R.T.1
-
3
-
-
0036213622
-
Rapamycin eluting stent: The onset of a new era in interventional cardiology
-
Serruys, P.W., E. Regar, and A.J. Carter, Rapamycin eluting stent: the onset of a new era in interventional cardiology. Heart, 87: 305-307, 2002.
-
(2002)
Heart
, vol.87
, pp. 305-307
-
-
Serruys, P.W.1
Regar, E.2
Carter, A.J.3
-
4
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo, M. and E.K. Rowinsky, The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19(56): 6680-6686, 2000.
-
(2000)
Oncogene
, vol.19
, Issue.56
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
5
-
-
0034764605
-
PI 3-kinase, mTOR, protein synthesis, and cancer
-
Vogt, P.K., PI 3-kinase, mTOR, protein synthesis, and cancer. Trends Mol Med, 7(11): 482-484, 2001.
-
(2001)
Trends Mol Med
, vol.7
, Issue.11
, pp. 482-484
-
-
Vogt, P.K.1
-
6
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E.J., M.W. Albers, T.B. Shin, K. Ichikawa, C.T. Keith, W.S. Lane, and S.L. Schreiber, A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature, 369(6483): 756-758, 1994.
-
(1994)
Nature
, vol.369
, Issue.6483
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
7
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu, M.I., H. Katz, and V. Berlin, RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci USA, 91(26): 12574-125788, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.26
, pp. 12574-125788
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
8
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini, D.M., H. Erdjument-Bromage, M. Lui, P. Tempst, and S.H. Snyder, RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell, 78(1): 35-43, 1994.
-
(1994)
Cell
, vol.78
, Issue.1
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
9
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers, C.J., M.M. Martin, G.J. Brunn, J.M. Williams, F.J. Dumont, G. Wiederrecht, and R.T. Abraham, Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem, 270(2): 815-822, 1995.
-
(1995)
J Biol Chem
, vol.270
, Issue.2
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
Abraham, R.T.7
-
10
-
-
0027311858
-
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
-
Kunz, J., R. Henriquez, U. Schneider, M. Deuter-Reinhard, N.R. Movva, and M.N. Hall, Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell, 73(3): 585-596, 1993.
-
(1993)
Cell
, vol.73
, Issue.3
, pp. 585-596
-
-
Kunz, J.1
Henriquez, R.2
Schneider, U.3
Deuter-Reinhard, M.4
Movva, N.R.5
Hall, M.N.6
-
11
-
-
0028137771
-
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
-
Helliwell, S.B., P. Wagner, J. Kunz, M. Deuter-Reinhard, R. Henriquez, and M.N. Hall, TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell, 5(1): 105-118, 1994.
-
(1994)
Mol Biol Cell
, vol.5
, Issue.1
, pp. 105-118
-
-
Helliwell, S.B.1
Wagner, P.2
Kunz, J.3
Deuter-Reinhard, M.4
Henriquez, R.5
Hall, M.N.6
-
12
-
-
0030707562
-
TOR signalling and control of cell growth
-
Thomas, G. and M.N. Hall, TOR signalling and control of cell growth. Curr Opin Cell Biol, 9(6): 782-787, 1997.
-
(1997)
Curr Opin Cell Biol
, vol.9
, Issue.6
, pp. 782-787
-
-
Thomas, G.1
Hall, M.N.2
-
13
-
-
0033133990
-
The PIK-related kinases intercept conventional signaling pathways
-
Kuruvilla, F.G. and S.L. Schreiber, The PIK-related kinases intercept conventional signaling pathways. Chem Biol, 6(5): R129-R136, 1999.
-
(1999)
Chem Biol
, vol.6
, Issue.5
, pp. R129-R136
-
-
Kuruvilla, F.G.1
Schreiber, S.L.2
-
14
-
-
0029055145
-
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
-
Chen, J., X.F. Zheng, E.J. Brown, and S.L. Schreiber, Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci USA, 92(11): 4947-4951, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.11
, pp. 4947-4951
-
-
Chen, J.1
Zheng, X.F.2
Brown, E.J.3
Schreiber, S.L.4
-
15
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown, E.J., P.A. Beal, C.T. Keith, J. Chen, T.B. Shin, and S.L. Schreiber, Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature, 377(6548): 441-446, 1995.
-
(1995)
Nature
, vol.377
, Issue.6548
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
16
-
-
0035312747
-
Regulation of translation initiation by FRAP/mTOR
-
Gingras, A.C., B. Raught, and N. Sonenberg, Regulation of translation initiation by FRAP/mTOR. Genes Dev, 15(7): 807-826, 2001.
-
(2001)
Genes Dev
, vol.15
, Issue.7
, pp. 807-826
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
17
-
-
0033548071
-
The FKBP12-rapamycin-binding domain is required for FKBP12-rapamy-cin-associated protein kinase activity and G1 progression
-
Vilella-Bach, M., P. Nuzzi, Y. Fang, and J. Chen, The FKBP12-rapamycin-binding domain is required for FKBP12-rapamy-cin-associated protein kinase activity and G1 progression. J Biol Chem, 274(7): 4266-4272, 1999.
