Chromosomal mutagen sensitivity associated with mutations in BRCA genes

Cytogenetic and Genome Research

Volumn 104, Issue 1-4, 2004, Pages 325-332

  Speit, G ^a   Trenz, K ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE;

BREAST CANCER; BREAST CARCINOGENESIS; CANCER GENETICS; CANCER SUSCEPTIBILITY; CANCER THERAPY; CELL CYCLE G0 PHASE; CELL CYCLE G2 PHASE; CHROMOSOME MUTATION; CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; GENE MUTATION; HUMAN; IRRADIATION; LYMPHOBLASTOID CELL; LYMPHOCYTE; MICRONUCLEUS TEST; MUTAGENESIS; ONCOGENE; PRIORITY JOURNAL; RADIATION EXPOSURE;

BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL LINE; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; DNA REPAIR; DRUG RESISTANCE; FEMALE; G2 PHASE; GENES, BRCA1; GENES, BRCA2; HUMANS; LYMPHOCYTES; MUTAGENS; MUTATION; PENETRANCE; RADIATION TOLERANCE; TUMOR CELLS, CULTURED;

EID: 2642540828     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077511     Document Type: Conference Paper

References (57)

1. Abbott DW, Thompson ME, Robinson-Benion C, Tomlinson G, Jensen RA, Holt JT: BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair. J biol Chem 274:18808-18812 (1999).
2. Abrahams PJ, Houweling A, Cornelissen-Steijger PD, Jaspers NG, Darroudi F, Meijers CM, Mullenders LH, Filon R, Arwert F, Pinedo HM, Natarajan AP, Terleth C, Van Zeeland AA, van der Eb AJ: Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes. Mutat Res 407:189-201 (1998).
3. Alapetite C, Thirion P, de la Rochefordiere A, Cosset JM, Moustacchi E: Analysis by alkaline comet assay of cancer patients with severe reactions to radiotherapy: defective rejoining of radioinduced DNA strand breaks in lymphocytes of breast cancer patients. Int J Cancer 83:83-90 (1999).
4. Baeyens A, Thierens H, Claes K, Poppe B, Messiaen L, De Ridder L, Vral A: Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition. Br J Cancer 87:1379-1385 (2002).
5. Baldeyron C, Jacquemin E, Smith J, Jacquemont C, De Oliveira I, Gad S, Feunteun J, Stoppa-Lyonnet D, Papadopoulo D: A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. Oncogene 21:1401-1410 (2002).
6. Baria K, Warren C, Roberts SA, West CM, Evans DG, Varley JM, Scott D: Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60:390-394, 2000. Cancer Res 61:5948-5949 (2001a). Cancer Res 61:5948-5949 (2001a).
7. Baria K, Warren C, Roberts SA, West CM, Evans DG, Varley JM, Scott D: Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60:390-394, 2000. Cancer Res 61:5948-5949 (2001a). Cancer Res 61:5948-5949 (2001a).
8. Baria K, Warren C, Roberts SA, West CM, Scott D: Chromosomal radiosensitivity as a marker of predisposition to common cancers? Br J Cancer 84:892-896 (2001b).
9. Berwick M, Vineis P: Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J natl Cancer Inst 92:874-897 (2000).
10. Berwick M, Matullo G, Vineis P: Studies of DNA repair and human cancer: an update, in Wilson SH, Suk WA (eds): Biomarkers of Environmentally Associated Disease; Technologies, Concepts, and Perspectives, pp 83-107 (Lewis Publishers, Boca Raton 2002).
11. Buchholz TA, Wu X, Hussain A, Tucker SL, Mills GB, Haffty B, Bergh S, Story M, Geara FB, Brock WA: Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. Int J Cancer 97:557-561 (2002).
12. Burrill W, Barber JB, Roberts SA, Bulman B, Scott D: Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. Int J Radiat Biol 76:1617-1619 (2000).
13. Cianciulli AM, Venturo I, Leonardo F, Antonaci S, Greco G, Lopez M, Gandolfo GM: Mutagen sensitivity and cancer susceptibility in patients with multiple primary cancers. Oncol Rep 2:1021-1025 (1995).
