Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents

Journal of Endocrinology

Volumn 175, Issue 2, 2002, Pages

  McCowen, K C ^a   Maykel, J A ^a   Bistrian, B R ^a   Ling, P R ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GHRELIN; GLUCOSE; INSULIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE INHIBITION; HORMONE RELEASE; HYPERINSULINEMIA; INFUSION; INSULIN BLOOD LEVEL; INSULIN RESPONSE; MALE; NONHUMAN; NUTRIENT; PREDICTION; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; REVIEW; STEADY STATE; STOMACH PARIETAL CELL; TIME;

EID: 0036854343     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.175r007     Document Type: Review

References (18)

1. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K & Nakao K 2001 Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. Journal of Clinical Endocrinology and Metabolism 86 4753-4758.
2. Ariyasu H, Takaya K, Hosoda H, Iwakura H, Ebihara K, Mori K, Hosoda K, Akamizu T, Kojima M, Kangawa K & Nakao K 2002 Delayed short term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143 3341-3350.
3. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F & Ghigo E 2000 Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. Journal of Endocrinological Investigation 23 493-495.
4. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA & Kasuga M 2001 Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120 337-345.
5. Caixas A, Bashore C, Nash W, Pi-Sunyer F & Laferrere B 2002 Insulin, unlike food intake, does not suppress ghrelin in human subjects. Journal of Clinical Endocrinology and Metabolism 87 1902-1905.
6. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE & Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 1714-1719.
7. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP & Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New England Journal of Medicine 346 1623-1630.
8. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660.
9. Lee HM, Wang G, Englander EW, Kojima M & Greeley GH Jr 2002 Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143 185-190.
10. Ling PR, Sierra P, Qu Z & Bistrian BR 1997 Insulin-like growth factor-I improves glucose utilization in tumor necrosis factor-treated rats under hyperinsulinemic-euglycemic conditions. Metabolism 46 1052-1058.
11. Marandi S, De Keyser N, Saliez A, Maernoudt AS, Sokal EM, Stilmant C, Rider MH & Buts JP 2002 Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosalhydrolases. American Journal of Physiology. Gastrointestinal and Liver Physiology 280 G229-G240.
12. Ravussin E, Tschop M, Morales S, Bouchard C & Heiman ML 2001 Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. Journal of Clinical Endocrinology and Metabolism 86 4547-4551.
13. Reifen R, Khoshoo V & Dinari G 1999 Effect of parenteral nutrition on oral intake. Journal of Pediatric Endocrinology and Metabolism 12 203-205.
14. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal IVIS, Tanaka M, Nozoe S, Hosoda H, Kangawa K & Matsukura S 2002 Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. Journal of Clinical Endocrinology and Metabolism 87 240-244.
15. Stratton RJ & Elia M 1999 The effects of enteral tube feeding and parenteral nutrition on appetite sensations and food intake in health and disease. Clinical Nutrition 18 63-70.
16. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K & Matsukura S 2001 Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochemical and Biophysical Research Communications 281 1220-1225.
17. Tschop M, Smiley DL & Heiman ML 2000 Ghrelin induces adiposity in rodents Nature 407 908-913.
18. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E & Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50 707-709.