The role of innate mediators in inflammatory response

Molecular Immunology

Volumn 38, Issue 12-13, 2002, Pages 887-890

  Liew, Foo Y ^a   McInnes, Iain B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

IL 15; IL 18; Innate cytokines; Rheumatoid arthritis

Indexed keywords

CYTOKINE; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

CELL TYPE; CONFERENCE PAPER; HUMAN; IMMUNE RESPONSE; IMMUNITY; INFLAMMATION; MACROPHAGE; MEDIATOR; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVITIS; SYNOVIUM; T LYMPHOCYTE;

ANIMALS; ARTHRITIS, RHEUMATOID; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-15; INTERLEUKIN-18; MACROPHAGES; MODELS, IMMUNOLOGICAL; SYNOVIAL MEMBRANE; T-LYMPHOCYTES;

EID: 0036247665     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(02)00014-7     Document Type: Conference Paper

References (26)

1. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis.
2. Defining therapeutic targets by using adenovirus: Blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
3. Interleukin-18
4. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
5. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
6. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
7. A proinflammatory role for IL-18 in rheumatoid arthritis
8. An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
9. Defective Interleukin (IL)-18-mediated natural killer and T helper cell Type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
10. A role for IL-18 in neutrophil activation
11. Infliximab and methotrexate in the treatment of rheumatoid arthritis
12. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
13. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis
14. Interleukin 18: A pleiotropic participant in chronic inflammation
15. A role for IL-15 in rheumatoid arthritis?
16. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
17. Interleukin 15: A proinflammatory role in rheumatoid arthritis synovitis
18. Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCID mouse-human rheumatoid arthritis model in vivo
19. Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
20. Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways
21. CD40-CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1beta production by monocytes
22. Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology
23. Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis
24. Expression and cleavage of tumor necrosis factor-alpha and tumor necrosis factor receptors by human monocytic cell lines upon direct contact with stimulated T cells
25. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
26. Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18