-
(1999)
J Biol Chem
, vol.274
, Issue.7
, pp. 4266-4272
-
-
Vilella-Bach, M.1
Nuzzi, P.2
Fang, Y.3
Chen, J.4
-
18
-
-
0035976615
-
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
-
Fang, Y., M. Vilella-Bach, R. Bachmann, A. Flanigan, and J. Chen, Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science, 294(5548): 1942-1945, 2001.
-
(2001)
Science
, vol.294
, Issue.5548
, pp. 1942-1945
-
-
Fang, Y.1
Vilella-Bach, M.2
Bachmann, R.3
Flanigan, A.4
Chen, J.5
-
19
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi, J., J. Chen, S.L. Schreiber, and J. Clardy, Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science, 273(5272): 239-242, 1996.
-
(1996)
Science
, vol.273
, Issue.5272
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
20
-
-
0028800996
-
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
-
Keith, C.T. and S.L. Schreiber, PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science, 270(5233): 50-51, 1995.
-
(1995)
Science
, vol.270
, Issue.5233
, pp. 50-51
-
-
Keith, C.T.1
Schreiber, S.L.2
-
21
-
-
0037462453
-
The ATRs, ATMs, and TORs are giant HEAT repeat proteins
-
Perry, J. and N. Kleckner, The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell, 112(2): 151-155, 2003.
-
(2003)
Cell
, vol.112
, Issue.2
, pp. 151-155
-
-
Perry, J.1
Kleckner, N.2
-
22
-
-
0033553624
-
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
-
Sabatini, D.M., R.K. Barrow, S. Blackshaw, P.E. Burnett, M.M. Lai, M.E. Field, B.A. Bahr, J. Kirsch, H. Betz, and S.H. Snyder, Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science, 284(5417): 1161-1164, 1999.
-
(1999)
Science
, vol.284
, Issue.5417
, pp. 1161-1164
-
-
Sabatini, D.M.1
Barrow, R.K.2
Blackshaw, S.3
Burnett, P.E.4
Lai, M.M.5
Field, M.E.6
Bahr, B.A.7
Kirsch, J.8
Betz, H.9
Snyder, S.H.10
-
23
-
-
0031590781
-
Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells
-
Withers, D.J., D.M. Ouwens, B.T. Nave, G.C. van der Zon, C.M. Alarcon, M.E. Cardenas, J. Heitman, J.A. Maassen, and P.R. Shepherd, Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. Biochem Biophys Res Commun, 241(3): 704-709, 1997.
-
(1997)
Biochem Biophys Res Commun
, vol.241
, Issue.3
, pp. 704-709
-
-
Withers, D.J.1
Ouwens, D.M.2
Nave, B.T.3
Van Der Zon, G.C.4
Alarcon, C.M.5
Cardenas, M.E.6
Heitman, J.7
Maassen, J.A.8
Shepherd, P.R.9
-
24
-
-
0037007014
-
FKBP12-rapam-ycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
-
Desai, B.N., B.R. Myers, and S.L. Schreiber, FKBP12-rapam-ycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci USA, 99(7): 4319-4324, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.7
, pp. 4319-4324
-
-
Desai, B.N.1
Myers, B.R.2
Schreiber, S.L.3
-
25
-
-
0346422440
-
FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus
-
Drenan, R.M., X. Liu, P.G. Bertram, and X.F. Zheng, FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus. J Biol Chem, 279(1): 772-778, 2004.
-
(2004)
J Biol Chem
, vol.279
, Issue.1
, pp. 772-778
-
-
Drenan, R.M.1
Liu, X.2
Bertram, P.G.3
Zheng, X.F.4
-
26
-
-
0034687688
-
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapam-ycin-sensitive signaling and translation initiation
-
Kim, J.E. and J. Chen, Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapam-ycin-sensitive signaling and translation initiation. Proc Natl Acad Sci USA, 97(26): 14340-14345, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.26
, pp. 14340-14345
-
-
Kim, J.E.1
Chen, J.2
-
27
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
-
Chung, J., C.J. Kuo, G.R. Crabtree, and J. Blenis, Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell, 69(7): 1227-1236, 1992.
-
(1992)
Cell
, vol.69
, Issue.7
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
Blenis, J.4
-
28
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
Barbet, N.C., U. Schneider, S.B. Helliwell, I. Stansfield, M.F. Tuite, and M.N. Hall, TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell, 7(1): 25-42, 1996.
-
(1996)
Mol Biol Cell
, vol.7
, Issue.1
, pp. 25-42
-
-
Barbet, N.C.1
Schneider, U.2
Helliwell, S.B.3
Stansfield, I.4
Tuite, M.F.5
Hall, M.N.6
-
29
-
-
0029808294
-
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
-
Di Como, C.J. and K.T. Arndt, Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev, 10(15): 1904-1916, 1996.
-
(1996)
Genes Dev
, vol.10
, Issue.15
, pp. 1904-1916
-
-
Di Como, C.J.1
Arndt, K.T.2
-
30
-
-
0033540030
-
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
-
Beck, T. and M.N. Hall, The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature, 402(6762): 689-692, 1999.
