Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 3, 1999, Pages 895-898

  Nestel, Paul J ^c   Pomeroy, Sylvia ^d   Sally, Kay ^d   Komesaroff, Paul ^d   Behrsing, Julie ^d   Cameron, James D ^a   West, Leanne ^b  

^a LA TROBE UNIVERSITY   (Australia)

^b Novogen Ltd   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHANIN A; CHOLESTEROL; DAIDZEIN; ESTROGEN; FOLLITROPIN; FORMONONETIN; GENISTEIN; GLUCOSE; ISOFLAVONE; ISOFLAVONE DERIVATIVE; LIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTERY COMPLIANCE; ARTICLE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; MEAN ARTERIAL PRESSURE; MENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; URINARY EXCRETION;

EID: 0038371593     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.3.895     Document Type: Article

References (23)

1. Colditz GA, Willett WC, Stampfer MJ, Rosner N, Speizer FE, Hennekens CH. 1987 Menopause and the risk of coronary heart disease in women. N Engl J Med. 16:1105-1110.
2. Barrett-Connor E, Bush TL. 1991 Estrogen and coronary heart disease in women. JAMA. 265:861-1867.
3. Sudhir K, Jennings GL, Funder JW, Komesaroff PA. 1996 Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension. 28:330-334.
4. Gilligan DM, Quyyumi AA, Cannon RO. 1994 Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation. 89:2545-2551.
5. Nestel PJ, Yamashita T, Sasahara T, et al. 1997 Soy isoflavones improve arterial compliance but not plasma lipids in menopausal women. Arterioscler Thromb Vasc Biol. 17:3392-3398.
6. Anthony MS, Clarkson TB, Bullock BC, Wagner JD. 1997 Soy protein vs. soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys. Arterioscler Thromb Vasc Biol. 17:2524-2531.
7. Tikkanen M, Wahala K, Ojala S, Vihma V, Adlercreutz H. 1998 Effect of phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA. 95:3106-3110.
8. Tanaka H, DeSouza CA, Seals DR. 1998 Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol. 18:127-132.
9. Dart AM, Qi XL. 1995 Determinants of arterial stiffness in Chinese migrants to Australia. Atherosclerosis. 117:263-272.
10. Liu Z, Brin KP, Yin FC. 1986 Estimation of total arterial compliance: an improved method and evaluation of current methods. Am J Physiol. 251:H588-H600.
11. Cameron JD, Dart AM. 1994 Exercise training increases total systemic arterial compliance in humans. Am J Physiol. 266:H693-H701.
12. Bush TL, Barrett-Connor E, Cowan LD, et al. 1987 Cardiovascular mortality and non contraceptive use of estrogen in women: results from the Lipid Research Clinics Program follow-up study. Circulation. 75:1102-1109.
13. Anderson JW, Johnstone BM, Cook-Newell ME. 1995 Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 333:276-282.
14. Taddei S, Virdis A, Ghiadoni L, et al. 1996 Menopause is associated with endothelial dysfunction in women. Hypertension. 28:576-582.
15. Gangar KF, Vyas S, Whitehead M, Crook D, Meire H, Campbell S. 1991 Pulsatility index in internal carotid artery in relation to transdermal oestradiol and time since menopause. Lancet. 338:839-842.
16. Rajkumar C, Kingwell BA, Cameron JD, et al. 1997 D.Horomonal therapy increases arterial compliance in postmenopausal women. J Am Coll Cardiol. 30:350-356.
17. Nestel PJ, Pomeroy SE, Sasahara T, et al. 1997 Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol. 17:1163-1170.
18. Yamashita T, Sasahara T, Pomeroy S, Collier G, Nestel PJ. 1998 Arterial compliance, blood pressure, plasma leptin and plasma lipids are improved with weight reduction equally with meat based diet and plant based diet. Metabolism. 47:1308-1314.
19. Dart A, Silagy C, Dewar E, Jennings G, McNeil J. 1993 Aortic distensibility and left ventricular structure and function in isolated systolic hypertension. Eur Heart J. 14:1465-1470.
20. Lieberman EH, Gerhard MD, Uehata A, et al. 1994 Estrogen improves endothelium dependent flow-mediated vasodilation in postmenopausal women. Ann Intern Med. 121:936-941.
21. McGrath BP, Liang YL, Teede H, Shiel LM, Cameron JD, Dart A. 1998 Age-related deterioration in arterial structure and function in postmenopausal women. Impact of hormone replacement therapy. Arterioscler Thromb Vasc Biol. 18:1149-1156.
22. Gatzka CD, Cameron JD, Kingwell BA, Dart AM. 1998 Relation between coronary artery disease, aortic stiffness, and left ventricular structure in a population sample. Hypertension. 32:575-578.
23. Lehmann ED, Hopkins KD, Rawesh A, Joseph RC, Kongola K, Coppack SW, Gosling RG. 1998 Relation between number of cardiovascular risk factors/events and noninvasive doppler ultrasound assessments of aortic compliance. Hypertension. 32:565-569.