IL-12 p40 Homodimer-Dependent Macrophage Chemotaxis and Respiratory Viral Inflammation Are Mediated through IL-12 Receptor β11

Journal of Immunology

Volumn 171, Issue 12, 2003, Pages 6866-6874

  Russell, Tonya D ^a   Yan, Qingyun ^a   Fan, Guangshun ^a   Khalifah, Anthony P ^a   Bishop, D Keith ^b   Brody, Steven L ^a   Walter, Michael J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTACTIC FACTOR; DIMER; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12P40; INTERLEUKIN RECEPTOR; INTERLEUKIN-12 RECEPTOR; INTERLEUKIN-12 SUBUNIT P40; LEUKOCYTE ANTIGEN; PROTEIN P80; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BIOSYNTHESIS; CELL CULTURE; CELL STRAIN 3T3; CHEMISTRY; CHEMOTAXIS; CONTROLLED STUDY; CYTOLOGY; CYTOPLASM; DIMERIZATION; DOWN REGULATION; EMBRYO; GENE DELETION; GENETICS; IMMUNOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE; METABOLISM; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; NUTRITIONAL DEFICIENCY; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTION; RNA VIRUS INFECTION; SENDAI VIRUS; VIROLOGY; VIRUS INFECTION; WILD TYPE;

EID: 0345735824     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.12.6866     Document Type: Article

References (64)