-
(1999)
Nature
, vol.402
, Issue.6762
, pp. 689-692
-
-
Beck, T.1
Hall, M.N.2
-
31
-
-
0034649569
-
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
-
Shamji, A.F., F.G. Kuruvilla, and S.L. Schreiber, Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol, 10(24): 1574-1581, 2000.
-
(2000)
Curr Biol
, vol.10
, Issue.24
, pp. 1574-1581
-
-
Shamji, A.F.1
Kuruvilla, F.G.2
Schreiber, S.L.3
-
32
-
-
0037076314
-
The TORcontrolled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine
-
Crespo, J.L., T. Powers, B. Fowler, and M.N. Hall, The TORcontrolled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci USA, 99(10): 6784-6789, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.10
, pp. 6784-6789
-
-
Crespo, J.L.1
Powers, T.2
Fowler, B.3
Hall, M.N.4
-
33
-
-
0034645038
-
Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
-
Komeili, A., K.P. Wedaman, E.K. O’Shea, and T. Powers, Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol, 151(4): 863-878, 2000.
-
(2000)
J Cell Biol
, vol.151
, Issue.4
, pp. 863-878
-
-
Komeili, A.1
Wedaman, K.P.2
O’Shea, E.K.3
Powers, T.4
-
34
-
-
0028207001
-
Rapamycin selectively represses translation of the “polypyrimidine tract” mRNA family
-
Jefferies, H.B., C. Reinhard, S.C. Kozma, and G. Thomas, Rapamycin selectively represses translation of the “polypyrimidine tract” mRNA family. Proc Natl Acad Sci USA, 91(10): 4441-4445, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.10
, pp. 4441-4445
-
-
Jefferies, H.B.1
Reinhard, C.2
Kozma, S.C.3
Thomas, G.4
-
35
-
-
0029162384
-
Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes
-
Terada, N., K. Takase, P. Papst, A.C. Nairn, and E.W. Gelfand, Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes. J Immunol, 155(7): 3418-3426, 1995.
-
(1995)
J Immunol
, vol.155
, Issue.7
, pp. 3418-3426
-
-
Terada, N.1
Takase, K.2
Papst, P.3
Nairn, A.C.4
Gelfand, E.W.5
-
36
-
-
0032568269
-
Translation control: Connecting mitogens and the ribosome
-
Peterson, R.T. and S.L. Schreiber, Translation control: connecting mitogens and the ribosome. Curr Biol, 8(7): R248-R250, 1998.
-
(1998)
Curr Biol
, vol.8
, Issue.7
, pp. R248-R250
-
-
Peterson, R.T.1
Schreiber, S.L.2
-
37
-
-
0028032355
-
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
-
Terada, N., H.R. Patel, K. Takase, K. Kohno, A.C. Nairn, and E.W. Gelfand, Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci USA, 91(24): 11477-11481, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, Issue.24
, pp. 11477-11481
-
-
Terada, N.1
Patel, H.R.2
Takase, K.3
Kohno, K.4
Nairn, A.C.5
Gelfand, E.W.6
-
38
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn, G.J., C.C. Hudson, A. Sekulic, J.M. Williams, H. Hosoi, P.J. Houghton, J.C. Lawrence Jr., and R.T. Abraham, Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science, 277(5322): 99-101, 1997.
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence, J.C.7
Abraham, R.T.8
-
39
-
-
0030716488
-
Regulation of eIF-4E BP1 phosphorylation by mTOR
-
Hara, K., K. Yonezawa, M.T. Kozlowski, T. Sugimoto, K. Andrabi, Q.P. Weng, M. Kasuga, I. Nishimoto, and J. Avruch, Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem, 272(42): 26457-26463, 1997.
-
(1997)
J Biol Chem
, vol.272
, Issue.42
, pp. 26457-26463
-
-
Hara, K.1
Yonezawa, K.2
Kozlowski, M.T.3
Sugimoto, T.4
Andrabi, K.5
Weng, Q.P.6
Kasuga, M.7
Nishimoto, I.8
Avruch, J.9
-
40
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett, P.E., R.K. Barrow, N.A. Cohen, S.H. Snyder, and D.M. Sabatini, RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA, 95: 1432-1437, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
41
-
-
0033607531
-
Immunopurified mammalian target of rapamy-cin phosphorylates and activates p70 S6 kinase alpha in vitro
-
Isotani, S., K. Hara, C. Tokunaga, H. Inoue, J. Avruch, and K. Yonezawa, Immunopurified mammalian target of rapamy-cin phosphorylates and activates p70 S6 kinase alpha in vitro. J Biol Chem, 274(48): 34493-34498, 1999.
-
(1999)
J Biol Chem
, vol.274
, Issue.48
, pp. 34493-34498
-
-
Isotani, S.1
Hara, K.2
Tokunaga, C.3
Inoue, H.4
Avruch, J.5
Yonezawa, K.6
-
42
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
Gingras, A.C., S.P. Gygi, B. Raught, R.D. Polakiewicz, R.T. Abraham, M.F. Hoekstra, R. Aebersold, and N. Sonenberg, Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev, 13(11): 1422-1437, 1999.
