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Volumn 63, Issue 23, 2003, Pages 8181-8187

Homologous Recombination Deficiency Leads to Profound Genetic Instability in Cells Derived from Xrcc2-Knockout Mice

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN; PROTEIN XRCC2; RAD51 PROTEIN; UNCLASSIFIED DRUG;

EID: 0345734278     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (86)

References (54)
  • 1
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent, D. C., Hoeijmakers, J. H., and Kanaar, R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet., 2: 196-206, 2001.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 2
    • 0032127849 scopus 로고    scopus 로고
    • Role of the human RAD51 protein in homologous recombination and double-stranded-break repair
    • Baumann, P., and West, S. C. Role of the human RAD51 protein in homologous recombination and double-stranded-break repair. Trends Biochem. Sci., 23: 247-251, 1998.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 247-251
    • Baumann, P.1    West, S.C.2
  • 3
    • 0032913521 scopus 로고    scopus 로고
    • A surfeit of RAD51-like genes?
    • Thacker, J. A surfeit of RAD51-like genes? Trends Genet., 15: 166-168, 1999.
    • (1999) Trends Genet. , vol.15 , pp. 166-168
    • Thacker, J.1
  • 5
    • 0035893241 scopus 로고    scopus 로고
    • Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange
    • Sigurdsson, S., Van Komen, S., Bussen, W., Schild, D., Albala, J. S., and Sung, P. Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange. Genes Dev., 15: 3308-3318, 2001.
    • (2001) Genes Dev. , vol.15 , pp. 3308-3318
    • Sigurdsson, S.1    Van Komen, S.2    Bussen, W.3    Schild, D.4    Albala, J.S.5    Sung, P.6
  • 6
    • 0034672057 scopus 로고    scopus 로고
    • Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice
    • Deans, B., Griffin, C. S., Maconochie, M., and Thacker, J. Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. EMBO J., 19: 6675-6685, 2000.
    • (2000) EMBO J. , vol.19 , pp. 6675-6685
    • Deans, B.1    Griffin, C.S.2    Maconochie, M.3    Thacker, J.4
  • 7
    • 0032694294 scopus 로고    scopus 로고
    • The role of homologous recombination processes in the repair of severe forms of DNA damage in mammalian cells
    • Thacker, J. The role of homologous recombination processes in the repair of severe forms of DNA damage in mammalian cells. Biochimie, 81: 77-85, 1999.
    • (1999) Biochimie , vol.81 , pp. 77-85
    • Thacker, J.1
  • 8
    • 0035796042 scopus 로고    scopus 로고
    • Homologous recombinational repair of DNA ensures mammalian chromosome stability
    • Thompson, L. H., and Schild, D. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat. Res., 477: 131-153, 2001.
    • (2001) Mutat. Res. , vol.477 , pp. 131-153
    • Thompson, L.H.1    Schild, D.2
  • 9
    • 0033576687 scopus 로고    scopus 로고
    • The nonbomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
    • Karanjawala, Z. E., Grawunder, U., Hsieh, C. L., and Lieber, M. R. The nonbomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr. Biol., 9: 1501-1504, 1999.
    • (1999) Curr. Biol. , vol.9 , pp. 1501-1504
    • Karanjawala, Z.E.1    Grawunder, U.2    Hsieh, C.L.3    Lieber, M.R.4
  • 11
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    • Ferguson, D. O., Sekiguchi, J. M., Chang, S., Frank, K. M., Gao, Y., DePinho, R. A., and Alt, F. W. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc. Natl. Acad. Sci. USA, 97: 6630-6633, 2000.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6630-6633
    • Ferguson, D.O.1    Sekiguchi, J.M.2    Chang, S.3    Frank, K.M.4    Gao, Y.5    DePinho, R.A.6    Alt, F.W.7
  • 13
    • 0035822641 scopus 로고    scopus 로고
    • Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
    • d'Adda di Fagagna, F., Hande, M. P., Tong, W. M., Roth, D., Lansdorp, P. M., Wang, Z. Q., and Jackson, S. P. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol., 11: 1192-1196, 2001.
