Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion

American Journal of Pathology

Volumn 151, Issue 5, 1997, Pages 1257-1263

  Bielawska, Alicja E ^a   Shapiro, John P ^c   Jiang, Li ^c   Melkonyan, Hovsep S ^c   Piot, Christophe ^b   Wolfe, Christopher L ^b   Tomei, L David ^c   Hannun, Yusuf A ^a   Umansky, Samuil R ^c  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LXR Biotechnology Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CORONARY ARTERY OBSTRUCTION; ELECTROPHORESIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; LEFT CORONARY ARTERY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CERAMIDES; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOSINE;

EID: 0030698045     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL: Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 1994, 94:1621-1628
2. Umansky SR, Cuenco GM, Khutzian SS, Barr PJ, Tomei LD: Postischemic apoptotic death of rat neonatal cardiomyocytes. Cell Death Differ 1995, 2:235-241
3. Umansky SR, Pisarenko OI, Serebryakova LI, Studneva IM, Tskitishvili OV, Khutsian SS, Sukhova TI, Lichtenstein AV, Ossina NK, Kiefer MC, Tomei LD: Dog cardiomyocyte death induced in vivo by ischemia and reperfusion. Basic Appl Myol 1996, 6:227-235
4. Itoh G, Tamura J, Suzuki M, Suzuki Y, Ikeda H, Koike M, Nomura M, Jie T, Ito K: DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis. Am J Pathol 1995, 146:1325-1331
5. Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer AM: Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci USA 1995, 92:8031-8035
6. Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S, Reed JC, Olivetti G, Anversa P: Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 1996, 74:86-107
7. Fliss H, Gattinger D: Apoptosis in ischemic and reperfused rat myocardium. Circ Res 1996, 79:949-956
8. Saraste A, Pulkki K, Kallajoki M, Henriksen K, Parvinen M, Voipo-Pulkki LM: Apoptosis in human acute myocardial infarction. Circulation 1997, 95:320-323
9. Boyle EM Jr, Pohlman TH, Cornejo CJ, Verrier ED: Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion. Ann Thorac Surg 1996, 62:1868-1875
10. Karmazyn M: Ischemic and reperfusion injury in the heart: cellular mechanisms and pharmacological interventions. Can J Physiol Pharmacol 1991, 69:719-730
11. Fox KAA: Reperfusion injury: laboratory phenomenon or clinical reality? Cardiovasc Res 1992, 26:656-659
12. Korsmeyer SJ, Yin XM, Oltvai ZN, Veis-Novack DJ, Linette GP: Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. Biochim Biophys Acta 1995, 1271:63-66
13. Payne CM, Bernstein C, Bernstein H: Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal-transduction pathways. Leuk Lymphoma 1995, 19:43-93
14. Slater AF, Stefan C, Nobel I, van den Dobbelsteen DJ, Orrenius S: Signaling mechanisms and oxidative stress in apoptosis. Toxicol Lett 1995, 82-83:149-153
15. Dbaibo GS, Obeid LM, Hannun YA: Tumor necrosis factor -α (TNF-α) signal transduction through ceramide. J Biol Chem 1993, 268:17762-17766
16. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A, Testi R: Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 1993, 177:1547-1552
17. Kolesnick R, Golde DW: The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 1994, 77:325-328
18. Tepper CG, Jayadev S, Liu B, Bielawska A, Wolff R, Yonehara S Hannun YA, Seldin MF: Role of ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci USA 1995, 92:8443-8447
19. Haimovitz-Friedman A, Kan CC, Ehleiter D, Persaud RS, McLoughlin M, Fuks Z, Kolesnick RN: Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J Exp Med 1994, 180:525-535
20. Esteve P, del Peso L, Lacal JC: Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals: ceramides function as a progression factor for apoptosis. Oncogene 1995, 11:2657-2665
21. Jayadev S, Liu B, Bielawska AE, Lee JY, Nazaire F, Pushkareva MY, Obeid LM, Hannun YA: Role for ceramide in cell cycle arrest. J Biol Chem 1995, 270:2047-2052
22. Hannun YA, Obeid LM: Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci 1995, 20:73-77
23. Kolesnick R, Fuks Z: Ceramide: a signal for apoptosis or mitogenesis? J Exp Med 1995, 181:1949-1952
24. Hannun YA: Functions of ceramide in coordinating cellular responses to stress. Science 1996, 274:1855-1859
25. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R: Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995, 82: 1-20
26. Obeid LM, Linardic CM, Karolak LA, Hannun YA: Programmed cell death induced by ceramide. Science 1993, 259:1769-1771
27. 1-adrenergic receptor interaction: evidence for independent regulation of growth and beating. Circ Res 1985, 56: 884-894
28. Wolfe CL, Sievers RE, Visseren FL, Donnelly TJ: Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 1993, 87:881-892
29. Barbosa V, Sievers RE, Zaugg CE, Wolfe CL: Preconditioning ischemia time determines the degree of glycogen depletion and infarct size reduction in rat hearts. Am Heart J 1996, 131:224-230
30. Mutter MM, Sievers RE, Barbosa V, Wolfe CL: Heat-shock protein induction in rat hearts: a direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation 1994, 89:355-360
31. Auyeung Y, Sievers RE, Weng D, Barbosa V, Wolfe CL: Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. Circulation 1995, 92:3318-3322
32. Leist M, Ganter F, Bohlinger I, Germann PG, Tiegs G, Wendel A: Murine hepatocytes apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest. J Immunol 1994, 153:1778-1787
33. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:911-917
34. Ames BN, Dubin DT: The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. J Biol Chem 1960, 235:769-775
35. Preiss J, Loomis CR, Bishop WR, Stein R, Niedel JE, Bell RM: Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes and ras- and s/s-transformed normal rat kidney cells, J Biol Chem 1986, 261:8597-8600
36. Van Veldhoven PP, Bishop WR, Bell RM: Enzymatic quantitation of sphingosine in the picomole range in cultured cells. Anal Biochem 1989, 183:177-189
37. Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, Glembotski CC, Quintana PJE, Sabbadini RA: Tumor necrosis factor α-induced apoptosis in cardiac myocytes. J Clin Invest 1996, 98:2854-2865
38. Inokuchi J, Momosaki K, Shimeno H, Nagamatsu A, Radin NS: Effect of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells. J Cell Physiol 1989, 141:573-583
39. Barbour S, Edidin M, Felding-Habermann B, Taylor-Nortan J, Radin NS, Fenderson BA: Glycolipid depletion using a ceramide analogue (PDMP) alters growth, adhesion, and membrane lipid organization in human A431 cells. J Cell Physiol 1992, 150:610-619
40. Bielawska A, Greenberg MS, Perry D, Jayadev S, Shayman J, McKay C, Hannun YA: (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as inhibitor of ceramidase: J Biol Chem 1996, 271:12646-12654
41. Kubota M, Marita K, Nakagomi T, Tamura A, Shimasaki H, Ueta N, Yoshida S: Sphingomyelin changes in rat cerebral cortex during focal ischemia. Neural Res 1996, 18:337-341
42. Kerr JF, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257
43. Umansky S: Apoptosis: molecular and cellular mechanisms (a review). Mol Biol (Translated from Molekulyarnaya Biologiya) 1996, 30:285-295
44. Vaux DL, Strasser A: The molecular biology of apoptosis. Proc Natl Acad Sci USA 1996, 93:2239-2244
45. Nunez G, Merino R, Grillot D, Gonzalez-Garcia M: Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival. Immunol Today 1994, 15:582-588
46. Whyte M: ICE/CED-3 proteases in apoptosis: Trends Cell Biol 1996, 6:245-248