-
(1999)
Genes Dev
, vol.13
, Issue.11
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
Polakiewicz, R.D.4
Abraham, R.T.5
Hoekstra, M.F.6
Aebersold, R.7
Sonenberg, N.8
-
43
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh, M., N. Pullen, P. Brennan, D. Cantrell, P.B. Dennis, and G. Thomas, Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem, 277(22): 20104-20112, 2002.
-
(2002)
J Biol Chem
, vol.277
, Issue.22
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
44
-
-
0035965295
-
The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism
-
Erbay, E. and J. Chen, The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism. J Biol Chem, 276: 36079-36082, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 36079-36082
-
-
Erbay, E.1
Chen, J.2
-
45
-
-
0348110375
-
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
-
Erbay, E., I.H. Park, P.D. Nuzzi, C.J. Schoenherr, and J. Chen, IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. J Cell Biol, 163(5): 931-936, 2003.
-
(2003)
J Cell Biol
, vol.163
, Issue.5
, pp. 931-936
-
-
Erbay, E.1
Park, I.H.2
Nuzzi, P.D.3
Schoenherr, C.J.4
Chen, J.5
-
47
-
-
0027336002
-
P70s6k function is essential for G1 progression
-
Lane, H.A., A. Fernandez, N.J. Lamb, and G. Thomas, p70s6k function is essential for G1 progression. Nature, 363(6425): 170-172, 1993.
-
(1993)
Nature
, vol.363
, Issue.6425
, pp. 170-172
-
-
Lane, H.A.1
Fernandez, A.2
Lamb, N.J.3
Thomas, G.4
-
48
-
-
0345732640
-
MTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
-
Fingar, D.C., C.J. Richardson, A.R. Tee, L. Cheatham, C. Tsou, and J. Blenis, mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol, 24(1): 200-216, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, Issue.1
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
49
-
-
0036516869
-
The emerging roles of translation factor eIF4E in the nucleus
-
Strudwick, S. and K.L. Borden, The emerging roles of translation factor eIF4E in the nucleus. Differentiation, 70(1): 10-22, 2002.
-
(2002)
Differentiation
, vol.70
, Issue.1
, pp. 10-22
-
-
Strudwick, S.1
Borden, K.L.2
-
50
-
-
0025314596
-
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5 cap
-
Lazaris-Karatzas, A., K.S. Montine, and N. Sonenberg, Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5 cap. Nature, 345(6275): 544-547, 1990.
-
(1990)
Nature
, vol.345
, Issue.6275
, pp. 544-547
-
-
Lazaris-Karatzas, A.1
Montine, K.S.2
Sonenberg, N.3
-
51
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto, E. and M.N. Hall, Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol, 4(2): 117-126, 2003.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, Issue.2
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
52
-
-
0034976004
-
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
-
Miron, M., J. Verdu, P.E. Lachance, M.J. Birnbaum, P.F. Lasko, and N. Sonenberg, The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol, 3(6): 596-601, 2001.
-
(2001)
Nat Cell Biol
, vol.3
, Issue.6
, pp. 596-601
-
-
Miron, M.1
Verdu, J.2
Lachance, P.E.3
Birnbaum, M.J.4
Lasko, P.F.5
Sonenberg, N.6
-
53
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar, D.C., S. Salama, C. Tsou, E. Harlow, and J. Blenis, Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev, 16(12): 1472-1487, 2002.
-
(2002)
Genes Dev
, vol.16
, Issue.12
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
54
-
-
0037178786
-
MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim, D.H., D.D. Sarbassov, S.M. Ali, J.E. King, R.R. Latek, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell, 110(2): 163-175, 2002.
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
55
-
-
0037718389
-
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
-
Schalm, S.S., D.C. Fingar, D.M. Sabatini, and J. Blenis, TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol, 13(10): 797-806, 2003.
-
(2003)
Curr Biol
, vol.13
, Issue.10
, pp. 797-806
-
-
Schalm, S.S.1
Fingar, D.C.2
Sabatini, D.M.3
Blenis, J.4
-
56
-
-
0344663973
-
PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1
-
Fang, Y., I.H. Park, A.L. Wu, G. Du, P. Huang, M.A. Frohman, S.J. Walker, H.A. Brown, and J. Chen, PLD1 Regulates mTOR Signaling and Mediates Cdc42 Activation of S6K1. Curr Biol, 13(23): 2037-2044, 2003.
-
(2003)
Curr Biol
, vol.13
, Issue.23
, pp. 2037-2044
-
-
Fang, Y.1
Park, I.H.2
Wu, A.L.3
Du, G.4
Huang, P.5
Frohman, M.A.6
Walker, S.J.7
Brown, H.A.8
Chen, J.9
-
57
-
-
0032528917
-
Amino acid availability regulates p70 S6 kinase and multiple translation factors
-
Wang, X., L.E. Campbell, C.M. Miller, and C.G. Proud, Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem J, 334(Pt 1): 261-267, 1998.
