Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

Journal of Clinical Immunology

Volumn 16, Issue 3, 1996, Pages 134-143

  Kennedy, Mary K ^a   Park, Linda S ^a  

^a AMGEN INC   (United States)

Author keywords

IL 15 receptor; IL 2; IL 2 receptor; Interleukin 15 (IL 15)

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

AUTOIMMUNITY; ETIOLOGY; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; HUMANS; INTERLEUKIN-15; RECEPTORS, INTERLEUKIN-15; RECEPTORS, INTERLEUKIN-2;

EID: 0029888721     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01540911     Document Type: Review

References (56)

1. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Anderson DM, Giri JG: Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965-968, 1994
2. Burton JD, Bamford RN, Peters C, Grant AJ, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91:4935-4939, 1994
3. Anderson DM, Johnson L, Glaccum MB, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW, Grabstein K, Cosman D: Chromosomal assignment and genomic structure of III5. Genomics 25:701-706, 1995
4. Cosman D, Anderson DM, Grabstein KH, Shanebeck K, Kumaki S, Ahdieh M, Giri JG: IL-15, a novel T cell growth factor, that shares components of the receptor for IL-2. In Cytokines: Basic Principles and Practical Applications, S Romagnani, G Del Prete, AK Abbas (eds). Rome, Ares-Serono Symposia, 1994, pp 79-86
5. Bamford RN, Battiata AP, Burton J, Sharma H, Waldmann TA: IL-15/IL-T production by the adult T-cell leukemia line HuT-102 is associated with an HTLV-I-R/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc Natl Acad Sci USA (in press)
6. Mohamadzadeh M, Takashima A, Dougherty I, Knop J, Bergstresser PR, Cruz PD Jr: Ultraviolet B radiation up-regulates the expression of IL-15 in human skin. J Immunol 155:4492-4496, 1995
7. Doherty TM, Seder RA, Sher A: Induction and regulation of interleukin-15 expression in murine macrophages. J Immunol 156:735-741, 1996
8. Minami Y, Kono T, Miyazaki T, Taniguchi T: The IL-2 receptor complex: Its structure, function, and target genes. Annu Rev Immunol 11:245-268, 1993
9. Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA: The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91:4940-4944, 1994
10. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D: Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. BMBO J 13:2822-2830, 1994
11. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM: Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J 14:3654-3663, 1995
12. Kumaki S, Ochs HD, Timour M, Schooley K, Ahdieh M, Hill H, Sugamura K, Anderson D, Zhu Q, Cosman D, Giri JG: Characterization of B-cell lines established from two X-linked severe combined immunodeficiency patients: Interleukin-15 binds to the B cells but is not internalized efficiently. Blood 86:1428-1436, 1995
13. Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA, Valentine V, Shapiro DN, Morris SW, Park LS, Cosman D: The human IL-15 receptor: functional characterization of the α chain and close linkage of the IL15RA and IL2RA genes. J Biol Chem 270:29862-29869, 1995
14. Cosman D, Lyman SD, Idzerda RL, Beckmann MP, Park LS, Goodwin RG, March CJ: A new cytokine receptor superfamily. Trends Biochem Sci 15:265-270, 1990
15. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934-6938, 1990
16. Miyajima A, Kitamura T, Harada N, Yokota T, Arai K: Cytokine receptors and signal transduction. Annu Rev Immunol 10:295-331, 1992
17. Perkins SJ, Haris PI, Sim RB, Chapman D: A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods. Biochemistry 27:4004-4012, 1988
18. Carson WE, Giri JG, Lindemann MJ, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisenman J, Grabstein K, Caligiuri MA: Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180:1395-1403, 1994
19. Matthews DJ, Clark PA, Herbert J, Morgan G, Armitage RJ, Kinnon C, Minty A, Grabstein KH, Caput D, Ferrara P, Callard R: Function of the interleukin-2 (IL-2) receptor γ-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15. Blood 85:38-42, 1995
20. Lin J-X, Migone T-S, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ: The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331-339, 1995
21. Balasubramanian S, Chernov-Rogan T, Davis AM, Whitchorn E, Tate E, Bell MP, Zurawski G, Barrett RW: Ligand binding kinetics of IL-2 and IL-15 to heteromers formed by extracellular domains of the three IL-2 receptor subunits. Int Immunol 7:1839-1849, 1995
22. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521-530, 1995
23. Ma A, Datta M, Margosian B, Chen J, Horak I: T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med 182:1567-1572, 1995
24. + T cells. Eur J Immunol 25:3053-3059, 1995
25. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253-261, 1993
26. Nemoto T, Takeshita T, Ishii N, Kondo M, Higuchi M, Satomi S, Nakamura M, Mori S, Sugamura K: Differences in the interleukin-2 (IL-2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL-2 receptor. Eur J Immunol 25:3001-3005, 1995