    • (2001) Curr. Biol. , vol.11 , pp. 1192-1196
    • D'Adda Di Fagagna, F.1    Hande, M.P.2    Tong, W.M.3    Roth, D.4    Lansdorp, P.M.5    Wang, Z.Q.6    Jackson, S.P.7
  • 14
    • 0033213392 scopus 로고    scopus 로고
    • Brca1 controls homology-directed DNA repair
    • Moynahan, M. E., Chiu, J. W., Koller, B. H., and Jasin, M. Brca1 controls homology-directed DNA repair. Mol. Cell., 4: 511-518, 1999.
    • (1999) Mol. Cell , vol.4 , pp. 511-518
    • Moynahan, M.E.1    Chiu, J.W.2    Koller, B.H.3    Jasin, M.4
  • 15
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan, M. E., Pierce, A. J., and Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell., 7: 263-272, 2001.
    • (2001) Mol. Cell , vol.7 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 16
    • 0035801472 scopus 로고    scopus 로고
    • Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
    • Tutt, A., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C., Thacker, J., and Ashworth, A. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J., 20: 4704-4716, 2001.
    • (2001) EMBO J. , vol.20 , pp. 4704-4716
    • Tutt, A.1    Bertwistle, D.2    Valentine, J.3    Gabriel, A.4    Swift, S.5    Ross, G.6    Griffin, C.7    Thacker, J.8    Ashworth, A.9
  • 17
    • 0035902551 scopus 로고    scopus 로고
    • Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
    • Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z. C., Willers, H., Iliakis, G., and Powell, S. N. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc. Natl. Acad. Sci. USA, 98: 8644-8649, 2001.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8644-8649
    • Xia, F.1    Taghian, D.G.2    DeFrank, J.S.3    Zeng, Z.C.4    Willers, H.5    Iliakis, G.6    Powell, S.N.7
  • 21
    • 0034213735 scopus 로고    scopus 로고
    • Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
    • Yu, V. P., Koehler, M., Steinlein, C., Schmid, M., Hanakahi, L. A., van Gool, A. J., West, S. C., and Venkitaraman, A. R. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev., 14: 1400-1406, 2000.
    • (2000) Genes Dev. , vol.14 , pp. 1400-1406
    • Yu, V.P.1    Koehler, M.2    Steinlein, C.3    Schmid, M.4    Hanakahi, L.A.5    Van Gool, A.J.6    West, S.C.7    Venkitaraman, A.R.8
  • 23
    • 84883840386 scopus 로고
    • Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
    • Todaro, G. J., and Green, H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell. Biol., 17: 299-313, 1963.
    • (1963) J. Cell. Biol. , vol.17 , pp. 299-313
    • Todaro, G.J.1    Green, H.2
  • 25
    • 0029586977 scopus 로고
    • X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter
    • Lee, H., Lee, Y. H., Huh, Y. S., Moon, H., and Yun, Y. X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter. J. Biol. Chem., 270: 31405-31412, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 31405-31412
    • Lee, H.1    Lee, Y.H.2    Huh, Y.S.3    Moon, H.4    Yun, Y.5
  • 26
    • 0033166981 scopus 로고    scopus 로고
    • Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
    • Lee, H., Trainer, A. H., Friedman, L. S., Thistlethwaite, F. C., Evans, M. J., Ponder, B. A., and Venkitaraman, A. R. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2. Mol. Cell., 4: 1-10, 1999.
