메뉴 건너뛰기




Volumn 61, Issue 1, 2006, Pages 3-14

Regulatory T cells: Which role in the pathogenesis and treatment allergic disorders?

Author keywords

Allergy; Th1; Th2; Treg

Indexed keywords

ALLERGEN; ANTIALLERGIC AGENT; CPG OLIGODEOXYNUCLEOTIDE; IMIDAZOQUINOLINE DERIVATIVE; PEPTIDE; RECOMBINANT INTERLEUKIN 10; RECOMBINANT LYMPHOTOXIN;

EID: 33644929566     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2006.01005.x     Document Type: Review
Times cited : (89)

References (84)
  • 1
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S Sakaguchi N Asano M Itoh M Toda M Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 1995 155 1151 1164
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 2
    • 0036597371 scopus 로고    scopus 로고
    • CD4+CD25+ suppressor T cells: Many questions than answers
    • Shevach EM CD4+CD25+ suppressor T cells: many questions than answers Annu Rev Immunol 2002 2 389 400
    • (2002) Annu Rev Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 3
    • 0037364804 scopus 로고    scopus 로고
    • Natural vs adaptive regulatory T cells
    • Bluestone JA Abbas AK Natural vs adaptive regulatory T cells Nat Rev Immunol 2003 3 253 257
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 4
    • 10744226674 scopus 로고    scopus 로고
    • Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    • Cosmi L Liotta F Lazzeri E Francalanci M Angeli R Mazzinghi B et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes Blood 2003 102 4107 4114
    • (2003) Blood , vol.102 , pp. 4107-4114
    • Cosmi, L.1    Liotta, F.2    Lazzeri, E.3    Francalanci, M.4    Angeli, R.5    Mazzinghi, B.6
  • 5
    • 21244433093 scopus 로고    scopus 로고
    • Peripheral CD8(+)CD25(+) T lymphocytes from MHC class II-deficient mice exhibit regulatory activity
    • Bienvenu B Martin B Auffray C Cordier C Becourt C Lucas B Peripheral CD8(+)CD25(+) T lymphocytes from MHC class II-deficient mice exhibit regulatory activity J Immunol 2005 175 246 253
    • (2005) J Immunol , vol.175 , pp. 246-253
    • Bienvenu, B.1    Martin, B.2    Auffray, C.3    Cordier, C.4    Becourt, C.5    Lucas, B.6
  • 6
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y Kuchroo VK Inobe J Hafler DA Weiner HL Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis Science 1994 265 1237 1240
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 8
    • 18144366988 scopus 로고    scopus 로고
    • Functional analysis of highly defined, FACS isolated populations of human regulatory CD4+CD25+ T cells
    • Baecher-Allen C Wolf E Hafler DA Functional analysis of highly defined, FACS isolated populations of human regulatory CD4+CD25+ T cells Clin Immunol 2005 115 10 18
    • (2005) Clin Immunol , vol.115 , pp. 10-18
    • Baecher-Allen, C.1    Wolf, E.2    Hafler, D.A.3
  • 9
    • 0037026003 scopus 로고    scopus 로고
    • Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    • Annunziato F Cosmi L Liotta F Lazzeri E Manetti R Vanini V et al. Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes J Exp Med 2002 196 379 387
    • (2002) J Exp Med , vol.196 , pp. 379-387
    • Annunziato, F.1    Cosmi, L.2    Liotta, F.3    Lazzeri, E.4    Manetti, R.5    Vanini, V.6
  • 10
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read S Malmstrom V Powrie F Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 2000 192 295 302
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 11
    • 1642379813 scopus 로고    scopus 로고
    • GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations
    • Ronchetti S Zollo O Bruscoli S Agostini M Bianchini R Nocentini G et al. GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations Eur J Immunol 2004 34 613 622
    • (2004) Eur J Immunol , vol.34 , pp. 613-622
    • Ronchetti, S.1    Zollo, O.2    Bruscoli, S.3    Agostini, M.4    Bianchini, R.5    Nocentini, G.6
  • 13
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S Nomura T Sakaguchi S Control of regulatory T cell development by the transcription factor Foxp3 Science 2003 299 1057 1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 14
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila TA Blaeser F Ho N Lederman HM Voulgaropoulos C Helms C et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome J Clin Invest 2000 106 R75 R81
