메뉴 건너뛰기




Volumn 11, Issue 2, 2006, Pages 337-352

Antisense-based cancer therapeutics: Are we there yet?

Author keywords

Antisense oligonucleotide; Chemotherapy; Oncogene; Radiation therapy; Target validation

Indexed keywords

AEG 35156; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; AP 12009; APRINOCARSEN; AV 4126; AV 4557; CGP 69846A; EL 625; GEMCITABINE; GENE EXPRESSION MODULATOR 231; GTI 2040; GTI 2501; INDIUM 111; INX 3001; ISIS 23722; ISIS 2503; ISIS 3521; LERAFAON; LR 3001; LY 2181308; MG 98; OBLIMERSEN; OGX 011; SPC 2996; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEGLIN;

EID: 33646571240     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.11.2.337     Document Type: Review
Times cited : (17)

References (107)
  • 1
    • 1842419766 scopus 로고    scopus 로고
    • Therapeutic integration of signal transduction targeting agents and conventional anti-cancer treatments
    • MELISI D, TROIANI T, DAMIANO V, TORTORA G, CIARDIELLO F: Therapeutic integration of signal transduction targeting agents and conventional anti-cancer treatments. Endocr. Relat. Cancer (2004) 11:51-68.
    • (2004) Endocr. Relat. Cancer , vol.11 , pp. 51-68
    • Melisi, D.1    Troiani, T.2    Damiano, V.3    Tortora, G.4    Ciardiello, F.5
  • 2
    • 0036031772 scopus 로고    scopus 로고
    • Therapeutics targeting signal transduction for patients with colorectal carcinoma
    • DE BONO JS, ROWINSKY EK: Therapeutics targeting signal transduction for patients with colorectal carcinoma. Br. Med. Bull. (2002) 64:227-254.
    • (2002) Br. Med. Bull. , vol.64 , pp. 227-254
    • De Bono, J.S.1    Rowinsky, E.K.2
  • 3
    • 14644410433 scopus 로고    scopus 로고
    • Novel antisense anti-MDM2 mixed-backbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms
    • ZHANG R, WANG H, AGRAWAL S: Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms. Curr. Cancer Drug Targets (2005) 5:43-49. A case study of a second-generation MBO from antisense design to full-scale preclinical evaluation.
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 43-49
    • Zhang, R.1    Wang, H.2    Agrawal, S.3
  • 4
    • 3042645268 scopus 로고    scopus 로고
    • Antisense approaches in prostate cancer
    • CHI KN, GLEAVE ME: Antisense approaches in prostate cancer. Expert Opin. Biol. Ther. (2004) 4:927-936. A critical review of various antisense targets in prostate cancer and the molecules being used in preclinical and clinical prostate cancer studies.
    • (2004) Expert Opin. Biol. Ther. , vol.4 , pp. 927-936
    • Chi, K.N.1    Gleave, M.E.2
  • 5
    • 0037694089 scopus 로고    scopus 로고
    • Second neoplasms after megavoltage radiation for pediatric tumors
    • GOLD DG, NEGLIA JP, DUSENBERY KE: Second neoplasms after megavoltage radiation for pediatric tumors. Cancer (2003) 97:2588-2596.
    • (2003) Cancer , vol.97 , pp. 2588-2596
    • Gold, D.G.1    Neglia, J.P.2    Dusenbery, K.E.3
  • 6
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • ZAMECNIK P, STEPHENSON M: Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA (1978) 75:280-284.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 280-284
    • Zamecnik, P.1    Stephenson, M.2
  • 7
    • 26044434170 scopus 로고    scopus 로고
    • Antisense approaches in drug discovery and development
    • RAYBURN ER, WANG W, ZHANG R, WANG H: Antisense approaches in drug discovery and development. Prog. Drug Res. (2005) 53:227-274.
    • (2005) Prog. Drug Res. , vol.53 , pp. 227-274
    • Rayburn, E.R.1    Wang, W.2    Zhang, R.3    Wang, H.4
  • 8
    • 14344262646 scopus 로고    scopus 로고
    • RNA silencing technologies in drug discovery and target validation
    • RAYBURN E, WANG H, HE J, ZHANG R: RNA silencing technologies in drug discovery and target validation. Letters in Drug Design and Discovery (2005) 2:1-18. A comprehensive review on various RNA silencing technologies, including antisense oligos, ribozymes and RNAi.
    • (2005) Letters in Drug Design and Discovery , vol.2 , pp. 1-18
    • Rayburn, E.1    Wang, H.2    He, J.3    Zhang, R.4
  • 10
    • 0031596318 scopus 로고    scopus 로고
    • Vitravene - Another piece in the mosaic
    • CROOKE S: Vitravene - another piece in the mosaic. Antisense Nucleic Acid Drug Dev. (1998) 8:vii-viii. Summary of preclinical and clinical studies of the first marketed antisense drug.
    • (1998) Antisense Nucleic Acid Drug Dev. , vol.8
    • Crooke, S.1
  • 11
    • 1942517960 scopus 로고    scopus 로고
    • Use of antisense oligonucleotides in functional genomics and target validation
    • RAVICHANDRAN LV, DEAN NM, MARCUSSON EG: Use of antisense oligonucleotides in functional genomics and target validation. Oligonucleotides (2004) 14:49-64.
    • (2004) Oligonucleotides , vol.14 , pp. 49-64
    • Ravichandran, L.V.1    Dean, N.M.2    Marcusson, E.G.3
  • 12
    • 6344244639 scopus 로고    scopus 로고
    • Overview of target validation and the impact of oligonucleotides
    • JONES SW, LINDSAY MA: Overview of target validation and the impact of oligonucleotides. Curr. Opin. Mol. Ther. (2004) 6:546-550.
    • (2004) Curr. Opin. Mol. Ther. , vol.6 , pp. 546-550
    • Jones, S.W.1    Lindsay, M.A.2
  • 13
    • 0034779647 scopus 로고    scopus 로고
    • Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways
    • SHANKAR SL, MANI S, O'GUIN KN, KANDIMALLA ER, AGRAWAL S, SHAFIT-ZAGARDO B: Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways. J. Neurochem. (2001) 79:426-436.