1. Walter, M. J., N. Kajiwara, P. Karanja, M. Castro, and M. J. Holtzman. 2001. IL-12 p40 production by barrier epithelial cells during airway inflammation. J. Exp. Med. 193:339.
2. Walter, M. J., J. D. Morton, N. Kajiwara, E. Agapov, and M. J. Holtzman. 2002. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J. Clin. Invest. 110:165.
3. Holtzman, M. J., J. D. Morton, L. P. Shornick, J. W. Tyner, M. P. O'Sullivan, A. Antao, M. Lo. M. Castro, and M. J. Walter. 2002. Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm. Physiol. Rev. 82:19.
4. Holtzman, M. J., M. Castro, D. C. Look, M. O'Sullivan, and M. J. Walter. 2000. Regulation of epithelial-leukocyte interactions and epithelial immune-response genes. In Asthma and Rhinitis, Vol. 1. W. Busse and S. Holgate, eds. Blackwell, Cambridge, MA, p. 784.
5. Chung, C. Y., S. Funamoto, and R. A. Firtel. 2001. Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem. Sci. 26:557.
6. Condeelis, J. 2001. How is actin polymerization nucleated in vivo? Trends Cell. Biol. 11:288.
7. Small, J. V., T. Stradal, E. Vignal, and K. Rottner. 2002. The lamellipodium: where motility begins. Trends Cell. Biol. 12:112.
8. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. E. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, C. L. Stremlo, T. Truit, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
9. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
10. Ling, P., M. K. Gately, U. Gubler, A. S. Stern, P. Lin, K. Hollfelder, C. Su, Y. Pan, and J. Hakimi. 1995. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J. Immunol. 154:116.
11. Gillessen, S., D. Carvajal, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. Gately. 1995. Mouse interleukin- 12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25:200.
12. Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p4O to form a cytokine, IL-23, with biologic activities similar as well as distinct from IL-12. Immunity 13:715.
13. Devergne, O., M. Hummel, H. Koeppen, M. Le Beau, E. Nathanson, E. Kieff, and M. Birkenbach. 1996. A novel interleukin-12 p40 related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J. Virol. 70:1143.
14. Devergne, O., M. Birkenbach, and E. Kieff. 1997. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. USA 94:12041.
15. + T cells. Immunity 16:779.
16. Heinzel, F. P., A. M. Hujer, F. N. Ahmed, and R. M. Rerko. 1997. In vivo production and function of IL-fL- 12 p40 p4O homodimers. J. Immunol. 158:4381.
17. Wang, X., V. L. Wilkinson, F. J. Podlaski, C. Wu, A. S. Stern, D. H. Presky, and J. Magram. 1999. Characterization of mouse interleukin- 12 p40 homodimer binding to the interleukin-12 receptor subunits. Eur. J. Immunol. 29:2007.
18. Ha, S. J., C. H. Lee, S. B. Lee, C. M, Kim, K. L. Jang, H. S. Shin, and Y. C. Sung. 1999. A novel function of IL-12p40 as a chemotactic molecule for macrophages. J. Immunol. 163:2902.
19. Kopp, T., D. Kieffer, A. Rot, S. Strommer, G. Stingl, and T. S. Kupper. 2001. Inflammatory skin disease in K14/p40 transgenic mice: evidence for interleukin-12-like activities of p40. J. Invest. Dermatol. 117:618.
20. Yoshimoto, T., C. Wang, T. Yoneto, S. Waki, S. Sunaga, Y. Komagata, M. Mitsuyama, J. Miyazaki, and H. Nariuchi. 1998. Reduced T helper 1 responses in IL-12 p40 transgenic mice. J. Immunol. 160:588.
21. Chen, L., D. Chen, E. Block, M. O'Donnell, D. W. Kufe, and S. K. Clinton. 1997. Eradication of murine bladder carcinoma by intratumor injection of a bicistronicadenoviral vector carrying cDNAs for the IL- 12 heterodimer and its inhibitor by the IL-12 p4O subunit homodimer. J. Immunol. 159:351.
22. Holscher, C., R. A. Atkinson, B. Arendse, N. Brown, E. Myburgh, G. Alber, and F. Brombacher. 2001. A protective and agonistic function of IL-12p40 in mycobacterial infection. J. Immunol. 167:6957.
23. Grohmann, U., M. L. Belladonna, C. Vacca, R. Bianchi, F. Fallarino, C. Orabona, M. C. Fioretti, and P. Puccetti. 2001. Positive regulatory role of IL-12 in macrophages and modulation by IFN-γ. J. Immunol. 167:221.
24. Abu-Amer, Y., F. P. Ross, K. P. McHugh, A. Livolsi, J. Peyron, and S. L. Teitelbaum. 1998. Tumor necrosis factor-a activation of nuclear transcription factor-KB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of IKBα. J. Biol. Chem. 45:29417.
25. Lam, J., S. Takeshita, J. E. Barker, O. Kanagawa, F. P. Ross, and S. L. Teitelbaum. 2000. TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J. Clin. Invest. 106:1481.
26. 3 integrin specifically impairs osteoclast function. J. Clin. Invest. 107:1137.
27. Mattner, F., S. Fischer, S. Guckes, S. Jin, H. Kaulen, E. Schmitt, E. Rude, and G. Tieno. 1993. The interleukin- 12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23:2202.
28. Yule, K. A., and S. R. White. 1999. Migration of 3T3 and lung fibroblasts in response to calcitonin gene-related peptide and bombesin. Exp. Lung. Res. 25:261.
29. Nosaka, T., T. Kawashima. K. Misawa, K. Ikuta, A. L. Mui, and T. Kitamura. 1999. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18:4754.
30. Kawakami, Y., T. Miura, R. Bissonnette, D. Hata, W. N. Khan, T. Kitamura, M. Maeda-Yamamoto, S. E. Hartman, L. Yao, F. W. Alt, and T. Kawakami. 1997. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc. Natl. Acad. Sci. USA 94:3938.
31. Onishi, M., T. Nosaka, K. Misawa, A. L. Mui, D. Gorman, M. McMahon, A. Miyajima, and T. Kitamura. 1998. Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18:3871.
32. Walter, M. J., D. C. Look, R. M. Tidwell, W. T. Roswit, and M. J. Holtzman. 1997. Targeted inhibition of interferon-γ-dependent ICAM-1 expression using dominant-negative Statl. J. Biol. Chem. 272:28582.
33. Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392.
