The N-end rule: Functions, mysteries, uses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 22, 1996, Pages 12142-12149

  Varshavsky, Alexander ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

apoptosis; N degron; peptide import; proteolysis; ubiquitin

Indexed keywords

UBIQUITIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; CONFERENCE PAPER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS REGULATION; SEQUENCE ANALYSIS; TRANSLATION REGULATION;

EUKARYOTA; FUNGI; MAMMALIA;

EID: 0029861143     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.22.12142     Document Type: Article

References (79)

1. Lévy, F., Johnsson, N., Rümenapf, T. & Varshavsky, A. (1996) Proc. Natl. Acad. Sci. USA 93, 4907-4912.
2. Baker, R. T. & Varshavsky, A. (1991) Proc. Natl. Acad. Sci. USA 88, 1090-1094.
3. Murray, A. & Hunt, T. (1993) in The Cell Cycle (Freeman, NY), pp. 60-62.
4. Varshavsky, A. (1991) Cell 64, 13-15.
5. Bachmair, A., Finley, D. & Varshavsky, A. (1986) Science 234, 179-186.
6. Varshavsky, A. (1992) Cell 69, 725-735.
7. Varshavsky, A. (1996) Cold Spring Harbor Symp. Quant. Biol. 60, 461-478.
8. Tobias, J. W., Shrader, T. E., Rocap, G. & Varshavsky, A. (1991) Science 254, 1374-1377.
9. Bachmair, A. & Varshavsky, A. (1989) Cell 56, 1019-1032.
10. Shrader, T. E., Tobias, J. W. & Varshavsky, A. (1993) J. Bacteriol. 175, 4364-4374.
11. Gonda, D. K., Bachmair, A., Wünning, I., Tobias, J. W., Lane, W. S. & Varshavsky, A. (1989) J. Biol. Chem. 264, 16700-16712.
12. Johnson, E. S., Gonda, D. K. & Varshavsky, A. (1990) Nature (London) 346, 287-291.
13. Schatz, G. & Dobberstein, B. (1996) Science 271, 1519-1526.
14. Nishizawa, M., Furuno, N., Okazaki, K., Tanaka, H., Ogawa, Y. & Sagata, N. (1993) EMBO J. 12, 4021-4027.
15. Dohmen, R. J., Wu, P. & Varshavsky, A. (1994) Science 263, 1273-1276.
16. Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D., Gonda, D. K. & Varshavsky, A. (1989) Science 243, 1576-1583.
17. Spence, J., Sadis, S., Haas, A. L. & Finley, D. (1995) Mol. Cell. Biol. 15, 1265-1273.
18. Hershko, A. (1991) Trends Biochem. Sci. 16, 265-268.
19. Jentsch, S. (1992) Annu. Rev. Genet. 26, 179-207.
20. Hochstrasser, M. (1995) Curr. Biol. 7, 215-223.
21. Pahl, H. L. & Baeuerle, P. A. (1996) Curr. Opin. Cell Biol. 8, 340-347.
22. Dohmen, R. J., Madura, K., Bartel, B. & Varshavsky, A. (1991) Proc. Natl. Acad. Sci. USA 88, 7351-7355.
23. Madura, K., Dohmen, R. J. & Varshavsky, A. (1993) J. Biol. Chem. 268, 12046-12054.
24. Rechsteiner, M., Hoffman, L. & Dubiel, W. (1993) J. Biol. Chem. 268, 6065-6068.
25. Hilt, W. & Wolf, D. H. (1996) Trends. Biochem. Sci. 21, 96-102.
26. Varshavsky, A., Byrd, C., Davydov, I. V., Dohmen, R. J., Du, F., et al. (1996) in Ubiquitin and the Biology of the Cell, eds. Finley, D. & Peters, J.-M. (Plenum, New York), in press.
27. Bartel, B., Wünning, I. & Varshavsky, A. (1990) EMBO J. 9, 3179-3189.
28. Reiss, Y., Kaim, D. & Hershko, A. (1988) J. Biol. Chem. 263, 2693-2698.
29. Wolf, S., Lottspeich, F. & Baumeister, W. (1993) FEBS Lett. 326, 42-44.
30. Gottesman, S. & Maurizi, M. R. (1992) Microbiol. Rev. 56, 592-621.
31. Baker, R. T. & Varshavsky, A. (1995) J. Biol. Chem. 270, 12065-12074.
32. Wickner, S., Gottesman, S., Skowyra, D., Hoskins, J., McKenney, K. & Maurizi, M. R. (1994) Proc. Natl. Acad. Sci. USA 91, 12218-12222.
33. Grigoryev, S., Stewart, A. E., Kwon, Y. T., Arfin, S. M., Bradshaw, R. A., Copeland, N. J. & Varshavsky, A. (1996) J. Biol. Chem. 271, in press.
34. Stewart, A. E., Arfin, S. M. & Bradshaw, R. A. (1995) J. Biol. Chem. 270, 25-28.
35. Balzi, E., Choder, M., Chen, W., Varshavsky, A. & Goffeau, A. (1990) J. Biol. Chem. 265, 7464-7471.
36. Dayal, V. K., Chakraborty, G., Sturman, J. A. & Ingoglia, N. A. (1990) Biochim. Biophys. Acta 1038, 172-177.
37. Pickart, C. (1988) in Ubiquitin, ed. Rechsteiner, M. (Plenum, New York), pp. 77-99.