    • (2001) J. Neurochem. , vol.79 , pp. 426-436
    • Shankar, S.L.1    Mani, S.2    O'Guin, K.N.3    Kandimalla, E.R.4    Agrawal, S.5    Shafit-Zagardo, B.6
  • 14
    • 0346250160 scopus 로고    scopus 로고
    • Survivin, versatile modulation of cell division and apoptosis in cancer
    • ALTIERI DC: Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene (2003) 22:8581-8589.
    • (2003) Oncogene , vol.22 , pp. 8581-8589
    • Altieri, D.C.1
  • 15
    • 19444375104 scopus 로고    scopus 로고
    • DNA-based therapeutics and DNA delivery systems: A comprehensive review
    • PATIL SD, RHODES DG, BURGESS DJ: DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J. (2005) 8:E61-E77.
    • (2005) AAPS J. , vol.8
    • Patil, S.D.1    Rhodes, D.G.2    Burgess, D.J.3
  • 16
    • 25844435161 scopus 로고    scopus 로고
    • Technical improvements in the computational target search for antisense oligonucleotides
    • FAR RK, LEPPERT J, FRANK K, SCZAKIEL G: Technical improvements in the computational target search for antisense oligonucleotides. Oligonucleotides (2005) 15:223-233.
    • (2005) Oligonucleotides , vol.15 , pp. 223-233
    • Far, R.K.1    Leppert, J.2    Frank, K.3    Sczakiel, G.4
  • 17
    • 0242456160 scopus 로고    scopus 로고
    • The future of antisense therapy: Combination with anticancer treatments
    • BIROCCIO A, LEONETTI C, ZUPI G: The future of antisense therapy: combination with anticancer treatments. Oncogene (2003) 22:6579-6588.
    • (2003) Oncogene , vol.22 , pp. 6579-6588
    • Biroccio, A.1    Leonetti, C.2    Zupi, G.3
  • 18
    • 8844244644 scopus 로고    scopus 로고
    • Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy
    • KIM R, EMI M, TANABE K, TOGE T: Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy. Cancer (2004) 101:2491-2502.
    • (2004) Cancer , vol.101 , pp. 2491-2502
    • Kim, R.1    Emi, M.2    Tanabe, K.3    Toge, T.4
  • 19
    • 33646540619 scopus 로고    scopus 로고
    • Biodistribution of (68)Ga-labelled phosphodiester, phosphorothioate, and 2′-O-methyl phosphodiester oligonucleotides in normal rats
    • LENDVAI G, VELIKYAN I, BERGSTROM M et al.: Biodistribution of (68)Ga-labelled phosphodiester, phosphorothioate, and 2′-O-methyl phosphodiester oligonucleotides in normal rats. Eur. J. Pharm. Sci. (2005) 135:949-958. An example of the potential novel application of antisense oligos for imaging.
    • (2005) Eur. J. Pharm. Sci. , vol.135 , pp. 949-958
    • Lendvai, G.1    Velikyan, I.2    Bergstrom, M.3
  • 20
    • 4444376618 scopus 로고    scopus 로고
    • Antisense imaging of colon cancer-bearing nude mice with liposome-entrapped 99m-technetium-labeled antisense oligonucleotides of c-myc mRNA
    • ZHENG JG, TAN TZ: Antisense imaging of colon cancer-bearing nude mice with liposome-entrapped 99m-technetium-labeled antisense oligonucleotides of c-myc mRNA. World J. Gastroenterol. (2004) 10:2563-2566.
    • (2004) World J. Gastroenterol. , vol.10 , pp. 2563-2566
    • Zheng, J.G.1    Tan, T.Z.2
  • 21
    • 0141670432 scopus 로고    scopus 로고
    • Antisense imaging of epidermal growth factor-induced p21 (WAF-1/CIP-1) gene expression in MDA-MB-468 human breast cancer xenografts
    • WANG J, CHEN P, MRKOBRADA M, HU M, VALLIS KA, REILLY RM: Antisense imaging of epidermal growth factor-induced p21 (WAF-1/CIP-1) gene expression in MDA-MB-468 human breast cancer xenografts. Eur. J. Nucl. Med. Mol. Imaging (2003) 30:1273-1280.
    • (2003) Eur. J. Nucl. Med. Mol. Imaging , vol.30 , pp. 1273-1280
    • Wang, J.1    Chen, P.2    Mrkobrada, M.3    Hu, M.4    Vallis, K.A.5    Reilly, R.M.6
  • 22
    • 14544295783 scopus 로고    scopus 로고
    • Aptamers: An emerging class of therapeutics
    • NIMJEE SM, RUSCONI CP, SULLENGER BA: Aptamers: an emerging class of therapeutics. Ann. Rev. Med. (2005) 56:555-583. A review of protein binding oligos and their potential use for therapy.
    • (2005) Ann. Rev. Med. , vol.56 , pp. 555-583
    • Nimjee, S.M.1    Rusconi, C.P.2    Sullenger, B.A.3
  • 23
    • 0024041180 scopus 로고
    • Role of RNase H in hybrid-arrested translation by antisense oligonucleotides
    • WALDER RY, WALDER JA: Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA (1988) 85:5011-5015. This historic paper details the discovery of one of the mechanisms of antisense action.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 5011-5015
    • Walder, R.Y.1    Walder, J.A.2
  • 24
    • 0032700656 scopus 로고    scopus 로고
    • Molecular mechanisms of action of antisense drugs
    • CROOKE ST: Molecular mechanisms of action of antisense drugs. Biochim. Biophys. Acta (1999) 1489:31-44.
