Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy, balance, and metabolism

Endocrine

Volumn 29, Issue 1, 2006, Pages 61-71

  Perez Tilve, Diego ^a   Nogueiras, Ruben ^b   Mallo, Federico ^c   Benoit, Stephen C ^a   Tschoep, Matthias ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c UNIVERSITY OF VIGO   (Spain)

Author keywords

Gastrointestinal tract; Ghrelin; GLP 1; PYY

Indexed keywords

APPETITE STIMULANT; EXENDIN; EXENDIN 4; GASTROINTESTINAL HORMONE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HORMONE ANTAGONIST; INSULIN; LEPTIN; LIRAGLUTIDE; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; SIBUTRAMINE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANOREXIA; ARTICLE; DRUG HALF LIFE; DRUG POTENTIATION; DRUG TARGETING; ENERGY BALANCE; ENERGY METABOLISM; FAT BODY; GLUCOSE HOMEOSTASIS; HORMONAL REGULATION; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HYPERPHAGIA; HYPOPHYSIS; HYPOTHALAMUS; INSULIN RELEASE; KIDNEY; LUNG; LYMPHOCYTE; LYMPHOID TISSUE; NONHUMAN; NUTRITIONAL STATUS; OBESITY; ORGAN DISTRIBUTION; OVARY; PANCREAS; PLACENTA; PRIORITY JOURNAL; REGULATORY MECHANISM; SATIETY; SIDE EFFECT; SMALL INTESTINE; TASTE AVERSION; TESTIS;

EID: 33646862588     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1385/ENDO:29:1:61     Document Type: Article

References (167)

1. Howard, A. D., Feighner, S. D., Cully, D. F., et al. (1996). Science 273, 974-977.
2. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., and Kangawa, K. (1999). Nature 402, 656-660.
3. Tomasetto, C., Karam, S. M., Ribieras, S., et al. (2000). Gastroenterology 119, 395-405.
4. Inui, A. (2001). Nat. Rev. Neurosci. 2, 551-560.
5. Hosoda, H., Kojima, M., Matsuo, H., and Kangawa, K. (2000). J. Biol. Chem. 275, 21995-22000.
6. van der Lely, A. J., Tschop, M., Heiman, M. L., and Ghigo, E. (2004). Endocr. Rev. 25, 426-457.
