A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis

New England Journal of Medicine

Volumn 341, Issue 17, 1999, Pages 1264-1269

  Ziesche, Rolf ^a   Hofbauer, Elisabeth ^a   Wittmann, Karin ^a   Petkov, Ventzislav ^a   Block, Lutz Henning ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; PREDNISOLONE;

ADULT; AGED; ARTERIAL OXYGEN TENSION; ARTICLE; CHILL; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG EFFICACY; DRUG MIXTURE; DRUG SCREENING; FEMALE; FEVER; HUMAN; IDIOPATHIC DISEASE; LUNG FIBROSIS; MALE; MYALGIA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TOTAL LUNG CAPACITY;

CARRIER PROTEINS; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; GROWTH SUBSTANCES; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON-GAMMA, RECOMBINANT; MALE; MIDDLE AGED; PREDNISOLONE; PULMONARY FIBROSIS; PULMONARY GAS EXCHANGE; TOTAL LUNG CAPACITY; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033592753     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199910213411703     Document Type: Article

References (22)

1. Ryu JH, Colby TV, Hartman TE. Idiopathic pulmonary fibrosis: current concepts. Mayo Clin Proc 1998;73:1085-101.
2. Tukiainen P, Taskinen E, Holsti P, Korhola O, Valle M. Prognosis of cryptogenic fib rosin g alveolitis. Thorax 1983;38:349-55.
3. Specks U, Nerlich A, Colby TV, Wiest I, Timpl R. Increased expression of type VI collagen in lung fibrosis. Am J Respir Crit Care Med 1995;15: 1956-64.
4. Elias JA, Freundlich B, Kern JA, Rosenbloom J. Cytokine networks in the regulation of inflammation and fibrosis in the lung. Chest 1990;97:1439-45.
5. Bienkowski RS, Gotkin MG. Control of collagen deposition in mammalian lung. Proc Soc Exp Biol Med 1995;209:118-40.
6. Gurujeyalakshmi G, Giri SN. Molecular mechanisms of antifibrotic effect of Interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-β and procollagen I and III gene expression. Exp Lung Res 1995;21:791-808.
7. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor β1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997;100:768-76.
8. Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997;8:171-9.
9. Prior C, Haslam PL. In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases. Clin Exp Immunol 1992;88: 280-7.
10. Ziesche R, Kink E, Herold C, Podolsky A, Block LH. Therapy of chronic interstitial lung disease with a combination of interferon-γ and low-dose prednisolone. Chest 1996;110:Suppl:25S. abstract.
11. Watters LC, King TE, Schwarz MI, Waldron JA, Stanford RE, Cherniack RM. A clinical, radiographic, and physiologic scoring system for the longitudinal assessment of patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 1986;133:97-103.
12. Harnoncourt K, Feldner H, Forche G, et al. Die Standardisierung der Lungcenfunktionsdiagnostik. Osterreich Arzteztg 1982;37:1640-2.
13. IDV - data analysis and study planning: Testimate 5.2a. Report 6.0.08. Munich, Germany: Wessobrunner, 1998.
14. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci U S A 1991;88:6642-6.
15. Sempowski GD, Derdak S, Phipps RP. Interleukin-4 and interferon-gamma discordantly regulate collgen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol 1996;167:290-6.
16. Isaka Y, Brees DK, Ikegaya K, et al. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996; 2:418-23.
17. Qin L, Ding Y, Bromberg JS. Gene transfer of transforming growth factor-beta 1 prolongs murine cardiac allograft survival by inhibiting cell-mediated immunity. Hum Gene Ther 1996;7:1981-8.
18. Gilbert KM, Thoman M, Bauche K, Pham T, Weigle WO. Transforming growth factor-beta 1 induces antigen-specific unresponsiveness in naive T cells. Immunol Invest 1997;26:459-72.
19. Lawrence DA. Transforming growth factor-beta: a general review. Eur Cytokine Netw 1996;7:363-74.
20. Naganuma H, Sasaki A, Satoh E, et al. Transforming growth factor-beta inhibits interferon-gamma secretion by lymphokine-activated killer cells stimulated with tumor cells. Neurol Med Chir (Tokyo) 1996;36:789-95.
21. Lee YJ, Han Y, Lu HT, et al. TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. J Immunol 1997;158:2065-75.
22. Strober W, Kelsall B, Fuss I, et al. Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today 1997;18:61-4.