-
(1998)
Biochem J
, vol.334
, pp. 261-267
-
-
Wang, X.1
Campbell, L.E.2
Miller, C.M.3
Proud, C.G.4
-
58
-
-
0032561348
-
Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
-
Xu, G., G. Kwon, C.A. Marshall, T.A. Lin, J.C. Lawrence Jr., and M.L. McDaniel, Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem, 273(43): 28178-28184, 1998.
-
(1998)
J Biol Chem
, vol.273
, Issue.43
, pp. 28178-28184
-
-
Xu, G.1
Kwon, G.2
Marshall, C.A.3
Lin, T.A.4
Lawrence, J.C.5
McDaniel, M.L.6
-
59
-
-
0032486268
-
Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
-
Hara, K., K. Yonezawa, Q.-P. Weng, M.T. Kozlowski, C. Bel-ham, and J. Avruch, Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism. J Biol Chem, 273: 14484-14494, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 14484-14494
-
-
Hara, K.1
Yonezawa, K.2
Weng, Q.-P.3
Kozlowski, M.T.4
Bel-Ham, C.5
Avruch, J.6
-
60
-
-
0033534686
-
Amino acid-dependent control of p70(S6k). Involvement of tRNA aminoacylation in the regulation
-
Iiboshi, Y., P.J. Papst, H. Kawasome, H. Hosoi, R.T. Abraham, P.J. Houghton, and N. Terada, Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. J Biol Chem, 274(2): 1092-1099, 1999.
-
(1999)
J Biol Chem
, vol.274
, Issue.2
, pp. 1092-1099
-
-
Iiboshi, Y.1
Papst, P.J.2
Kawasome, H.3
Hosoi, H.4
Abraham, R.T.5
Houghton, P.J.6
Terada, N.7
-
61
-
-
0035145602
-
Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
-
Xu, G., G. Kwon, W.S. Cruz, C.A. Marshall, and M.L. McDaniel, Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes, 50(2): 353-360, 2001.
-
(2001)
Diabetes
, vol.50
, Issue.2
, pp. 353-360
-
-
Xu, G.1
Kwon, G.2
Cruz, W.S.3
Marshall, C.A.4
McDaniel, M.L.5
-
62
-
-
0141923009
-
Integration of growth factor and nutrient signaling: Implications for cancer biology
-
Shamji, A.F., P. Nghiem, and S.L. Schreiber, Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell, 12(2): 271-280, 2003.
-
(2003)
Mol Cell
, vol.12
, Issue.2
, pp. 271-280
-
-
Shamji, A.F.1
Nghiem, P.2
Schreiber, S.L.3
-
63
-
-
0029608743
-
Structural and functional analysis of pp70S6k
-
Cheatham, L., M. Monfar, M.M. Chou, and J. Blenis, Structural and functional analysis of pp70S6k. Proc Natl Acad Sci USA, 92(25): 11696-11700, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.25
, pp. 11696-11700
-
-
Cheatham, L.1
Monfar, M.2
Chou, M.M.3
Blenis, J.4
-
64
-
-
0029828590
-
The principal rapamycin-sensitive p70(S6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases
-
Dennis, P.B., N. Pullen, S.C. Kozma, and G. Thomas, The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol Cell Biol, 16(11): 6242-6251, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, Issue.11
, pp. 6242-6251
-
-
Dennis, P.B.1
Pullen, N.2
Kozma, S.C.3
Thomas, G.4
-
65
-
-
0028899789
-
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
-
Blommaart, E.F., J.J. Luiken, P.J. Blommaart, G.M. van Woerkom, and A.J. Meijer, Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem, 270(5): 2320-2326, 1995.
-
(1995)
J Biol Chem
, vol.270
, Issue.5
, pp. 2320-2326
-
-
Blommaart, E.F.1
Luiken, J.J.2
Blommaart, P.J.3
Van Woerkom, G.M.4
Meijer, A.J.5
-
66
-
-
0032561348
-
Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling
-
Xu, G., G. Kwon, C.A. Marshall, T.A. Lin, J.C. Lawrence Jr., and M.L. McDaniel, Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J Biol Chem, 273(43): 28178-28184, 1998.
-
(1998)
J Biol Chem
, vol.273
, Issue.43
, pp. 28178-28184
-
-
Xu, G.1
Kwon, G.2
Marshall, C.A.3
Lin, T.A.4
Lawrence, J.C.5
McDaniel, M.L.6
-
67
-
-
0033597129
-
Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
-
Kimball, S.R., L.M. Shantz, R.L. Horetsky, and L.S. Jefferson, Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J Biol Chem, 274(17): 11647-11652, 1999.
-
(1999)
J Biol Chem
, vol.274
, Issue.17
, pp. 11647-11652
-
-
Kimball, S.R.1
Shantz, L.M.2
Horetsky, R.L.3
Jefferson, L.S.4
-
68
-
-
0033808169
-
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sen-sitive pathway
-
Anthony, J.C., F. Yoshizawa, T.G. Anthony, T.C. Vary, L.S. Jefferson, and S.R. Kimball, Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sen-sitive pathway. J Nutr, 130(10): 2413-2419, 2000.