7. Thompson, N. M., Gill, D. A., Davies, R., et al. (2004). Endocrinology 145, 234-242.
8. Gauna, C., Meyler, F. M., Janssen, J. A., et al. (2004). J. Clin. Endocrinol. Metab. 89, 5035-5042.
9. Hosoda, H., Kojima, M., Mizushima, T., Shimizu, S., and Kangawa, K. (2003). J. Biol. Chem. 278, 64-70.
10. Gualillo, O., Lago, F., Gomez-Reino, J., Casanueva, F. F., and Dieguez, C. (2003). FEBS Lett. 552, 105-109.
11. Date, Y., Kojima, M., Hosoda, H., et al. (2000). Endocrinology 141, 4255-4261.
12. Simonsson, M., Eriksson, S., Hakanson, R., et al. (1988). Scand. J. Gastroenterol. 23, 1089-1099.
13. Cowley, M. A., Smith, R. G., Diano, S., et al. (2003). Neuron 37, 649-661.
14. Korbonits, M., Bustin, S. A., Kojima, M., et al. (2001). J. Clin. Endocrinol. Metab. 86, 881-887.
15. Caminos, J. E., Nogueiras, R., Blanco, M., et al. (2003). Endocrinology 144, 5089-5097.
16. Date, Y., Nakazato, M., Hashiguchi, S., et al. (2002). Diabetes 51, 124-129.
17. Wierup, N., Svensson, H., Mulder, H., and Sundler, F. (2002). Regul. Pept. 107, 63-69.
18. Wierup, N., Yang, S., McEvilly, R. J., Mulder, H., and Sundler, F. (2004). J. Histochem. Cytochem. 52, 301-310.
19. Egido, E. M., Rodriguez-Gallardo, J., Silvestre, R. A., and Marco, J. (2002). Eur. J. Endocrinol. 146, 241-244.
20. Broglio, F., Arvat, E., Benso, A., et al. (2001). J. Clin. Endocrinol. Metab. 86, 5083-5086.
21. Van den Berghe, G. (2002). Front. Neuroendocrinol. 23, 370-391.
22. Mori, K., Yoshimoto, A., Takaya, K., et al. (2000). FEBS Lett. 486, 213-216.
23. Yoshimoto, A., Mori, K., Sugawara, A., et al. (2002). J. Am. Soc. Nephrol. 13, 2748-2752.
24. Gnanapavan, S., Kola, B., Bustin, S. A., et al. (2002). J. Clin. Endocrinol. Metab. 87, 2988.
25. Dixit, V. D., Schaffer, E. M., Pyle, R. S., et al. (2004). J. Clin. Invest. 114, 57-66.
26. Taub, D. D., Conlon, K., Lloyd, A. R., Oppenheim, J. J., and Kelvin, D. J. (1993). Science 260, 355-358.
27. Volante, M., Fulcheri, E., Allia, E., Cerrato, M., Pucci, A., and Papotti, M. (2002). J. Histochem. Cytochem. 50, 1013-1021.
28. Itoh, T., Nagaya, N., Yoshikawa, M., et al. (2004). Am. J. Respir. Crit. Care Med. 170, 879-882.
29. Shimizu, Y., Nagaya, N., Isobe, T., et al. (2003). Clin. Cancer Res. 9, 774-778.
30. Gualillo, O., Caminos, J., Blanco, M., et al. (2001). Endocrinology 142, 788-794.
31. Tanaka, M., Hayashida, Y., Nakao, N., Nakai, N., and Nakashima, K. (2001). Biochim. Biophys. Acta 1522, 62-65.
32. Tena-Sempere, M., Barreiro, M. L., Gonzalez, L. C., et al. (2002). Endocrinology 143, 717-725.
33. Gaytan, F., Barreiro, M. L., Caminos, J. E., et al. (2004). J. Clin. Endocrinol. Metab. 89, 400-409.
34. Barreiro, M. L., Gaytan, F., Castellano, J. M., et al. (2004). Endocrinology 145, 4825-4834.
35. Caminos, J. E., Tena-Sempere, M., Gaytan, F., et al. (2003). Endocrinology 144, 1594-1602.
36. Gaytan, F., Barreiro, M. L., Chopin, L. K., et al. (2003). J. Clin. Endocrinol. Metab. 88, 879-887.
37. Schofl, C., Horn, R., Schill, T., Schlosser, H. W., Muller, M. J., and Brabant, G. (2002). J. Clin. Endocrinol. Metab. 87, 4607-4610.
38. Pagotto, U., Gambineri, A., Vicennati, V., Heiman, M. L., Tschop, M., and Pasquali, R. (2002). J. Clin. Endocrinol. Metab. 87, 5625-5629.
39. Gambineri, A., Pagotto, U., Tschop, M., et al. (2003). J. Endocrinol. Invest. 26, 629-634.
40. Orio, F. Jr., Lucidi, P., Palomba, S., et al. (2003). J. Clin. Endocrinol. Metab. 88, 942-945.
41. Tschop, M., Smiley, D. L., and Heiman, M. L. (2000). Nature 407, 908-913.
42. Toshinai, K., Mondal, M. S., Nakazato, M., et al. (2001). Biochem. Biophys. Res. Commun. 281, 1220-1225.
43. Callahan, H. S., Cummings, D. E., Pepe, M. S., Breen, P. A., Matthys, C. C., and Weigle, D. S. (2004). J. Clin. Endocrinol. Metab. 89, 1319-1324.
44. Ariyasu, H., Takaya, K., Tagami, T., et al. (2001). J. Clin. Endocrinol. Metab. 86, 4753-4758.
45. Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., and Weigle, D. S. (2001). Diabetes 50, 1714-1719.
46. Williams, D. L., Grill, H. J., Cummings, D. E., and Kaplan, J. M. (2003). Endocrinology 144, 5184-5187.
47. Nagaya, N., Kojima, M., Uematsu, M., et al. (2001). Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R1483-1487.
48. Tschop, M., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, E., and Heiman, M. L. (2001). Diabetes 50, 707-709.
