Serum IL-12 in systemic lupus erythematosus: Absence of p70 heterodimers but presence of p40 monomers correlating with disease activity

Lupus

Volumn 11, Issue 6, 2002, Pages 384-387

  Lauwerys, B R ^a   Van Snick, J ^a   Houssiau, F A ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Cytokines; IL 12; SLE

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; PROTEIN; PROTEIN P40; PROTEIN P70; UNCLASSIFIED DRUG;

ANTIBODY TITER; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISULFIDE BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; DIMERIZATION; HUMANS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; LUPUS ERYTHEMATOSUS, SYSTEMIC; MOLECULAR WEIGHT; PROTEIN SUBUNITS;

EID: 0036317685     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1191/0961203302lu213oa     Document Type: Article

References (15)

1. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist
2. In vivo production and function of IL-12 p40 homodimers
3. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
4. Impaired production of IL-12 in systemic lupus erythematosus. I. Excessive production of IL-10 suppresses production of IL-12 by monocytes
5. Impaired production of IL-12 in system lupus erythematosus. II: IL-12 production in vitro is correlated negatively with serum 1L-10, positively with serum IFN-gamma and negatively with disease activity in SLE
6. Impaired production of IL-12 in systemic lupus erythematosus. III: Deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression
7. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus
8. Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus
9. Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)-relation to Th1- and Th2-derived cytokines
10. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
11. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus
12. IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC)
13. Interleukin-10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients
14. Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
15. A novel function of IL 12p40 as a chemotactic molecule for macrophages