-
(2000)
J Nutr
, vol.130
, Issue.10
, pp. 2413-2419
-
-
Anthony, J.C.1
Yoshizawa, F.2
Anthony, T.G.3
Vary, T.C.4
Jefferson, L.S.5
Kimball, S.R.6
-
69
-
-
0031730304
-
Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes
-
Fox, H.L., P.T. Pham, S.R. Kimball, L.S. Jefferson, and C.J. Lynch, Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Am J Physiol, 275(5 Pt 1): C1232-C1238, 1998.
-
(1998)
Am J Physiol
, vol.275
, Issue.5
, pp. C1232-C1238
-
-
Fox, H.L.1
Pham, P.T.2
Kimball, S.R.3
Jefferson, L.S.4
Lynch, C.J.5
-
70
-
-
0036787462
-
Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells
-
McDaniel, M.L., C.A. Marshall, K.L. Pappan, and G. Kwon, Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells. Diabetes, 51(10): 2877-2885, 2002.
-
(2002)
Diabetes
, vol.51
, Issue.10
, pp. 2877-2885
-
-
McDaniel, M.L.1
Marshall, C.A.2
Pappan, K.L.3
Kwon, G.4
-
71
-
-
0032971333
-
Structural requirement of leucine for activation of p70 S6 kinase
-
Shigemitsu, K., Y. Tsujishita, H. Miyake, S. Hidayat, N. Tanaka, K. Hara, and K. Yonezawa, Structural requirement of leucine for activation of p70 S6 kinase. FEBS Lett, 447(2-3): 303-306, 1999.
-
(1999)
FEBS Lett
, vol.447
, Issue.2-3
, pp. 303-306
-
-
Shigemitsu, K.1
Tsujishita, Y.2
Miyake, H.3
Hidayat, S.4
Tanaka, N.5
Hara, K.6
Yonezawa, K.7
-
72
-
-
0031887111
-
Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters
-
Fox, H.L., S.R. Kimball, L.S. Jefferson, and C.J. Lynch, Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am J Physiol, 274(1 Pt 1): C206-C213, 1998.
-
(1998)
Am J Physiol
, vol.274
, Issue.1
, pp. C206-C213
-
-
Fox, H.L.1
Kimball, S.R.2
Jefferson, L.S.3
Lynch, C.J.4
-
73
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave, B.T., M. Ouwens, D.J. Withers, D.R. Alessi, and P.R. Shepherd, Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J, 344(Pt 2): 427-431, 1999.
-
(1999)
Biochem J
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
74
-
-
0032560521
-
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
-
Scott, P.H., G.J. Brunn, A.D. Kohn, R.A. Roth, and J.C. Lawrence Jr., Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci USA, 95(13): 7772-7777, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.13
, pp. 7772-7777
-
-
Scott, P.H.1
Brunn, G.J.2
Kohn, A.D.3
Roth, R.A.4
Lawrence, J.C.5
-
75
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic, A., C.C. Hudson, J.L. Homme, P. Yin, D.M. Otterness, L.M. Karnitz, and R.T. Abraham, A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res, 60(13): 3504-3513, 2000.
-
(2000)
Cancer Res
, vol.60
, Issue.13
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
76
-
-
0141733277
-
A nutrient sensor mechanism controls Drosophila growth
-
Colombani, J., S. Raisin, S. Pantalacci, T. Radimerski, J. Montagne, and P. Leopold, A nutrient sensor mechanism controls Drosophila growth. Cell, 114(6): 739-749, 2003.
-
(2003)
Cell
, vol.114
, Issue.6
, pp. 739-749
-
-
Colombani, J.1
Raisin, S.2
Pantalacci, S.3
Radimerski, T.4
Montagne, J.5
Leopold, P.6
-
77
-
-
0036776168
-
A novel pathway regulating the mammalian target of rapamycin (MTOR) signaling
-
Chen, J. and Y. Fang, A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling. Biochem Pharmacol, 64(7): 1071-1077, 2002.
-
(2002)
Biochem Pharmacol
, vol.64
, Issue.7
, pp. 1071-1077
-
-
Chen, J.1
Fang, Y.2
-
78
-
-
0038339003
-
Phospholipase D confers rapamycin resistance in human breast cancer cells
-
Chen, Y., Y. Zheng, and D.A. Foster, Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene, 22(25): 3937-3942, 2003.
-
(2003)
Oncogene
, vol.22
, Issue.25
, pp. 3937-3942
-
-
Chen, Y.1
Zheng, Y.2
Foster, D.A.3
-
79
-
-
0142070928
-
Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling
-
Ballou, L.M., Y.P. Jiang, G. Du, M.A. Frohman, and R.Z. Lin, Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling. FEBS Lett, 550(1-3): 51-56, 2003.
