Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 596, Issue 1-2 SPEC. ISS., 2006, Pages 64-75

  Ouyang, Yan ^a   Kwon, Yong Tae ^b   An, Jee Young ^b   Eller, Danny ^a   Tsai, Shih Chang ^a   Diaz Perez, Silvia ^a   Troke, Joshua J ^a   Teitell, Michael A ^a   Marahrens, York ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Fragile sites; Genome instability; Homologous recombination repair; Mitomycin C sensitivity; N end rule proteolytic pathway; Ubr2 ubiquitin ligase

Indexed keywords

DOUBLE STRANDED DNA; MITOMYCIN C; UBIQUITIN LIGASE UBR2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CHROMOSOME ANALYSIS; CHROMOSOME FRAGILITY; CONTROLLED STUDY; DNA CROSS LINKING; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO; FIBROBLAST; GAMMA IRRADIATION; GENETIC RECOMBINATION; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; INCIDENCE; METAPHASE; MICRONUCLEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ANIMALS; CELLS, CULTURED; CHROMOSOME FRAGILITY; DNA DAMAGE; DNA REPAIR; EMBRYO; FIBROBLASTS; GENES, REPORTER; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; RECOMBINATION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 33646007680     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.12.016     Document Type: Article

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