    • (1999) Biochim. Biophys. Acta , vol.1489 , pp. 31-44
    • Crooke, S.T.1
  • 25
    • 2342427578 scopus 로고    scopus 로고
    • Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs
    • WU H, LIMA W, ZHANG H, FAN A, SUN H, CROOKE S: Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs. J. Biol. Chem. (2004) 279:17181-17189. New details have been uncovered about the RNase H-mediated actions of antisense oligos.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17181-17189
    • Wu, H.1    Lima, W.2    Zhang, H.3    Fan, A.4    Sun, H.5    Crooke, S.6
  • 26
    • 0037733977 scopus 로고    scopus 로고
    • Antisense technologies. Improvement through novel chemical modifications
    • KURRECK J: Antisense technologies. Improvement through novel chemical modifications. Eur. J. Biochem. (2003) 270:1628-1644. A review of many of the modifications made to an tisense oligos during recent years.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 1628-1644
    • Kurreck, J.1
  • 27
    • 0032700356 scopus 로고    scopus 로고
    • Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides
    • AGRAWAL S: Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochim. Biophys. Acta. (1999) 1489:53-68. A critical review of antisense chemistry and the structure-activity relationship of modified oligos.
    • (1999) Biochim. Biophys. Acta. , vol.1489 , pp. 53-68
    • Agrawal, S.1
  • 28
    • 0037373763 scopus 로고    scopus 로고
    • Structural modifications of antisense oligonucleotides
    • URBAN E, NOE C: Structural modifications of antisense oligonucleotides. Il Farmaco (2003) 58:243-258.
    • (2003) Il Farmaco , vol.58 , pp. 243-258
    • Urban, E.1    Noe, C.2
  • 29
    • 1642430704 scopus 로고    scopus 로고
    • Antisense oligonucleotide-based therapeutics for cancer
    • DEAN N, BENNETT C: Antisense oligonucleotide-based therapeutics for cancer. Oncogene (2003) 22:9087-9096. A review of antisense oligos being used to target various molecular targets for cancer therapy.
    • (2003) Oncogene , vol.22 , pp. 9087-9096
    • Dean, N.1    Bennett, C.2
  • 30
    • 0034870685 scopus 로고    scopus 로고
    • Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin
    • ZELLWEGER T, MIYAKE H, JULY L, AKBARI M, KIYAMA S, GLEAVE M: Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin. Neoplasia (2001) 3:360-367.
    • (2001) Neoplasia , vol.3 , pp. 360-367
    • Zellweger, T.1    Miyake, H.2    July, L.3    Akbari, M.4    Kiyama, S.5    Gleave, M.6
  • 31
    • 0842347354 scopus 로고    scopus 로고
    • MDM2 and its splice variant messenger RNAs: Expression in tumors and down-regulation using antisense oligonucleotides
    • BARTEL F, HARRIS L, WURL P, TAUBERT H: MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides. Mol. Cancer Res. (2004) 2:29-35.
    • (2004) Mol. Cancer Res. , vol.2 , pp. 29-35
    • Bartel, F.1    Harris, L.2    Wurl, P.3    Taubert, H.4
  • 32
    • 3242749727 scopus 로고    scopus 로고
    • RNA modulation, repair and remodeling by splice switching oligonucleotides
    • KOLE R, WILLIAMS T, COHEN L: RNA modulation, repair and remodeling by splice switching oligonucleotides. Acta Biochim. Pol. (2004) 51:373-378. A review of one of the alternative uses for antisense oligos demonstrating the use of oligos that do not activate RNase H.
    • (2004) Acta Biochim. Pol. , vol.51 , pp. 373-378
    • Kole, R.1    Williams, T.2    Cohen, L.3
  • 33
    • 1342263789 scopus 로고    scopus 로고
    • 2′-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo
    • PRAKASH TP, JOHNSTON JF, GRAHAM MJ, CONDON TP, MANOHARAN M: 2′-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo. Nucleic Acids Res. (2004) 32:828-833.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 828-833
    • Prakash, T.P.1    Johnston, J.F.2    Graham, M.J.3    Condon, T.P.4    Manoharan, M.5
  • 34
    • 0031948835 scopus 로고    scopus 로고
    • Mixed backbone oligonucleotides: Improvement in oligonucleotide-induced toxicity in vivo
    • AGRAWAL S, ZHAO Q: Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo. Antisense Nucleic Acid Drug Dev. (1998) 8:135-139. One of the representative early publications about second-generation mixed-backbone antisense oligos.
    • (1998) Antisense Nucleic Acid Drug Dev. , vol.8 , pp. 135-139
    • Agrawal, S.1    Zhao, Q.2
  • 35
    • 0141482040 scopus 로고    scopus 로고
    • Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy
    • ZHANG Z, LI M, WANG H, AGRAWAL S, ZHANG R: Antisense therapy targeting MDM2 oncogene in prostate cancer: effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc. Natl. Acad. Sci. USA (2003) 100:11636-11641. Detailed in vitro and in vivo investigation of a second-generation mixed-backbone antisense oligo targeting the MDM2 oncogene.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11636-11641
    • Zhang, Z.1    Li, M.2    Wang, H.3    Agrawal, S.4    Zhang, R.5
  • 36
    • 0036248845 scopus 로고    scopus 로고
    • Antisense ami-MDM2 oligonucleotides as a novel approach to the treatment of glioblastoma multiforme
    • PRASAD G, WANG H, AGRAWAL S, ZHANG R: Antisense ami-MDM2 oligonucleotides as a novel approach to the treatment of glioblastoma multiforme. Anti-Cancer Res. (2002) 22:107-116.
    • (2002) Anti-Cancer Res. , vol.22 , pp. 107-116
    • Prasad, G.1    Wang, H.2    Agrawal, S.3    Zhang, R.4
  • 37
    • 0034078048 scopus 로고    scopus 로고
    • Peptide nucleic acid (PNA): Its medical and biotechnical applications and promise for the future
    • RAY A, NORDEN B: Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future. FASEB J. (2000) 14:1041-1060.
    • (2000) FASEB J. , vol.14 , pp. 1041-1060
    • Ray, A.1    Norden, B.2
  • 38
    • 16544368128 scopus 로고    scopus 로고
    • Antisense therapy in clinical oncology: Preclinical and clinical experiences
    • TAMM I: Antisense therapy in clinical oncology: preclinical and clinical experiences. Methods Mol. Med. (2005) 106:113-134.
    • (2005) Methods Mol. Med. , vol.106 , pp. 113-134
    • Tamm, I.1
  • 39
    • 1542326181 scopus 로고    scopus 로고
    • Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo
    • RIEDEL F, GOTTE K, LI M, HORMANN K, GRANDIS JR: Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo. Int. J. Oncol. (2003) 23:577-583.
    • (2003) Int. J. Oncol. , vol.23 , pp. 577-583
    • Riedel, F.1    Gotte, K.2    Li, M.3    Hormann, K.4    Grandis, J.R.5
  • 40
    • 0142250356 scopus 로고    scopus 로고
    • Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck
    • NIWA H, WENTZEL AL, LI M, GOODING WE, LUI VW, GRANDIS JR: Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck. Clin. Cancer Res. (2003) 9:5028-5035.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5028-5035
    • Niwa, H.1    Wentzel, A.L.2    Li, M.3    Gooding, W.E.4    Lui, V.W.5    Grandis, J.R.6
  • 42
    • 4043074259 scopus 로고    scopus 로고
    • Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: Cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis
    • PESSION A, TONELLI R, FRONZA R et al.: Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis. Int. J. Oncol. (2004) 24:265-272.
    • (2004) Int. J. Oncol. , vol.24 , pp. 265-272
    • Pession, A.1    Tonelli, R.2    Fronza, R.3
  • 43
    • 15244345318 scopus 로고    scopus 로고
    • Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP
    • CUMMINGS J, WARD TH, LACASSE E et al.: Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. Br. J. Cancer (2005) 92:532-538.
    • (2005) Br. J. Cancer , vol.92 , pp. 532-538
    • Cummings, J.1    Ward, T.H.2    Lacasse, E.3
  • 44
    • 1342332317 scopus 로고    scopus 로고
    • Applying antisense technology: Affinitak and other antisense oligonucleotides in clinical development
    • HOLMLUND JT: Applying antisense technology: affinitak and other antisense oligonucleotides in clinical development. Ann. NY Acad. Sci. (2003) 1002:244-251.
    • (2003) Ann. NY Acad. Sci. , vol.1002 , pp. 244-251
    • Holmlund, J.T.1
  • 45
    • 4444375998 scopus 로고    scopus 로고
    • Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect
    • HAYWARD RL, MACPHERSON JS, CUMMINGS J, MONIA BP, SMYTH JF, JODRELL DI: Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: genetic evidence for specificity of the antisense effect. Mol. Cancer Ther. (2004) 3:169-178.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 169-178
    • Hayward, R.L.1    Macpherson, J.S.2    Cummings, J.3    Monia, B.P.4    Smyth, J.F.5    Jodrell, D.I.6
  • 46
    • 1642377946 scopus 로고    scopus 로고
    • Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models
    • ZHANG Z, WANG H, PRASAD G et al.: Radiosensitization by antisense anti-MDM2 mixed-backbone oligonucleotide in in vitro and in vivo human cancer models. Clin. Cancer Res. (2004) 10:1263-1273.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1263-1273
    • Zhang, Z.1    Wang, H.2    Prasad, G.3
  • 47
    • 1342311410 scopus 로고    scopus 로고
    • HER-2-targeted antisense oligonucleotide results in sensitization of head and neck cancer cells to chemotherapeutic agents
    • RAIT AS, PIROLLO KF, ULICK D, CULLEN K, CHANG EH: HER-2-targeted antisense oligonucleotide results in sensitization of head and neck cancer cells to chemotherapeutic agents. Ann. NY Acad. Sci. (2003) 1002:78-89.
    • (2003) Ann. NY Acad. Sci. , vol.1002 , pp. 78-89
    • Rait, A.S.1    Pirollo, K.F.2    Ulick, D.3    Cullen, K.4    Chang, E.H.5
  • 48
    • 1342289728 scopus 로고    scopus 로고
    • Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM-231) targeted against protein kinase A type I
    • MANI S, GOEL S, NESTEROVA M et al.: Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM-231) targeted against protein kinase A type I. Ann. NY Acad. Sci. (2003) 1002:252-262.
    • (2003) Ann. NY Acad. Sci. , vol.1002 , pp. 252-262
    • Mani, S.1    Goel, S.2    Nesterova, M.3
  • 49
    • 4143129940 scopus 로고    scopus 로고
    • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers
    • KO YJ, DEVI GR, LONDON CA et al.: Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. J. Urol. (2004) 172:1140-1144.
    • (2004) J. Urol. , vol.172 , pp. 1140-1144
    • Ko, Y.J.1    Devi, G.R.2    London, C.A.3
  • 50
    • 14644439903 scopus 로고    scopus 로고
    • Chemosensitization by antisense oligonucleotides targeting MDM2
    • BIANCO R, CIARDIELLO F, TORTORA G: Chemosensitization by antisense oligonucleotides targeting MDM2. Curr. Cancer Drug Targets. (2005) 5:51-56.
    • (2005) Curr. Cancer Drug Targets. , vol.5 , pp. 51-56
    • Bianco, R.1    Ciardiello, F.2    Tortora, G.3
  • 51
    • 22644440641 scopus 로고    scopus 로고
    • Combined use of antisense oligonucleotides and chemotherapeutics in the treatment of refractory prostate cancer
    • BALTOGIANNIS D, CHARALABOPOULOS K, GIANNAKOPOULOS X, KARAKOSTA A, SOFIKITIS N: Combined use of antisense oligonucleotides and chemotherapeutics in the treatment of refractory prostate cancer. Exp. Oncol. (2005) 27:91-93.
    • (2005) Exp. Oncol. , vol.27 , pp. 91-93
    • Baltogiannis, D.1    Charalabopoulos, K.2    Giannakopoulos, X.3    Karakosta, A.4    Sofikitis, N.5
  • 52
    • 24044536333 scopus 로고    scopus 로고
    • Survivin as a target for new anticancer interventions
    • ZAFFARONI N, PENNATI M, DAIDONE MG: Survivin as a target for new anticancer interventions. J. Cell. Mol. Med. (2005) 9:360-372.