-
(2003)
FEBS Lett
, vol.550
, Issue.1-3
, pp. 51-56
-
-
Ballou, L.M.1
Jiang, Y.P.2
Du, G.3
Frohman, M.A.4
Lin, R.Z.5
-
80
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara, K., Y. Maruki, X. Long, K. Yoshino, N. Oshiro, S. Hidayat, C. Tokunaga, J. Avruch, and K. Yonezawa, Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell, 110(2): 177-189, 2002.
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
81
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., E. Jacinto, S. Wullschleger, A. Lorberg, J.L. Crespo, D. Bonenfant, W. Oppliger, P. Jenoe, and M.N. Hall, Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell, 10(3): 457-468, 2002.
-
(2002)
Mol Cell
, vol.10
, Issue.3
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
82
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim, D.H., D. Sarbassov dos, S.M. Ali, R.R. Latek, K.V. Guntur, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini, GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell, 11(4): 895-904, 2003.
-
(2003)
Mol Cell
, vol.11
, Issue.4
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov Dos, D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
83
-
-
0038482156
-
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
-
Choi, K.M., L.P. McMahon, and J.C. Lawrence, Jr., Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. J Biol Chem, 278(22): 19667-19673, 2003.
-
(2003)
J Biol Chem
, vol.278
, Issue.22
, pp. 19667-19673
-
-
Choi, K.M.1
McMahon, L.P.2
Lawrence, J.C.3
-
84
-
-
0037507252
-
The mammalian target of rapamycin (MTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
-
Nojima, H., C. Tokunaga, S. Eguchi, N. Oshiro, S. Hidayat, K. Yoshino, K. Hara, N. Tanaka, J. Avruch, and K. Yonezawa, The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem, 278(18): 15461-15464, 2003.
-
(2003)
J Biol Chem
, vol.278
, Issue.18
, pp. 15461-15464
-
-
Nojima, H.1
Tokunaga, C.2
Eguchi, S.3
Oshiro, N.4
Hidayat, S.5
Yoshino, K.6
Hara, K.7
Tanaka, N.8
Avruch, J.9
Yonezawa, K.10
-
85
-
-
0037137380
-
Growth Signaling: TSC takes its place
-
Marygold, S.J. and S.J. Leevers, Growth Signaling: TSC takes its place. Curr Biol, 12(22): R785-787, 2002.
-
(2002)
Curr Biol
, vol.12
, Issue.22
, pp. R785-R787
-
-
Marygold, S.J.1
Leevers, S.J.2
-
86
-
-
0036712741
-
TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
-
McManus, E.J. and D.R. Alessi, TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol, 4(9): E214-E216, 2002.
-
(2002)
Nat Cell Biol
, vol.4
, Issue.9
, pp. E214-E216
-
-
McManus, E.J.1
Alessi, D.R.2
-
87
-
-
0038540963
-
United at last: The tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling
-
Manning, B.D. and L.C. Cantley, United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans, 31(Pt 3): 573-578, 2003.
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 573-578
-
-
Manning, B.D.1
Cantley, L.C.2
-
88
-
-
0347716759
-
Rheb fills a GAP between TSC and TOR
-
Manning, B.D. and L.C. Cantley, Rheb fills a GAP between TSC and TOR. Trends Biochem Sci, 28(11): 573-576, 2003.
-
(2003)
Trends Biochem Sci
, vol.28
, Issue.11
, pp. 573-576
-
-
Manning, B.D.1
Cantley, L.C.2
-
89
-
-
0034161545
-
Functional interaction between RAFTl/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation
-
Kumar, V., P. Pandey, D. Sabatini, M. Kumar, P.K. Majumder, A. Bharti, G. Carmichael, D. Kufe, and S. Kharbanda, Functional interaction between RAFTl/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation. EMBO J, 19(5): 1087-1097, 2000.
-
(2000)
EMBO J
, vol.19
, Issue.5
, pp. 1087-1097
-
-
Kumar, V.1
Pandey, P.2
Sabatini, D.3
Kumar, M.4
Majumder, P.K.5
Bharti, A.6
Carmichael, G.7
Kufe, D.8
Kharbanda, S.9
-
90
-
-
0033520995
-
Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon
-
Parekh, D., W. Ziegler, K. Yonezawa, K. Hara, and P.J. Parker, Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon. J Biol Chem, 274(49): 34758-34764, 1999.
-
(1999)
J Biol Chem
, vol.274
, Issue.49
, pp. 34758-34764
-
-
Parekh, D.1
Ziegler, W.2
Yonezawa, K.3
Hara, K.4
Parker, P.J.5
-
91
-
-
0033548233
-
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis
-
Cuenda, A. and P. Cohen, Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis. J Biol Chem, 274(7): 4341-4346, 1999.
-
(1999)
J Biol Chem
, vol.274
, Issue.7
, pp. 4341-4346
-
-
Cuenda, A.1
Cohen, P.2
-
92
-
-
0035196116
-
Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities
-
Conejo, R., A.M. Valverde, M. Benito, and M. Lorenzo, Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities. J Cell Physiol, 186(1): 82-94, 2001.
