Soy protein versus soy phytoestrogens in the prevention of diet-induced coronary artery atherosclerosis of male cynomolgus monkeys

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 11, 1997, Pages 2524-2531

  Anthony, Mary S ^a   Clarkson, Thomas B ^a   Bullock, Bill C ^a   Wagner, Janice D ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Cynomolgus monkeys; Isoflavones; Males; Phytoestrogens; Soy protein

Indexed keywords

CASEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE; LACTALBUMIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOESTROGEN; PROTECTIVE AGENT; SOYBEAN PROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; BODY WEIGHT; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTAKE; TESTIS WEIGHT;

EID: 0031457547     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.11.2524     Document Type: Article

References (18)

1. Washburn SA, Adams MR, Clarkson TB, Adelman SJ. A conjugated equine estrogen with differential effects on uterine weight and plasma cholesterol in the rat. Am J Obstet Gynecol. 1993;169: 251-256.
2. Washburn SA, Honoré EK, Cline JM, et al. Effects of 17α-dihydroequilenin sulfate on atherosclerotic male and female rhesus monkeys. Am J Obstet Gynecol. 1996;175:341-351.
3. Anthony MS, Clarkson TB, Hughes CL, Morgan TM, Burke GL. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr. 1996;126:43-50.
4. Black LJ, Sato M, Rowley ER, et al. Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. J Clin Invest. 1994;93: 63-69.
5. Ke HZ, Simmons HA, Pirie CM, Crawford D, Thompson DD. Droloxifene, a new estrogen agonist/antagonist, prevents bone loss in ovariectomized rats. Endocrinology. 1995;136:2435-2441.
6. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med. 1991;20:47-63.
7. Colditz GA, Egan KM, Stampfer MJ. Hormone replacement therapy and risk of breast cancer: results from epidemiologic studies. Am J Obstet Gynecol. 1993;168:1473-1480.
8. Grady D, Gebretsadik T, Kerlikowske K, Ernster V, Pettiti D. Hormone replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynecol. 1995;85:304-313.
9. Robinson RW, Higano N, Cohen WD. Long-term effects of high-dosage estrogen therapy in men with coronary heart disease. J Chron Dis. 1963;16:155-161.
10. Oliver MF, Boyd GS. Influence of reduction of serum lipids on prognosis of coronary heart disease. Lancet. 1961;2:499-505.
11. Marmorston J, Moore FJ, Hopkins CE, Kuzma OT, Weiner J. Clinical studies of long-term estrogen therapy in men with myocardial infarction. Proc Soc Exp Biol Med. 1962;110:400-408.
12. Stamler J, Pick R, Katz LN, et al. Effectiveness of estrogens for therapy of myocardial infarction in middle-age men. JAMA. 1963; 183:632-638.
13. Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol, Clin Chem. 1974;20: 470-475.
14. Fossati P, Principe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982;28:2077-2080.
15. Manual of Laboratory Operations: Lipid Research Clinics Program. Vol 1. Lipid and Lipoprotein Analysis. Bethesda, Md: National Heart, Lung, and Blood Institute, National Institutes of Health; 1974. US Dept of Health, Education, and Welfare publication NIH 75-268.
16. Clarkson TB. Progression and regression of nonhuman primate coronary artery atherosclerosis: considerations of experimental design. In: Malinow MR, Blaton VH, eds. Regression of Atherosclerotic Lesions. New York, NY: Plenum Publishing; 1984:43-60.
17. Clarkson TB, Bond MG, Bullock BC, McLaughlin KJ, Sawyer JK. A study of atherosclerosis regression in Macaca mulatto. V. Changes in abdominal aorta and carotid and coronary arteries from animals with atherosclerosis induced for 38 months and then regressed for 24 or 48 months at plasma cholesterol concentrations of 300 or 200 mg/dL. Exp Mol Pathol. 1984;41:96-118.
18. Kaplan JR, Clarkson TB, Manuck SB. Pathogenesis of carotid bifurcation atherosclerosis in cynomolgus monkeys. Stroke. 1984; 15:994-1000.