    • (2000) J Clin Invest , vol.106
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3    Lederman, H.M.4    Voulgaropoulos, C.5    Helms, C.6
  • 15
    • 0026178213 scopus 로고
    • X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
    • Godfrey VL Wilkinson JE Russell LB X-linked lymphoreticular disease in the scurfy (sf) mutant mouse Am J Pathol 1991 138 1379 1387
    • (1991) Am J Pathol , vol.138 , pp. 1379-1387
    • Godfrey, V.L.1    Wilkinson, J.E.2    Russell, L.B.3
  • 16
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of Foxp3
    • Bennett CL Christie J Ramsdell F Brunkow ME Ferguson PJ Whiteself L et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of Foxp3 Nat Genet 2001 27 20 21
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whiteself, L.6
  • 20
    • 0035554674 scopus 로고    scopus 로고
    • T cell regulation: A special job or everyone's responsibility
    • Stockinger B Barthlott T Katassis G T cell regulation: a special job or everyone's responsibility Nat Immunol 2001 2 757 758
    • (2001) Nat Immunol , vol.2 , pp. 757-758
    • Stockinger, B.1    Barthlott, T.2    Katassis, G.3
  • 21
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD Gavin MA Rudensky AY Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 2003 4 330 336
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 22
    • 12844274909 scopus 로고    scopus 로고
    • Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    • Levings MK Gregori S Tresoldi E Cazzaniga S Bonini C Roncarolo MG Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells Blood 2005 105 1162 1169
    • (2005) Blood , vol.105 , pp. 1162-1169
    • Levings, M.K.1    Gregori, S.2    Tresoldi, E.3    Cazzaniga, S.4    Bonini, C.5    Roncarolo, M.G.6
  • 23
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4+ CD25+ regulatory T cells is mediated by surface-bound transforming growth factor β
    • Nakamura K Kitani A Strober W Cell contact-dependent immunosuppression by CD4+ CD25+ regulatory T cells is mediated by surface-bound transforming growth factor β J Exp Med 2001 194 629 644
    • (2001) J Exp Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 24
    • 11144354531 scopus 로고    scopus 로고
    • Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
    • Cosmi L Liotta F Angeli R Mazzinghi B Santarlasci V Manetti R et al. Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines Blood 2004 103 3117 3121
    • (2004) Blood , vol.103 , pp. 3117-3121
    • Cosmi, L.1    Liotta, F.2    Angeli, R.3    Mazzinghi, B.4    Santarlasci, V.5    Manetti, R.6
  • 25
    • 0037099613 scopus 로고    scopus 로고
    • CD4+CD25+ T cells can mediate suppressor function in the absence of transforming growth factor-β1production and responsiveness
    • Piccirillo CA Letterio JJ Thornton AM McHugh RS Mamura M Mizuhara H et al. CD4+CD25+ T cells can mediate suppressor function in the absence of transforming growth factor-β1production and responsiveness J Exp Med 2002 196 237 245
    • (2002) J Exp Med , vol.196 , pp. 237-245
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3    McHugh, R.S.4    Mamura, M.5    Mizuhara, H.6
  • 26
    • 0037379654 scopus 로고    scopus 로고
    • TGF-β: The missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression
    • Chen W Wahl SM TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression Cytokine Growth Factor Rev 2003 14 85 89
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 85-89
    • Chen, W.1    Wahl, S.M.2
  • 27
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+ CD25+ cells educate CD4+ CD25- cells to develop suppressive activity: The role of IL-2, TGF-β, and IL-10
    • Zheng SG Wang JH Gray JD Soucier H Horwitz DA Natural and induced CD4+ CD25+ cells educate CD4+ CD25- cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10 J Immunol 2004 172 5213 5221
    • (2004) J Immunol , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 28
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-β escape control by CD4+ CD25+ regulatory T cells
    • Fahlen L Read S Gorelik L Hurst SD Coffman RL Flavell RA et al. T cells that cannot respond to TGF-β escape control by CD4+ CD25+ regulatory T cells J Exp Med 2005 201 737 746
    • (2005) J Exp Med , vol.201 , pp. 737-746