49. Ariyasu, H., Takaya, K., Hosoda, H., et al. (2002). Endocrinology 143, 3341-3350.
50. Otto, B., Cuntz, U., Fruehauf, E., et al. (2001). Eur. J. Endocrinol. 145, 669-673.
51. Shiiya, T., Nakazato, M., Mizuta, M., et al. (2002). J. Clin. Endocrinol. Metab. 87, 240-244.
52. Cummings, D. E., Weigle, D. S., Frayo, R. S., et al. (2002). N. Engl. J. Med. 346, 1623-1630.
53. Cummings, D. E., Clement, K., Purnell, J. Q., et al. (2002). Nat. Med. 8, 643-644.
54. Korbonits, M. and Grossman, A. B. (2004). Eur. J. Endocrinol. 151(Suppl. 1), S67-70.
55. Gualillo, O., Caminos, J. E., Nogueiras, R., et al. (2002). Obes. Res. 10, 682-687.
56. Flanagan, D. E., Evans, M. L., Monsod, T. P., et al. (2003). Am. J. Physiol. Endocrinol. Metab. 284, E313-316.
57. McCowen, K. C., Maykel, J. A., Bistrian, B. R., and Ling, P. R. (2002). J. Endocrinol. 175, R7-11.
58. Mohlig, M., Spranger, J., Otto, B., Ristow, M., Tschop, M., and Pfeiffer, A. F. (2002). J. Endocrinol. Invest. 25, RC36-38.
59. Saad, M. F., Bernaba, B., Hwu, C. M., et al. (2002). J. Clin. Endocrinol. Metab. 87, 3997-4000.
60. Leonetti, F., Iacobellis, G., Ribaudo, M. C., et al. (2004). Regul. Pept. 122, 179-183.
61. Murdolo, G., Lucidi, P., Di Loreto, C., et al. (2003). Diabetes 52, 2923-2927.
62. Spranger, J., Ristow, M., Otto, B., et al. (2003). J. Endocrinol. Invest. 26, RC19-22.
63. McLaughlin, T., Abbasi, F., Lamendola, C., Frayo, R. S., and Cummings, D. E. (2004). J. Clin. Endocrinol. Metab. 89, 1630-1635.
64. Purnell, J. Q., Weigle, D. S., Breen, P., and Cummings, D. E. (2003). J. Clin. Endocrinol. Metab. 88, 5747-5752.
65. Katsuki, A., Urakawa, H., Gabazza, E. C., et al. (2004). Eur. J. Endocrinol. 151, 573-577.
66. Schaller, G., Schmidt, A., Pleiner, J., Woloszczuk, W., Wolzt, M., and Luger, A. (2003). Diabetes 52, 16-20.
67. Broglio, F., Gottero, C., Prodam, F., et al. (2004). Clin. Endocrinol. (Oxf.) 61, 503-509.
68. Cappiello, V., Ronchi, C., Morpurgo, P. S., et al. (2002). Eur. J. Endocrinol. 147, 189-194.
69. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Nature 372, 425-432.
70. Asakawa, A., Inui, A., Kaga, T., et al. (2001). Gastroenterology 120, 337-345.
71. Bagnasco, M., Kalra, P. S., and Kalra, S. P. (2002). Endocrinology 143, 726-729.
72. Chan, J. L., Bullen, J., Lee, J. H., Yiannakouris, N., and Mantzoros, C. S. (2004). J. Clin. Endocrinol. Metab. 89, 335-343.
73. Haqq, A. M., Farooqi, I. S., O'Rahilly, S., et al. (2003). J. Clin. Endocrinol. Metab. 88, 174-178.
74. Asakawa, A., Inui, A., Yuzuriha, H., et al. (2003). Gastroenterology 124, 1325-1336.
75. Batterham, R. L., Le Roux, C. W., Cohen, M. A., et al. (2003). J. Clin. Endocrinol. Metab. 88, 3989-3992.
76. Batterham, R. L., Cowley, M. A., Small, C. J., et al. (2002). Nature 418, 650-654.
77. Tschop, M., Castaneda, T. R., Joost, H. G., et al. (2004). Nature 430, 1 p following 165; discussion 162 p following 165.