    • (1999) Mol. Cell , vol.4 , pp. 1-10
    • Lee, H.1    Trainer, A.H.2    Friedman, L.S.3    Thistlethwaite, F.C.4    Evans, M.J.5    Ponder, B.A.6    Venkitaraman, A.R.7
  • 27
    • 0035933877 scopus 로고    scopus 로고
    • XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding
    • O'Regan, P., Wilson, C., Townsend, S., and Thacker, J. XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding. J. Biol. Chem., 276: 22148-22153, 2001.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22148-22153
    • O'Regan, P.1    Wilson, C.2    Townsend, S.3    Thacker, J.4
  • 28
    • 0031853105 scopus 로고    scopus 로고
    • Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISH
    • Griffin, C. S., Hill, M. A., Papworth, D. G., Townsend, K. M., Savage, J. R., and Goodhead, D. T. Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISH. Int. J. Radiat. Biol., 73: 591-598, 1998.
    • (1998) Int. J. Radiat. Biol. , vol.73 , pp. 591-598
    • Griffin, C.S.1    Hill, M.A.2    Papworth, D.G.3    Townsend, K.M.4    Savage, J.R.5    Goodhead, D.T.6
  • 29
    • 0028276217 scopus 로고
    • On the scoring of FISH-"painted" chromosome-type exchange aberrations
    • Savage, J. R., and Simpson, P. On the scoring of FISH-"painted" chromosome-type exchange aberrations. Mutat. Res., 307: 345-353, 1994.
    • (1994) Mutat. Res. , vol.307 , pp. 345-353
    • Savage, J.R.1    Simpson, P.2
  • 30
    • 0034306365 scopus 로고    scopus 로고
    • Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation
    • Griffin, C. S., Simpson, P. J., Wilson, C. R., and Thacker, J. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat. Cell Biol., 2: 757-761, 2000.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 757-761
    • Griffin, C.S.1    Simpson, P.J.2    Wilson, C.R.3    Thacker, J.4
  • 31
    • 0035874894 scopus 로고    scopus 로고
    • Homology-directed DNA repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation
    • Moynahan, M. E., Cui, T. Y., and Jasin, M. Homology-directed DNA repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. Cancer Res., 61: 4842-4850, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 4842-4850
    • Moynahan, M.E.1    Cui, T.Y.2    Jasin, M.3
  • 32
    • 0033569684 scopus 로고    scopus 로고
    • XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    • Pierce, A. J., Johnson, R. D., Thompson, L. H., and Jasin, M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev., 13: 2633-2638, 1999.
    • (1999) Genes Dev. , vol.13 , pp. 2633-2638
    • Pierce, A.J.1    Johnson, R.D.2    Thompson, L.H.3    Jasin, M.4
  • 33
    • 0032999346 scopus 로고    scopus 로고
    • Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
    • Sonoda, E., Sasaki, M. S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M., and Takeda, S. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol., 19: 5166-5169, 1999.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5166-5169
    • Sonoda, E.1    Sasaki, M.S.2    Morrison, C.3    Yamaguchi-Iwai, Y.4    Takata, M.5    Takeda, S.6
  • 35
    • 0026078809 scopus 로고
    • Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irsl
    • Tucker, J. D., Jones, N. J., Allen, N. A., Minkler, J. L., Thompson, L. H., and Carrano, A. V. Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irsl. Mutat. Res., 254: 143-152, 1991.
    • (1991) Mutat. Res. , vol.254 , pp. 143-152
    • Tucker, J.D.1    Jones, N.J.2    Allen, N.A.3    Minkler, J.L.4    Thompson, L.H.5    Carrano, A.V.6
  • 36
    • 0033598437 scopus 로고    scopus 로고
    • Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
    • Johnson, R. D., Liu, N., and Jasin, M. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature (Lond.), 401: 397-399, 1999.
    • (1999) Nature (Lond.) , vol.401 , pp. 397-399
    • Johnson, R.D.1    Liu, N.2    Jasin, M.3
  • 38
    • 0035807079 scopus 로고    scopus 로고
    • Repair of DNA interstrand cross-links
    • Dronkert, M. L., and Kanaar, R. Repair of DNA interstrand cross-links. Mutat. Res., 486: 217-247, 2001.
