Interleukin-12 is not essential for silicosis in mice

Particle and Fibre Toxicology

Volumn 3, Issue , 2006, Pages

  Davis, Gerald S ^a   Pfeiffer, Linda M ^a   Hemenway, David R ^b   Rincon, Mercedes ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b University of Vermont   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; COLLAGEN; GAMMA INTERFERON; HYDROXYPROLINE; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; MESSENGER RNA; PROTEIN P35; PROTEIN P40; SILICON DIOXIDE; TITANIUM DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL AGGREGATION; CELL PROLIFERATION; CONNECTIVE TISSUE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM HYPERPLASIA; FIBROBLAST; GENE DELETION; HISTOPATHOLOGY; HYPOTHESIS; IMMUNE RESPONSE; INHALATION; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; LUNG WEIGHT; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MACROPHAGE; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SILICOSIS; TH1 CELL; UPREGULATION; WILD TYPE;

ANIMALIA;

EID: 33646401148     PISSN: 17438977     EISSN: None     Source Type: Journal    
DOI: 10.1186/1743-8977-3-2     Document Type: Article

References (95)

1. Davis GS: Pathogenesis of silicosis: current concepts and hypotheses. Lung 1986, 164:139-154.
2. Graham WG: Silicosis. Clin Chest Med 1992, 13:253-267.
3. Davis GS, Gemsa D: Immunopathogenesis of Silicosis. In Immunopathology of Lung Disease Volume 21. 1st edetion. Edited by: Kradin RL and Robinson BWS. Boston, MA, Butterworth-Heinemann; 1996:445-467.
4. Beckett WC, Abraham JL, Becklake MR, Christiani DC, Cowie RL, Davis GS, Jones R, Kreiss K, Parker J, Wagner G: Adverse effects of crystalline silica exposure. American Thoracic Society Statement. Am J Respir Crit Care Med 1997, 155:761-765.
5. Mossman BT, Churg A: Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 1998, 157:1666-1680.
6. Fujimura N: Pathology and pathophysiology of pneumoconiosis. Curr Opin Pulm Med 2000, 6:140-144.
7. Castranova V, Vallyathan V: Silicosis and coal workers' pneumoconiosis. Environ Health Perspect 2000, 108 Suppl 4:675-684.
8. Davis GS, Leslie KO, Hemenway DR: Silicosis in mice: Effects of dose, time, and genetic strain. J Environ Pathol Toxicol Oncol 1998, 17:81-97.
9. Davis GS, Pfeiffer LM, Hemenway DR: Persistent over-expression of interleukin-1b and tumor necrosis factor-a in murine silicosis. J Environ Pathol Toxicol Oncol 1998, 17:99-114.
10. Garn H, Friedetzky A, Davis GS, Hemenway DR, Gemsa D: T-lymphocyte activation in the enlarged thoracic lymph nodes of rats with silicosis. Am J Respir Cell Mol Biol 1997, 16:309-316.
11. Davis GS, Pfeiffer LM, Hemenway DR: Expansion of interferon-gamma-producing lung lymphocytes in mouse silicosis. Am J Respir Cell Mol Biol 1999 Apr 1999, 20:813-824.
12. Davis GS, Pfeiffer LM, Hemenway DR: Interferon-gamma production by specific lung lymphocyte phenotypes in silicosis in mice. Am J Respir Cell Mol Biol 2000, 22:491-501.
13. Garn H, Friedetzky A, Kirchner A, Jager R, Gemsa D: Experimental silicosis: a shift to a preferential IFN-gamma-based Thl response in thoracic lymph nodes. Am J Physiol Lung Cell Mol Physiol 2000, 278:L1221-L1230.
14. Davis GS, Holmes CE, Pfeiffer LM, Hemenway DR: Lymphocytes, lymphokines, and silicosis. J Environ Pathol Toxicol Oncol 2001, 20 Suppl 1:53-65.
15. Barbarin V, Arras M, Misson P, Delos M, McGarry B, Phan SH, Lison D, Huaux F: Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice. Am J Respir Cell Mol Biol 2004, 31:78-85.
16. Billiau A: Interferon-gamma: biology and role in pathogenesis. Adv Immunol 1996, 62:61-130.
17. Vilcek J, Oliveira IC: Recent progress in the elucidation of interferon-gamma actions: molecular biology and biological functions. Int Arch Allergy Immunol 1994, 104:311-316.
18. Gurujeyalakshmi G, Giri SN: Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression. Exp Lung Res 1995, 21:791-808.
19. Sempowski GD, Derdak S, Phipps RP: Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol 1996 May 167:290-296.
20. Serpier H, Gillery P, Salmon-Ehr V, Garnotel R, Georges N, Kalis B, Maquart FX: Antagonistic effects of interferon-gamma and interleukin-4 on fibroblast cultures. J Invest Dermatol 1997 Aug 1997, 109:158-162.
