Expression of Ghrelin and Its Functional Receptor, the Type 1a Growth Hormone Secretagogue Receptor, in Normal Human Testis and Testicular Tumors

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 1, 2004, Pages 400-409

  Gaytan, F ^a   Barreiro, M L ^a   Caminos, J E ^b   Chopin, L K ^c   Herington, A C ^c   Morales, C ^a   Pinilla, L ^a   Paniagua, R ^d   Nistal, M ^e   Casanueva, F F ^b   Aguilar, E ^a   Dieguez C ^b   Tena Sempere, M ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^d UNIVERSITY OF ALCALÁ   (Spain)

^e UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; MESSENGER RNA; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SEQUENCE; EMBRYONAL CARCINOMA; EVALUATION; GENETIC CODE; GERM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEYDIG CELL; MALE; PACHYTENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SEMINIFEROUS TUBULE; SEMINOMA; SEQUENCE ANALYSIS; SERTOLI CELL; SOMATIC CELL; SPERMATOGENESIS; TESTIS; TESTIS FUNCTION; TESTIS TUMOR;

ADULT; AGED; CARCINOMA, EMBRYONAL; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LEYDIG CELL TUMOR; LEYDIG CELLS; MALE; MIDDLE AGED; PEPTIDE HORMONES; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEMINIFEROUS TUBULES; SEMINOMA; SERTOLI CELLS; TESTICULAR NEOPLASMS; TESTIS;

MAMMALIA;

EID: 10744220319     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031375     Document Type: Article

References (47)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone acylated peptide from stomach. Nature 402: 656-666
2. Kojima M, Hosoda H, Matsuo H, Kangawa K 2001 Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 12:118-122
3. 14-ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem 275:21995-22000
4. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K 2000 Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908-4911
5. Arvat E, Maccario M, di Vito L, Broglio F, Benso A, Gottero C, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E 2001 Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 86:1169-1174
6. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
7. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I 2000 Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology 141:4797-4800
8. Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
9. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
10. Furuta M, Funabashi T, Kimura F 2001 Intracerebroventricular ad ministration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 288:780-785
11. Okumura H, Nagaya N, Enomoto M, Nakagawa E, Oya H, Kangawa K 2002 Vasodilatory effect of ghrelin, an endogenous peptide from the stomach. J Cardiovasc Pharmacol 39:779-783
12. Broglio F, Arvat E, Benso A, Papotti M, Muccioli G, Deghenghi R, Ghigo E 2002 Ghrelin: endocrine and non-endocrine actions. J Pediatr Endocrinol Metab 15:1219-1227
13. Howard AD, Feighner SC, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund RP, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, van der Ploeg LHT 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
14. McKee KK, Palyha OC, Feighner SD, Hreniuk DL, Tan CP, Phillips MS, Smith RG, van der Ploeg LH, Howard AD 1997 Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol 11:415-423
15. Guan XH, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, van der Ploeg LH, Howard AD 1997 Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 48:23-29
16. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N, Bussolino F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Graziani A 2002 Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159:1029-1037
17. Ghe C, Cassoni P, Catapano F, Marrocco T, Deghenghi R, Ghigo E, Muccioli G, Papotti M 2002 The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells. Endocrinology 143:484-491
18. Tena-Sempere M, Barreiro ML, Gonzalez LC, Gaytan F, Zhang FP, Caminos JP, Pinilla L, Casanueva FF, Dieguez C, Aguilar E 2002 Novel expression and functional role of ghrelin in rat testis. Endocrinology 143:717-725
19. Barreiro ML, Gaytan F, Caminos JE, Pinilla L, Casanueva FF, Aguilar E, Dieguez C, Tena-Sempere M 2002 Cellular location and hormonal regulation of ghrelin in rat testis. Biol Reprod 67:1768-1776
20. Barreiro ML, Suominen JS, Gaytan F, Pinilla L, Chopin LK, Casanueva FF, Dieguez C, Aguilar E, Toppari J, Tena-Sempere M 2003 Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis. Biol Reprod 68:1631-1640
21. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M 2002 The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87:2988-2991
22. Jeffery PL, Herington AC, Chopin LK 2002 Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines. J Endocrinol 172:R7-R11
23. Suárez-Quian CA, Martínez-Garcia F, Nistal M, Regadera J 1999 Androgen receptor distribution in adult human testis. J Clin Endocrinol Metab 84:350-358
24. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
25. Hosoda H, Kojima M, Matsuo H, Kangawa K 2000 Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279:909-913
26. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K 2001 Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol 280:R1483-R1487
27. Garcia-Pardo L, Granados MD, Gaytan F, Padilla CA, Martinez-Galisteo E, Morales C, Sanchez-Criado JE, Barcena JA 1999 Immunolocalization of glutaredoxin in the human corpus luteum. Mol Hum Reprod 5:914-999
28. Gaytan F, Barreiro ML, Chopin LK, Herington AC, Morales C, Pinilla L, Casanueva FF, Aguilar E, Dieguez C, Tena-Sempere M 2003 Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 88:879-887
29. Caminos JE, Tena-Sempere M, Gaytan F, Sanchez-Criado JE, Barreiro ML, Nogueiras R, Casanueva FF, Aguilar E, Dieguez C 2003 Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology 144:1594-1602
30. Regadera J, Martínez-García F, González-Peramato P, Serrano A, Nistal M, Suárez-Quian C 2001 Androgen receptor expression in Sertoli cells as a function of seminiferous tubule maturation in the human cryptorchid testis. J Clin Endocrinol Metab 86:413-421
31. Tanaka M, Hayashida Y, Nakao N, Nakai N, Nakashima K 2001 Testisspecific and developmentally induced expression of a ghrelin gene-derived transcript that encodes a novel polypeptide in the mouse. Biochim Biophys Acta 1522:62-65
32. Erickson GF, Magoffin DA, Dyer CA, Hofeditz C 1985 The ovarian androgen producing cells: a review of structure/function relationships. Endocr Rev 6:371-399
33. Balvers M, Spiess A-N, Domagalski R, Hunt N, Kilic E, Mukhopadhyay AK, Hanks E, Charlton HM, Ivell R 1998 Relaxin-like factor expression as marker of differentiation in the mouse testis and ovary. Endocrinology 139:2960-2970
34. Kishimoto M, Okimura Y, Nakata H, Kudo T, Iguchi G, Takahashi Y, Kaji H, Chihara K 2003 Cloning and characterization of the 5′-flanking region of the human ghrelin gene. Biochem Biophys Res Commun 305:186-192
35. Tena-Sempere M, Huhtaniemi I 2003 Gonadotropins and gonadotropin receptors. In: Fauser BCJM, ed. Reproductive medicine: molecular, cellular and genetic fundamentals. New York: Parthenon; 225-244
36. Yan W, Linderborg J, Suominen J, Toppari J 1999 Stage-specific regulation of stem cell factor gene expression in the rat seminiferous epithelium. Endocrinology 140:1499-1504
37. Yan W, Suominen J, Toppari J 2000 Stem cell factor protects germ cells from apoptosis in vitro. J Cell Sci 113:161-168
38. Papotti M, Ghé C, Cassoni P, Catapano F, Deghenghi R, Ghigo E, Muccioli G 2000 Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab 85:3803-3807
39. Pappoti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E 2001 Ghrelin-producing endocrine tumors of the stomach and intestine. J Clin Endocrinol Metab 86:5052-5059
40. Volante M, Allia E, Gugliotta P, Funaro A, Broglio F Deghenghi R, Muccioli G, Ghigo E, Pappoti M 2002 Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 87:1300-1308
41. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB 2001 The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 86:881-887
42. Teerds KJ, de Rooij DG, Rommerts FFG, Wensing CJG 1988 The regulation of the proliferation and the differentiation of rat Leydig cell precursors after EDS administration or daily hCG treatment. J Androl 9:343-351
43. Korbonits M, Jacobs RA, Aylwin SJ, Burrin JM, Dahia PL, Monson JP, Honegger J, Fahlbush R, Trainer PJ, Chew SL, Besser GM, Grossman AB 1998 Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors. J Clin Endocrinol Metab 83: 3624-3630
44. Cassoni P, Papotti M, Catapano F, Ghe C, Deghenghi R, Ghigo E, Muccioli G 2000 Specific binding sites for synthetic growth hormone secretagogues in nontumoral and neoplastic human thyroid tissue. J Endocrinol 165:139-146
45. Cassoni P, Papotti M, Ghè C, Catapano F, Sapino A, Graziani A, Deghenghi R, Reissmann T, Ghigo E, Muccioli G 2001 Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues in human breast carcinomas and cell lines. J Clin Endocrinol Metab 86:1738-1745
46. Jeffery PL, Herington AC, Chopin LK 2003 The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer. Cytokine Growth Factor Rev 14:113-122
47. Tena-Sempere M, Barreiro ML 2002 Leptin in male reproduction: the testis paradigm. Mol Cell Endocrinol 188:9-13