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Volumn 164, Issue 4, 1998, Pages 533-548

Lipid second messengers derived from glycerolipids and sphingolipids, and their role in smooth muscle function

Author keywords

Ceramide; Diacylglycerol; Glycerophospholipid; Lipid second messenger; Signal transduction; Sphingolipid; Vascular smooth muscle

Indexed keywords

CALCIUM ION; CERAMIDE; GLYCEROLIPID; GLYCEROPHOSPHOLIPID; GUANINE NUCLEOTIDE BINDING PROTEIN; HORMONE; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE; PROTEIN KINASE C; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; RECEPTOR; SPHINGOLIPID; SPHINGOMYELIN; VASOCONSTRICTOR AGENT;

EID: 0032445275     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-201X.1998.tb10703.x     Document Type: Conference Paper
Times cited : (25)

References (138)
  • 1
    • 0031012382 scopus 로고    scopus 로고
    • Cell-permeable ceramides prevent the activation of phosholipase D by ADP-ribosylation factor and RhoA
    • Abousalham, A., Liossis, C., O'Brien, L. & Brindley, D.N. 1997. Cell-permeable ceramides prevent the activation of phosholipase D by ADP-ribosylation factor and RhoA. J Biol Chem 272, 1069-1075
    • (1997) J Biol Chem , vol.272 , pp. 1069-1075
    • Abousalham, A.1    Liossis, C.2    O'Brien, L.3    Brindley, D.N.4
  • 2
    • 0025120244 scopus 로고
    • Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
    • Anderson, N.G., Maller, G.L., Tonks, N.K. & Sturgill, T.W. 1990. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343, 651-653.
    • (1990) Nature , vol.343 , pp. 651-653
    • Anderson, N.G.1    Maller, G.L.2    Tonks, N.K.3    Sturgill, T.W.4
  • 3
    • 0029741690 scopus 로고    scopus 로고
    • The sphingomyelin-ceramide signaling pathway is involved in oxidized low-density lipoprotein-induced cell-proliferation
    • Auge, N., Andrieu, N., Negresalvayre, A., Thiers, J.C., Levade, T. & Salvayre, R. 1996. The sphingomyelin-ceramide signaling pathway is involved in oxidized low-density lipoprotein-induced cell-proliferation. J Biol Chem 271, 19251-19255.
    • (1996) J Biol Chem , vol.271 , pp. 19251-19255
    • Auge, N.1    Andrieu, N.2    Negresalvayre, A.3    Thiers, J.C.4    Levade, T.5    Salvayre, R.6
  • 4
    • 0028282612 scopus 로고
    • Endothelin stimulates phosphatidylcholine hydrolysis through both PLC and PLD pathways in mesangial cells
    • Baldi, E., Musial, A. & Kester, M. 1994. Endothelin stimulates phosphatidylcholine hydrolysis through both PLC and PLD pathways in mesangial cells. Am J Physiol 266, F957-F965.
    • (1994) Am J Physiol , vol.266
    • Baldi, E.1    Musial, A.2    Kester, M.3
  • 5
    • 0026740688 scopus 로고
    • The biologically active phospholipid, lysophosphatidic acid induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D
    • van der Bend, R.L., de Widt, J., van Corven, E. J., Moolenaar, W.H. & van Blitterswijk, W.J. 1992. The biologically active phospholipid, lysophosphatidic acid induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Biochem J 285, 235-240.
    • (1992) Biochem J , vol.285 , pp. 235-240
    • Van Der Bend, R.L.1    De Widt, J.2    Van Corven, E.J.3    Moolenaar, W.H.4    Van Blitterswijk, W.J.5
  • 6
    • 0023062987 scopus 로고
    • Inositol trisphosphate and diacylglycerol: Two interacting second messengers
    • Berridge, M.J. 1987. Inositol trisphosphate and diacylglycerol: two interacting second messengers. Ann Rev Biochem 56, 159-193.
    • (1987) Ann Rev Biochem , vol.56 , pp. 159-193
    • Berridge, M.J.1
  • 7
    • 0025356574 scopus 로고
    • The regulation and cellular functions of phosphatidylcholine hydrolysis
    • Billah, M.M. & Anthes, J.C. 1990. The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J 269, 281-291.
    • (1990) Biochem J , vol.269 , pp. 281-291
    • Billah, M.M.1    Anthes, J.C.2
  • 8
    • 0023927373 scopus 로고
    • Functions of diacylglycerol in glycerolipid metabolism, signal transduction and cellular transformation
    • Bishop, W.R. & Bell, R.M. 1988. Functions of diacylglycerol in glycerolipid metabolism, signal transduction and cellular transformation. Oncogene Res 2, 205-218.
    • (1988) Oncogene Res , vol.2 , pp. 205-218
    • Bishop, W.R.1    Bell, R.M.2
  • 9
    • 0029097310 scopus 로고
    • Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C
    • Bjorkoy, G., Overvaten, A., Diaz-Meco, M.T., Moscat, J. & Johansen, T. 1995. Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. J Biol Chem 270, 21299-21306.
    • (1995) J Biol Chem , vol.270 , pp. 21299-21306
    • Bjorkoy, G.1    Overvaten, A.2    Diaz-Meco, M.T.3    Moscat, J.4    Johansen, T.5
  • 10
    • 0032521767 scopus 로고    scopus 로고
    • Hypothesis: Ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains
    • van Blitterswijk, W.J. 1998. Hypothesis: ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains. Biochem J 331, 677-680.
    • (1998) Biochem J , vol.331 , pp. 677-680
    • Blitterswijk, W.J.1
  • 11
    • 0012145222 scopus 로고    scopus 로고
    • Phosphatidic acid
    • R.M. Bell, J.H. Exton, S.M. Prescott & Snyder, F. (eds) Plenum Press, New York
    • Bocckino, S.B., Exton, J.H. 1996. Phosphatidic acid. In: R.M. Bell, J.H. Exton, S.M. Prescott & Snyder, F. (eds) Handbook of Lipid Research, Vol. 8, pp. 75-123. Plenum Press, New York.
    • (1996) Handbook of Lipid Research , vol.8 , pp. 75-123
    • Bocckino, S.B.1    Exton, J.H.2
  • 12
    • 0029780055 scopus 로고    scopus 로고
    • + channels in arterial smooth-muscle through protein-kinase-c
    • + channels in arterial smooth-muscle through protein-kinase-c. J Gen Physiol 108, 315-323.
    • (1996) J Gen Physiol , vol.108 , pp. 315-323
    • Bonev, A.D.1    Nelson, M.T.2
  • 13
    • 0029027589 scopus 로고
    • Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells:Spatial and temporal modulation of PDGF chemotactic signal transduction
    • Bornfeldt, K.E., Graves, L.M., Raines, E.W. et al. 1995. Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells:spatial and temporal modulation of PDGF chemotactic signal transduction. J Cell Biol 130, 193-206.
    • (1995) J Cell Biol , vol.130 , pp. 193-206
    • Bornfeldt, K.E.1    Graves, L.M.2    Raines, E.W.3
  • 14
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R., Verheij, M., HaimovitzFriedman, A., Scotto, A., Fuks, Z. & Kolesnick, R. 1995. Ceramide synthase mediates daunorubicin induced apoptosis: an alternative mechanism for generating death signals. Cell 82, 405-414.
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    HaimovitzFriedman, A.3    Scotto, A.4    Fuks, Z.5    Kolesnick, R.6
  • 15
    • 0032536364 scopus 로고    scopus 로고
    • Metabolic fate of exogenous diacylglycerols in A10 smooth muscle cells
    • Chuang, M. & Severson, D.L. 1998. Metabolic fate of exogenous diacylglycerols in A10 smooth muscle cells. Biochim Biophys Acta-Lipids Lipid Metabolism 1390, 149-159.
