Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicity and reduces its allergenicity

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 1 I, 2000, Pages 124-134

  Tighe, Helen ^a   Takabayashi, Kenji ^a   Schwartz, David ^c   Van Nest, Gary ^c   Tuck, Stephen ^c   Eiden, Joseph J ^c   Kagey Sobotka, Anne ^d   Creticos, Peter S ^d   Lichtenstein, Lawrence M ^d   Spiegelberg, Hans L ^b   Raz, Eyal ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Dynavax Technologies Corporation   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Allergen ISS conjugate; Basophil histamine release; CpG motifs; Immunostimulatory DNA sequence; Immunotherapy; Ragweed allergy

Indexed keywords

ALUMINUM POTASSIUM SULFATE; DNA; GAMMA INTERFERON; HISTAMINE; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 5; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; RAGWEED ANTIGEN;

ALLERGENICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BASOPHIL; CONJUGATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DNA SEQUENCE; DRUG MIXTURE; FEMALE; HISTAMINE RELEASE; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOSTIMULATION; IMMUNOTHERAPY; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPLEEN CELL; TH1 CELL; TH2 CELL;

EID: 0343953087     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.107927     Document Type: Article

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