    • (2005) J. Cell. Mol. Med. , vol.9 , pp. 360-372
    • Zaffaroni, N.1    Pennati, M.2    Daidone, M.G.3
  • 53
    • 0035347408 scopus 로고    scopus 로고
    • Potentiation of antitumor activity of irinotecan by chemically modified oligonucleotides
    • AGRAWAL S, KANDIMALLA E, YU D et al.: Potentiation of antitumor activity of irinotecan by chemically modified oligonucleotides. Int. J. Oncol. (2001) 18:1061-1069.
    • (2001) Int. J. Oncol. , vol.18 , pp. 1061-1069
    • Agrawal, S.1    Kandimalla, E.2    Yu, D.3
  • 54
    • 0035186743 scopus 로고    scopus 로고
    • Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
    • WANG H, NAN L, YU D, AGRAWAL S, ZHANG R: Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin. Cancer Res. (2001) 7:3613-3624.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3613-3624
    • Wang, H.1    Nan, L.2    Yu, D.3    Agrawal, S.4    Zhang, R.5
  • 55
    • 0036548741 scopus 로고    scopus 로고
    • Antisense anti-MDM2 mixed backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms
    • WANG H, WANG S, NAN L, YU D, AGRAWAL S, ZHANG R: Antisense anti-MDM2 mixed backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: in vivo activity and mechanisms. Intl. J. Oncol. (2002) 20:745-752.
    • (2002) Intl. J. Oncol. , vol.20 , pp. 745-752
    • Wang, H.1    Wang, S.2    Nan, L.3    Yu, D.4    Agrawal, S.5    Zhang, R.6
  • 56
    • 1342332342 scopus 로고    scopus 로고
    • Chemosensitization and radiosensitization of human cancer by antisense anti-MDM2 oligonucleotides: In vitro and in vivo activities and mechanisms
    • WANG H, OLIVER P, ZHANG Z, AGRAWAL S, ZHANG R: Chemosensitization and radiosensitization of human cancer by antisense anti-MDM2 oligonucleotides: in vitro and in vivo activities and mechanisms. Ann. NY Acad. Sci. (2003) 1002:217-235.
    • (2003) Ann. NY Acad. Sci. , vol.1002 , pp. 217-235
    • Wang, H.1    Oliver, P.2    Zhang, Z.3    Agrawal, S.4    Zhang, R.5
  • 57
    • 14144254480 scopus 로고    scopus 로고
    • Targeting the proapoptotic factor Bcl-2 in non-Hodgkin's lymphoma
    • KLASA RJ: Targeting the proapoptotic factor Bcl-2 in non-Hodgkin's lymphoma. Oncology (2004) 18:25-31.
    • (2004) Oncology , vol.18 , pp. 25-31
    • Klasa, R.J.1
  • 58
    • 21044431880 scopus 로고    scopus 로고
    • A Phase II, pharmacokinetic, and biological correlative study of oblimersen sodium and docetaxel in patients with hormone-refractory prostate cancer
    • TOLCHER AW, CHI K, KUHN J et al.: A Phase II, pharmacokinetic, and biological correlative study of oblimersen sodium and docetaxel in patients with hormone-refractory prostate cancer. Clin. Cancer Res. (2005) 11:3854-3861.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3854-3861
    • Tolcher, A.W.1    Chi, K.2    Kuhn, J.3
  • 59
    • 12444297637 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
    • DAVIS AJ, GELMON KA, SIU LL et al.: Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest. New Drugs. (2003) 21:85-97.
    • (2003) Invest. New Drugs. , vol.21 , pp. 85-97
    • Davis, A.J.1    Gelmon, K.A.2    Siu, L.L.3
  • 60
    • 0037385301 scopus 로고    scopus 로고
    • Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer: An NCIC clinical trials group study (NCIC IND.116)
    • OZA AM, ELIT L, SWENERTON K et al.: Phase II study of CGP 69846A (ISIS 5132) in recurrent epithelial ovarian cancer: an NCIC clinical trials group study (NCIC IND.116). Gynecol. Oncol. (2003) 89:129-133.
    • (2003) Gynecol. Oncol. , vol.89 , pp. 129-133
    • Oza, A.M.1    Elit, L.2    Swenerton, K.3
  • 61
    • 0036023413 scopus 로고    scopus 로고
    • A randomized Phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer
    • TOLCHER AW, REYNO L, VENNER PM et al.: A randomized Phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin. Cancer Res. (2002) 8:2530-2535.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2530-2535
    • Tolcher, A.W.1    Reyno, L.2    Venner, P.M.3
  • 62
    • 0035992350 scopus 로고    scopus 로고
    • Phase II randomized study of ISIS-3521 and ISIS-5132 in patients with locally advanced or metastatic colorectal cancer: A National Cancer Institute of Canada clinical trials group study
    • CRIPPS MC, FIGUEREDO AT, OZA AM et al.: Phase II randomized study of ISIS-3521 and ISIS-5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study. Clin. Cancer Res. (2002) 8:2188-2192.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2188-2192
    • Cripps, M.C.1    Figueredo, A.T.2    Oza, A.M.3
  • 63
    • 8444253256 scopus 로고    scopus 로고
    • Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: A Phase I study
    • RUDIN CM, MARSHALL JL, HUANG CH et al.: Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a Phase I study. Clin. Cancer Res. (2004) 10:7244-7251.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 7244-7251
    • Rudin, C.M.1    Marshall, J.L.2    Huang, C.H.3
  • 64
    • 0035447768 scopus 로고    scopus 로고
    • A Phase I trial of H-ras antisense oligonucleotide ISIS-2503 administered as a continuous intravenous infusion in patients with advanced carcinoma
    • CUNNINGHAM CC, HOLMLUND JT, GEARY RS et al.: A Phase I trial of H-ras antisense oligonucleotide ISIS-2503 administered as a continuous intravenous infusion in patients with advanced carcinoma. Cancer (2001) 92:1265-1271.