    • (1998) Biochim Biophys Acta-Lipids Lipid Metabolism , vol.1390 , pp. 149-159
    • Chuang, M.1    Severson, D.L.2
  • 16
    • 0026080604 scopus 로고
    • 5-Hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: A role for protein kinase C in smooth muscle contraction
    • Clark, A.H. & Garland, C.J. 1991. 5-Hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction. Br J Pharmacol 102, 415-421.
    • (1991) Br J Pharmacol , vol.102 , pp. 415-421
    • Clark, A.H.1    Garland, C.J.2
  • 17
    • 0028848344 scopus 로고
    • Differential regulation of sphingomyelinase and ceramidase activities by growth-factors and cytokines - Implications for cellular proliferation and differentiation
    • Coroneos, E., Martinez, M., Mckenna, S. & Kester, M. 1995. Differential regulation of sphingomyelinase and ceramidase activities by growth-factors and cytokines - implications for cellular proliferation and differentiation. J Biol Chem 270, 23305-23309.
    • (1995) J Biol Chem , vol.270 , pp. 23305-23309
    • Coroneos, E.1    Martinez, M.2    McKenna, S.3    Kester, M.4
  • 18
    • 0030134434 scopus 로고    scopus 로고
    • Stimulation of actin stress fiber formation mediated by activation of phospholipase-d
    • Cross, M.J., Roberts, S., Ridley, A.J. et al. 1996. Stimulation of actin stress fiber formation mediated by activation of phospholipase-d. Curr Biol 6, 588-597.
    • (1996) Curr Biol , vol.6 , pp. 588-597
    • Cross, M.J.1    Roberts, S.2    Ridley, A.J.3
  • 19
    • 0025876649 scopus 로고
    • Static and dynamic lipid assymmetry in cell membranes
    • Devaux, P.F. 1991. Static and dynamic lipid assymmetry in cell membranes. Biochemistry 30, 1163-1173.
    • (1991) Biochemistry , vol.30 , pp. 1163-1173
    • Devaux, P.F.1
  • 20
    • 0030933201 scopus 로고    scopus 로고
    • Involvement of phosphatidylcholine-secific phospholipase C in platelet-derived growth factor-induced activation of the mitogen-activated protein kinase pathway in Rat-1 fibroblasts
    • van Dijk, M. C. M., Muriana, F. J. G., deWidt, J., Hilkmann, H. & vanBlitterswijk, W. J. 1997. Involvement of phosphatidylcholine-s[ecific phospholipase C in platelet-derived growth factor-induced activation of the mitogen-activated protein kinase pathway in Rat-1 fibroblasts. J Biol Chem 272, 11011-11016.
    • (1997) J Biol Chem , vol.272 , pp. 11011-11016
    • Dijk, M.C.M.1    Muriana, F.J.G.2    DeWidt, J.3    Hilkmann, H.4    VanBlitterswijk, W.J.5
  • 21
    • 0026723048 scopus 로고
    • Ceramide stimulates a cytosolic protein phosphatas.c
    • Dobrowsky, R.T. & Hannun, Y.A. 1992. Ceramide stimulates a cytosolic protein phosphatas.c J Biol Chem 267, 5048-5051.
    • (1992) J Biol Chem , vol.267 , pp. 5048-5051
    • Dobrowsky, R.T.1    Hannun, Y.A.2
  • 22
    • 0029586594 scopus 로고
    • KSR, a novel player in the Ras pathway
    • Downward, J. 1995, KSR, a novel player in the Ras pathway. Cell 83, 831-834.
    • (1995) Cell , vol.83 , pp. 831-834
    • Downward, J.1
  • 23
    • 0025162155 scopus 로고
    • Signalling through phosphatidylcholine breakdown
    • Exton, J.H. 1990. Signalling through phosphatidylcholine breakdown. J Biol Chem 265, 1-4.
    • (1990) J Biol Chem , vol.265 , pp. 1-4
    • Exton, J.H.1
  • 24
    • 0030892164 scopus 로고    scopus 로고
    • Phospholipase D: Enzymology, mechanisms of regulation, and function
    • Exton, J.H. 1997. Phospholipase D: Enzymology, mechanisms of regulation, and function. Physiol Her 77, 303-320.
    • (1997) Physiol Her , vol.77 , pp. 303-320
    • Exton, J.H.1
  • 25
    • 0028075696 scopus 로고
    • Vascular smooth-muscle cells contain at (1) Angiotensin receptors coupled to phospholipase-d activation
    • Freeman, E.J. & Tallant, E.A. 1994. Vascular smooth-muscle cells contain at (1) Angiotensin receptors coupled to phospholipase-d activation. Biochem J 304, 543-548.
    • (1994) Biochem J , vol.304 , pp. 543-548
    • Freeman, E.J.1    Tallant, E.A.2
  • 27
    • 0030846622 scopus 로고    scopus 로고
    • Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes
    • GalveRoperh, I., Haro, A. & DiazLaviada, I. 1997. Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes. FEBS Lett 415, 271-274.
    • (1997) FEBS Lett , vol.415 , pp. 271-274
    • GalveRoperh, I.1    Haro, A.2    DiazLaviada, I.3
  • 28
    • 84911789024 scopus 로고
    • Regulation of Protein kinase C by lipid cofactors
    • E. Elson, W. Frazier, & I., Glaser (eds) Plenum Press, New York
    • Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M. 1986. Regulation of Protein kinase C by lipid cofactors. In: E. Elson, W. Frazier, & I., Glaser (eds) Cell Membranes; Methods and Reviews. Plenum Press, New York.
    • (1986) Cell Membranes; Methods and Reviews
    • Ganong, B.R.1    Loomis, C.R.2    Hannun, Y.A.3    Bell, R.M.4
  • 29
    • 0028984918 scopus 로고
    • Activation of phospholipase-c and phospholipase-d by stimulation of adenosine a (1), Bradykinin or p-2u receptors does not correlate well with protein-kinase-c activation
    • Gerwins, P. & Fredholm, B.B. 1995. Activation of phospholipase-c and phospholipase-d by stimulation of adenosine a (1), Bradykinin or p-2u receptors does not correlate well with protein-kinase-c activation. Naunyn-Schmiedebergs Arch Pharmacol 351, 194-201.
    • (1995) Naunyn-Schmiedebergs Arch Pharmacol , vol.351 , pp. 194-201
    • Gerwins, P.1    Fredholm, B.B.2
  • 30
    • 0028128763 scopus 로고
    • Sphingosine-1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
    • Ghosh, S., Bian, J. & Gill, D.L. 1994. Sphingosine-1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J Biol Chem 269, 22628-22635.
    • (1994) J Biol Chem , vol.269 , pp. 22628-22635
    • Ghosh, S.1    Bian, J.2    Gill, D.L.3
  • 31
    • 0029935339 scopus 로고    scopus 로고
    • Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic-acid -phosphatidic-acid regulates the translocation of raf-1 in 12-o-tetradecanoylphorbol-13-acetate-stimulated madin-darby canine kidney-cells
    • Ghosh, S., Strum, J.C., Sciorra, V.A., Daniel, L. & Bell, R.M. 1996. Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic-acid -phosphatidic-acid regulates the translocation of raf-1 in 12-o-tetradecanoylphorbol-13-acetate-stimulated madin-darby canine kidney-cells. J Biol Chem 271, 8472-8480.