78. Riediger, T., Bothe, C., Becskei, C., and Lutz, T. A. (2004). Neuroendocrinology 79, 317-326.
79. Adams, S. H., Won, W. B., Schonhoff, S. E., Leiter, A. B., and Paterniti, J. R. Jr. (2004). Endocrinology 145, 4967-4975.
80. Cohen, M. A., Ellis, S. M., Le Roux, C. W., et al. (2003). J. Clin. Endocrinol. Metab. 88, 4696-4701.
81. Murakami, N., Hayashida, T., Kuroiwa, T., et al. (2002). J. Endocrinol. 174, 283-288.
82. Kishimoto, M., Okimura, Y., Nakata, H., et al. (2003). Biochem. Biophys. Res. Commun. 305, 186-192.
83. Nakazato, M., Murakami, N., Date, Y., et al. (2001). Nature 409, 194-198.
84. Horvath, T. L., Diano, S., Sotonyi, P., Heiman, M., and Tschop, M. (2001). Endocrinology 142, 4163-4169.
85. Kamegai, J., Tamura, H., Shimizu, T., Ishii, S., Sugihara, H., and Wakabayashi, I. (2000). Endocrinology 141, 4797-4800.
86. Zigman, J. M. and Elmquist, J. K. (2003). Endocrinology 144, 3749-3756.
87. Tamura, H., Kamegai, J., Shimizu, T., Ishii, S., Sugihara, H., and Oikawa, S. (2002). Endocrinology 143, 3268-3275.
88. Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., and Tschop, M. (2004). Endocrinology 145, 4645-4652.
89. Faulconbridge, L. F., Cummings, D. E., Kaplan, J. M., and Grill, H. J. (2003). Diabetes 52, 2260-2265.
90. Tschop, M., Statnick, M. A., Suter, T. M., and Heiman, M. L. (2002). Endocrinology 143, 558-568.
91. Choi, K., Roh, S. G., Hong, Y. H., et al. (2003). Endocrinology 144, 754-759.
92. Ott, V., Fasshauer, M., Dalski, A., et al. (2002). Horm. Metab. Res. 34, 640-645.
93. le Roux, C. W., Neary, N. M., Halsey, T. J., et al. (2005). J. Clin. Endocrinol. Metab. 90, 4521-4524.
94. Wren, A. M., Small, C. J., Ward, H. L., et al. (2000). Endocrinology 141, 4325-4328.
95. Druce, M. R., Small, C. J., and Bloom, S. R. (2004). Endocrinology 145, 2660-2665.
96. Masuda, Y., Tanaka, T., Inomata, N., et al. (2000). Biochem. Biophys. Res. Commun. 276, 905-908.
97. Lee, H. M., Wang, G., Englander, E. W., Kojima, M., and Greeley, G. H. Jr. (2002). Endocrinology 143, 185-190.
98. Dezaki, K., Hosoda, H., Kakei, M., et al. (2004). Diabetes 53, 3142-3151.
99. Reimer, M. K., Pacini, G., and Ahren, B. (2003). Endocrinology 144, 916-921.
100. Arosio, M., Ronchi, C. L., Gebbia, C., Cappiello, V., Beck-Peccoz, P., and Peracchi, M. (2003). J. Clin. Endocrinol. Metab. 88, 701-704.