38. Scheffner, M., Nuber, U. & Huibregtse, J. M. (1995) Nature (London) 373, 81-83.
39. Arnason, T. A. & Ellison, M. J. (1994) Mol. Cell. Biol. 14, 7876-7883.
40. Johnson, E. S., Ma, P. C. M., Ota, I. M. & Varshavsky, A. (1995) J. Biol. Chem. 270, 17442-17456.
41. Baboshina, O. V. & Haas, A. L. (1996) J. Biol. Chem. 271, 2832-2831.
42. McGrath, J. P., Jentsch, S. & Varshavsky, A. (1991) EMBO J. 10, 227-237.
43. Negrutskii, B. S. & Deutscher, M. P. (1991) Proc. Natl. Acad. Sci. USA 88, 4991-4995.
44. Knighton, D. R., Kan, C. C., Howland, E., Janson, C. A., Hostomska, Z., Welsh, K. M. & Matthews, D. A. (1994) Nat. Struct. Biol. 1, 186-194.
45. Özkaynak, E., Finley, D., Solomon, M. J. & Varshavsky, A. (1987) EMBO J. 6, 1429-1440.
46. Finley, D., Bartel, B. & Varshavsky, A. (1989) Nature (London) 338, 394-401.
47. Watkins, J. F., Sung, P., Prakash, L. & Prakash, S. (1993) Mol. Cell. Biol. 13, 7757-7765.
48. Li, X. & Chang, Y. H. (1995) Proc. Natl. Acad. Sci. USA 92, 12357-12361.
49. Arfin, S. M. & Bradshaw, S. A. (1988) Biochemistry 27, 7979-7984.
50. Sherman, F., Stewart, J. W. & Tsunasawa, S. (1985) Bioessays 3, 27-31.
51. Sadis, S., Atienza, C. & Finley, D. (1995) Mol. Cell. Biol. 15, 4086-4095.
52. Ghislain, M., Dohmen, R. J., Lévy, F. & Varshavsky, A. (1996) EMBO J., in press.
53. Kaiser, C. A., Preuss, D., Grisafi, P. & Botstein, D. (1987) Science 235, 312-317.
54. Scherer, D. C., Brockman, J. A., Chen, Z. J., Maniatis, T. & Ballard, D. (1995) Proc. Natl. Acad. Sci. USA 92, 11259-11263.
55. Deveraux, Q., Ustrell, V., Pickart, C. & Rechsteiner, M. (1994) J. Biol. Chem. 269, 7059-7061.
56. Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J. & Howley, P. M. (1990) Cell 63, 1129-1136.
57. Johnston, J. A., Johnson, E. S., Waller, P. R. H. & Varshavsky, A. (1995) J. Biol. Chem. 270, 8172-8178.
58. Ota, I. M. & Varshavsky, A. (1992) Proc. Natl. Acad. Sci. USA 89, 2355-2359.
59. Ota, I. M. & Varshavsky, A. (1993) Science 262, 566-569.
60. Maeda, T., Wurgler-Murphy, S. M. & Sato, H. (1994) Nature (London) 369, 242-245.
61. Alagramam, K., Naider, F. & Becker, J. M. (1995) Mol. Microbiol. 15, 225-234.
62. Knight, S. A. B., Tamai, K. T., Kosman, D. J. & Thiele, D. J. (1994) Mol. Cell. Biol. 14, 7792-7804.
63. Ellis, R. E., Yuan, J. & Horvitz, H. R. (1991) Annu. Rev. Cell Biol. 7, 663-698.
64. Aizenman, E., Engelberg-Kulka, H. & Glaser, G. (1996) Proc. Natl. Acad. Sci. USA 93, 6059-6063.
65. Kayalar, C., Örd, T., Testa, M. P., Zhong, L.-T. & Bredesen, D. E. (1996) Proc. Natl. Acad. Sci. USA 93, 2234-2238.
66. Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W. W., Kamen, R., Weichselbaum, R. & Kufe, D. (1995) EMBO J. 14, 6148-6156.
67. Thornberry, N. A., Bull, H. G., Galaycay, J. R., Chapman, K. T., Howard, A. D., et al. (1992) Nature (London) 356, 768-774.
68. Madura, K. & Varshavsky, A. (1994) Science 265, 1454-1458.
69. Levis, M. J. & Bourne, H. R. (1992) J. Cell Biol. 119, 1297-1307.
70. Strauss, J. H. & Strauss, E. G. (1994) Microbiol. Rev. 58, 491-562.
71. deGroot, R. J., Rümenapf, T., Kuhn, R. J., Strauss, E. G. & Strauss, J. H. (1991) Proc. Natl. Acad. Sci. USA 88, 8967-8971.
72. Dougherty, W. G. & Semler, B. L. (1993) Microbiol. Rev. 57, 781-822.
73. Nishizawa, M., Okazaki, K., Furuno, N., Watanabe, N. & Sagata, N. (1992) EMBO J. 11, 2433-2446.
74. Watanabe, N., Hunt, T., Ikawa, Y. & Sagata, N. (1991) Nature (London) 352, 247-248.
75. Wiertz, E. J. H. J., Jones, T. R., Sun, L., Bogyo, M., Geuze, H. J. & Ploegh, H. L. (1996) Cell 84, 769-779.
76. Hiller, M. M., Finger, A., Scheiger, M. & Wolf, D. H. (1996) Science 273, 1725-1728.
77. Park, E. C., Finley, D. & Szostak, J. W. (1992) Proc. Natl. Acad. Sci. USA 89, 1249-1252.
78. Cormack, B. P. & Struhl, K. (1992) Cell 69, 685-694.
79. Varshavsky, A. (1995) Proc. Natl. Acad. Sci. USA 92, 3663-3667.