    • (1996) J Biol Chem , vol.271 , pp. 8472-8480
    • Ghosh, S.1    Strum, J.C.2    Sciorra, V.A.3    Daniel, L.4    Bell, R.M.5
  • 34
    • 0028339322 scopus 로고
    • Cell-permeable ceramides inhibit the stimulation of DNA-synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts
    • Gomezmunoz, A., Martin, A., O'Brien, L. & Brindley, D.N. 1994. Cell-permeable ceramides inhibit the stimulation of DNA-synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J Biol Chem 269, 8937-8943.
    • (1994) J Biol Chem , vol.269 , pp. 8937-8943
    • Gomezmunoz, A.1    Martin, A.2    O'Brien, L.3    Brindley, D.N.4
  • 35
    • 0029008006 scopus 로고
    • Arachidonic-acid and diacylglycerol release associated with inhibition of myosin light-chain dephosphorylation in rabbit smooth-muscle
    • Gong, M.C., Kinter, M.T., Somlyo, A.V. & Somlyo, A.P. 1995. Arachidonic-acid and diacylglycerol release associated with inhibition of myosin light-chain dephosphorylation in rabbit smooth-muscle. J Physiol-London 486, 113-122.
    • (1995) J Physiol-London , vol.486 , pp. 113-122
    • Gong, M.C.1    Kinter, M.T.2    Somlyo, A.V.3    Somlyo, A.P.4
  • 36
    • 0023000847 scopus 로고
    • Sustained diacylglycerol formation from inositol phospholipids in angiotensin II stimulated vascular smooth muscle cells
    • Griendling, K.K., Rittenhouse, S.E., Brock, T.A., Eckstein, L.S., Gimbrone, L.M. & Alexander, R.W. 1986. Sustained diacylglycerol formation from inositol phospholipids in angiotensin II stimulated vascular smooth muscle cells. J Biol Chem 261, 5901-5906.
    • (1986) J Biol Chem , vol.261 , pp. 5901-5906
    • Griendling, K.K.1    Rittenhouse, S.E.2    Brock, T.A.3    Eckstein, L.S.4    Gimbrone, L.M.5    Alexander, R.W.6
  • 37
    • 0026689897 scopus 로고
    • Norepinephrine-induced phosphatidylcholine hydrolysis by phospholipases D and C in rat tail artery
    • GU, H., Trajkovic, S. & LaBelle, E.F. 1992. Norepinephrine-induced phosphatidylcholine hydrolysis by phospholipases D and C in rat tail artery. Am J Physiol 262, C1376-C1383.
    • (1992) Am J Physiol , vol.262
    • Gu, H.1    Trajkovic, S.2    LaBelle, E.F.3
  • 38
    • 0027756153 scopus 로고
    • Activation of actin polymerisation by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts
    • Ha, K.S. & Exton, J.H. 1993. Activation of actin polymerisation by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts. J Cell Biol 123, 1789-1796.
    • (1993) J Cell Biol , vol.123 , pp. 1789-1796
    • Ha, K.S.1    Exton, J.H.2
  • 39
    • 0027991902 scopus 로고
    • Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing Phospholipase D and actin polymerisation by a pertussis toxin sensitive mechanism
    • Ha, K.S., Yeo, E.J. & Exton, J.H. 1994. Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing Phospholipase D and actin polymerisation by a pertussis toxin sensitive mechanism. Biochem J 303, 55-59.
    • (1994) Biochem J , vol.303 , pp. 55-59
    • Ha, K.S.1    Yeo, E.J.2    Exton, J.H.3
  • 40
    • 0032498569 scopus 로고    scopus 로고
    • Integrin-induced protein kinase C alpha and C epsilon translocation to focal adhesions mediates vascular smooth muscle cell spreading
    • Haller, H., Lindschau, C., Maasch, C., Olthoff, H., Kurscheid, D. & Luft, F.C. 1998. Integrin-induced protein kinase C alpha and C epsilon translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ Res 82, 157-165.
    • (1998) Circ Res , vol.82 , pp. 157-165
    • Haller, H.1    Lindschau, C.2    Maasch, C.3    Olthoff, H.4    Kurscheid, D.5    Luft, F.C.6
  • 41
    • 0027994349 scopus 로고
    • The Sphingomyelin cycle and the second messenger function of ceramide
    • Hannun, Y.A. 1994. The Sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269, 3125-3128.
    • (1994) J Biol Chem , vol.269 , pp. 3125-3128
    • Hannun, Y.A.1
  • 42
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular-responses to stress
    • Hannun, Y.A. 1996. Functions of ceramide in coordinating cellular-responses to stress. Science 274, 1855-1859.
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 43
    • 0028952938 scopus 로고
    • Transduction of physical force by the vascular wall: Role of phospholipase and cytochrome P450 metabolites of arachidonic acid
    • Harder, D.R., Narayanan, J., Gebremedhin, D. & Roman, R.J. 1995. Transduction of physical force by the vascular wall: role of phospholipase and cytochrome P450 metabolites of arachidonic acid. TCM 5, 7-14.
    • (1995) TCM , vol.5 , pp. 7-14
    • Harder, D.R.1    Narayanan, J.2    Gebremedhin, D.3    Roman, R.J.4
  • 44
    • 0028218044 scopus 로고
    • Tyrosine kinase pathways and the regulation of smooth muscle contractility
    • Hollenberg, M.D. 1994. Tyrosine kinase pathways and the regulation of smooth muscle contractility. Tr Pharmacol Sci 15, 108-113.
    • (1994) Tr Pharmacol Sci , vol.15 , pp. 108-113
    • Hollenberg, M.D.1
  • 45
    • 0028447767 scopus 로고
    • Solution structure of a cysteine rich domain of rat protein kinase C
    • Hommel, U., Zurini, M. & Luyten, M. 1994. Solution structure of a cysteine rich domain of rat protein kinase C. Nature Structural Biol 1, 383-387.
    • (1994) Nature Structural Biol , vol.1 , pp. 383-387
    • Hommel, U.1    Zurini, M.2    Luyten, M.3
  • 47
    • 0030889241 scopus 로고    scopus 로고
    • Cloning of a novel human diacylglycerol kinase (DGK theta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain
    • Houssa, B., Schaap, D., vanderWal, J. et al. 1997. Cloning of a novel human diacylglycerol kinase (DGK theta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. J Biol Chem 272, 10422-10428.
    • (1997) J Biol Chem , vol.272 , pp. 10422-10428
    • Houssa, B.1    Schaap, D.2    VanderWal, J.3
  • 49
    • 0029951162 scopus 로고    scopus 로고
    • Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase
    • Huwiler, A., Brunner, J. et al. 1996. Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. Proc Natl Acad Sci 93, 6959-6963.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 6959-6963
    • Huwiler, A.1    Brunner, J.2
  • 50
    • 0023105540 scopus 로고
    • Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum
    • Imai, A. & Gershengorn, M.C. 1987. Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum. Nature 325, 726-728.
    • (1987) Nature , vol.325 , pp. 726-728
    • Imai, A.1    Gershengorn, M.C.2
  • 51
    • 0031003386 scopus 로고    scopus 로고
    • Interaction of smooth muscle myosin phosphatase with phospholipids
    • Ito, M., Feng, J.H., Tsujino, S. et al. 1997. Interaction of smooth muscle myosin phosphatase with phospholipids. Biochem 36, 7607-7614.
    • (1997) Biochem , vol.36 , pp. 7607-7614
    • Ito, M.1    Feng, J.H.2    Tsujino, S.3
  • 52
    • 0027669148 scopus 로고
    • Sphingolipids as mediators of effects of platelet derived growth factor in vascular smooth muscle cells
    • Jacobs, L.S. & Kester, M. 1993. Sphingolipids as mediators of effects of platelet derived growth factor in vascular smooth muscle cells. Am J Physiol 265, C740-C747.