34. Kitamura, T., M. Onishi, S. Kinoshita, A. Shibuya, A. Miyajima, and G. P. Nolan. 1995. Efficient screening of retroviral cDNA expression libraries. Proc. Natl. Acad. Sci. USA 92:9146.
35. Dawson-Saunders, B., and R. G. Trapp. 1994. Comparing three or more means, In Basic and Clinical Biostatistics. Appleton and Lange, East Norwalk, CT, p. 134-136.
36. Aksamit, R. R., W. Falk, and E. J. Leonard. 1981. Chemotaxis by mouse macrophage cell lines. J. Immunol. 126:2194.
37. Heit, B., S. Tavener, E. Raharjo, and P. Kubes. 2002. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J. Cell Biol. 159:91.
38. Senior, R. M., G. L. Griffin, H. D. Perez, and R. O. Webster. 1988. Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts. J. Immunol. 141:3570.
39. Banda, M. J., A. G. Rice, G. L. Griffin, and R. M. Senior. 1988. αI-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 263:4481.
40. Matsui, T., J. H. Pierce, T. P. Fleming, J. S. Greenberger, W. J. LaRochelle, M. Ruggiero, and S. A. Aaronson. 1989. Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc. Natl. Acad. Sci. USA 86:8314.
41. Eriksson. A., A. Siegbahn, B. Westermark, C. H, Heldin, and L. Claesson-Welsh. 1992. PDGF α- and β-receptors activate unique and common signal transduction pathways. EMBO J. 11:543.
42. Nobes, C. D., and A. Hall. 1999. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144:1235.
43. Jimenez, C., R. A. Portela, M. Mellado, J. M. Rodriguez-Frade, J. Collard, A. Serrano, A. C. Martinez, J. Avila, and A. C. Carrera. 2000. Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J. Cell Biol. 151:249.
44. Altare, F., A. Durandy, D. Lammas, J. Emile, S. Lamhamedi, F. Le Deist, P. Drysdale, E. Jouanguy, R. Doffinger, F. Bemaudin, et al. 1998. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280:1432.
45. de Jong, R. D., F. Altare, I. Haagen. D. G. Elferink, T. de Boer, P. J. C. van Breda Vriesman, P. J. Kabel, J. M. T. Draaisma, J. T. van Dissel, F. P. Kroon, et al. 1998. Severe mycobacterial and Salmonella infections in interleukin-12 receptor deficient patients. Science 280:1435.
46. Fieschi, C., S. Dupuis, E. Catherinot, J. Feinberg, J. Bustamante, A. Breiman, F. Altare, R. Baretto, F. Le Deist, S. Kayal, et al. 2003. Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor betal deficiency: medical and immunological implications. J. Exp. Med. 197:527.
47. Elloumi-Zghal, H., M. R. Barbouche, J. Chemli, M. Bejaoui, A. Harbi, N. Snoussi, S. Abdelhak, and K. Dellagi. 2002. Clinical and genetic heterogeneity of inherited autosomal recessive susceptibility to disseminated Mycobacterium bovis bacille Calmette-Guérin infection. J. Infect. Dis. 185:1468.
48. Sakai, T., M. Matsuoka, M. Aoki, K. Nosaka, and H. Mitsuya. 2001. Missense mutation of the interleukin-12 receptorβ1 chain-encoding gene is associated with impaired immunity against Mycobacterium avium complex infection. Blood 97:2688.
49. Aksu, G., C. Tirpan, C. Cavusoglu, S. Soydan, F. Altare, J. L. Casanova, and N. Kutukculer. 2001. Mycobacterium fortuitum-chelonae complex infection in a child with complete interleukin-12 receptor βl deficiency. Pediatr. Infect. Dis. J. 20:551.
50. Leemans, J. C., N. P. Juffermans, S. Florquin, N. van Rooijen, M. J. Vervoordeldonk, A. Verbon, S. J. van Deventer, and T. van der Poll. 2001. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J. Immunol. 166:4604.
51. Nakano, Y., T. Kasahara, N. Mukaida, Y. C. Ko, M. Nakano, and K, Matsushima. 1994. Protection against lethal bacterial infection in mice by monocyte-chemo-tactic and -activating factor. Infect. Immun. 62:377.
52. Fairweather, D., S. Yusung, S. Frisancho, M. Barrett, S. Gatewood, R. Steele, and N. R. Rose. 2003. IL- 12 Receptor β1 and Toll-like receptor 4 increase IL-1β 19- and IL-18-associated myocarditis and Coxsackievirus replication. J. Immunol. 170:4731.
53. Lane, J. R., D. A. Neumann, A. Lafond-Walker, A. Herskowitz, and N. R. Rose. 1991. LPS promotes CB3-induced myocarditis in resistant B10.A mice. Cell. Immunol. 136:219.
54. Lane, J. R., D. A. Neumann, A. Lafond-Walker, A. Herskowitz, and N. R. Rose. 1992. Interleukin I or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice. J. Exp. Med. 175:1123.
55. Wu, C., J. Ferrante, M. K. Gately, and J. Magram., 1997. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J. Immunol. 159:1658.
56. Wu, C., X. Wang, M. Gadina, J. J. O'shea, D. H. Presky, and J. Magram. 2000. IL-12 receptor β2 (IL-12Rβ2)-Deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J. Immunol. 165:6221.
57. Pahan, K., F. G. Sheikh, X. Liu, S. Hilger, M. McKinney, and T. M. Petro. 2001. Induction of nitric-oxide synthase and activation of NF-KB by interleukin-12 p40 in microglial cells. J. Biol. Chem. 276:7899.
58. Chua, A. O., V. L. Wilkinson, D. H. Presky, and U. Gubler. 1995. Cloning and characterization of a mouse IL- 12 receptor-β component. J. Immunol. 155:4286.
59. Presky, D. H., H. Yang, L. J. Minetti. A. O. Chua, N. Nabavi, C. Wu, M, K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002.
60. Cumock, A. P., M. K. Logan, and S. G. Ward. 2002. Chemokine signaling: pivoting around multiple phosphoinositide 3-kinases. Immunology 105:125.
61. Wymann, M. P., S. Sozzani. F. Altruda,. A. Mantovani. and E. Hirsch. 2000. Lipids on the move: phosphoinositide 3-kinases in leukocyte function. Trends Immunol. Today 21:260.
62. Ponzetto, C., A. Bardelli, F. Maina, P. Longati, G. Panayotou, R. Dhand, M. D. Waterfield, and P. M. Comoglio. 1993. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol. Cell. Biol. 13:4600.
63. Carpenter, C. L., K. R. Auger, M. Chanudhuri, M. Yoakim, B. Schaffhausen, S. Shoelson, and L. C. Cantley. 1993. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J. Biol.Chem. 268:9478.
64. Parham, C., M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh. F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:5699.