14. Fenech M: The advantages and disadvantages of the cytokinesis-block micronucleus method. Mutat Res 392:11-18 (1997).
15. Foray N, Randrianarison V, Marot D, Perricaudet M, Lenoir G, Feunteun J: Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. Oncogene 18:7334-7342 (1999).
16. Futaki M, Liu JM: Chromosomal breakage syndromes and the BRCA1 genome surveillance complex. Trends molec Med 7:560-565 (2001).
17. Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA: BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science 281:1009-1012 (1998).
18. Helzlsouer KJ, Harris EL, Parshad R, Fogel S, Bigbee WL, Sanford KK: Familial clustering of breast cancer: possible interaction between DNA repair proficiency and radiation exposure in the development of breast cancer. Int J Cancer 64:14-17 (1995).
19. Helzlsouer KJ, Harris EL, Parshad R, Perry HR, Price FM, Sanford KK: DNA repair proficiency: potential susceptibility factor for breast cancer. J natl Cancer Inst 88:754-755 (1996).
20. Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature 411:366-374 (2001).
21. Hu JJ, Smith TR, Miller MS, Lohman K, Case LD: Genetic regulation of ionizing radiation sensitivity and breast cancer risk. Environ molec Mutagen 39:208-215 (2002).
22. Jaloszynski P, Kujawski M, Czub-Swierczek M, Markowska J, Szyfter K: Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay. Mutat Res 385:223-233 (1997).
23. Lavin MF, Bennett I, Ramsay J, Gardiner RA, Seymour GJ, Farrell A, Walsh M: Identification of a potentially radiosensitive subgroup among patients with breast cancer. J natl Cancer Inst 86:1627-1634 (1994).
24. Le Page F, Randrianarison V, Marot D, Cabannes J, Perricaudet M, Feunteun J, Sarasin A: BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res 60:5548-5552 (2000).
25. Mohrenweiser HM: Individual susceptibility to exposures: a role for genetic variation in DNA repair genes: In Wilson SH, Suk WA (eds): Biomarkers of Environmentally Associated Disease; Technologies, Concepts, and Perspectives, pp 63-82 (Lewis Publishers, Boca Raton 2002).
26. Nieuwenhuis B, Assen-Bolt AJ, Waarde-Verhagen MA, Sijmons RH, Van der Hout AH, Bauch T, Streffer C, Kampinga HH: BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage. Int J Radiat Biol 78:285-295 (2002).
27. Obe G, Pfeiffer P, Savage JR, Johannes C, Goedecke W, Jeppesen P, Natarajan AT, Martinez-Lopez W, Folle GA, Drets ME: Chromosomal aberrations: formation, identification and distribution. Mutat Res 504:17-36 (2002).
28. Parshad R, Price FM, Bohr VA, Cowans KH, Zujewski JA, Sanford KK: Deficient DNA repair capacity, a predisposing factor in breast cancer. Br J Cancer 74:1-5 (1996).
29. Patel RK, Trivedi AH, Arora DC, Bhatavdekar JM, Patel DD: DNA repair proficiency in breast cancer patients and their first-degree relatives. Int J Cancer 73:20-24 (1997).
30. Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert M: Direct DNA binding by Brca1. Proc natl Acad Sci, USA 98:6086-6091 (2001).
31. Peto J, Collins N, Barfoot R, Seal S, Warren W, Rahman N, Easton DF, Evans C, Deacon J, Stratton MR: Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J natl Cancer Inst 91:943-949 (1999).
32. Rajeswari N, Ahuja YR, Malini U, Chandrashekar S, Balakrishna N, Rao KV, Khar A: Risk assessment in first degree female relatives of breast cancer patients using the alkaline Comet assay. Carcinogenesis 21:557-561 (2000).
33. Ramsay J, Birrell G: Normal tissue radiosensitivity in breast cancer patients. Int J Radiat Oncol Biol Phys 31:339-344 (1995).
34. Rao NM, Pai SA, Shinde SR, Ghosh SN: Reduced DNA repair capacity in breast cancer patients and unaffected individuals from breast cancer families. Cancer Genet Cytogenet 102:65-73 (1998).