    • (2001) Cancer , vol.92 , pp. 1265-1271
    • Cunningham, C.C.1    Holmlund, J.T.2    Geary, R.S.3
  • 65
    • 12244260756 scopus 로고    scopus 로고
    • A Phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer
    • ADJEI AA, DY GK, ERLICHMAN C et al.: A Phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer. Clin. Cancer Res. (2003) 9:115-123.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 115-123
    • Adjei, A.A.1    Dy, G.K.2    Erlichman, C.3
  • 66
    • 16644402183 scopus 로고    scopus 로고
    • Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: A North Central Cancer Treatment Group Phase II trial
    • ALBERTS SR, SCHROEDER M, ERLICHMAN C et al.: Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group Phase II trial. J. Clin. Oncol. (2004) 22:4944-4950.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4944-4950
    • Alberts, S.R.1    Schroeder, M.2    Erlichman, C.3
  • 67
    • 0032990451 scopus 로고    scopus 로고
    • Technology evaluation: Leukemia therapy, University of Pennsylvania
    • ORR RM: Technology evaluation: leukemia therapy, University of Pennsylvania. Curr. Opin. Mol. Ther. (1999) 1:399-403.
    • (1999) Curr. Opin. Mol. Ther. , vol.1 , pp. 399-403
    • Orr, R.M.1
  • 68
    • 0035987887 scopus 로고    scopus 로고
    • Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism
    • ARORA V, CATE ML, GHOSH C, IVERSEN PL: Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism. Drug Metab. Dispos. (2002) 30:757-762.
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 757-762
    • Arora, V.1    Cate, M.L.2    Ghosh, C.3    Iversen, P.L.4
  • 69
    • 0027933160 scopus 로고
    • In vivo toxicological effects of rel A antisense phosphorothioates in CD-1 mice
    • SARMIENTO UM, PEREZ JR, BECKER JM, NARAYANAN R: In vivo toxicological effects of rel A antisense phosphorothioates in CD-1 mice. Antisense Res. Dev. (1994) 4:99-107.
    • (1994) Antisense Res. Dev. , vol.4 , pp. 99-107
    • Sarmiento, U.M.1    Perez, J.R.2    Becker, J.M.3    Narayanan, R.4
  • 70
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • KRIEG AM, YI AK, MATSON S et al.: CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (1995) 374:546-549.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 71
    • 0032697942 scopus 로고    scopus 로고
    • A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
    • LEVIN AA: A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta. (1999) 1489:69-84.
    • (1999) Biochim. Biophys. Acta. , vol.1489 , pp. 69-84
    • Levin, A.A.1
  • 72
    • 24744470522 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer
    • CHI KN, EISENHAUER E, FAZLI L et al.: A Phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J. Natl. Cancer Inst. (2005) 97:1287-1296.
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 1287-1296
    • Chi, K.N.1    Eisenhauer, E.2    Fazli, L.3
  • 73
    • 0347627362 scopus 로고    scopus 로고
    • The role of protein kinase C-α (PKC-α) in malignancies of the gastrointestinal tract
    • LAHN M, PATERSON BM, SUNDELL K, MA D: The role of protein kinase C-α (PKC-α) in malignancies of the gastrointestinal tract. Eur. J. Cancer. (2004) 40:10-20.
    • (2004) Eur. J. Cancer. , vol.40 , pp. 10-20
    • Lahn, M.1    Paterson, B.M.2    Sundell, K.3    Ma, D.4
  • 74
    • 20644469046 scopus 로고    scopus 로고
    • Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: Pharmacokinetics, pharmacodynamics, and clinical activity
    • MARCUCCI G, STOCK W, DAI G et al.: Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity. J. Clin. Oncol. (2005) 23:3404-3411.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3404-3411
    • Marcucci, G.1    Stock, W.2    Dai, G.3
  • 75
    • 14844303966 scopus 로고    scopus 로고
    • The prospect of silencing disease using RNA interference
    • SHANKAR P, MANJUNATH N, LIEBERMAN J: The prospect of silencing disease using RNA interference. JAMA (2005) 293:1367-1373. A review of the advantages of and problems facing therapeutic use of RNAi.
    • (2005) JAMA , vol.293 , pp. 1367-1373
    • Shankar, P.1    Manjunath, N.2    Lieberman, J.3
  • 76
    • 0043212038 scopus 로고    scopus 로고
    • Innovations in oligonucleotide drug delivery
    • LYSIK M, WU-PONG S: Innovations in oligonucleotide drug delivery. J. Pharm. Sci. (2003) 92:1559-1573.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1559-1573
    • Lysik, M.1    Wu-Pong, S.2
  • 77
    • 0038327578 scopus 로고    scopus 로고
    • Ten years of antisense inhibition of brain G-protein-coupled receptor function
    • VAN OEKELEN D, LUYTEN WH, LEYSEN JE: Ten years of antisense inhibition of brain G-protein-coupled receptor function. Brain Res. Brain Res. Rev. (2003) 42:123-142.
    • (2003) Brain Res. Brain Res. Rev. , vol.42 , pp. 123-142
    • Van Oekelen, D.1    Luyten, W.H.2    Leysen, J.E.3
  • 79
    • 0347926089 scopus 로고    scopus 로고
    • NLS bioconjugates for targeting therapeutic genes to the nucleus
    • ESCRIOU V, CARRIERE M, SCHERMAN D, WILS P: NLS bioconjugates for targeting therapeutic genes to the nucleus. Adv. Drug Deliv. Rev. (2003) 55:295-306.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 295-306
    • Escriou, V.1    Carriere, M.2    Scherman, D.3    Wils, P.4
  • 80
    • 3042822059 scopus 로고    scopus 로고
    • Increased uptake of antisense oligonucleotides by delivery as double stranded complexes
    • ASTRIAB-FISHER A, FISHER M, JULIANO R, HERDEWIJN P: Increased uptake of antisense oligonucleotides by delivery as double stranded complexes. Biochem. Pharmacol. (2004) 68:403-407.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 403-407
    • Astriab-Fisher, A.1    Fisher, M.2    Juliano, R.3    Herdewijn, P.4
  • 81
    • 32944470318 scopus 로고    scopus 로고
    • Poly-L-lysine-modified silica nanoparticles: A potential oral gene delivery system
    • LI Z, ZHU S, GAN K et al.: Poly-L-lysine-modified silica nanoparticles: a potential oral gene delivery system. J. Nanosci. Nanotechnol. (2005) 5:1199-1203.
