Interleukin 18: Tipping the balance towards a T helper cell 1 response

Journal of Experimental Medicine

Volumn 194, Issue 3, 2001, Pages

  Swain, S L ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 18;

CYTOKINE PRODUCTION; CYTOTOXICITY; HELPER CELL; HUMAN; IMMUNE RESPONSE; NOTE; POLARIZATION; PRIORITY JOURNAL;

EID: 0035817331     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.3.F11     Document Type: Note

References (33)

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2. A newly defined interleukin-1?
3. Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
4. Cloning of a novel receptor subunit, ACPL, required for interleukin-18 signaling
5. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
6. Activation of interferon-γ inducing factor mediated by interleukin-1 converting enzyme
7. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-independent Th I development
8. + T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells
9. Murine micrioglial produce and respond to interleukin-18
10. Immunohistochemical and immunoelectron microscopic detection of interferon-γ-inducing factor (interleukin-18) in mouse intestinal epithelial cells
11. Production of IL-18 (IFN-γ-inducing factor) messenger RNA and functional protein by murine keratinocytes
12. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation
13. Production of interleukin-18 in human tuberculosis
14. Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-I-dependent pathway
15. Interleukin-18: A novel cytokine that augments both innate and acquired immunity
16. IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins
17. Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins
18. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells
19. Defective interleukin (IL)-18-mediated natural killer and T helper cell type I responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
20. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
21. IL-18-stimulated GADD45b required in cytokine-induced, but not TcR-induced IFN-γ production
22. IL-18 is a potent co-inducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
23. A critical role for IL-18 in primary and memory responses to Listeria monocytogenes that extends beyond its effects on interferon γ production
24. Interleukin-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13
25. The possible role of interleukin (IL)-12 and interferon-γ-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice
26. IL-18 promotes type I cytokine production from NK cells and T cells in human intracellular infection
27. Caspase-I activation of IL-Iβ and IL-18 are essential for Shigella flexneri-induced inflammation
28. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
29. IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells
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31. Interleukin-18 regulates both Th1 and Th2 responses
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33. Interferon γ eliminates responding CD4 T cells during Mycobacterial infection by inducing apoptosis of activated CD4 T cells