27. Johnston JA, Bacon CM, Finbloom DS, Rees RC, Kaplan D, Shibuya K, Ortaldo JR, Gupta S, Chen YQ, Giri JG, O'Shea JJ: Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci USA 92:8705-8709, 1995
28. Malek TR, Ashwell JD, Germain RN, Shevach EM, Miller J: The murine interleukin-2 receptor: Biochemical structure and regulation of expression. Immunol Rev 92:81-101, 1986
29. Rose-John S, Heinrich PC: Soluble receptors for cytokines and growth factors: Generation and biological function. Biochem J 300:281-290, 1994
30. Seder RA, Grabstein KG, Berzofsky JA, McDyer JF: Cytokine interactions in human immunodeficiency virus-infected individuals: roles of (IL)-2, IL-12, and IL-15. J Exp Med 182:1067-1078, 1995
31. Wilkinson PC, Liew FY: Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181:1255-1259, 1995
32. McInnes IB, Al-Mughales J, Field M, Leung BP, Huang F, Dixon R, Sturrock RD, Wilkinson PC, Liew FY: The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Medicine 2:175-182, 1996
33. Lewko WM, Smith TL, Bowman DJ, Good RW, Oldham RK: Interleukin-15 and the growth of tumor derived activated T-cells. Cancer Biother 10:13-20, 1995
34. c-chains of the IL-2 receptor. J Invest Dermatol 105:837-843, 1995
35. Kennedy MK, Picha KS, Shanebeck KD, Anderson DM, Grabstein KH: Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones. Eur J Immunol 24:2271-2278, 1994
36. Gamero AM, Ussery D, Reintgen DS, Puleo CA, Djeu JY: Interleukin 15 induction of lymphokine-activated killer cell function against autologous tumor cells in melanoma patient lymphocytes by a CD18-dependent, perforin-related mechanism. Cancer Res 55:4988, 1995
37. Flamand L, Stefanescu I, Menezes J: Human herpesvirus-6 enhances natural killer cell cytotoxicily via IL-15. J Clin Invest (in press)
38. Armitage RJ, Macduff BM, Eisenman J, Paxton R, Grabstein KH: IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J Immunol 154:483-490, 1995
39. Quinn LS, Haugk KL, Grabstein KH: Interleukin-15: A novel anabolic cytokine for skeletal muscle. Endocrinology 136:3669-3672, 1995
40. Reinecker H-C, Podolsky DK: Human intestinal epithelial cells express functional cytokine receptors sharing the common γc chain of the interleukin 2 receptor. Proc Natl Acad Sci USA 92:8353-8357, 1995
41. Munger W, DeJoy SQ, Jeyaseelan R Sr, Torley LW, Grabstein KH, Eisenman J, Paxton R, Cox T, Wick MM, Kerwar SS: Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: Comparison with interleukin-2. Cell Immunol 165:289-293, 1995
42. Rosenberg SA, Mulé JJ, Spiess PJ, Reichert CM, Schwarz SL: Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2. J Exp Med 161:1169-1188, 1985
43. + cytotoxic T lymphocytes and macrophages. Immunobiology 186:214-229, 1992
44. Siegel JP, Puri RK: Interleukin-2 toxicity. J Clin Oncol 9:694-704, 1991
45. Dubinett SM, Huang M, Lichtenstein A, McBride WH, Wang J, Markovitz G, Kelley D, Grody WW, Mintz LE, Dhanani S: Tumor necrosis factor-α plays a central role in interleukin-2-induced pulmonary vascular leak and lymphocyte accumulation. Cell Immunol 157:170-180, 1994
46. Damle NK, Doyle LV, Bender JR, Bradley EC: Interleukin 2-activated human lymphocytes exhibit enhanced adhesion to normal vascular endothelial cells and cause their lysis. J Immunol 138:1779-1785, 1987
47. Kovacs EJ, Beckner SK, Longo DL, Varesio L, Young HA: Cytokine gene expression during the generation of human lymphokine-activated killer cells: Early induction of interleukin 1 β by interleukin 2. Cancer Res 49:940-944, 1989
48. Kumaki S, Kondo M, Takeshita T, Asao H, Nakamura M, Sugamura K: Cloning of the mouse interleukin 2 receptor γ chain: Demonstration of functional differences between the mouse and human receptors. Biochem Biophys Res Commun 193:356-363, 1993
49. Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein K, Caligiuri MA: Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells. J Clin Invest 96:2578-2582, 1995
50. Vita R, Brezinschek RI, Lipsky PE, Oppenheimer-Marks N: Interleukin-15 increases the transendothelial migration of human T cells. Arth Rheum 38:5235, 1995 (abstr)
51. Firestein GS, Xu W-D, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, Zvaifler NJ: Cytokines in chronic inflammatory arthritis. 1. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med 168:1573-1586, 1988
52. Iannone F, Corrigall VM, Kingsley GH, Panayi GS: Evidence for the continuous recruitment and activation of T cells into the joints of patients with rheumatoid arthritis. Eur J Immunol 24:2706-2713, 1994
53. Kündig T, Schorle H, Bachmann MF, Hengartner H, Zinkernagel RM, Horak I: Immune responses in interleukin-2-deficient mice. Science 262:1059-1061, 1993
54. Schorle H, Holtschke T, Hünig T, Schimpl A, Horak I: Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621-624, 1991
55. Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB: IL-2 knockout recipient mice reject islet cell allografts. J Immunol 155:489-498, 1995
56. Suzuki H, Kündig TM, Furlonger C, Wakeman A, Timms E, Matsuyama T, Schmits R, Simard JJL, Ohashi PS, Griesser H, Taniguchi T, Paige CJ, Mak TW: Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268:1472-1476, 1995