Clinical review: A critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 3, 2006, Pages 772-780

  Dewell, Antonella ^a   Hollenbeck, Piper L W ^b   Hollenbeck, Clarie B ^a  

^a SAN JOSE STATE UNIVERSITY   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; BILE ACID SEQUESTRANT; CHOLESTEROL; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE DERIVATIVE; LIGNAN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; PHYTOESTROGEN; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; SOYBEAN PROTEIN; STATINE DERIVATIVE;

AUTOIMMUNE DISEASE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; COGNITIVE DEFECT; CORONARY ARTERY DISEASE; DIET; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFECT; EVIDENCE BASED MEDICINE; FOOD ANALYSIS; GENOTOXICITY; HUMAN; HYPERCHOLESTEROLEMIA; MEDICAL LITERATURE; META ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SOYBEAN; SYSTEMATIC REVIEW; THYROID DISEASE; TREATMENT OUTCOME;

CHOLESTEROL; CORONARY DISEASE; DIETARY SUPPLEMENTS; HUMANS; ISOFLAVONES; SOYBEAN PROTEINS;

GLYCINE MAX;

EID: 33644820082     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2004-2350     Document Type: Review

References (87)

1. Clarkson TB 2002 Soy, soy phytoestrogens and cardiovascular disease. J Nutr 132:566S-569S
2. Messina M, Gardner C, Barnes S 2002 Gaining insight into the health effects of soy but a long way still to go: commentary on the fourth international symposium on the role of soy in preventing and treating chronic disease. J Nutr 132:547S-551S
3. Lichtenstein AH 2001 Got soy? Am J Clin Nutr 73:667-668
4. Kerckhoffs DAJM, Brouns F, Hornstra G, Mensink RP 2002 Effects on the human serum lipoprotein profile of β-glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. J Nutr 132:2492-2505
5. Meeker DR, Kesten HD 1940 Experimental atherosclerosis and high protein diets. Proc Soc Exp Biol Med 45:543-545
6. Anthony MS, Clarkson, TB, Bullock BC, Wagner JD 1997 Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys. Arterioscler Thromb Vasc Biol 17:2425-2531
7. Nagata C, Takatsuka N, Kurisu Y, Shimizu H 1998 Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr 128:209-213
8. Potter SM 1995 Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J Nutr 125:606S-611S
9. Food and Drug Administration 1999 Food labeling: health claims; soy protein and coronary artery disease. Fed Regist 64:57699-57733
10. The Nutrition Committee of the American Heart Association 2000 AHA dietary guidelines. Revision 2000: a statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 102:2284-2299
11. Carrol KK 1991 Review of clinical studies on cholesterol-lowering response to soy protein. J Am Diet Assoc 91:820-827
12. Anderson JW, Johnstone BM, Cook-Newell ME 1995 Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333:276-282
13. Baum JA, Teng H, Erdman Jr JW, Weigel RM, Klein BP, Persky VW, Freels S, Surya P, Bakhit RM, Ramos E, Shay NF, Potter SM 1998 Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am J Clin Nutr 68:545-551
14. Potter SM, Baum JA, Teng H, Stillman, RJ, Shay NF, Erdman Jr JW 1998 Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 58:1375S-1379S
15. Crouse III JR, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL 1999 A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 159:2070-2076
16. Washburn S, Burke GL, Morgan T, Anthony M 1999 Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 6:7-13
17. Merz-Demlow BE, Duncan AM, Wangen KE, Xu X, Carr TP, Phipps WR, Kurzer MS 2000 Soy isoflavones improve plasma lipids in normocholesterolemic premenopausal women. Am J Clin Nutr 71:1462-1469
18. Teixeira SR, Potter SM, Weigel R, Hannum S, Erdman Jr JW, Hasler CM 2000 Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am J Clin Nutr 71:1077-1084
