Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 158-164

  Hom, Roy K ^a   Gailunas, Andrea F ^a   Mamo, Shumeye ^a   Fang, Larry Y ^a   Tung, Jay S ^a   Walker, Donald E ^a   Davis, David ^a   Thorsett, Eugene D ^a   Jewett, Nancy E ^a   Moon, Joseph B ^b   John, Varghese ^a  

^a ELAN PHARMACEUTICALS   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE INHIBITOR; CARBOXYLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; N [1 (3,5 DIFLUOROBENZYL) 2 HYDROXY 4 ISOBUTYLCARBAMOYLPENTYL] N',N' DIPROPYLISOPHTHALAMIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG INHIBITION; DRUG PENETRATION; DRUG POTENCY; DRUG SYNTHESIS; IC 50; PHASE TRANSITION; STRUCTURE ACTIVITY RELATION;

AMIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; DIPEPTIDES; DRUG DESIGN; ENDOPEPTIDASES; ETHYLENES; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PHTHALIC ACIDS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9144267815     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0304008     Document Type: Article

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