Increased plasma ghrelin level in lung cancer cachexia

Clinical Cancer Research

Volumn 9, Issue 2, 2003, Pages 774-778

  Shimizu, Yoshito ^a   Nagaya, Noritoshi ^b   Isobe, Takeshi ^a   Imazu, Michinori ^a   Okumura, Hiroyuki ^b   Hosoda, Hiroshi ^b   Kojima, Masayasu ^b   Kangawa, Kenji ^b   Kohno, Nobuoki ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; GHRELIN; NAVELBINE; PACLITAXEL;

ADULT; AGED; ANOREXIA; ARTICLE; BLOOD LEVEL; CACHEXIA; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; FEMALE; FOOD INTAKE; HUMAN; LUNG CANCER; MALE; PRIORITY JOURNAL;

EID: 0037314839     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Dewys, W. D., Begg, C., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Jr., Engstrom, P. F., Ezdinli, E. Z., Horton, J., Johnson, G. J., Moertel, C. G., Oken, M. M., Perlia, C., Rosenbaum, C., Silverstein, M. N., Skeel, R. T., Sponzo, R. W., and Tormey, D. C. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am. J. Med., 69: 491-497, 1980.
2. Nixon, D. W., Heymsfield, S. B., Cohen, A. E., Kutner, M. H., Ansley, J., Lawson, D. H., and Rudman, D. Protein-calorie undernutrition in hospitalized cancer patients. Am. J. Med., 68: 683-690, 1980.
3. Lanzotti, V. J., Thomas, D. R., Boyle, L. E., Smith, T. L., Gehan, E. A., and Samuels, M. L. Survival with inoperable lung cancer: an integration of prognostic variables based on simple clinical criteria. Cancer (Phila.), 39: 303-313, 1977.
4. Donaldson, S. S., and Lenon, R. A. Alterations of nutritional status: impact of chemotherapy and radiation therapy. Cancer (Phila.), 43: 2036-2052, 1979.
5. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., and Kangawa, K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402: 656-660, 1999.
6. Tschop, M., Smiley, D. L., and Heiman, M. L. Ghrelin induces adiposity in rodents. Nature (Lond.), 407: 908-913, 2000.
7. Wren, A. M., Small, C. J., Ward, H. L., Murphy, K. G., Dakin, C. L., Taheri, S., Kennedy, A. R., Roberts, G. H., Morgan, D. G., Ghatei, M. A., and Bloom, S. R. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology, 141: 4325-4328, 2000.
8. Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., and Matsukura, S. A role for ghrelin in the central regulation of feeding. Nature (Lond.), 409: 194-198, 2001.
9. Shintani, M., Ogawa, Y., Ebihara, K., Aizawa-Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., Kangawa, K., and Nakao, K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes, 50: 227-232, 2001.
10. Rowland, K. M., Jr., Loprinzi, C. L., Shaw, E. G., Maksymiuk, A. W., Kuross, S. A., Jung, S. H., Kugler, J. W., Tschetter, L. K., Ghosh, C., Schaefer, P. L., Owen, D., Washburn, J. H., Jr., Webb, T. A., Mailliard, J. A., and Jett, J. R. Randomized double-blind placebo-controlled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensive-stage small-cell lung cancer: a North Central Cancer Treatment Group study. J. Clin. Oncol., 14: 135-141, 1996.
11. Hosoda, H., Kojima, M., Matsuo, H., and Kangawa, K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem. Biophys. Res. Commun., 279: 909-913, 2000.
12. Miller, A. B., Hoogstraten, B., Staquet, M., and Winkler, A. Reporting results of cancer treatment. Cancer (Phila.), 47: 207-214, 1981.
13. Buccheri, G., Ferrigno, D., and Tamburini, M. Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. Eur. J. Cancer, 32A: 1135-1141, 1996.
14. Toshinai, K., Mondal, M. S., Nakazato, M., Date, Y., Murakami, N., Kojima, M., Kangawa, K., and Matsukura, S. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem. Biophys. Res. Commun., 281: 1220-1225, 2001.
15. Copeland, E. M., III, Daly, J. M., and Dudrick, S. J. Nutrition as an adjunct to cancer treatment in the adult. Cancer Res., 37: 2451-2456, 1977.
16. Goldberg, R. M., Loprinzi, C. L., Mailliard, J. A., O'Fallon, J. R., Krook, J. E., Ghosh, C., Hestorff, R. D., Chong, S. F., Reuter, N. F., and Shanahan, T. G. Pentoxifylline for treatment of cancer anorexia and cachexia? A randomized, double-blind, placebo-controlled trial. J. Clin. Oncol., 13: 2856-2859, 1995.