35. Riches AC, Bryant PE, Steel CM, Gleig A, Robertson AJ, Preece PE, Thompson AM: Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer patients with distinctive tumour characteristics. Br J Cancer 85:1157-1161 (2001).
36. Roberts SA, Spreadborough AR, Bulman B, Barber JB, Evans DG, Scott D: Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer? Am J hum Genet 65:784-794 (1999).
37. Rothfuss A, Schutz P, Bochum S, Volm T, Eberhardt E, Kreienberg R, Vogel W, Speit G: Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60:390-394 (2000).
38. Roy SK, Trivedi AH, Bakshi SR, Patel SJ, Shukla PH, Bhatavdekar JM, Patel DD, Shah PM: Bleomycin-induced chromosome damage in lymphocytes indicates inefficient DNA repair capacity in breast cancer families. J expl clin Cancer Res 19:169-173 (2000).
39. Scott D, Spreadborough A, Levine E, Roberts SA: Genetic predisposition in breast cancer. Lancet 344:1444 (1994).
40. Scott D, Barber JB, Levine EL, Burrill W, Roberts SA: Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition? Br J Cancer 77:614-620 (1998).
41. Scott D, Barber JB, Spreadborough AR, Burrill W, Roberts SA: Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. Int J Radiat Biol 75:1-10 (1999).
42. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM: Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88:265-275 (1997).
43. Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM: Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell 4:1093-1099 (1999).
44. Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX: A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 17:3115-3124 (1998).
45. Smith TR, Miller MS, Lohman KK, Case LD, Hu JJ: DNA damage and breast cancer risk. Carcinogenesis 24:883-889 (2003).
46. Speit G, Hartmann A: The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Meth molec Biol 113:203-212 (1999).
47. Speit G, Trenz K, Schutz P, Bendix R, Dork T: Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation in comparison to ataxia telangiectasia heterozygote cells. Cytogenet Cell Genet 91:261-266 (2000).
48. Teare MD, Wallace SA, Harris M, Howell A, Birch JM: Cancer experience in the relatives of an unselected series of breast cancer patients. Br J Cancer 70:102-111 (1994).
49. Terzoudi GI, Jung T, Hain J, Vrouvas J, Margaritis K, Donta-Bakoyianni C, Makropoulos V, Angelakis P, Pantelias GE: Increased G2 chromosomal radiosensitivity in cancer patients: the role of cdk1/cyclin-B activity level in the mechanisms involved. Int J Radiat Biol 76:607-615 (2000).
50. Trenz K, Rothfuss A, Schutz P, Speit G: Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. Mutat Res 500:89-96 (2002).
51. Trenz K, Landgraf J, Speit G: Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. Breast Cancer Res Treat 78:69-79 (2003a).
52. Trenz K, Lugowski S, Jahrsdörfer U, Jainta S, Vogel W, Speit G: Enhanced sensitivity of peripheral blood from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics. Mutat Res 544:279-288 (2003b).
53. Tucker JD, Preston RJ: Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat Res 365:147-159 (1996).
54. Venkitaraman AR: Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J Cell Sci 114:3591-3598 (2001).
55. Venkitaraman AR: Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 108:171-182 (2002).
56. Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev 14:927-939 (2000).
57. Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD, Lee WH: Association of BRCA1 with the Rad50-hMre11-p95 complex and the DNA damage response. Science 285:747-750 (1999).