KMI-008, a novel β-Secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-State mimic: Design and synthesis of substrate-based octapeptides

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 24, 2003, Pages 4273-4276

  Shuto, Daisuke ^a   Kasai, Soko ^a   Kimura, Tooru ^a   Liu, Ping ^a   Hidaka, Koushi ^a   Hamada, Takashi ^a   Shibakawa, Saeko ^a   Hayashi, Yoshio ^a   Hattori, Chinatsu ^b   Szabo, Beata ^b   Ishiura, Shoichi ^b   Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE INHIBITOR; ENZYME INHIBITOR; KMI 008; OCTAPEPTIDE; PHENYLNORSTATINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0344927114     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.09.053     Document Type: Article

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