19. Gardner CD, Newell KA, Cherin R, Haskell W 2001 The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 73:728-735
20. Scheiber MD, Liu JH, Subbiah MT, Subbiah MT, Rebar RW, Setchell KD 2001 Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 8:384-392
21. Teede HJ, Dalais FS, Kotsopoulos D, Liang Y-L, Davis S, McGrath BP 2001 Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 86:3053-3060
22. Wangen KE, Duncan AM, Xu X, Kurzer MS 2001 Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73:225-231
23. 1 concentrations and hemostatic risk factors for coronary heart disease in healthy subjects. Am J Clin Nutr 76:373-377
24. Jenkins DJA, Kendall CWC, Jackson CJC, Connelly PW, Parker T, Faulkner D, Vidgen E, Cunnane SC, Leiter LA, Josse RG 2002 Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 76:365-372
25. Lichtenstein AH, Jalbert SM, Adlercreutz H, Goldin BR, Rasmussen H, Schaefer EJ, Ausma LM 2002 Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscl Thromb Vasc Biol 22:1852-1858
26. Cuevas AM, Irribarra VL, Castillo OA, Yañez MD, Germain AM 2003 Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur J Clin Nutr 57:889-894
27. Blum A, Lang N, Vidger F, Israeli P, Gumanovsky M, Lupovitz S, Elgazi A, Peleg A, Ben-Ami M 2003 Effects of soy protein on endothelium-dependent vasodilation and lipid profile in postmenopausal women with mild hypercholesterolemia. Clin Invest Med 26:20-26
28. Sagara M, Kanda T, NJelekera M, Teramoto T, Armitage L, Birt N, Birt C, Yamori Y 2003 Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland. J Am Coll Nutr 23:85-91
29. Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EHF, Aleman A, Lampe JW, van der Schouw YT 2004 Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292:65-74
30. Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Owen A, Abbey, M 1997 Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscl Thromb Vasc Biol 17:3392-3398
31. Nestel PJ, Pomeroy S, Kay S, Komesaroff P, Behrsing J, Cameron JD, West L 1999 Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab 84:895-898
32. Hodgson JM, Puddey IB, Beilin LJ, Mori TA, Croft KD 1998 Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 128:728-732
33. Samman S, Lyons Wall PM, Chan GS, Smith SJ, Petocz P 1999 The effect of supplementation with isoflavones on plasma lipids and oxidisability of low density lipoprotein in premenopausal women. Atherosclerosis 147:277-283
34. Howes JB, Sullivan D, Lai N, Nestel P, Pomeroy S, West L, Eden JA, Howes LG 2000 The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia. Atherosclerosis 152:143-147
35. Simons LA, von Konigsmark M, Simons J, Celermajer DS 2000 Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 85:1297-1301
36. Clifton-Bligh PB, Baber RJ, Fulcher GR, Nery ML, Moreton T 2001 The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause 8:259-265
37. Dewell A, Hollenbeck CB, Bruce B 2002 The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab 87:118-121
38. Uesugi T, Fukui Y, Yamori Y 2002 Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: a four-week study. J Am Coll Nutr 21:97-102
39. Setchell KDR 1998 Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 68:1333S-1346S
40. Miksiceck RJ 1994 Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 49:153-160
41. Setchell KDR, Cassidy A 1999 Dietary isoflavones: biological effects and relevance to human health. J Nutr 129:758S-767S
42. Davis SR, Murkies AL, Wilcox G 1998 Phytoestrogens in clinical practice. Integr Med 1:27-34
43. Tham DM, Gardner CD, Haskell WL 1998 Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 83:2223-2235