-
(2001)
J Cell Physiol
, vol.186
, Issue.1
, pp. 82-94
-
-
Conejo, R.1
Valverde, A.M.2
Benito, M.3
Lorenzo, M.4
-
93
-
-
0030934472
-
The mitogenic and myogenic actions of insulinlike growth factors utilize distinct signaling pathways
-
Coolican, S.A., D.S. Samuel, D.Z. Ewton, F.J. McWade, and J.R. Florini, The mitogenic and myogenic actions of insulinlike growth factors utilize distinct signaling pathways. J Biol Chem, 272(10): 6653-6662, 1997.
-
(1997)
J Biol Chem
, vol.272
, Issue.10
, pp. 6653-6662
-
-
Coolican, S.A.1
Samuel, D.S.2
Ewton, D.Z.3
McWade, F.J.4
Florini, J.R.5
-
94
-
-
0037053334
-
Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin
-
Shu, L., X. Zhang, and P.J. Houghton, Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin. J Biol Chem, 277(19): 16726-16732, 2002.
-
(2002)
J Biol Chem
, vol.277
, Issue.19
, pp. 16726-16732
-
-
Shu, L.1
Zhang, X.2
Houghton, P.J.3
-
95
-
-
0028885873
-
Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
-
Yeh, W.C., B.E. Bierer, and S.L. McKnight, Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci USA, 92(24): 11086-11090, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.24
, pp. 11086-11090
-
-
Yeh, W.C.1
Bierer, B.E.2
McKnight, S.L.3
-
96
-
-
0034823939
-
Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion
-
Gagnon, A., S. Lau, and A. Sorisky, Rapamycin-sensitive phase of 3T3-L1 preadipocyte differentiation after clonal expansion. J Cell Physiol, 189(1): 14-22, 2001.
-
(2001)
J Cell Physiol
, vol.189
, Issue.1
, pp. 14-22
-
-
Gagnon, A.1
Lau, S.2
Sorisky, A.3
-
97
-
-
7044234995
-
Regulation of PPARgamma activity by mammalian target of rapamycin and amino acids in adipogenesis
-
JE Kim, Chen, J. Regulation of PPARgamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 53: 2748-2756, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 2748-2756
-
-
Kim, J.E.1
Chen, J.2
-
98
-
-
0035578226
-
Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway
-
Martin, P.M. and A.E. Sutherland, Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway. Dev Biol, 240(1): 182-193, 2001.
-
(2001)
Dev Biol
, vol.240
, Issue.1
, pp. 182-193
-
-
Martin, P.M.1
Sutherland, A.E.2
-
99
-
-
0030803256
-
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome
-
Hinnebusch, A.G., Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome. J Biol Chem, 272(35): 21661-21664, 1997.
-
(1997)
J Biol Chem
, vol.272
, Issue.35
, pp. 21661-21664
-
-
Hinnebusch, A.G.1
-
100
-
-
0033635215
-
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
-
Dong, J., H. Qiu, M. Garcia-Barrio, J. Anderson, and A.G. Hinnebusch, Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain. Mol Cell, 6(2): 269-279, 2000.
-
(2000)
Mol Cell
, vol.6
, Issue.2
, pp. 269-279
-
-
Dong, J.1
Qiu, H.2
Garcia-Barrio, M.3
Anderson, J.4
Hinnebusch, A.G.5
-
101
-
-
0036440779
-
Regulation of mammalian translation factors by nutrients
-
Proud, C.G., Regulation of mammalian translation factors by nutrients. Eur J Biochem, 269(22): 5338-5349, 2002.
-
(2002)
Eur J Biochem
, vol.269
, Issue.22
, pp. 5338-5349
-
-
Proud, C.G.1
-
102
-
-
0032962927
-
Amino acid signaling in Saccharomyces cerevisiae: A permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
-
Iraqui, I., S. Vissers, F. Bernard, J.O. de Craene, E. Boles, A. Urrestarazu, and B. Andre, Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease. Mol Cell Biol, 19(2): 989-1001, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.2
, pp. 989-1001
-
-
Iraqui, I.1
Vissers, S.2
Bernard, F.3
De Craene, J.O.4
Boles, E.5
Urrestarazu, A.6
Andre, B.7
-
103
-
-
0037662713
-
Regulation of targets of mTOR (Mammalian target of rapamycin) signalling by intracellular amino acid availability
-
Beugnet, A., A.R. Tee, P.M. Taylor, and C.G. Proud, Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J, 372(Pt 2): 555-566, 2003.
-
(2003)
Biochem J
, vol.372
, pp. 555-566
-
-
Beugnet, A.1
Tee, A.R.2
Taylor, P.M.3
Proud, C.G.4
-
104
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
Dennis, P.B., A. Jaeschke, M. Saitoh, B. Fowler, S.C. Kozma, and G. Thomas, Mammalian TOR: a homeostatic ATP sensor. Science, 294(5544): 1102-1105, 2001.
-
(2001)
Science
, vol.294
, Issue.5544
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
105
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki, K., T. Zhu, and K.L. Guan, TSC2 mediates cellular energy response to control cell growth and survival. Cell, 115(5): 577-590, 2003.
-
(2003)
Cell
, vol.115
, Issue.5
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
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