    • (2005) J. Nanosci. Nanotechnol. , vol.5 , pp. 1199-1203
    • Li, Z.1    Zhu, S.2    Gan, K.3
  • 82
    • 14844300910 scopus 로고    scopus 로고
    • Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system. Part 1: Physicochemical characterization
    • LOCHMANN D, WEYERMANN J, GEORGENS C, PRASSL R, ZIMMER A: Albumin-protamine-oligonucleotide nanoparticles as a new antisense delivery system. Part 1: physicochemical characterization. Eur. J. Pharm. Biopharm. (2005) 59:419-429.
    • (2005) Eur. J. Pharm. Biopharm. , vol.59 , pp. 419-429
    • Lochmann, D.1    Weyermann, J.2    Georgens, C.3    Prassl, R.4    Zimmer, A.5
  • 83
    • 14844307118 scopus 로고    scopus 로고
    • Albumin-protamine-oligonucleotide-nanoparticles as a new antisense delivery system. Part 2: Cellular uptake and effect
    • WEYERMANN J, LOCHMANN D, GEORGENS C, ZIMMER A: Albumin-protamine- oligonucleotide-nanoparticles as a new antisense delivery system. Part 2: cellular uptake and effect. Eur. J. Pharm. Biopharm. (2005) 59:431-438.
    • (2005) Eur. J. Pharm. Biopharm. , vol.59 , pp. 431-438
    • Weyermann, J.1    Lochmann, D.2    Georgens, C.3    Zimmer, A.4
  • 84
    • 14944381961 scopus 로고    scopus 로고
    • Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: Therapeutic implications
    • PASTORINO F, BRIGNOLE C, MARIMPIETRI D et al.: Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications. Ann. NY Acad. Sci. (2004) 1028:90-103.
    • (2004) Ann. NY Acad. Sci. , vol.1028 , pp. 90-103
    • Pastorino, F.1    Brignole, C.2    Marimpietri, D.3
  • 85
    • 23944459514 scopus 로고    scopus 로고
    • Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD(2) immunoliposome: Immune cell-mediated anti-tumor activities
    • BRIGNOLE C, MARIMPIETRI D, PAGNAN G et al.: Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD(2) immunoliposome: immune cell-mediated anti-tumor activities. Cancer Lett. (2005) 228:181-186.
    • (2005) Cancer Lett. , vol.228 , pp. 181-186
    • Brignole, C.1    Marimpietri, D.2    Pagnan, G.3
  • 86
    • 21744452813 scopus 로고    scopus 로고
    • Efficacy of an intratumoral controlled release formulation of clusterin antisense oligonucleotide complexed with chitosan containing paclitaxel or docetaxel in prostate cancer xenograft models
    • SPRINGATE CM, JACKSON JK, GLEAVE ME, BURT HM: Efficacy of an intratumoral controlled release formulation of clusterin antisense oligonucleotide complexed with chitosan containing paclitaxel or docetaxel in prostate cancer xenograft models. Cancer Chemother. Pharmacol. (2005) 56:239-247.
    • (2005) Cancer Chemother. Pharmacol. , vol.56 , pp. 239-247
    • Springate, C.M.1    Jackson, J.K.2    Gleave, M.E.3    Burt, H.M.4
  • 87
    • 10744229758 scopus 로고    scopus 로고
    • Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
    • KIPSHIDZE NN, PORTER TR, DANGAS G et al.: Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model. Cardiovasc. Radiat. Med. (2003) 4:152-159.
    • (2003) Cardiovasc. Radiat. Med. , vol.4 , pp. 152-159
    • Kipshidze, N.N.1    Porter, T.R.2    Dangas, G.3
  • 88
    • 1542476778 scopus 로고    scopus 로고
    • In vivo distribution of c-myc antisense oligodeoxynucleotides local delivered by gelatin-coated platinum-indium stents in rabbits and its effect on apoptosis
    • ZHANG XX, CUI CC, XU XG, HU XS, FANG WH, KUANG BJ: In vivo distribution of c-myc antisense oligodeoxynucleotides local delivered by gelatin-coated platinum-indium stents in rabbits and its effect on apoptosis. Chin. Med. J. (Engl.) (2004) 117:258-263.
    • (2004) Chin. Med. J. (Engl.) , vol.117 , pp. 258-263
    • Zhang, X.X.1    Cui, C.C.2    Xu, X.G.3    Hu, X.S.4    Fang, W.H.5    Kuang, B.J.6
  • 89
    • 4444370741 scopus 로고    scopus 로고
    • Engineering synthetic vectors for improved DNA delivery: Insights from intracellular pathways
    • ROTH C, SUNDARAM S: Engineering synthetic vectors for improved DNA delivery: insights from intracellular pathways. Ann. Rev. Biomed. Eng. (2004) 6:397-426.
    • (2004) Ann. Rev. Biomed. Eng. , vol.6 , pp. 397-426
    • Roth, C.1    Sundaram, S.2
  • 90
    • 8544230612 scopus 로고    scopus 로고
    • Cationic compounds used in lipoplexes and polyplexes for gene delivery
    • ZHANG S, XU Y, WANG B, QIAO W, LIU D, LI Z: Cationic compounds used in lipoplexes and polyplexes for gene delivery. J. Control Release (2004) 100:165-180.
    • (2004) J. Control Release , vol.100 , pp. 165-180
    • Zhang, S.1    Xu, Y.2    Wang, B.3    Qiao, W.4    Liu, D.5    Li, Z.6
  • 91
    • 0030598376 scopus 로고    scopus 로고
    • Modulation of oligonucleotide-induced immune stimulation by cyclodextrin analogs
    • ZHAO Q, TEMSAMANI J, IADAROLA PL, AGRAWAL S: Modulation of oligonucleotide-induced immune stimulation by cyclodextrin analogs. Biochem. Pharmacol. (1996) 52:1537-1544.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 1537-1544
    • Zhao, Q.1    Temsamani, J.2    Iadarola, P.L.3    Agrawal, S.4
  • 92
    • 0034958529 scopus 로고    scopus 로고
    • Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys
    • WEBB M, TORTORA N, CREMESE M et al.: Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys. Antisense Nucleic Acid Drug Dev. (2001) 11:155-163.