44. Wang H, Murphy PA 1994 Isoflavone content in commercial soybean foods. J Agric Food Chem 42:1666-1673
45. Coward L, Barnes NC, Setchell KDR, Barnes S 1993 Genistein, daidzein, and their β-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41:1961-1967
46. Anderson RL, Wolf WJ 1995 Compositional changes in trypsin inhibitors, phytic acid, saponins and isoflavones related to soybean processing. J Nutr 125:581S-588S
47. 2001 SPINS/Soyatech Study in Association with Arthur D. Little. Soyfoods: The U.S. Market 2001. Bar Harbor, ME: Soyatech
48. Friedewald WT, Levy RI, Fredrickson DS 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502
49. Nestel P 2002 Role of soy protein in cholesterol-lowering. How good is it? Arterioscl Thromb Vasc Biol 22:1743-1744
50. Sirtori CR 2001 Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis. Drug Saf 24:665-682
51. Weggemans RM, Trautwein EA 2003 Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a meta-analysis. Eur J Clin Nutr 57:940-946
52. Sirtori CR, Lovati MR 2001 Soy proteins and cardiovascular disease. Curr Atheroscelor Rep 3:47-53
53. Erdman JW 2000 Soy protein and cardiovascular disease: a statement for healthcare professionals from the nutrition committee of the AHA. Circulation 102:2555-2559
54. Kurowska EM, Carroll KK 1994 Hypercholesterolemic responses in rabbits to selected groups of dietary essential amino acids. J Nutr 124:364-370
55. Huff MW, Hamilton RMG, Carroll KK 1977 Plasma cholesterol levels in rabbits fed low fat, cholesterol-free, semipurified diets: effects of dietary proteins, protein hydrolysates and amino acid mixtures. Atherosclerosis 28:187-195
56. Tasker T, Potter SM 1993 Influence of dietary proteins and amino acid variation on plasma lipids, HMG-CoA reductase activity, and reduced glutathione concentrations in inbred versus outbred gerbils. J Nutr Biochem 4:458-462
57. Lovati MR, Manzoni C, Corsini A, Granata A., Sirtori CR 1992 Low density lipoproteins receptor activity is modulated by soybean globulins in cell culture. J Nutr 122:1971-1978
58. Lovati MR, Manzoni C, Gianazza E, Sirtori CR 1998 Soybean protein products as regulators of liver low-density lipoprotein receptors I: identification of active β-conglycinin subunits. J Agric Food Chem 46:2474-2480
59. Manzoni C, Lovati MR, Gianazza E, Sirtori CR 1998 Soybean protein products as regulators of liver low-density lipoprotein receptors II: α-α′ rich commercial soy concentrate and α′ deficient mutant differently affect low-density lipoprotein receptor activation. J Agric Food Chem 46:2481-2484
60. Lovati MR, Manzoni C, Gianazza E, Arnoldi, A, Kurowska E, Carroll KK, Sirtori, CR 2000 Soy protein peptides regulate cholesterol homeostasis in Hep G2 cells. J Nutr 130:2543-2549
61. Lovati MR, Manzoni C, Canavesi A, Sirtori M, Vaccarino V, Marchi M, Gaddi G, Sirtori CR 1987 Soybean protein diets increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J Clin Invest 80:125-130
62. Rothman S, Liebow C, Isenman L 2001 Conservation of digestive enzymes. Physiol Rev 82:1-18
63. Jenkins DJA, Kendall CWC, Marchie A, Faulkner D, Wong JMW, de Souza R, Emam A, Parker TL, Vidgen E, Trautwein EA, Lapsley KG, Josse RG, Leiter LA, Singer W, Connelly PW 2005 Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. Am J Clin Nutr 81:380-387
64. Jenkins DJA, Kendall CWC, Faulkner D, Vidgen E, Trautwein EA, Parker TL, Marchie A, Koumbridis G, Lapsley KG, Leiter LA, Singer W, Connelly PW 2002 A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins and viscous fibers in hypercholesterolemia. Metabolism 51:1596-1604
