Lineage commitment in lymphocytes: Controlling the immune response

Journal of Clinical Investigation

Volumn 108, Issue 7, 2001, Pages

  Glimcher, L H ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TRANSCRIPTION FACTOR;

ALLERGIC DISEASE; AUTOIMMUNE DISEASE; CELL LINEAGE; CONFERENCE PAPER; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MAF; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034784578     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (93)

1. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
2. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
3. Lymphocyte responses and cytokines
4. Cytokines induce the development of functionally heterogeneous T helper cell subsets
5. Transcriptional regulation of cytokine gene expression
6. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
7. T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation
8. Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones
9. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
10. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
11. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniases
12. T cell shift: Key to AIDS therapy?
13. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-dependent mechanism
14. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM
15. Checkpoints in the progression of autoimmune disease: Lessons from diabetes models
16. Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo
17. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
18. Airway remodeling in asthma
19. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
20. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis
21. Surface expression of α4 integrin by CD4 T cells in required for their entry into brain parenchyma
22. Regulatory T cell clones induced by oral tolerance and suppression of autoimmune encephalomyelitis
23. Oral tolerance to myelin basic protein and natural recovery from experimental allergic encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor-β, interleukin 4, and prostaglandin E expression in the brain
24. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis
25. CD28-DB7 costimulatory blockade by CTLA41g prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system
26. + T cells
27. +T cells through IL-12 produced by Listeria-induced macrophages
28. + T cells for ab-TCR transgenic mice: IL-12 can substitute for macrophages to stimulate IFNγ production
29. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones
30. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
31. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones
32. Cytokine regulation of T-cell function: Potential for therapeutic intervention
33. IFN-γ modulates the early development of Th1 and Th2 response in a murine model of cutaneous Leishmaniasis
34. + T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming
35. Interleukin-12 and its role in the generation of Th1 cells
36. IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells
37. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
38. IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses
39. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
40. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
41. Disruption of the murine IL-4 gene blocks Th2 cytokine responses
42. Generation and analysis of interleukin-4 deficient mice
43. An interleukin 4 (IL-4) independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice
44. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
45. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
46. H2 differentiation in allergic airway inflammation
47. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
48. NFATc1 and NFATc2 together control both T and B cell activation and differentiation
49. Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development
50. Sequential involvement of NFAT and Egr transcription factors in FasL regulation
51. Genes that regulate interleukin-4 expression in T cells
52. Transcription factors in lymphocyte development: T and B cells get together
53. +T helper lymphocytes
54. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
55. Human GATA-3: A lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene
56. Transcription factor GATA-3 is required for development of the T-cell lincage
57. Contingent genetic regulatory events in T lymphocyte activation
58. Characterization of antigen receptor response elements within the interleukin-2 enhancer
59. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins
60. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus
61. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
62. NF-AT components define a family of transcription factors targeted in T-cell activation
63. Transcription factors of the NFAT family: Regulation and function
64. Identification of a putative regulator of early T cell activation genes
65. NFAT-driven interleukin-4 transcription potentiated by NIP45
66. Tumor necosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45)
67. Cmaf promotes Th2 and attenuates Th1 differentiation by both IL-4 dependent and independent mechanisms
68. Marking interleukin-4 producing cells by knock-in of the interleukin-4 gene
69. The transcription factor c-Maf controls the production of IL-4 but not other Th2 cytokines
70. Variable effects of transgenic c-Maf on autoimmune diabetes
71. Transcriptional regulation of Th1/Th2 polarization
72. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
73. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
74. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo
75. Multistage regulation of Th1-type immune responses by the transcription factor IRF-1
76. Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon γ production from CD4+ versus CD8+ T cells
77. Cloning of the T gene required in mesoderm formation in the mouse
78. Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease
79. T-box family reunion
80. Brachyury and the T-box genes
81. T-Brain-1: A homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex
82. Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor
83. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
84. Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome
85. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
86. Muscular involvement in the Holt-Oram syndrome
87. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity
88. Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds
89. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins
90. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
91. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
92. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
93. Lineage commitment in the immune system: The T helper lymphocyte grows up