    • (2001) Antisense Nucleic Acid Drug Dev. , vol.11 , pp. 155-163
    • Webb, M.1    Tortora, N.2    Cremese, M.3
  • 93
    • 0031457918 scopus 로고    scopus 로고
    • Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats
    • AGRAWAL S, ZHAO Q, JIANG Z, OLIVER C, GILES H, HEATH J, SEROTA D: Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats. Antisense Nucleic Acid Drug Dev. (1997) 7:575-584.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 575-584
    • Agrawal, S.1    Zhao, Q.2    Jiang, Z.3    Oliver, C.4    Giles, H.5    Heath, J.6    Serota, D.7
  • 94
    • 0031018954 scopus 로고    scopus 로고
    • Toxicological properties of several novel oligonucleotide analogs in mice
    • HENRY S, ZUCKERMAN J, ROJKO J et al.: Toxicological properties of several novel oligonucleotide analogs in mice. Anti-Cancer Drug Des. (1997) 12:1-14.
    • (1997) Anti-Cancer Drug Des. , vol.12 , pp. 1-14
    • Henry, S.1    Zuckerman, J.2    Rojko, J.3
  • 96
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • KRIEG AM: CpG motifs in bacterial DNA and their immune effects. Ann. Rev. Immunol. (2002) 20:709-760. A review of the effects of CpG-containing oligos on the immune system.
    • (2002) Ann. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 97
    • 0030591705 scopus 로고    scopus 로고
    • Effect of G-rich sequences on the synthesis, purification, binding, cell uptake, and hemolytic activity of oligonucleotides
    • AGRAWAL S, IADAROLA P, TEMSAMANI J, ZHAO Q, SHAW D: Effect of G-rich sequences on the synthesis, purification, binding, cell uptake, and hemolytic activity of oligonucleotides. Bioorg. Med. Chem. Lett. (1996) 6:2219-2224.
    • (1996) Bioorg. Med. Chem. Lett. , vol.6 , pp. 2219-2224
    • Agrawal, S.1    Iadarola, P.2    Temsamani, J.3    Zhao, Q.4    Shaw, D.5
  • 98
    • 1042275580 scopus 로고    scopus 로고
    • G-3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner
    • LAI JC, BENIMETSKAYA L, SANTELLA RM, WANG Q, MILLER PS, STEIN CA: G-3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner. Mol. Cancer Ther. (2003) 2:1031-1043.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 1031-1043
    • Lai, J.C.1    Benimetskaya, L.2    Santella, R.M.3    Wang, Q.4    Miller, P.S.5    Stein, C.A.6
  • 99
    • 2642556483 scopus 로고    scopus 로고
    • Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate
    • RAOOF AA, CHIU P, RAMTOOLA Z et al.: Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate. J. Pharm. Sci. (2004) 93:1431-1439.
    • (2004) J. Pharm. Sci. , vol.93 , pp. 1431-1439
    • Raoof, A.A.1    Chiu, P.2    Ramtoola, Z.3
  • 100
    • 22944457857 scopus 로고    scopus 로고
    • Synthetic oligodeoxynucleotides containing deoxycitidyl-deoxyguanosine dinucleotides (CpG ODNs) and modified analogues as novel anticancer therapeutics
    • WANG H, RAYBURN E, ZHANG R: Synthetic oligodeoxynucleotides containing deoxycitidyl-deoxyguanosine dinucleotides (CpG ODNs) and modified analogues as novel anticancer therapeutics. Curr. Pharm. Des. (2005) 11:2889-2907. A comprehensive review of the various applications of CpG oligos and their effects on the immune system.
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 2889-2907
    • Wang, H.1    Rayburn, E.2    Zhang, R.3
  • 101
    • 0742287262 scopus 로고    scopus 로고
    • CpG DNA and cancer immunotherapy: Orchestrating the antitumor immune response
    • WOOLDRIDGE JE, WEINER GJ: CpG DNA and cancer immunotherapy: orchestrating the antitumor immune response. Curr. Opin. Oncol. (2003) 15:440-445.
    • (2003) Curr. Opin. Oncol. , vol.15 , pp. 440-445
    • Wooldridge, J.E.1    Weiner, G.J.2
  • 103
    • 0036951195 scopus 로고    scopus 로고
    • Functional repair of a mutant chloride channel using a trans-splicing ribozyme
    • ROGERS CS, VANOYE CG, SULLENGER BA, GEORGE AL JR: Functional repair of a mutant chloride channel using a trans-splicing ribozyme. J. Clin. Invest. (2002) 110:1783-1789.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1783-1789
    • Rogers, C.S.1    Vanoye, C.G.2    Sullenger, B.A.3    George Jr., A.L.4
  • 104
    • 13844272635 scopus 로고    scopus 로고
    • Synthetic hammerhead ribozymes as therapeutic tools to control disease genes
    • CITTI L, RAINALDI G: Synthetic hammerhead ribozymes as therapeutic tools to control disease genes. Curr. Gene Ther. (2005) 5:11-24. A critical review of the various potential therapeutic uses of ribozymes.
    • (2005) Curr. Gene Ther. , vol.5 , pp. 11-24
    • Citti, L.1    Rainaldi, G.2
  • 105
    • 13444287967 scopus 로고    scopus 로고
    • Assembly and function of RNA silencing complexes
    • SONTHEIMER EJ: Assembly and function of RNA silencing complexes. Nat. Rev. Mol. Cell Biol. (2005) 6:127-138.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 127-138
    • Sontheimer, E.J.1
  • 106
    • 9144273425 scopus 로고    scopus 로고
    • RNA-interference-based functional genomics in mammalian cells: Reverse genetics coming of age
    • SILVA J, CHANG K, HANNON GJ, RIVAS FV: RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age. Oncogene (2004) 23:8401-8409.
    • (2004) Oncogene , vol.23 , pp. 8401-8409
    • Silva, J.1    Chang, K.2    Hannon, G.J.3    Rivas, F.V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.