21. Ziesche R, Hofbauer E, Wittmann K, Petkov V, Block LH: A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. N Engl J Med 1999, 341:1264-1269.
22. Ziesche R, Block LH: Mechanisms of antifibrotic action of interferon gamma-1b in pulmonary fibrosis. Wien Klin Wochenschr 2000, 112:785-790.
23. Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH: The interieukin-12/interieukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998 1998, 16:495-521.
24. Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K: Regulation of interferon-gamma production by IL-12 and IL-18. Curr Opin Immunol 1998, 10:259-264.
25. Munder M, Mallo M, Eichmann K, Modolell M: Murine macrophages secrete interferon-gamma upon combined stimulation with IL-12 and IL-18: a novel pathway of autocrine macrophage activation. J Exp Med 1998, 187:2103-2108.
26. Nakahira M, Ahn HJ, Park WR, Gao P, Tomura M, Park CS, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H: Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein I. J Immunol 2002, 168:1146-1153.
27. Fehniger TA, Caligiuri MA: Interleukin 15: biology and relevance to human disease. Blood 2001, 97:14-32.
28. Lodolce J, Burkett P, Koka R, Boone D, Chien M, Chan F, Madonia M, Chai S, Ma A: Interleukin-15 and the regulation of lymphoid homeostasis. Mol Immunol 2002, 39:537-544.
29. Shibuya A: Development and functions of natural killer cells. Int J Hematol 2003, 78:1-6.
30. Briard D, Brouty-Boye D, Azzarone B, Jasmin C: Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. J Immunol 2002, 168:4326-4332.
31. Ranson T, Vosshenrich CA, Corcuff E, Richard O, Muller W, Di Santo JP: IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 2003, 101:4887-4893.
32. Magram J, Sfarra. J, Connaughton S, Faherty D, Warrier R, Carvajal D, Wu CY, Stewart C, Sarmiento U, Gately MK: IL-12-deficient mice are defective but not devoid of type 1 cytokine responses. Ann N Y Acad Sci 1996, 795:60-70.
33. Magram J, Connaughton SE, Warrier RR, Carvajal DM, Wu CY, Ferrante J, Stewart C, Sarmiento U, Faherty DA, Gately MK: IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996, 4:471-481.
34. Schroder K, Hertzog PJ, Ravasi T, Hume DA: Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 2004, 75:163-189.
35. Muhl H, Pfeilschifter J: Anti-inflammatory properties of proinflammatory interferon-gamma. Int Immunopharmacol 2003, 3:1247-1255.
36. Hubbard AK, Timblin CR, Shukla A, Rincon M, Mossman BT: Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice. Am J Physiol Lung Cell Mol Physiol 2002, 282:L968-L975.
37. Brown JM, Pfau JC, Holian A: Immunoglobulin and lymphocyte responses following silica exposure in New Zealand mixed mice. Inhal Toxicol 2004, 16:133-139.
38. Arras M, Huaux F, Vink A, Delos M, Coutelier JP, Many MC, Barbarin V, Renauld JC, Lison D: Interleukin-9 reduces lung fibrosis and type 2 immune polarization induced by silica particles in a murine model. Am J Respir Cell Mol Biol 2001, 24:368-375.
39. Barbarin V, Petrek M, Kolek V, Van SJ, Huaux F, Lison D: Characterization of p40 and IL-10 in the BALF of patients with pulmonary sarcoldosis. J Interferon Cytokine Res 2003, 23:449-456.
40. Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D: A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 2002, 169:2653-2661.
41. Altindag ZZ, Baydar T, Isimer A, Sahin G: Neopterin as a new biomarker for the evaluation of occupational exposure to silica. International Archives of Occupational & Environmental Health 2003, 76:318-322.
42. Desaki M, Sugawara I, Iwakura Y, Yamamoto K, Takizawa H: Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo. Toxicol Appl Pharmacol 2002, 185:1-7.
43. Chen Y, Chen J, Dong J, Liu W: Antifibrotic effect of interferon gamma in silicosis model of rat. Toxicol Lett 2005, 155:353-360.
44. Schoenhault DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, McComas W, Familletti PC, Gately MK, Gubler U: Cloning and expression of murine IL-12. J Immunol 1992, 148:3433-3440.