    • (1993) Am J Physiol , vol.265
    • Jacobs, L.S.1    Kester, M.2
  • 54
    • 0028174030 scopus 로고
    • NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine phospholipase C from Bacillus Cereus acquire a transformed phenotype
    • Johansen, T., Bjorkoy, G., Overvaten, A. et al. 1994. NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine phospholipase C from Bacillus Cereus acquire a transformed phenotype. Molec Cellul Biol 14, 646-654.
    • (1994) Molec Cellul Biol , vol.14 , pp. 646-654
    • Johansen, T.1    Bjorkoy, G.2    Overvaten, A.3
  • 55
    • 0031559598 scopus 로고    scopus 로고
    • Ceramide: A novel cell signaling mechanism for vasodilation
    • Johns, D.G., Osborn, H. & Webb, R.C. 1997. Ceramide: A novel cell signaling mechanism for vasodilation. Biochem Biophys Res Comm 237, 95-97.
    • (1997) Biochem Biophys Res Comm , vol.237 , pp. 95-97
    • Johns, D.G.1    Osborn, H.2    Webb, R.C.3
  • 56
    • 0028953260 scopus 로고
    • Evidence that ceramide selectively inhibits protein-kinase C-alpha translocation and modulates bradykinin activation of phospholipase D
    • Jones, M.J. & Murray, A.W. 1995. Evidence that ceramide selectively inhibits protein-kinase C-alpha translocation and modulates bradykinin activation of phospholipase D. J Biol Chem 270, 5007-5013.
    • (1995) J Biol Chem , vol.270 , pp. 5007-5013
    • Jones, M.J.1    Murray, A.W.2
  • 57
    • 0027533593 scopus 로고
    • Stimulation of phospholipase D activity and phosphatidic acid production by norepinephrine in rat aorta
    • Jones, A.W., Shukla, S.D. & Geisbuhler, B. 1993. Stimulation of phospholipase D activity and phosphatidic acid production by norepinephrine in rat aorta. Am J Physiol 264, C609-C615.
    • (1993) Am J Physiol , vol.264
    • Jones, A.W.1    Shukla, S.D.2    Geisbuhler, B.3
  • 58
    • 0027197994 scopus 로고
    • Substrate recognition by ceramide-activated protein kinase: Evidence that kinase activity is proline directed
    • Joseph, C.K., Byun, H.S., Bittman, R. & Kolesnick, R. 1993. Substrate recognition by ceramide-activated protein kinase: evidence that kinase activity is proline directed. J Biol Chem 268, 20002-20006.
    • (1993) J Biol Chem , vol.268 , pp. 20002-20006
    • Joseph, C.K.1    Byun, H.S.2    Bittman, R.3    Kolesnick, R.4
  • 59
    • 0001166775 scopus 로고    scopus 로고
    • Phosphoinositide-specific phospholipase C: Structural basis for catalysis and regulatory interactions
    • Katan, M. & Williams, R.L. 1997. Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions. Cell Der Biol 8, 287-296.
    • (1997) Cell Der Biol , vol.8 , pp. 287-296
    • Katan, M.1    Williams, R.L.2
  • 60
    • 0029009762 scopus 로고
    • Requirement for phosphatidylinositol transfer protein in epidermal growth factor signalling
    • Kauffmann-Zeh, A., Thomas, G.M.H., Ball, A. et al. 1995. Requirement for phosphatidylinositol transfer protein in epidermal growth factor signalling. Science 268, 1188-1190.
    • (1995) Science , vol.268 , pp. 1188-1190
    • Kauffmann-Zeh, A.1    Thomas, G.M.H.2    Ball, A.3
  • 61
    • 0029102822 scopus 로고
    • Residues in the 2nd cysteine rich region of protein kinase C-δ relevant to phorbol ester binding as revealed by site-directed mutagenesis
    • Kazaneitz, M.G., Wang, S., Milne, G.W.A., Lewin, N.E., Liu, H.L. & Blumberg, P.M. 1995. Residues in the 2nd cysteine rich region of protein kinase C-δ relevant to phorbol ester binding as revealed by site-directed mutagenesis. J Biol Chem 270, 21852-21859.
    • (1995) J Biol Chem , vol.270 , pp. 21852-21859
    • Kazaneitz, M.G.1    Wang, S.2    Milne, G.W.A.3    Lewin, N.E.4    Liu, H.L.5    Blumberg, P.M.6
  • 62
    • 0029021180 scopus 로고
    • Phosphotyrosine-dependenr targeting of mitogen-activated protein kinase in differentiated contractile vascular cells
    • Khalil, R.A., Menice, C.B., Wang, C.-L.A. & Morgan, K.G. 1995. Phosphotyrosine-dependenr targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res 76, 1101-1108.
    • (1995) Circ Res , vol.76 , pp. 1101-1108
    • Khalil, R.A.1    Menice, C.B.2    Wang, C.-L.A.3    Morgan, K.G.4
  • 63
    • 0028297068 scopus 로고
    • The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
    • Kolesnick, R. & Golde, D.W. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77, 325-328.
    • (1994) Cell , vol.77 , pp. 325-328
    • Kolesnick, R.1    Golde, D.W.2
  • 64
    • 0030700216 scopus 로고    scopus 로고
    • Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C
    • Kubo, M., Quayle, J.M. & Standen, N.B. 1997. Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C. J PhysiolLondon 503, 489-496.
    • (1997) J Physiollondon , vol.503 , pp. 489-496
    • Kubo, M.1    Quayle, J.M.2    Standen, N.B.3
  • 65
    • 0029929668 scopus 로고    scopus 로고
    • Phospholipase D is activated by G protein and not by calcium ions in vascular smooth muscle
    • LaBelle, E.F., Fulbright, R.M., Barsotti, R.J., Gu, H. & Polyak, E. 1996. Phospholipase D is activated by G protein and not by calcium ions in vascular smooth muscle. Am J Physiol 270, H1031-H1037.
    • (1996) Am J Physiol , vol.270
    • LaBelle, E.F.1    Fulbright, R.M.2    Barsotti, R.J.3    Gu, H.4    Polyak, E.5
  • 66
    • 0025730677 scopus 로고
    • Angiotensin II induced phosphatidylcholine hydrolysis in cultured vascular smooth muscle cells
    • Lassegue, B., Alexander, R.W., Clark, M. & Griendling, K.K. 1991. Angiotensin II induced phosphatidylcholine hydrolysis in cultured vascular smooth muscle cells. Biochem J 276, 19-25.
    • (1991) Biochem J , vol.276 , pp. 19-25
    • Lassegue, B.1    Alexander, R.W.2    Clark, M.3    Griendling, K.K.4
  • 67
    • 0025852233 scopus 로고
    • Dissociation of protein kinase c activation and diacylglycerol formation
    • Leach, K.L., Ruff, V.A., Wright, T.M., Pessin, M.S. & Raben, D.M. 1991. Dissociation of protein kinase c activation and diacylglycerol formation. J Biol Chem 266, 3215-3221.
    • (1991) J Biol Chem , vol.266 , pp. 3215-3221
    • Leach, K.L.1    Ruff, V.A.2    Wright, T.M.3    Pessin, M.S.4    Raben, D.M.5
  • 68
    • 0028002620 scopus 로고
    • Signal-transduction in vascular smooth-muscle - Diacylglycerol second messengers and PKC action
    • Lee, M.W. & Severson, D.L. 1994. Signal-transduction in vascular smooth-muscle - diacylglycerol second messengers and PKC action. Am J Physiol 267, 659-678.
    • (1994) Am J Physiol , vol.267 , pp. 659-678
    • Lee, M.W.1    Severson, D.L.2
  • 69
    • 0028567280 scopus 로고
    • Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: Comparison with other protein kinase C isotypes and other acidic lipids
    • Limatola, C., Schaap, D., Moolenaar, W.H. & van Blitterswijk, W. J. 1994. Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: Comparison with other protein kinase C isotypes and other acidic lipids. Biochem J 304, 1001-1008.
