Recent developments of structure based β-secretase inhibitors for Alzheimer's disease

Current Topics in Medicinal Chemistry

Volumn 5, Issue 16, 2005, Pages 1609-1622

  Ghosh, Aurn K ^a   Kumaragurubaran, Nagaswamy ^a   Tang, Jordan ^b  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

amyloid precursor protein; Secretase; Alzheimer's disease; Amyloid peptide; Aspartyl protease inhibitors; BACE 1; Drug development; Memapsin 2; Neurodegenerative disease

Indexed keywords

AMIDE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; BETA SECRETASE INHIBITOR; ETHYLAMINE; KMI 008; OM 00 3; OM 99 1; OM 99 2; PEPSTATIN; PEPTIDE DERIVATIVE; PROTEINASE INHIBITOR; STATINE DERIVATIVE; TK 13; TK 14; TK 15; TK 16; TK 17; TK 18; TK 19; TK 20; TK 21; TK 3; UNCLASSIFIED DRUG; URETHAN DERIVATIVE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR WEIGHT; REVIEW; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33645091918     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802605775009711     Document Type: Review

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