45. Iwatsubo Y, Pairon JC, Boutin C, Menard O, Massin N, Caillaud D, Orlowski E, Galateau-Salle F, Bignon J, Brochard P: Pleural mesothelioma: dose-response relation at low levels of asbestos exposure in a French population-based case-control study [see comments]. Am J Epidemiol 1998 Jul 15 148:133-142.
46. Walter MJ, Kajiwara N, Karanja P, Castro M, Holtzman MJ: Interleukin 12 p40 production by barrier epithelial cells during airway inflammation. J Exp Med 2001, 193:339-351.
47. Airoldi I, Guglielmino R, Carra G, Corcione A, Gerosa F, Taborelli G, Trinchieri G, Pistoia V: The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes. Haematologica 2002, 87:434-442.
48. Isler P, Galve de Rochemonteix B, Songeon F, Boehringer N, Nicod LP: Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10. Am J Respir Cell Mol Biol 1999, 20:270-278.
49. Kline JN, Hunninghake GW: T-lymphocyte dysregulation in asthma. Proc Soc Exp Biol Med 1994 Dec 207:243-253.
50. Lipscomb MF, Huffnagle GB, Lovchik JA, Lyons CR, Pollard AM, Yates JL: The role of T lymphocytes in pulmonary microbial defense mechanisms. Arch Pathol Lab Med 1993 Dec 117:1225-1232.
51. Iwatsubo Y, Pairon JC, Boutin C, Menard O, Massin N, Caillaud D, Orlowski E, Galateau-Salle F, Bignon J, Brochard P: Pleural mesothelioma: dose-response relation at low levels of asbestos exposure in a French population-based case-control study [see comments]. Am J Epidemiol 1998 Jul 15 148:133-142.
52. Flynn JL, Goldstein MM, Triebold KJ, Sypek J, Wolf S, Bloom BR: IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J Immunol 1995 Sep 1 155:2515-2524.
53. Catanzarite VA, Willms D: Adult respiratory distress syndrome in pregnancy: report of three cases and review of the literature. Obstet Gynecol Surv 1997 Jun 52:381-392.
54. Chen SY, Takeoka Y, Pike-Nobile L, Ansari AA, Boyd R, Gershwin ME: Autoantibody production and cytokine profiles of MHC class 1 (beta2- microglobulin) gene deleted New Zealand black (NZB) mice. Clin Immunol Immunopathol 1997 Sep 84:318-327.
55. Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Wills-Karp M: Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995 Nov 1 182:1527-1536.
56. Tripp CS, Kanagawa O, Unanue ER: Secondary response to Listeria infection requires IFN-g but is partially independent of IL-12. J Immunol 1995, 155:3427-3432.
57. Wysocka M, Kubin M, Viera L, Ozman L, Garotta G, Scott P, Trinchieri G: Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur J Immunol 1995, 25:672-676.
58. Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W: Antibodies to interleukin-12 abrogate established experimental colitis in mice. J Exp Med 1995, 182:1281-1290.
59. Cooper AM, Magram J, Ferrante J, Orme IM: Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis. J Exp Med 1997, 186:39-45.
60. Decken K, Kohler G, Palmer-Lehmann K, Wunderlin A, Mattner F, Magram J, Gately MK, Alber G: Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun 1998, 66:4994-5000.
61. Mattner F, Magram J, Ferrante J, Launois P, Di Padova K, Behin R, Gately MK, Louis JA, Alber G: Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur J Immunol 1996, 26:1553-1559.
62. McIntyre KW, Shuster DJ, Gillooly KM, Warrier RR, Connaughton SE, Hall LB, Arp LH, Gately MK, Magram J: Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice. Eur J Immunol 1996, 26:2933-2938.
63. Wilson ME, Recker TJ, Rodriguez NE, Young BM, Burnell KK, Streit JA, Kline JN: The TGF-beta response to Leishmania chagasi in the absence of IL-12. Eur J Immunol 2002, 32:3556-3565.
64. Papadakos PJ, Johnson DS, Abramowicz JS, Sherer DM: Adult respiratory distress syndrome: a consideration with rapid respiratory decompensation in association with preeclampsia. Am J Crit Care 1993 Jan 2:65-67.
65. Chen L, Chen D, Block E, O'Donnell M, Kufe DW, Clinton SK: Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer. J Immunol 1997, 159:351-359.
66. Kato K, Shimozato O, Hoshi K, Wakimoto H, Hamada H, Yagita H, Okumura K: Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc Natl Acad Sci U S A 1996, 93:9085-9089.
67. Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK: IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol 1996, 157:1951-1957.