    • Fahlen, L.1    Read, S.2    Gorelik, L.3    Hurst, S.D.4    Coffman, R.L.5    Flavell, R.A.6
  • 29
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD2- naïve T cells to CD4+CD25+ regulatory T cells bt TGF-b induction of transcription factor Foxp3
    • Chen W Jin W Hardegen N Lei K-J Li L Marinos N et al. Conversion of peripheral CD4+CD2- naïve T cells to CD4+CD25+ regulatory T cells bt TGF-b induction of transcription factor Foxp3 J Exp Med 2003 198 1875 1886
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.-J.4    Li, L.5    Marinos, N.6
  • 30
    • 4744356110 scopus 로고    scopus 로고
    • Tgf-b induces Foxp3+ T-regulatory cells from naive CD4+CD25+ precursors
    • Fu S Zhang N Yopp AC Chen D Mao M Chen D et al. Tgf-b induces Foxp3+ T-regulatory cells from naive CD4+CD25+ precursors Am J Transplant 2004 4 1614 1627
    • (2004) Am J Transplant , vol.4 , pp. 1614-1627
    • Fu, S.1    Zhang, N.2    Yopp, A.C.3    Chen, D.4    Mao, M.5    Chen, D.6
  • 31
    • 9144219649 scopus 로고    scopus 로고
    • TGF-β signalling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+ CD25+ T cells
    • Huber S Schramm C Lehr HA Mann A Schmitt S Becker C et al. TGF-β signalling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+ CD25+ T cells J Immunol 2004 173 6526 6531
    • (2004) J Immunol , vol.173 , pp. 6526-6531
    • Huber, S.1    Schramm, C.2    Lehr, H.A.3    Mann, A.4    Schmitt, S.5    Becker, C.6
  • 32
    • 17144400393 scopus 로고    scopus 로고
    • TGFβ1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • Marie JC Letterio JJ Gavin M Rudensky AY TGFβ1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells J Exp Med 2005 201 1061 1067
    • (2005) J Exp Med , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 33
    • 0022465625 scopus 로고
    • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl JH Wakefield LM Roberts AB Jakowlew S Alvarez-Mon M Derynck R et al. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth J Exp Med 1986 163 1037 1050
    • (1986) J Exp Med , vol.163 , pp. 1037-1050
    • Kehrl, J.H.1    Wakefield, L.M.2    Roberts, A.B.3    Jakowlew, S.4    Alvarez-Mon, M.5    Derynck, R.6
  • 34
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massague J TGF-β signal transduction Annu Rev Biochem 1998 67 753 791
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 35
    • 0036006811 scopus 로고    scopus 로고
    • The ever-increasing complexity of TGF-b signalling
    • Roberts AB The ever-increasing complexity of TGF-b signalling Cytokine Growth Factor Rev 2002 13 3 5
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 3-5
    • Roberts, A.B.1
  • 36
    • 17444414236 scopus 로고    scopus 로고
    • GITR: A multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily
    • Nocentini G Riccardi C GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily Eur J Immunol 2005 35 1016 1022
    • (2005) Eur J Immunol , vol.35 , pp. 1016-1022
    • Nocentini, G.1    Riccardi, C.2
  • 38
    • 0030069074 scopus 로고    scopus 로고
    • Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes
    • Kanangat S Blair P Reddy R Daheshia M Godfrey V Rouse BT et al. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes Eur J Immunol 1996 26 161 165
    • (1996) Eur J Immunol , vol.26 , pp. 161-165
    • Kanangat, S.1    Blair, P.2    Reddy, R.3    Daheshia, M.4    Godfrey, V.5    Rouse, B.T.6
  • 39
    • 1342308180 scopus 로고    scopus 로고
    • Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation in atopic status and expression of allergic disease
    • Ling EM Smith T Nguyen XD Pridgein C Dallman M Arbery J et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation in atopic status and expression of allergic disease Lancet 2004 363 608 615
    • (2004) Lancet , vol.363 , pp. 608-615
    • Ling, E.M.1    Smith, T.2    Nguyen, X.D.3    Pridgein, C.4    Dallman, M.5    Arbery, J.6
  • 40
    • 2942685507 scopus 로고    scopus 로고
    • Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    • Akdis M Verhagen J Taylor A Karamloo F Karagiannidis C Crameri R et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells J Exp Med 2004 199 1567 1575
    • (2004) J Exp Med , vol.199 , pp. 1567-1575
    • Akdis, M.1    Verhagen, J.2    Taylor, A.3    Karamloo, F.4    Karagiannidis, C.5    Crameri, R.6
