Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 6, 1997, Pages 575-584

  Agrawal, Sudhir ^a   Zhao, Qiuyan ^a   Jiang, Zhiwei ^a   Oliver, Carolyn ^b   Giles, Herschel ^b   Heath, James ^b   Serota, David ^b,c  

^a HYBRIDON INC   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c MPI RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; METHYLPHOSPHONIC ACID; OLIGODEOXYNUCLEOTIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CLINICAL CHEMISTRY; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; HEMATOLOGY; HEMATOPOIETIC CELL; HEPATOMEGALY; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY HYPERTROPHY; LYMPH NODE; MALE; NECROSIS; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM; SPLENOMEGALY; THROMBOCYTOPENIA;

ANIMALIA;

EID: 0031457918     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.575     Document Type: Article

References (8)

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4. AGRAWAL, S., MAYRAND, S.M., ZAMECNIK, P.C., and PEDERSON, T. (1990). Site-specific excision from RNA by RNase H and mixed phosphate backbone oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 87, 1401-1405.
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7. HENRY, S.P., GRILLONE, L.R., ORR, J.L., BRUNER, R.H., and KORNBRUST, DJ. (1997). Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats. Toxicology 116, 77-88.
8. ZHAO, Q., TEMSAMANI, J., ZHOU R.Z., DAI, L., ROSKEY, A., and AGRAWAL, S. (1997). Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice. Antisense Nucleic Acid Drug Dev. 7, 159-164.