68. Lauwerys BR, Van Snick J, Houssiau FA: Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity. Lupus 2002, 11:384-387.
69. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000, 13:715-725.
70. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal MR, Moore KW: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002, 168:5699-5708.
71. Pirhonen J, Matikainen S, Julkunen I: Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 2002, 169:5673-5678.
72. Huaux F, Lardot C, Arras M, Delos M, Many MC, Coutelier JP, Buchet JP, Renauld JC, Lison D: Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations. Am J Respir Cell Mol Biol 1999, 20:561-572.
73. Russell TD, Yan Q, Fan G, Khalifah AP, Bishop DK, Brody SL, Walter MJ: IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1. J Immunol 2003, 171:6866-6874.
74. Dinarello CA: IL-18: A TH1-inducing, proinflammatory cytokine and a new member of the IL-1 family. J Allergy Clin Immunol 1999, 103:11-24.
75. Swain SL: Interleukin 18: tipping the balance towards a T helper cell 1 response. J Exp Med 2001, 194:F11-F14.
76. Reddy P: Interleukin-18: recent advances. Curr Opin Hematol 2004, 11:405-410.
77. Hubbard AK: Role for T lymphocytes in silica-induced pulmonary inflammation. Lab Invest 1989, 61:46-52.
78. Farrar JD, Asnagli H, Murphy KM: T helper subset development: roles of instruction, selection, and transcription. Journal of Clinical Investigation 2002, 109:431-435.
79. Glimcher LH: Lineage commitment in lymphocytes: controlling the immune response. Journal of Clinical Investigation 108(7):s25-s30, 2001, 108:s25-s30.
80. Farrar MA, Schreiber RD: The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 1993, 11:571-611.
81. Rosloniec EF, Latham K, Guedez YB: Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity. Arthritis Research 4(6):333-6, 2002, 4:333-336.
82. Kunkel SL, Chensue SW, Lukacs N, Hogaboam C: Cytokine phenotypes serve as a paradigms for experimental immune-mediated lung diseases and remodeling. American Journal of Respiratory Cell & Molecular Biology 29(3 Suppl):S63-6, 2003, 29:s63-s66.
83. Strieter RM, Keane MP: Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis. J Clin Invest 2004, 114:165-168.
84. Strieter RM, Belperio JA, Keane MP: Host innate defenses in the lung: the role of cytokines. Curr Opin Infect Dis 2003, 16:193-198.
85. Zhang P, Summer WR, Bagby GJ, Nelson S: Innate immunity and pulmonary host defense. Immunol Rev 2000, 173:39-51.
86. Muro S, Taha R, Tsicopoulos A, Olivenstein R, Tonnel AB, Christodoulopoulos P, Wallaert B, Hamid Q: Expression of IL-15 in inflammatory pulmonary diseases. J Allergy Clin Immunol 2001, 108:970-975.
87. Liew FY, McInnes IB: The role of innate mediators in inflammatory response. Mol Immunol 2002, 38:887-890.
88. Benczik M, Gaffen SL: The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol Invest 2004, 33:109-142.
89. Cooper MA, Bush JE, Fehniger TA, VanDeusen JB, Waite RE, Liu Y, Aguila HL, Caligiuri MA: In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. Blood 2002, 100:3633-3638.
90. Kennedy MK, Park LS: Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex. J Clin Immunol 1996, 16:134-143.
91. Ohteki T: Critical role for IL-15 in innate immunity. Curr Mol Med 2002, 2:371-380.
92. Ranson T, Vosshenrich CA, Corcuff E, Richard O, Laloux V, Lehuen A, Di Santo JP: IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc Natl Acad Sci U S A 2003, 100:2663-2668.
93. Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, Matsuki N, Charrier K, Sedger L, Willis CR, Brasel K, Morrissey PJ, Stocking K, Schuh JCL, Joyce S, Peschon JJ: Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 2000, 191:771-780.
94. Hemenway DR, MacAskill SM: Design, development and test results of a horizontal flow inhalation toxicology facility. Am Ind Hyg Assoc J 1982, 43:874-879.
95. Hemenway DR, Sylvester D, Gale PN, Vacek P, Evans JN: Effectiveness of animal rotation in achieving uniform dust exposure and lung dust deposition in horizontal flow chambers. Am Ind Hyg Assoc J 1983, 44:655-658.