    • (1994) Biochem J , vol.304 , pp. 1001-1008
    • Limatola, C.1    Schaap, D.2    Moolenaar, W.H.3    Van Blitterswijk, W.J.4
  • 70
    • 0031037134 scopus 로고    scopus 로고
    • Interleukin 1-beta-induced protein kinase C-zeta activation is mimicked by exogenous phospholipase D
    • Limatola, C., Barabino, B., Nista, A. & Santoni, A. 1997. Interleukin 1-beta-induced protein kinase C-zeta activation is mimicked by exogenous phospholipase D, Biochem J 321, 497-501.
    • (1997) Biochem J , vol.321 , pp. 497-501
    • Limatola, C.1    Barabino, B.2    Nista, A.3    Santoni, A.4
  • 71
    • 0027978352 scopus 로고
    • Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle
    • Linardic, L.A. & Hannun, Y.A. 1994. Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle. J Biol Chem 269, 23530-23537.
    • (1994) J Biol Chem , vol.269 , pp. 23530-23537
    • Linardic, L.A.1    Hannun, Y.A.2
  • 72
    • 0028265959 scopus 로고
    • Lipid second messengers
    • Liscovitch, M. & Cantley, L. 1994. Lipid second messengers. Cell 77, 329-334.
    • (1994) Cell , vol.77 , pp. 329-334
    • Liscovitch, M.1    Cantley, L.2
  • 73
    • 0026598466 scopus 로고
    • Activation of multiple mechanisms including phospholipase D by endothelin-1 in rat aorta
    • Liu, Y., Geisbuhler, B. & Jones, A.W. 1992. Activation of multiple mechanisms including phospholipase D by endothelin-1 in rat aorta. Am J Physiol 262, C941-C949.
    • (1992) Am J Physiol , vol.262
    • Liu, Y.1    Geisbuhler, B.2    Jones, A.W.3
  • 74
    • 0027968517 scopus 로고
    • Renaturation and TNFα stimulation of a 97kDa ceramide-activated protein kinase
    • Liu, J., Mathias, S., Yang, Z. & Kolesnick, R. 1994. Renaturation and TNFα stimulation of a 97kDa ceramide-activated protein kinase. J Biol Chem 269, 3047-3052.
    • (1994) J Biol Chem , vol.269 , pp. 3047-3052
    • Liu, J.1    Mathias, S.2    Yang, Z.3    Kolesnick, R.4
  • 75
  • 76
    • 0345668170 scopus 로고    scopus 로고
    • Activation of phospholipase D by endothelin-1 in rat small arteries; regulation by tyrosine kinases and calcium
    • Liu, G., Ohanian, V., Heagerty, A.M. & Ohanian, J. 1996. Activation of phospholipase D by endothelin-1 in rat small arteries; regulation by tyrosine kinases and calcium (Abstract). Clin Sci 91, 2.
    • (1996) Clin Sci , vol.91 , pp. 2
    • Liu, G.1    Ohanian, V.2    Heagerty, A.M.3    Ohanian, J.4
  • 77
    • 0027965006 scopus 로고
    • Protein kinase ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase
    • Lozano, J., Berra, E., Municio, M.M. et al. 1994. Protein kinase ζ isoform is critical for κB-dependent promoter activation by sphingomyelinase. J Biol Chem 269, 19200-19202.
    • (1994) J Biol Chem , vol.269 , pp. 19200-19202
    • Lozano, J.1    Berra, E.2    Municio, M.M.3
  • 78
    • 0028784682 scopus 로고
    • Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells
    • Malarkey, K., Chilvers, E.R., Lawson, M.F. & Plevin, R. 1995. Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells. Br J Pharmacol 116, 2267-2273.
    • (1995) Br J Pharmacol , vol.116 , pp. 2267-2273
    • Malarkey, K.1    Chilvers, E.R.2    Lawson, M.F.3    Plevin, R.4
  • 80
    • 0025889011 scopus 로고
    • Characterisation of a ceramide activated protein kinase: Stimulation by tumour necrosis factor α
    • Mathias, S., Dressler, K. & Kolesnick, R. 1991. Characterisation of a ceramide activated protein kinase: stimulation by tumour necrosis factor α. Proc Natl Acad Sci 88, 10009-10013.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 10009-10013
    • Mathias, S.1    Dressler, K.2    Kolesnick, R.3
  • 81
    • 0025283928 scopus 로고
    • An update of the enzymology and regulation of sphingomyelin metabolism
    • Merrill, A.H. & Jones, D.D. 1990. An update of the enzymology and regulation of sphingomyelin metabolism. Biochim Biophys Acta 1044, 1-12.
    • (1990) Biochim Biophys Acta , vol.1044 , pp. 1-12
    • Merrill, A.H.1    Jones, D.D.2
  • 82
    • 0031031859 scopus 로고    scopus 로고
    • Sphingolipids - The enigmatic lipid class: Biochemistry, physiology, and pathophysiology
    • Merrill, A.H., Schmelz, E.M., Dillehay, D.L. et al. 1997. Sphingolipids - The enigmatic lipid class: Biochemistry, physiology, and pathophysiology. Toxicol Appl Pharmacol 142, 208-225.
    • (1997) Toxicol Appl Pharmacol , vol.142 , pp. 208-225
    • Merrill, A.H.1    Schmelz, E.M.2    Dillehay, D.L.3
  • 84
    • 0028903101 scopus 로고
    • Lysophosphatidic acid signalling
    • Moolenaar, W.H. 1995. Lysophosphatidic acid signalling. Curr Opin Cell Biol 7, 203-210.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 203-210
    • Moolenaar, W.H.1
  • 86
    • 0029757119 scopus 로고    scopus 로고
    • The solution structure of the raf-1 cysteine-rich domain - A novel ras and phospholipid-binding site
    • Mott, H.R., Carpenter, J.W., Zhong, S., Ghosh, S., Bell, R.M. & Campbell, S.L. 1996. The solution structure of the raf-1 cysteine-rich domain - a novel ras and phospholipid-binding site. Proc Natl Acad Sci 93, 8312-8317.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 8312-8317
    • Mott, H.R.1    Carpenter, J.W.2    Zhong, S.3    Ghosh, S.4    Bell, R.M.5    Campbell, S.L.6
  • 87
    • 0029003788 scopus 로고
    • PKCζ is a molecular switch in signal transduction of TNTα, bifunctionally regulated by ceramide and arachidonic acid
    • Muller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D. & Pfizenmaier, K. 1995. PKCζ is a molecular switch in signal transduction of TNTα, bifunctionally regulated by ceramide and arachidonic acid. EMBO J 14, 1961-1969.
    • (1995) EMBO J , vol.14 , pp. 1961-1969
    • Muller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, D.5    Pfizenmaier, K.6
  • 88
    • 0040885889 scopus 로고    scopus 로고
    • Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
    • Muller, G., Storz, P., Bourteele, S. et al. 1998. Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling. EMBO J 17, 732-742.
    • (1998) EMBO J , vol.17 , pp. 732-742
    • Muller, G.1    Storz, P.2    Bourteele, S.3
  • 89
    • 0021227676 scopus 로고
    • The role of protein kinase C in cell surface signal transduction and tumour promotion
    • Nishizuka, Y. 1984. The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308, 693-698.
    • (1984) Nature , vol.308 , pp. 693-698
    • Nishizuka, Y.1
  • 90
    • 0029060391 scopus 로고
    • Protein Kinase C and lipid signalling for sustained cellular responses
    • Nishizuka, Y. 1995. Protein Kinase C and lipid signalling for sustained cellular responses. FASEB J 9, 484-496.
    • (1995) FASEB J , vol.9 , pp. 484-496
    • Nishizuka, Y.1
  • 91
    • 0030583120 scopus 로고    scopus 로고
    • Human inducible notric oxide synthase gene is transcriptionally regulated by nuclear factor kappa-B dependent mechanism
    • Nunokawa, Y., Oikawa, S. & Tanaka, S. 1996. Human inducible notric oxide synthase gene is transcriptionally regulated by nuclear factor kappa-B dependent mechanism. Biochem Biophys Res Commun 223, 347-352.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 347-352
    • Nunokawa, Y.1    Oikawa, S.2    Tanaka, S.3
  • 92
    • 0028302125 scopus 로고
    • Membrane-associated diacylglycerol kinase-activity is increased by noradrenaline, but not by angiotensin-II, in arterial smooth-muscle
    • Ohanian, J. & Heagerty, A.M. 1994. Membrane-associated diacylglycerol kinase-activity is increased by noradrenaline, but not by angiotensin-II, in arterial smooth-muscle. Biochem J 300, 51-56.
    • (1994) Biochem J , vol.300 , pp. 51-56
    • Ohanian, J.1    Heagerty, A.M.2
  • 93
    • 0027256082 scopus 로고
    • Regulation of diacylglycerol metabolism by vasoconstrictor hormones in intat small artenes
    • Ohanian, J., Izzard, A.S., Littlewood, M. & Heagerty, A.M. 1993. Regulation of diacylglycerol metabolism by vasoconstrictor hormones in intat small artenes. Circ Res 72, 1163-1171.
    • (1993) Circ Res , vol.72 , pp. 1163-1171
    • Ohanian, J.1    Izzard, A.S.2    Littlewood, M.3    Heagerty, A.M.4
  • 94
    • 0031050809 scopus 로고    scopus 로고
    • Involvement of tyrosine phosphorylation in endothelin-1 -induced calcium-sensitization in rat small mesenteric arteries
    • Ohanian, J., Ohanian, V., Shaw, L., Bruce, C. & Heagerty, A.M. 1997. Involvement of tyrosine phosphorylation in endothelin-1 -induced calcium-sensitization in rat small mesenteric arteries. Br J Pharmacol 120, 653-661.
    • (1997) Br J Pharmacol , vol.120 , pp. 653-661
    • Ohanian, J.1    Ohanian, V.2    Shaw, L.3    Bruce, C.4    Heagerty, A.M.5
  • 95
    • 0029665098 scopus 로고    scopus 로고
    • Identification of protein-kinase-c isoforms in rat mesenteric small arteries and their possible role in agonist-induced contraction
    • Ohanian, V., Ohanian, J., Shaw, L., Scarth, S., Parker, P.J. & Heagerty, A.M. 1996. Identification of protein-kinase-c isoforms in rat mesenteric small arteries and their possible role in agonist-induced contraction, Circ Res 78, 806-812.
    • (1996) Circ Res , vol.78 , pp. 806-812
    • Ohanian, V.1    Ohanian, J.2    Shaw, L.3    Scarth, S.4    Parker, P.J.5    Heagerty, A.M.6
  • 96
    • 0025288586 scopus 로고
    • Agonist-induced production of diacylglycerol and phosphatidic acid in intact resistance arteries-Evidence that accumulation of diacylglycerol is not a prerequisite for contraction
    • Ohanian, J., Ollerenshaw, J., Collins, P. & Heagerty, A.M. 1990. Agonist-induced production of diacylglycerol and phosphatidic acid in intact resistance arteries-Evidence that accumulation of diacylglycerol is not a prerequisite for contraction. J Biol Chem 265, 8921-8928.
    • (1990) J Biol Chem , vol.265 , pp. 8921-8928
    • Ohanian, J.1    Ollerenshaw, J.2    Collins, P.3    Heagerty, A.M.4
  • 97
    • 0024795059 scopus 로고
    • Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation
    • Okazaki, T., Bell, R.M. & Hannun, Y.A. 1989. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Rial Cbem 264, 19076-19080.
    • (1989) J Rial Cbem , vol.264 , pp. 19076-19080
    • Okazaki, T.1    Bell, R.M.2    Hannun, Y.A.3
  • 98
    • 0031013369 scopus 로고    scopus 로고
    • Inhibition of carnitine palmitoyltransferase-1 augments sphingolipid synthesis and palmitate-induced apoptosis
    • Paumen, M.B., Ishida, Y., Muramatsu, M., Yamamoto, M. & Honjo, T. 1997. Inhibition of carnitine palmitoyltransferase-1 augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272, 3324-3329.
    • (1997) J Biol Chem , vol.272 , pp. 3324-3329
    • Paumen, M.B.1    Ishida, Y.2    Muramatsu, M.3    Yamamoto, M.4    Honjo, T.5
  • 99
    • 0038985463 scopus 로고    scopus 로고
    • Stress-induced apoptosis and the sphingomyelin pathway
    • Pena, L.A., Fuks, Z. & Kolesnick, R. 1997. Stress-induced apoptosis and the sphingomyelin pathway. Biochem Pharmacol 53, 615-621.
    • (1997) Biochem Pharmacol , vol.53 , pp. 615-621
    • Pena, L.A.1    Fuks, Z.2    Kolesnick, R.3
  • 100
    • 0025317855 scopus 로고
    • Molecular species analysis of mitogen stimulated 1,2-diglyceride in fibroblasts: Comparison of α-thrombin, epidermal growth factor
    • Pessin, M.S., Baldassare, J. & Raben, D.M. 1990. Molecular species analysis of mitogen stimulated 1,2-diglyceride in fibroblasts: comparison of α-thrombin, epidermal growth factor. J Biol Chem 265, 7959-7966.
    • (1990) J Biol Chem , vol.265 , pp. 7959-7966
    • Pessin, M.S.1    Baldassare, J.2    Raben, D.M.3
  • 101
    • 0030760711 scopus 로고    scopus 로고
    • Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions
    • Pettitt, T.R., Martin, A., Horton, T., Liossis, C., Lord, J.M. & Wakelam, M.J.O. 1997. Diacylglycerol and phosphatidate generated by phospholipases C and D, respectively, have distinct fatty acid compositions and functions. J Biol Chem 272, 17354-17359.
    • (1997) J Biol Chem , vol.272 , pp. 17354-17359
    • Pettitt, T.R.1    Martin, A.2    Horton, T.3    Liossis, C.4    Lord, J.M.5    Wakelam, M.J.O.6
  • 102
    • 0029889045 scopus 로고    scopus 로고
    • Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase-2 (Erk-2) And c-jun n-terminal kinase (Jnk) Signal cascades in airway smooth-muscle
    • Pyne, S., Chapman, J., Steele, L. & Pyne, N.J. 1996. Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase-2 (Erk-2) And c-jun n-terminal kinase (Jnk) Signal cascades in airway smooth-muscle. Eur J Biochem 237, 819-826.
    • (1996) Eur J Biochem , vol.237 , pp. 819-826
    • Pyne, S.1    Chapman, J.2    Steele, L.3    Pyne, N.J.4
  • 103
    • 0028820881 scopus 로고
    • Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth-muscle -the role of ca2+ and protein-kinase-c
    • Pyne, S. & Pyne, N.J. 1995. Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth-muscle -the role of ca2+ and protein-kinase-c. Biochem J 311, 637-642.
    • (1995) Biochem J , vol.311 , pp. 637-642
    • Pyne, S.1    Pyne, N.J.2
  • 104
    • 0029912997 scopus 로고    scopus 로고
    • The differential regulation of cyclic-amp by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal-regulated kinase-2 in airway smooth-muscle
    • Pyne, S. & Pyne, N.J. 1996. The differential regulation of cyclic-amp by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal-regulated kinase-2 in airway smooth-muscle. Biochem J 315, 917-923.