101. Sun, Y., Ahmed, S., and Smith, R. G. (2003). Mol. Cell. Biol. 23, 7973-7981.
102. Wortley, K. E., Anderson, K. D., Garcia, K., et al. (2004). Proc. Natl. Acad. Sci. USA 101, 8227-8232.
103. Tatemoto, K. and Mutt, V. (1980). Nature 285, 417-418.
104. Ali-Rachedi, A., Varndell, I. M., Adrian, T. E., et al. (1984). Histochemistry 80, 487-491.
105. El-Salhy, M., Grimelius, L., Wilander, E., et al. (1983). Histochemistry 77, 15-23.
106. Pappas, T. N., Debas, H. T., and Taylor, I. L. (1985). Gastroenterology 89, 1387-1392.
107. Broome, M., Hokfelt, T., and Terenius, L. (1985). Acta Physiol. Scand. 125, 349-352.
108. Lundberg, J. M., Terenius, L., Hokfelt, T., and Tatemoto, K. (1984). J. Neurosci. 4, 2376-2386.
109. Dumont, Y., Fournier, A., St-Pierre, S., and Quirion, R. (1996). Synapse 22, 139-158.
110. Lynch, D. R., Walker, M. W., Miller, R. J., and Snyder, S. H. (1989). J. Neurosci. 9, 2607-2619.
111. Yang, H., Li, W. P., Reeve, J. R. Jr., Rivier, J., and Tache, Y. (1998). Br. J. Pharmacol. 123, 1549-1554.
112. Grandt, D., Schimiczek, M., Beglinger, C., et al. (1994). Regul. Pept. 51, 151-159.
113. Eberlein, G. A., Eysselein, V. E., Schaeffer, M., et al. (1989). Peptides 10, 797-803.
114. Morley, J. E., Levine, A. S., Grace, M., and Kneip, J. (1985). Brain Res. 341, 200-203.
115. Corp, E. S., McQuade, J., Krasnicki, S., and Conze, D. B. (2001). Peptides 22, 493-499.
116. Harding, R. K. and McDonald, T. J. (1989). Peptides 10, 21-24.
117. Batterham, R. L., Cohen, M. A., Ellis, S. M., et al. (2003). N. Engl. J. Med. 349, 941-948.
118. Pittner, R. A., Moore, C. X., Bhavsar, S. P., et al. (2004). Int. J. Obes. Relat. Metab. Disord. 28, 963-971.
119. Chelikani, P. K., Haver, A. C., and Reidelberger, R. D. (2005). Endocrinology 146, 879-888.
120. Halatchev, I. G., Ellacott, K. L., Fan, W., and Cone, R. D. (2004). Endocrinology 145, 2585-2590.
121. Challis, B. G., Pinnock, S. B., Coll, A. P., Carter, R. N., Dickson, S. L., and O'Rahilly, S. (2003). Biochem. Biophys. Res. Commun. 311, 915-919.
122. Challis, B. G., Coll, A. P., Yeo, G. S., et al. (2004). Proc. Natl. Acad. Sci. USA 101, 4695-4700.
123. Marsh, D. J., Hollopeter, G., Huszar, D., et al. (1999). Nat. Genet. 21, 119-122.
124. Koda, S., Date, Y., Murakami, N., et al. (2005). Endocrinology 146, 2369-2375.
125. Halatchev, I. G. and Cone, R. D. (2005). Cell Metab. 1, 159-168.
126. Drucker, D. J. (2002). Gastroenterology 122, 531-544.
127. Baggio, L. L. and Drucker, D. J. (2004). Best Pract. Res. Clin. Endocrinol. Metab. 18, 531-554.
128. Brubaker, P. L. and Anini, Y. (2003). Can. J. Physiol. Pharmacol. 81, 1005-1012.
129. Roberge, J. N. and Brubaker, P. L. (1993). Endocrinology 133, 233-240.
130. Kieffer, T. J., McIntosh, C. H., and Pederson, R. A. (1995). Endocrinology 136, 3585-3596.
131. Hartmann, B., Thulesen, J., Kissow, H., et al. (2000). Endocrinology 141, 4013-4020.
132. Turton, M. D., O'Shea, D., Gunn, I., et al. (1996). Nature 379, 69-72.
133. Navarro, M., Rodriquez de Fonseca, F., Alvarez, E., et al. (1996). J. Neurochem. 67, 1982-1991.
134. Meeran, K., O'Shea, D., Edwards, C. M., et al. (1999). Endocrinology 140, 244-250.
135. Naslund, E., Barkeling, B., King, N., et al. (1999). Int. J. Obes. Relat. Metab. Disord. 23, 304-311.
136. Gutzwiller, J. P., Drewe, J., Goke, B., et al. (1999). Am. J. Physiol. 276, R1541-1544.
137. Flint, A., Raben, A., Astrup, A., and Holst, J. J. (1998). J. Clin. Invest. 101, 515-520.
138. Merchenthaler, I., Lane, M., and Shughrue, P. (1999). J. Comp. Neurol. 403, 261-280.
139. Larsen, P. J., Tang-Christensen, M., and Jessop, D. S. (1997). Endocrinology 138, 4445-4455.
140. Van Dijk, G., Lindskog, S., Holst, J. J., Steffens, A. B., and Ahren, B. (1996). Am. J. Physiol. 270, E1015-1021.
141. Tang-Christensen, M., Vrang, N., and Larsen, P. J. (1998). Diabetes 47, 530-537.
142. Tang-Christensen, M., Larsen, P. J., Goke, R., et al. (1996). Am. J. Physiol. 271, R848-856.
143. Hwa, J. J., Ghibaudi, L., Williams, P., Witten, M. B., Tedesco, R., and Strader, C. D. (1998). Peptides 19, 869-875.
144. McMahon, L. R. and Wellman, P. J. (1998). Am. J. Physiol. 274, R23-29.
145. McMahon, L. R. and Wellman, P. J. (1997). Pharmacol. Biochem. Behav. 58, 673-677.
146. Kinzig, K. P., D'Alessio, D. A., and Seeley, R. J. (2002). J. Neurosci. 22, 10470-10476.
147. Thiele, T. E., Van Dijk, G., Campfield, L. A., et al. (1997). Am. J. Physiol. 272, R726-730.
148. Gutzwiller, J. P., Goke, B., Drewe, J., et al. (1999). Gut 44, 81-86.
149. Toft-Nielsen, M. B., Madsbad, S., and Holst, J. J. (1999). Diabetes Care 22, 1137-1143.
150. Delgado-Aros, S., Kim, D. Y., Burton, D. D., et al. (2002). Am. J. Physiol. Gastrointest. Liver Physiol. 282, G424-431.
151. Kastin, A. J., Akerstrom, V., and Pan, W. (2002). J. Mol. Neurosci. 18, 7-14.
152. Scrocchi, L. A., Brown, T. J., MaClusky, N., et al. (1996). Nat. Med. 2, 1254-1258.
153. Jeppesen, P. B. (2003). J. Nutr. 133, 3721-3724.
154. Drucker, D. J. (1999). Trends Endocrinol. Metab. 10, 153-156.
155. Munroe, D. G., Gupta, A. K., Kooshesh, F., et al. (1999). Proc. Natl. Acad. Sci. USA 96, 1569-1573.
156. Chance, W. T., Foley-Nelson, T., Thomas, I., and Balasubramaniam, A. (1997). Am. J. Physiol. 273, G559-563.
157. Tavakkolizadeh, A., Shen, R., Abraham, P., et al. (2000). Curr. Surg. 57, 502.
158. Tang-Christensen, M., Larsen, P. J., Thulesen, J., Romer, J., and Vrang, N. (2000). Nat. Med. 6, 802-807.
159. Tsai, C. H., Hill, M., Asa, S. L., Brubaker, P. L., and Drucker, D. J. (1997). Am. J. Physiol. 273, E77-84.
160. Sorensen, L. B., Flint, A., Raben, A., Hartmann, B., Holst, J. J., and Astrup, A. (2003). Int. J. Obes. Relat. Metab. Disord. 27, 450-456.
161. Schmidt, P. T., Naslund, E., Gryback, P., et al. (2003). Regul. Pept. 116, 21-25.
162. Dakin, C. L., Small, C. J., Park, A. J., Seth, A., Ghatei, M. A., and Bloom, S. R. (2002). Am. J. Physiol. Endocrinol. Metab. 283, E1173-1177.
163. Gros, L., Thorens, B., Bataille, D., and Kervran, A. (1993). Endocrinology 133, 631-638.
164. Yamamoto, H., Lee, C. E., Marcus, J. N., et al. (2002). J. Clin. Invest. 110, 43-52.
165. Dakin, C. L., Small, C. J., Batterham, R. L., et al. (2004). Endocrinology 145, 2687-2695.
166. Finer, N. (2002). Best Pract. Res. Clin. Endocrinol. Metab. 16, 717-742.
167. Strader, A. D. and Woods, S. C. (2005). Gastroenterology 128, 175-191.