  • 41
    • 3042594506 scopus 로고    scopus 로고
    • Allergen-responsive CD+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    • Karlsson MR Rugtveit J Brandtzaeg P Allergen-responsive CD+CD25+ regulatory T cells in children who have outgrown cow's milk allergy J Exp Med 2004 199 1679 1688
    • (2004) J Exp Med , vol.199 , pp. 1679-1688
    • Karlsson, M.R.1    Rugtveit, J.2    Brandtzaeg, P.3
  • 42
    • 0344177206 scopus 로고    scopus 로고
    • Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts
    • Turcanu V Maleki SJ Lack G Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts J Clin Invest 2003 111 1065 1072
    • (2003) J Clin Invest , vol.111 , pp. 1065-1072
    • Turcanu, V.1    Maleki, S.J.2    Lack, G.3
  • 46
    • 0024417450 scopus 로고
    • Hay fever, hygiene and household size
    • Strachan DP Hay fever, hygiene and household size Br Med J 1989 299 1259 1260
    • (1989) Br Med J , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 47
    • 0037136585 scopus 로고    scopus 로고
    • Environmental exposure to endotoxin and its relation to asthma in school-age children
    • Braun-Fahrlander C Riedler J Herz U Eder W Waswer M Grize L et al. Environmental exposure to endotoxin and its relation to asthma in school-age children N Engl J Med 2002 347 869 877
    • (2002) N Engl J Med , vol.347 , pp. 869-877
    • Braun-Fahrlander, C.1    Riedler, J.2    Herz, U.3    Eder, W.4    Waswer, M.5    Grize, L.6
  • 48
    • 1542511733 scopus 로고    scopus 로고
    • Immunologic influences on allergy and the TH1/TH2 balance
    • Romagnani S Immunologic influences on allergy and the TH1/TH2 balance J Allergy Clin Immunol 2004 113 395 400
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 395-400
    • Romagnani, S.1
  • 49
    • 0037134046 scopus 로고    scopus 로고
    • Allergy, parasites, and the hygiene hypothesis
    • Yazdanbakhah M Kremsner PG van Ree R Allergy, parasites, and the hygiene hypothesis Science 2002 296 490 494
    • (2002) Science , vol.296 , pp. 490-494
    • Yazdanbakhah, M.1    Kremsner, P.G.2    Van Ree, R.3
  • 50
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF The effect of infections on susceptibility to autoimmune and allergic diseases N Engl J Med 2002 347 911 920
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 51
    • 3042798442 scopus 로고    scopus 로고
    • The increased prevalence of allergy and the hygiene hypothesis: Missing immune deviation, reduced immune suppression, or both
    • Romagnani S The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both Immunology 2004 112 352 363
    • (2004) Immunology , vol.112 , pp. 352-363
    • Romagnani, S.1
  • 52
    • 11844276029 scopus 로고    scopus 로고
    • Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune response
    • Revets H Pynaert G Grooten J De Baetselier P Lipoprotein I, a TLR2/4 ligand modulates Th2-driven allergic immune response J Immunol 2005 174 1097 1103
    • (2005) J Immunol , vol.174 , pp. 1097-1103
    • Revets, H.1    Pynaert, G.2    Grooten, J.3    De Baetselier, P.4
  • 53
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune response
    • Mazmanian SK Liu CH Tzianabos AO Kasper DL An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune response Cell 2005 122 107 118
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 55
    • 23244443617 scopus 로고    scopus 로고
    • IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells
    • King IL Segal BM IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells J Immunol 2005 175 641 645
    • (2005) J Immunol , vol.175 , pp. 641-645
    • King, I.L.1    Segal, B.M.2
  • 56
    • 9244223651 scopus 로고    scopus 로고
    • Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
    • Stock P Akbari O Berry G Freeman GJ DeKruyff RH Umetsu DT Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity Nat Immunol 2004 5 1149 1156
    • (2004) Nat Immunol , vol.5 , pp. 1149-1156
    • Stock, P.1    Akbari, O.2    Berry, G.3    Freeman, G.J.4    Dekruyff, R.H.5    Umetsu, D.T.6
  • 57
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti R Parronchi P Giudizi MG Piccinni MP Maggi E Trinchieri G et al. Natural killer cell stimulatory factor (interleukin-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells J Exp Med 1993 177 1199 1204
