Effect of food restriction on ghrelin in normal-cycling female rats and in pregnancy

Obesity Research

Volumn 10, Issue 7, 2002, Pages 682-687

  Gualillo, Oreste ^a   Caminos, Jorge E ^c   Nogueiras, Rubén ^c   Seoane, Luisa M ^c   Arvat, Eva ^b   Ghigo, Ezio ^b   Casanueva, Felipe F ^c   Diéguez, Carlos ^c,d  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d NONE   (Spain)

Author keywords

Food restriction; Ghrelin; Pregnancy

Indexed keywords

GHRELIN; MESSENGER RNA; PEPTIDE HORMONE;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; ESTRUS; FEMALE; FOOD DEPRIVATION; GENE EXPRESSION; GENETICS; NORTHERN BLOTTING; PHYSIOLOGY; PREGNANCY; RAT; SPRAGUE DAWLEY RAT; STOMACH;

ANIMALS; BLOTTING, NORTHERN; ESTRUS; FEMALE; FOOD DEPRIVATION; GENE EXPRESSION; PEPTIDE HORMONES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STOMACH;

EID: 0036636369     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2002.92     Document Type: Article

References (22)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo M, Kangawa K. Ghrelin is a growth hormone releasing acylated peptide from stomach. Nature. 1999;402:656-60.
2. Bowers CY Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54:1316-29.
3. Takaya K, Ariyasu H, Kanamoto N, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab. 2001;86:1464-9.
4. Seoane LM, Tovar S, Baldelli R, et al. Ghrelin elicits a marked stimulatory effect on GH secretion in freely moving rats. Eur J Endocrinol. 2000;143:R7-R9.
5. Arvat E, Divito L, Broglio F, et al. Preliminary evidence that ghrelin, the natural GH secretagogue receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest. 2000; 8:493-5.
6. Inui A. Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci. 2001;2:551-60.
7. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000;141:4325-8.
8. Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001;120:337-45.
9. Toshinai K, Mondai MS, Nakazato M, et al. Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun. 2001;281:1220-5.
10. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001;50:707-9.
11. Woodall SM, Breier BH, Johnston BM, Gluckman PD. A model of intrauterinc growth retardation caused by chronic maternal undernutrition in the rat: effects on the somatotrophic axis and postnatal growth. J Endocrinol. 1996;150:231-42.
12. Gualillo O, Caminos JE, Blanco M, et al. Ghrelin, a novel placental derived hormone. Endocrinology. 2001;142:788-94.
13. Gualillo O, Caminos JE, Kojima M, et al. Gender and gonadal influences on ghrelin mRNA levels in rats. Eur J Endocrinol. 2001;144:687-90.
14. Torsello A, Luoni M, Schweiger F, et al. Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. Eur J Pharmacol. 1998; 360:123-9.
15. Okada K, Ishii S, Minami S, Sugihara H, Shibasaki T, Wakabayashi I. Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology. 1996;11:5155-8.
16. Willesen MG, Kristensen P, Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology. 1999;70: 306-16.
17. Tschop M, Smiley DL, Helman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407:908-13.
18. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M. Ghrelin and the regulation of energy balance-a hypothalamic perspective. Endocrinology. 2001;142:4163-9.
19. Gluckman PD, Harding JE. The physiology and pathophysiology of intrauterine growth retardation. Horm Res. 1997;48: 11-6.
20. Nieuwenhuizen AG, Schuiling GA, Seijsener AFJ, Moes H, Koiter TR. Effects of food restriction on glucose tolerance, insulin secretion and islet cell proliferation in pregnant rats. Physiol Behav. 1999;65:671-7.
21. Dieguez C, Casanueva FF. Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation. Eur J Endocrinol. 2000;142:413-7.
22. Nagaya N, Uematsu M, Kojima M, et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation. 2001;104:1430-5.