Glucocorticoids drive human CD8+ T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production

European Journal of Immunology

Volumn 30, Issue 8, 2000, Pages 2344-2354

  Luko, Chantal Masungi ^a   Vansanten, Georgette ^a   Ryelandt, Marion ^a   Denis, Olivier ^b   Wuilmart, Christian ^a   Andris, Fabienne ^a   Van Acker, Annette ^a   Brait, Maryse ^a   Cloquet, Jean Philippe ^a   Ismaili, Naima ^c   Nisol, Francoise ^b   Latinne, Dominique ^b   Brown, Alan ^d   Leo, Oberdan ^a   Bazin, Hervé ^b   Urbain, Jacques ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c Université de Bruxelles   (Belgium)

^d KANSAS STATE UNIVERSITY   (United States)

Author keywords

CD8; Glucocorticoid; IL 10

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; DEXAMETHASONE; FEMALE; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-10; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033846725     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2000)30:8<2344::AID-IMMU2344>3.0.CO;2-7     Document Type: Article

References (44)

1. Role of T cells in asthma
2. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
3. + T cells can be primed in vitro to produce IL-4
4. Generation of polarized antigen-specific CD8 effector populations: Reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
5. - T cells into subpopulations with distinct cytokine profiles
6. - T helper type 2 cells
7. + T cells can switch to interleukin-5 production and induce airway eosinophilia
8. + T cells in atopic disease
9. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression
10. + subsets
11. + lymphocytes
12. + lymphocytes by inhibiting IL-12 production
13. A cellular abnormality in glucocorticoid resistant asthma
14. + T lymphocyte is a site of steroid resistance in asthma
15. Cytokines induce the development of functionally heterogeneous T helper cell subsets
16. The immunology of exceptional individuals: The lesson of centenarians
17. Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines
18. + T cells
19. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen- presenting capacity of monocytes via down-regulation of class II MHC expression
20. Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid resistant asthma
21. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa
22. Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen induced rhinitis
23. Contrasting effects of glucocorticolds on the capacity of T cells to produce the growth factors interleukin-2 and interleukin-4
24. + T cells in vitro
25. Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells
26. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production
27. Up-regulation of HLA class II, but not ICAM-1, by GM-CSF or IL-3 in synergy with dexamethasone
28. Antiproliferative effect of IFN-gamma in immune regulation III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma
29. Immunomodulatory properties of interferon-gamma. An update
30. +T cell subset inhibits antigen-specific T cell responses and prevents colitis
31. + T cells
32. Interleukin-10 regulation in normal subjects and patients with asthma
33. Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: Effect of timing of recombinant human IL-10 administration
34. Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group
35. IL-10 as a therapeutic strategy in the treatment of rheumatoid arthritis
36. Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients
37. Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse
38. Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro
39. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1α, granulocyte-macrophage colony stimulating factor, and interferon-γ release from alveolar macrophages in asthma
40. Role of interleukin-10 in specific immunotherapy
41. Control of immune pathology by regulatory T cells
42. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-betal-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
43. + T cells
44. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction