A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men

European Journal of Clinical Nutrition

Volumn 58, Issue 3, 2004, Pages 403-408

  Nestel, Paul ^a   Cehun, M ^a   Chronopoulos, A ^a   DaSilva, L ^a   Teede, H ^a   McGrath, B ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Biochanin; Formononetin; Isoflavones; LDL cholesterol; Red clover

Indexed keywords

BIOCHANIN A; DAIDZEIN; GENISTEIN; HYPOCHOLESTEROLEMIC AGENT; ISOFLAVONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; RED CLOVER EXTRACT;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EXCRETION; DRUG ISOLATION; DRUG URINE LEVEL; FEMALE; FLOWER; HUMAN; MALE; RANDOMIZED CONTROLLED TRIAL; RED CLOVER; TIME; TREATMENT FAILURE; VOLUNTEER;

AGED; ANALYSIS OF VARIANCE; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GENISTEIN; HUMANS; ISOFLAVONES; MALE; MIDDLE AGED; POSTMENOPAUSE; SEX FACTORS; TREATMENT OUTCOME; TRIFOLIUM;

TRIFOLIUM; TRIFOLIUM PRATENSE;

EID: 1842528017     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1601796     Document Type: Article

References (27)

1. Anderson JW, Johnstone BM & Cook-Newell MB (1995): Meta-analysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 333, 276-382.
2. Baum JA, Teng H, Erdman Jr JW, Weigel RM, Klein BP, Persky VW, Freels S, Surya P, Bakhit RM, Ramos E, Shay NF & Potter SM (1998 : Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am. J. Clin. Nutr. 68, 545-551.
3. Busby MG, Jeffcoat AR, Bloedon LT, Koch MA, Black T, Dix KJ, Heizer WD, Thomas BF, Hill JM, Crowell JA & Zeisel SH (2002): Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am. J. Clin. Nutr. 75, 126-136.
4. Clifton PM & Nestel PJ (1992): Influence of gender, body mass index, and age on response of plasma lipids to dietary fat plus cholesterol. Arterioscler. Thromb. 12, 955-962.
5. Cobb MA, Teitlebaum H, Risch N, Jekel J & Ostfeld A (1992): Influence of dietary fat, apolipoprotein E phenotype, and sex on plasma lipoprotein levels. Circulation 86, 849-857.
6. Crouse JR, Morgan T, Terry JG, Ellis J, Vitolins M & Burke GL (1999): A randomized trial comparing the effect of casein with that of soy protein containing various amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch. Intern. Med. 159, 2070-2076.
7. Erdman Jr JW (2000): Soy protein and cardiovascular disease. A statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation 102, 2555-2559.
8. Gardner CD, Newell KA, Cherin R & Haskell WL (2001): The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73, 728-735.
9. Geil PB, Anderson JW & Gustafson NJ (1995): Women and men with hypercholesterolemia respond similarly to an American Heart Association step 1 diet. J. Am. Diet. Assoc. 95, 436-441.
10. Hodgson JM, Puddey IB, Beilin LJ, Mori TA & Croft KD (1998): Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: A randomized controlled trial in humans. J. Nutr. 128, 728-732.
11. Howes JB, Sullivan D, Lai N, Nestel P, Pomeroy S, West L, Eden JA & Howes LG (2000): The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post-menopausal women with mild to moderate hypercholesterolaemia. Atherosclerosis 152, 143-147.
12. Jenkins DA, Kendall CWC, Jackson C-J C, Connelly PW, Parker T, Faulkner D, Vidgen E, Cunnane SC, Leiter LA & Josse RG (2002): Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am. J. Clin. Nutr. 76, 4365-4372.
13. Lichtenstein AH, Jalbert SM, Adlercreutz H, Goldin BR, Rasmussen H, Schaefer EJ & Ausman LA (2002): Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler. Thromb. Vasc. Biol. 22, 1852-1858.
14. Lovati MR, Manzoni C, Canavesi A, Sirtori M, Vaccarino V, Marchi M, Gaddi A & Sirtori CR (1987): Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J. Clin. Invest. 80, 1498-1502.
15. Meinertz H, Nilausen K & Hilden J (2002): Alcohol-extracted, but not intact dietary soy protein lowers lipoprotein(a) markedly. Arterioscler. Thromb. Vasc. Biol. 22, 312-316.
16. Morito K, Hirose T, Kinjo J, Hirakawa T, Okawa M, Nohara T, Ogawa S, Inoue S, Muramatsu S & Masamune Y (2001): Interaction of phytoestrogens with estrogen receptors α and β. Biol. Pharm. Bull. 24, 351-356.
17. Nestel PJ, Pomeroy S, Kay S, Komesaroff P, Behrsing J, Cameron JD & West L (1999): Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J. Clin. Endocrinol. Metab. 84, 895-898.
18. Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Owen A & Abbey M (1997): Soy isoflavones improve arterial compliance but not plasma lipids in menopausal women. Arterioscler. Thromb. Vasc. Biol. 17, 3392-3398.
19. Rowland IR, Wiseman H, Sanders TA, Adlercreutz H & Bowey EA (2000): Interindividual variation in metabolism of soy isoflavones and lignans: Influence of habitual diet on equol production by the gut flora. J. Nutr. 36, 27-32.
20. Savolainen MJ, Rantala M, Kervinen K, Jarvi L, Suvanto K, Rantala T & Kesaniemi YA (1991): Magnitudes of dietary effects on plasma concentration: Role of sex and apoprotein E phenotype. Atherosclerosis 86, 145-152.
21. Setchell KT (1998): Phytoestrogens: the biochemistry, physiology and implications for human health of soy isoflavones. Am. J. Clin. Nutr. 68(Suppl), 1333S-1346S.
22. Simons LA, von Konigsmark M, Simons J & Celermajer DS (2000): Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am. J. Cardiol. 85, 1297-1301.
23. Teede HJ, Dalais F, Kotsopoulos D, Liang YL & McGrath BP (2001): Soy protein dietary supplementation containing phytoestrogens improves lipid profiles and blood pressure: A double-blind, randomized, placebo-controlled study in men and post-menopausal women. J. Clin. Endocr. Metab. 86, 3053-3060.
24. Teixeira SR, Potter SM, Weigel R, Hannum S, Erdman Jr JW & Hasler CM (2000): Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am. J. Clin. Nutr. 71, 1077-1084.
25. Tsunoda N, Pomeroy S & Nestel P (2002): Absorption in humans of isoflavones from soy and red clover is similar. J. Nutr. 132, 2199-2201.
26. Vigna GB, Pansini F & Bonaccorsi G (2000): Plasma lipoproteins in soy-treated postmenopausal women: A double-blind, placebo-controlled trial. Nutr. Metab. Cardiovasc. Dis. 10, 315-322.
27. Wangen KE, Duncan AM, Xu X & Kurzer MS (2001): Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am. J. Clin. Nutr. 73, 225-231.