    • (1996) Biochem J , vol.315 , pp. 917-923
    • Pyne, S.1    Pyne, N.J.2
  • 105
    • 0000193668 scopus 로고    scopus 로고
    • Diacylglycerols. Biosynthetic (eds) intermediates and lipid second messengers
    • R.M. Bell, J.H. Exton & S.M. Prescott (eds) Plenum Press, New York
    • Quest, F.G., Raben, D.M. & Bell, R.M. 1996. Diacylglycerols. Biosynthetic (eds) intermediates and lipid second messengers. In: R.M. Bell, J.H. Exton & S.M. Prescott (eds) Handbook of Lipid, pp. 1-58. Plenum Press, New York.
    • (1996) Handbook of Lipid , pp. 1-58
    • Quest, F.G.1    Raben, D.M.2    Bell, R.M.3
  • 106
    • 0023626217 scopus 로고
    • Protein kinase C in the regulation of smooth muscle contraction
    • Rasmussen, H., Takuwa, Y. & Park, S. 1987. Protein kinase C in the regulation of smooth muscle contraction. FASEB J 1, 177-185.
    • (1987) FASEB J , vol.1 , pp. 177-185
    • Rasmussen, H.1    Takuwa, Y.2    Park, S.3
  • 107
    • 0025443040 scopus 로고
    • 2+], not diacylglycerol, is the primary regulator of sustained swine arterial smooth muscle contraction
    • 2+], not diacylglycerol, is the primary regulator of sustained swine arterial smooth muscle contraction. Hypertens 15, 692-698.
    • (1990) Hypertens , vol.15 , pp. 692-698
    • Rembold, C.M.1    Weaver, B.A.2
  • 108
    • 0031049371 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and regulation of swine carotid artery contraction
    • Rembold, C.M. & Weaver, B.A. 1997. Tyrosine phosphorylation and regulation of swine carotid artery contraction. J Vasc Res 34, 1-10.
    • (1997) J Vasc Res , vol.34 , pp. 1-10
    • Rembold, C.M.1    Weaver, B.A.2
  • 109
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson, M. & Cobb, M. 1997. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9, 180-186.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-186
    • Robinson, M.1    Cobb, M.2
  • 110
    • 0029870414 scopus 로고    scopus 로고
    • Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts
    • Sasaki, T., Hazeki, K., Hazeki, O., Ui, M. & Katada, T. 1996. Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts. Biochem J 315, 1035-1040.
    • (1996) Biochem J , vol.315 , pp. 1035-1040
    • Sasaki, T.1    Hazeki, K.2    Hazeki, O.3    Ui, M.4    Katada, T.5
  • 111
    • 0030760220 scopus 로고    scopus 로고
    • Bombesin-stimulated ceramide production and MAP kinase activation in rabbit rectosigmoid smooth muscle cells
    • Sbrissa, D., Yamada, H., Hajra, A. & Bitar, K.N. 1997. Bombesin-stimulated ceramide production and MAP kinase activation in rabbit rectosigmoid smooth muscle cells. Am J Physiol 35, G1615-G1625.
    • (1997) Am J Physiol , vol.35
    • Sbrissa, D.1    Yamada, H.2    Hajra, A.3    Bitar, K.N.4
  • 112
    • 0026458406 scopus 로고
    • TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
    • Schutze, S., Potthof, K., Machleidt, T., Berkovic, D., Wiegmann, K. & Kronke, M. 1992. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell 71, 765-776.
    • (1992) Cell , vol.71 , pp. 765-776
    • Schutze, S.1    Potthof, K.2    Machleidt, T.3    Berkovic, D.4    Wiegmann, K.5    Kronke, M.6
  • 113
    • 0030968634 scopus 로고    scopus 로고
    • TAK1 mediates the ceramide signaling to stress-activated protein kinase c-Jun N-terminal kinase
    • Shirakabe, K., Yamaguchi, K., Shibuya, H. et al. 1997. TAK1 mediates the ceramide signaling to stress-activated protein kinase c-Jun N-terminal kinase. J Biol Chem 272, 8141-8144.
    • (1997) J Biol Chem , vol.272 , pp. 8141-8144
    • Shirakabe, K.1    Yamaguchi, K.2    Shibuya, H.3
  • 114
    • 0027194917 scopus 로고
    • Protein kinase c and tyrosine kinase activity contribute to mitogenic signalling by endothelin-1
    • Simonson, M.S. & Herman, W.H. 1993. Protein kinase c and tyrosine kinase activity contribute to mitogenic signalling by endothelin-1. J Biol Chem 268, 9347-9357.
    • (1993) J Biol Chem , vol.268 , pp. 9347-9357
    • Simonson, M.S.1    Herman, W.H.2
  • 115
    • 0030907067 scopus 로고    scopus 로고
    • Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D
    • Singer, W.D., Brown, H.A. & Sternweis, P.C. 1997. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Ann Rev Biochem 66, 475-510.
    • (1997) Ann Rev Biochem , vol.66 , pp. 475-510
    • Singer, W.D.1    Brown, H.A.2    Sternweis, P.C.3
  • 116
    • 0031051559 scopus 로고    scopus 로고
    • Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases
    • Smith, E.R., Jones, P.L., Boss, J.M. & Merrill, A.H. 1997. Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases. J Biol Chem 272, 5640-5646.
    • (1997) J Biol Chem , vol.272 , pp. 5640-5646
    • Smith, E.R.1    Jones, P.L.2    Boss, J.M.3    Merrill, A.H.4
  • 117
    • 0028043535 scopus 로고
    • Signal-transduction and regulation in smooth-muscle
    • Somlyo, A.P. & Somlyo, A.V. 1994. Signal-transduction and regulation in smooth-muscle. Nature 372, 231-236.
    • (1994) Nature , vol.372 , pp. 231-236
    • Somlyo, A.P.1    Somlyo, A.V.2
  • 118
    • 0031607140 scopus 로고    scopus 로고
    • Roles of sphingosine-1-phosphate in cell growth, differentiation, and death
    • Spiegel, S., Cuvillier, O., Edsall, L. et al. 1998. Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. Biochem-Moscow 63, 69-73.
    • (1998) Biochem-Moscow , vol.63 , pp. 69-73
    • Spiegel, S.1    Cuvillier, O.2    Edsall, L.3
  • 119
    • 0029996139 scopus 로고    scopus 로고
    • Signal-transduction through lipid 2nd-messengers
    • Spiegel, S., Foster, D. & Kolesnick, R. 1996a. Signal-transduction through lipid 2nd-messengers. Cur Opin Cell Biol 8, 159-167.
    • (1996) Cur Opin Cell Biol , vol.8 , pp. 159-167
    • Spiegel, S.1    Foster, D.2    Kolesnick, R.3
  • 120
    • 0029862561 scopus 로고    scopus 로고
    • Sphingolipid metabolism and cell-growth regulation
    • Spiegel, S. & Merrill, A. H. 1996b. Sphingolipid metabolism and cell-growth regulation. FASEB J 10, 1388-1397.
    • (1996) FASEB J , vol.10 , pp. 1388-1397
    • Spiegel, S.1    Merrill, A.H.2
  • 121
    • 77956795073 scopus 로고
    • Sphingolipids
    • D.E. Vance & J.E. Vance (eds) Elsevier, Amsterdam
    • Sweely, C.C. 1991. Sphingolipids. In: D.E. Vance & J.E. Vance (eds) Biochemistry of Lipids, Lipoproteins and Membranes Vol. 20, pp. 327-361. Elsevier, Amsterdam.