    • (2001) Mutat. Res. , vol.486 , pp. 217-247
    • Dronkert, M.L.1    Kanaar, R.2
  • 40
    • 0034600975 scopus 로고    scopus 로고
    • Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells
    • Johnson, R. D., and Jasin, M. Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J., 19: 3398-3407, 2000.
    • (2000) EMBO J. , vol.19 , pp. 3398-3407
    • Johnson, R.D.1    Jasin, M.2
  • 41
    • 0036245495 scopus 로고    scopus 로고
    • Segmental duplications and the evolution of the primate genome
    • Samonte, R. V., and Eichler, E. E. Segmental duplications and the evolution of the primate genome. Nat. Rev. Genet., 3: 65-72, 2002.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 65-72
    • Samonte, R.V.1    Eichler, E.E.2
  • 42
    • 0032076660 scopus 로고    scopus 로고
    • Something from nothing: The evolution and utility of satellite repeats
    • Csink, A. K., and Henikoff, S. Something from nothing: the evolution and utility of satellite repeats. Trends Genet., 14: 200-204. 1998.
    • (1998) Trends Genet. , vol.14 , pp. 200-204
    • Csink, A.K.1    Henikoff, S.2
  • 43
    • 0030463946 scopus 로고    scopus 로고
    • Lack of chromosome territoriality in yeast: Promiscuous rejoining of broken chromosome ends
    • Haber, J. E., and Leung, W. Y. Lack of chromosome territoriality in yeast: promiscuous rejoining of broken chromosome ends. Proc. Natl. Acad. Sci. USA, 93: 13949-13954, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13949-13954
    • Haber, J.E.1    Leung, W.Y.2
  • 44
    • 0034621854 scopus 로고    scopus 로고
    • Frequent chromosomal translocations induced by DNA double-strand breaks
    • Richardson, C., and Jasin, M. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature (Lond.), 405: 697-700, 2000.
    • (2000) Nature (Lond.) , vol.405 , pp. 697-700
    • Richardson, C.1    Jasin, M.2
  • 45
    • 0035872477 scopus 로고    scopus 로고
    • Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks
    • Rothkamm, K., Kuhne, M., Jeggo, P. A., and Lobrich, M. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res., 61: 3886-3893, 2001.
    • (2001) Cancer Res. , vol.61 , pp. 3886-3893
    • Rothkamm, K.1    Kuhne, M.2    Jeggo, P.A.3    Lobrich, M.4
  • 46
    • 0037418835 scopus 로고    scopus 로고
    • Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity
    • Takada, S., Kelkar, A., and Theurkauf, W. E. Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity. Cell, 113: 87-99, 2003.
    • (2003) Cell , vol.113 , pp. 87-99
    • Takada, S.1    Kelkar, A.2    Theurkauf, W.E.3
  • 47
    • 0033168376 scopus 로고    scopus 로고
    • DNA recombination: The replication connection
    • Haber, J. E. DNA recombination: the replication connection. Trends Biochem. Sci., 24: 271-275, 1999.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 271-275
    • Haber, J.E.1
  • 48
    • 0032126530 scopus 로고    scopus 로고
    • The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family
    • Cartwright, R., Tambini, C. E., Simpson, P. J., and Thacker, J. The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. Nucleic Acids Res., 26: 3084-3089, 1998.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 3084-3089
    • Cartwright, R.1    Tambini, C.E.2    Simpson, P.J.3    Thacker, J.4
  • 49
    • 0035890321 scopus 로고    scopus 로고
    • Haplo-insufficiency? Let me count the ways
    • Quon, K. C., and Bems, A. Haplo-insufficiency? Let me count the ways. Genes Dev., 15: 2917-2921, 2001.
    • (2001) Genes Dev. , vol.15 , pp. 2917-2921
    • Quon, K.C.1    Bems, A.2


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