65. Gerhard GT, Connor SL, Wander RC, Connor WE 2000 Plasma lipid and lipoprotein responsiveness to dietary fat and cholesterol in premenopausal African American and white women. Am J Clin Nut 72:56-63
66. Beauchesne-Rondeau E, Gascon W, Bergeron J, Jacques H 2003 Plasma lipids and lipoproteins in hypercholesterolemic men fed a lipid-lowering diet containing lean beef, lean fish, or poultry. Am J Clin Nutr 77:587-593
67. Scott LW, Junn JK, Pownall HJ, Brauchi DJ, McMann MC, Herd JA, Harris KB, Savell JW, Cross HR, Gotto AM 1994 Effects of beef and chicken consumption on plasma lipid levels in hypercholesterolemic men. Arch Intern Med 154:1261-1267
68. Davison MH, Hunninghake D, Maki KC, Kwiterovich PI, Kafonnek S 1999 Comparison of the effects of lean red meat vs lean white meat on serum lipid levels among free-living persons with hypercholesterolemia. Arch Intern Med 159:1331-1338
69. Setchell KDR, Brown NM, Lydeking-Olsen E 2002 The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 132:3577-3584
70. Lydeking-Olsen E, Meinertz H, Nilausen K, Setchell KDR, Damhus M, Jensen TH 2002 Lipoprotein effects of soy milk and progesterone for prevention of bone loss in post menopausal hypercholesterolemic women. J Nutr 132:608S (Abstract)
71. Nestel P, Cehun M, Chronopoulos A, DaSilva L, Teede H, McGrath B 2004 Biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men. Eur J Clin Nutr 58:403-408
72. Dewell A, Hollenbeck CB, Bruce B 2002 Authors' response. Soy supplement - why is the effect so elusive? J Clin Endocrinol Metab 87:3508-3509
73. Law MR, Wald NJ, Rudnicka AR 2003 Quantifiying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 326:1423
74. Gotto AM 2002 Management of dyslipidemia. Am J Med 112:10S-18S
75. National Cholesterol Education Program 2001 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486-2497
76. Liener IE 1994 Implications of antinutritional components in soybean foods. Crit Rev Food Sci Nutr 34:31-67
77. Kotsonis FN, Burdock GA, Flamm WG 2001 Food toxicology. In: Klaassen Curtis, ed. Casarett and Doull's toxicology: the basic science of poisons 6th ed. New York: McGraw-Hill Medical Publishing Division; 1049-1088
78. Shibamoto T, Bjeldanes LF 1993 Introduction to food toxicology. New York: Academic Press; 78-79
79. Frölich W 1995. Bioavailability of micronutrients in a fibre-rich diet, especially related to minerals. Eur J Clin Nutr 49:116-122
80. Maga JA 1982 Phytate: its chemistry, occurrence, food interactions, nutritional significance, and methods of analysis. J Agric Food Chem 30:1-9
81. Fort P, Moses N, Fasano M 1990 Breast and soy-formula feedings in early infancy and the prevalence of autoimmune thyroid disease in children. J Am Coll Nutr 9:164-167
82. White LR, Petrovitch H, Ross GW 2000 Brain aging and midlife tofu consumption. J Am Coll Nutr 19:242-258
83. Rackis JJ, Gumbmann MR, Liener IE 1985 The USDA trypsin inhibitor study. I. Background, objectives, and procedural details. Plant Foods Hum Nutr 35:213-242
84. Liener IE, Nitsan Z, Srisangnam C, Rackis JJ, Gumbmann MR 1985 The USDA trypsin inhibitor study. II. Timed related biochemical changes in the pancreas of rats. Plant Foods Hum Nutr 35:243-257
85. Spangler WL, Gumbmann MR, Liener IE, Rackis JJ 1985 The USDA trypsin inhibitor study. III. Sequential development of pancreatic pathology in rats. Plant Foods Hum Nutr 35:259-274
86. Gumbmann MR, Spangler WL, Dugan GM, Rackis JJ, Liener IE 1985 The USDA trypsin inhibitor study. IV. The chronic effects of soy flour and soy protein isolate on the pancreas in rats after two years. Plant Foods Hum Nutr 35:275-314
87. Ariyo AA, Villablanca AC 2002 Estrogens and lipids. Can HRT designer estrogens, and phytoestrogens reduce cardiovascular risk markers after menopause? Postgrad Med 111:23-30