    • (1993) J Exp Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6
  • 58
    • 0026507228 scopus 로고
    • Reciprocal regulatory role of IFN-g and IL-4 on the in vitro development of human Th1 and Th2 cells
    • Maggi E Parronchi P Manetti R Simonelli C Piccinni MP Rugiu FS et al. Reciprocal regulatory role of IFN-g and IL-4 on the in vitro development of human Th1 and Th2 cells J Immunol 1992 148 2142 2147
    • (1992) J Immunol , vol.148 , pp. 2142-2147
    • Maggi, E.1    Parronchi, P.2    Manetti, R.3    Simonelli, C.4    Piccinni, M.P.5    Rugiu, F.S.6
  • 59
    • 0026700113 scopus 로고
    • IL-4 and IFN(s) (alpha and gamma) exhibit opposite regulatory effects on the development of cytolytic potential by TH1 or TH2 human T cell clones
    • Parronchi P De Carli M Manetti R Simonelli C Sampognaro S Piccinni MP et al. IL-4 and IFN(s) (alpha and gamma) exhibit opposite regulatory effects on the development of cytolytic potential by TH1 or TH2 human T cell clones J Immunol 1992 149 2977 2982
    • (1992) J Immunol , vol.149 , pp. 2977-2982
    • Parronchi, P.1    De Carli, M.2    Manetti, R.3    Simonelli, C.4    Sampognaro, S.5    Piccinni, M.P.6
  • 60
    • 0029089972 scopus 로고    scopus 로고
    • Polyinosinic acid:polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12
    • Manetti R Annunziato F Tomasevic L Gianno V Parronchi P Romagnani S et al. Polyinosinic acid:polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12 Eur J Immunol 1999 25 2656 2660
    • (1999) Eur J Immunol , vol.25 , pp. 2656-2660
    • Manetti, R.1    Annunziato, F.2    Tomasevic, L.3    Gianno, V.4    Parronchi, P.5    Romagnani, S.6
  • 61
    • 0033485399 scopus 로고    scopus 로고
    • Phosphorothioate oligodeoxynucletides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors
    • Parronchi P Brugnolo F Annunziato F Manuelli C Sampognaro S Mavilia C et al. Phosphorothioate oligodeoxynucletides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors J Immunol 1999 163 5946 5953
    • (1999) J Immunol , vol.163 , pp. 5946-5953
    • Parronchi, P.1    Brugnolo, F.2    Annunziato, F.3    Manuelli, C.4    Sampognaro, S.5    Mavilia, C.6
  • 62
    • 0037323845 scopus 로고    scopus 로고
    • The novel synthetic immune response modifier R-848 (Resiquimod) has a powerful effect on the in vitro switching of human allergen-specific CD4+ Th2 lymphocytes into IFN-γ-producing cells
    • Brugnolo F Sampognaro S Fintoni T Cosmi L Annunziato F Manuelli C et al. The novel synthetic immune response modifier R-848 (Resiquimod) has a powerful effect on the in vitro switching of human allergen-specific CD4+ Th2 lymphocytes into IFN-γ-producing cells J Allergy Clin Immunol 2003 111 380 388
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 380-388
    • Brugnolo, F.1    Sampognaro, S.2    Fintoni, T.3    Cosmi, L.4    Annunziato, F.5    Manuelli, C.6
  • 64
    • 17844371968 scopus 로고    scopus 로고
    • Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy
    • Marshall JD Abtahi S Eiden JJ Tuck S Milley R Haycock F et al. Immunostimulatory sequence DNA linked to the Amb a 1 allergen promotes T(H)1 cytokine expression while downregulating T(H)2 cytokine expression in PBMCs from human patients with ragweed allergy J Allergy Clin Immunol 2001 108 191 197
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 191-197
    • Marshall, J.D.1    Abtahi, S.2    Eiden, J.J.3    Tuck, S.4    Milley, R.5    Haycock, F.6
  • 65
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman DM Immunotherapeutic uses of CpG oligodeoxynucleotides Nat Rev Immunol 2004 4 1 10
    • (2004) Nat Rev Immunol , vol.4 , pp. 1-10
    • Klinman, D.M.1
  • 66
    • 0343953087 scopus 로고    scopus 로고
    • Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity
    • Tighe H Takabayashi K Schwartz D Van Nest G Tuck S Eiden JJ et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity J Allergy Clin Immunol 2000 106 124 134
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 124-134
    • Tighe, H.1    Takabayashi, K.2    Schwartz, D.3    Van Nest, G.4    Tuck, S.5    Eiden, J.J.6
  • 68
    • 3042718066 scopus 로고    scopus 로고
    • Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA
    • Simons FE Shikishima Y Van Nest G Eiden JJ HayGlass KT Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA J Allergy Clin Immunol 2004 113 1144 1151
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1144-1151
    • Simons, F.E.1    Shikishima, Y.2    Van Nest, G.3    Eiden, J.J.4    Hayglass, K.T.5
  • 69
    • 17844370271 scopus 로고    scopus 로고
    • Immmunostimulatory oligonucleotides in therapy of allergic diseases
    • Lazarczyk M Grzela K Grzela T Immmunostimulatory oligonucleotides in therapy of allergic diseases Expert Opin Biol Ther 2005 5 525 536
    • (2005) Expert Opin Biol Ther , vol.5 , pp. 525-536
    • Lazarczyk, M.1    Grzela, K.2    Grzela, T.3
  • 70
  • 71
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human disease
    • Blobe GC Schiemann WP Lodish HF Role of transforming growth factor β in human disease N Engl J Med 2000 342 1350 1358
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 73
    • 17144405680 scopus 로고    scopus 로고
    • Potential role of interleukin-10 secreting regulatory T cells in allergy and asthma
    • Hawylowicz CM O'Garra A Potential role of interleukin-10 secreting regulatory T cells in allergy and asthma Nat Rev Immunol 2005 5 271 283
    • (2005) Nat Rev Immunol , vol.5 , pp. 271-283
    • Hawylowicz, C.M.1    O'Garra, A.2
  • 75
    • 0038283161 scopus 로고    scopus 로고
    • Interleukin-10 therapy - Review of a new approach
    • Asadullah K Sterry W Volk HD Interleukin-10 therapy - review of a new approach Pharmacol Rev 2003 55 241 269
    • (2003) Pharmacol Rev , vol.55 , pp. 241-269
    • Asadullah, K.1    Sterry, W.2    Volk, H.D.3
  • 77
    • 0033846725 scopus 로고    scopus 로고
    • Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production
    • Richards DF Fernandez M Caulfield J Hawrylowicz CM Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production Eur J Immunol 2000 30 2344 2354
    • (2000) Eur J Immunol , vol.30 , pp. 2344-2354
    • Richards, D.F.1    Fernandez, M.2    Caulfield, J.3    Hawrylowicz, C.M.4
  • 78
    • 17144419991 scopus 로고    scopus 로고
    • Correction of the defect in glucocorticoid-induced IL-10 synthesis in T cells from glucocorticoid resistant asthmatic patients
    • Hawrylowicz C Correction of the defect in glucocorticoid-induced IL-10 synthesis in T cells from glucocorticoid resistant asthmatic patients J Allergy Clin Immunol 2004 113 Suppl. A735
    • (2004) J Allergy Clin Immunol , vol.113 , Issue.SUPPL. , pp. 735
    • Hawrylowicz, C.1
  • 79
    • 0038730917 scopus 로고    scopus 로고
    • Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial
    • Kalliomaki M Salminen S Poussa T Avilommi H Isolauri E Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial Lancet 2003 361 1869 1871
    • (2003) Lancet , vol.361 , pp. 1869-1871
    • Kalliomaki, M.1    Salminen, S.2    Poussa, T.3    Avilommi, H.4    Isolauri, E.5
  • 80
    • 0036278230 scopus 로고    scopus 로고
    • Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells
    • Zuani-Amorim C Sawicka E Manlius C Le Moine A Brunet LR Kemeny DM et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells Nat Med 2002 8 625 629
    • (2002) Nat Med , vol.8 , pp. 625-629
    • Zuani-Amorim, C.1    Sawicka, E.2    Manlius, C.3    Le Moine, A.4    Brunet, L.R.5    Kemeny, D.M.6
  • 82
    • 22644443548 scopus 로고    scopus 로고
    • Mucosal immunity and allergic responses: Lack of regulation and/or lack of microbial stimulation
    • Prioult G Nagler-Anderson C Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation Immunol Rev 2005 206 204 218
    • (2005) Immunol Rev , vol.206 , pp. 204-218
    • Prioult, G.1    Nagler-Anderson, C.2
  • 83
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche M Wraith DC Peptide-based therapeutic vaccines for allergic and autoimmune diseases Nat Med 2005 11 569 576
    • (2005) Nat Med , vol.11 , pp. 569-576
    • Larche, M.1    Wraith, D.C.2
  • 84
    • 0037031090 scopus 로고    scopus 로고
    • Effects of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial
    • Oldfield WL Larche M Kay AB Effects of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial Lancet 2002 360 47 53
    • (2002) Lancet , vol.360 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.