    • (1991) Biochemistry of Lipids, Lipoproteins and Membranes , vol.20 , pp. 327-361
    • Sweely, C.C.1
  • 123
    • 0028915824 scopus 로고
    • Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric arteries
    • Toma, C., Jensen, P.E., Prieto, D., Hughes, A., Mulvany, M.J. & Aalkjaer, C. 1995. Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric arteries. Br J Pharmacol 114, 1266-1272.
    • (1995) Br J Pharmacol , vol.114 , pp. 1266-1272
    • Toma, C.1    Jensen, P.E.2    Prieto, D.3    Hughes, A.4    Mulvany, M.J.5    Aalkjaer, C.6
  • 124
    • 0028987695 scopus 로고
    • Phospholipase d-induced phosphatidate production in intact small arteries during noradrenaline stimulation -involvement of both G-protein and tyrosine-phosphorylation-linked pathways
    • Ward, D.T., Ohanian, J., Heagerty, A.M. & Ohanian, V. 1995. Phospholipase d-induced phosphatidate production in intact small arteries during noradrenaline stimulation -involvement of both G-protein and tyrosine-phosphorylation-linked pathways. Biochem J 307, 451-456.
    • (1995) Biochem J , vol.307 , pp. 451-456
    • Ward, D.T.1    Ohanian, J.2    Heagerty, A.M.3    Ohanian, V.4
  • 125
    • 0344373543 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the focal contact proteins paxillin and p125FAK by noradrenaline is calcium-dependent but PKC-independent in rat small arteries
    • Ward, D.T., Ohanian, J., Heagerty, A.M. & Ohanian, V. 1997. Tyrosine phosphorylation of the focal contact proteins paxillin and p125FAK by noradrenaline is calcium-dependent but PKC-independent in rat small arteries (Abstract). Hypertens 30, 505.
    • (1997) Hypertens , vol.30 , pp. 505
    • Ward, D.T.1    Ohanian, J.2    Heagerty, A.M.3    Ohanian, V.4
  • 126
    • 0029993903 scopus 로고    scopus 로고
    • Serotonin stimulates protein tyrosyl phosphorylation and vascular contraction via tyrosine kinase
    • Watts, S.W., Yeum, C.H., Campbell, G. & Webb, R.C. 1996. Serotonin stimulates protein tyrosyl phosphorylation and vascular contraction via tyrosine kinase. J Vasc Res 33, 288-298.
    • (1996) J Vasc Res , vol.33 , pp. 288-298
    • Watts, S.W.1    Yeum, C.H.2    Campbell, G.3    Webb, R.C.4
  • 128
    • 0028108015 scopus 로고
    • Functional dichotomy of neutral and acidic sphingomyelinases in tumour necrosis factor signalling
    • Wiegmann, K., Schutze, S., Machleidt, T., Witte, D. & Kronke, M. 1994. Functional dichotomy of neutral and acidic sphingomyelinases in tumour necrosis factor signalling. Cell 78, 1005-1015.
    • (1994) Cell , vol.78 , pp. 1005-1015
    • Wiegmann, K.1    Schutze, S.2    Machleidt, T.3    Witte, D.4    Kronke, M.5
  • 129
    • 0027246243 scopus 로고
    • Endothelin-1 stimulated phospholipase D in A10 vascular smooth-muscle derived cells is dependent on tyrosine kinase - Evidence for involvement in stimulation of mitogenesis
    • Wilkes, L.C., Patel, V., Purkiss, J.R. & Boarder, M.R. 1993. Endothelin-1 stimulated phospholipase D in A10 vascular smooth-muscle derived cells is dependent on tyrosine kinase - evidence for involvement in stimulation of mitogenesis. FEBS Lett 322, 147-150.
    • (1993) FEBS Lett , vol.322 , pp. 147-150
    • Wilkes, L.C.1    Patel, V.2    Purkiss, J.R.3    Boarder, M.R.4
  • 130
    • 0028122397 scopus 로고
    • Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
    • Wolff, R.A., Dobrowsky, R.T., Bielawska, A. & Hannun, Y.A. 1994. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 269, 19605-19609.
    • (1994) J Biol Chem , vol.269 , pp. 19605-19609
    • Wolff, R.A.1    Dobrowsky, R.T.2    Bielawska, A.3    Hannun, Y.A.4
  • 131
    • 0030035301 scopus 로고    scopus 로고
    • Prostacyclin formation elicited by endothelin-1 in rat aorta is mediated via phospholipase-d activation and not phospholipase-C or A (2)
    • Wright, H.M. & Malik, K.U. 1996. Prostacyclin formation elicited by endothelin-1 in rat aorta is mediated via phospholipase-d activation and not phospholipase-C or A (2). Circ Res 79, 271-276.
    • (1996) Circ Res , vol.79 , pp. 271-276
    • Wright, H.M.1    Malik, K.U.2
  • 132
    • 0023927798 scopus 로고
    • Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts
    • Wright, T.M., Rangan, L.A., Shin, H.S. & Raben, D.M. 1988. Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. J Biol Chem 263, 9374-9380.
    • (1988) J Biol Chem , vol.263 , pp. 9374-9380
    • Wright, T.M.1    Rangan, L.A.2    Shin, H.S.3    Raben, D.M.4
  • 134
    • 0028838235 scopus 로고
    • Phosphorylation of Raf by ceramide-activated protein kinase
    • Yao, B., Zhang, Y., Delikat, S., Mathias, S., Basu, S. & Kolesnick, R. 1995b. Phosphorylation of Raf by ceramide-activated protein kinase. Nature 378, 307-310.
    • (1995) Nature , vol.378 , pp. 307-310
    • Yao, B.1    Zhang, Y.2    Delikat, S.3    Mathias, S.4    Basu, S.5    Kolesnick, R.6
  • 135
    • 0026700191 scopus 로고
    • Bombesin, vasopressin and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells - Identification of a novel tyrosine kinase as amajor substrate
    • Zachary, I., SinnettSmith, J. & Rozengurt, E. 1992. Bombesin, vasopressin and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells - identification of a novel tyrosine kinase as amajor substrate. J Biol Chem 267, 19031-19034.
    • (1992) J Biol Chem , vol.267 , pp. 19031-19034
    • Zachary, I.1    SinnettSmith, J.2    Rozengurt, E.3
  • 136
    • 0027536597 scopus 로고
    • Choline phospholipids: Signal transduction and carcinogenesis
    • Zeisel, Z.H. 1993. Choline phospholipids: Signal transduction and carcinogenesis. FASEB J 7, 551-557.
    • (1993) FASEB J , vol.7 , pp. 551-557
    • Zeisel, Z.H.1
  • 137
    • 0028979464 scopus 로고
    • Crystal structure of the Cys2 activator binding protein domain of protein kinase Cγ in complex with phorbol ester
    • Zhang, G., Kazaneitz, M.G., Blumberg, P.M. & Hurley, J.H. 1995. Crystal structure of the Cys2 activator binding protein domain of protein kinase Cγ in complex with phorbol ester. Cell 81, 917-924.
    • (1995) Cell , vol.81 , pp. 917-924
    • Zhang, G.1    Kazaneitz, M.G.2    Blumberg, P.M.3    Hurley, J.H.4
  • 138
    • 0343742670 scopus 로고    scopus 로고
    • Kinase suppressor of Ras is ceramide-activated protein kinase
    • Zhang, Y.H., Yao, B., Delikat, S. et al. 1997. Kinase suppressor of Ras is ceramide-activated protein kinase. Cell 89, 63-72.
    • (1997) Cell , vol.89 , pp. 63-72
    • Zhang, Y.H.1    Yao, B.2    Delikat, S.3


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