Circulating ghrelin concentrations in the polycystic ovary syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 2, 2003, Pages 942-945

  Orio Jr , Francesco ^a,d   Lucidi, Paola ^b   Palomba, Stefano ^c   Tauchmanova, Libuse ^a   Cascella, Teresa ^a   Russo, Tiziana ^c   Zullo, Fulvio ^c   Colao, Annamaria ^a   Lombardi, Gaetano ^a   De Feo, Pierpaolo ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLLITROPIN; GHRELIN; HYDROXYPROGESTERONE; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROLACTIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADULT; FASTING; FEMALE; HORMONES; HUMANS; INSULIN RESISTANCE; PEPTIDE HORMONES; POLYCYSTIC OVARY SYNDROME;

FALLOPIA;

EID: 0037323477     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-021451     Document Type: Article

References (30)

1. Lobo RA, Carmina E 2000 The importance of diagnosing the polycystic ovary syndrome. Ann Intern Med 132:989-993
2. Legro RS 2001 Polycystic ovary sindrome: the new millennium. Mol Cell Endocrinol 184:87-93
3. Carmina E, Lobo RA 1999 Polycystic ovary sindrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab 84:1897-1899
4. Dunaif A 1997 Insulin resistance and the polycystic ovary sindrome: mechanism and implications for pathoganesis. Endocr Rev 18:774-800
5. Legro RS, Urbanek M, Kunselman AR, Leiby BE, Dunaif A 2002 Self selected women with polycystic ovary sindrome are reproductively and metabolically abnormal and undertreated. Fertil Steril 78:51-57
6. Elting MW, Korsen TJM, Shoemaker J 2001 Obesity, rather than menstrual cycle pattern or follicle cohort size, determines hyperinsulinemia, dyslipidemia and hypertension in ageing women with polycystic ovary sindrome. Clin Endocrinol 55:767-776
7. Norman RJ, Davies MJ, Lord J, Moran LJ 2002 The role of lifestyle modification in polycystic ovary syndrome. Trends Endocrinol Metab 13:251-257
8. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K 2000 Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908-4911
9. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone releasing acylated from the stomach. Nature 402:656-660
10. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role of ghrelin in the central regulation of feeding. Nature 409:194-198
11. Tschöp M, Smiley D, Heiman M 2000 Ghrelin induces adiposity in rodents. Nature 407:906-912
12. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans J Clin Endocrinol Matab 86:5992-5995
13. Hewson A, Dickinson S 2000 Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 12:1047-1049
14. Ukkola O, Poykko S 2002 Ghrelin, growth and obesity. Ann Med 34:102-108
15. Cummings DE, Purnell JQ, Frayo RS, Sehmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggest a role in meal initiation in humans. Diabetes 50:1714-1719
16. Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C 2001 Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19-RC21
17. Ukkula O, Ravussin E, Jacubson P, Perusse L, Rankinen T, Tschop M, Heiman ML, Leon AS, Rao DC, Skinner JS, Wilmore JH, Sjostrom L, Bouchard C 2002 Role of ghrelin polymorphisms in obesity based on three different studies. Obes Res 10:782-791
18. Ferriman D, Gallwey JD 1961 Clinical assessment of body hair growth in women. J Clin Endocrinol Metab21:1440-1447
19. Fulghesu AM, Ciampelli M, Belosi C, Apa R, Pavone V, Lanzone A A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio. 2001 Fertil Steril 76:326-331
20. Morley JE, Patrick P, Perry III HM 2002 Evaluation of assays available to measure free testosterone. Metabolism 5:554-559
21. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
22. Janssen JA, van der Toorn FM, Hofland LJ, van Koetsveld P, Broglio F, Ghigo E, Lamberts SW, Jan van der Lely A 2001 Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy. Eur J Endocrinol 145:711-716
23. Lucidi P, Murdolo G, Di Loreto C, De Cicco A, Parlanti N, Fanelli C, Santeusanio F, Bolli GB, De Feo P 2002 Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes 51:2911-2914
24. Orio F Jr, Palomba S, Colao A, Tenuta M, Dentico C, Peretta M, Lombardi G, Nappi C, Orio F 2001 Growth hormone secretion after baclofen administration in different phases of the menstrual cycle in healthy women. Horm Res 55:131-136
25. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K 2001 Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86: 4753-4758
26. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50: 707-709
27. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, van der Lely AJ, Deghenghi R, Ghigo E 2001 Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86:5083-5086
28. Saad MF, Bernaba B, Hwyu CM, Jinagouda S, Fahmi S, Kogosov E, Boyadjian AR 2002 Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87:3997-4000
29. Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, Jorgensen JOL 2002 Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol 56:203-206
30. Schofl C, Rudiger H, Schill T, Schlosser HW, Muller MJ, Brabant G 2002 Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 87:4607-4610