Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women

American Journal of Cardiology

Volumn 85, Issue 11, 2000, Pages 1297-1301

  Simons, Leon A ^a   Von Konigsmark, Margaret ^a   Simons, Judith ^a   Celermajer, David S ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCERYL TRINITRATE; ISOFLAVONE DERIVATIVE; LIPID; LIPOPROTEIN; PHYTOESTROGEN; PHYTOLIFE 1; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ECHOGRAPHY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

AGED; CLIMACTERIC; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; ESTROGENS, NON-STEROIDAL; FEMALE; HUMANS; ISOFLAVONES; LIPIDS; LIPOPROTEINS; MIDDLE AGED; PHYTOESTROGENS; PLANT PREPARATIONS; POSTMENOPAUSE; VASODILATION;

EID: 0034213042     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9149(00)00759-1     Document Type: Article

References (28)

1. Belchetz T.E. Hormonal treatment of postmenopausal women. N Engl J Med. 330:1994;1062-1071.
2. Murkies A.L., Wilcox G., Davis S.R. Clinical review 92. Phytoestrogens. J Clin Endocrinol Metab. 83:1998;297-303.
3. Lock M. Ambiguities of aging Japanese experience and perceptions of menopause . Cult Med Psychiat. 10:1986;23-46.
4. Kerry N., Abbey M. The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro. Atherosclerosis. 140:1998;341-347.
5. Honore E.K., Williams J.K., Anthony M.S., Clarkson T.B. Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Steril. 67:1997;148-154.
6. Wagner J.D., Cefalu W.T., Anthony M.S., Litwak K.W., Zhang L., Clarkson T.B. Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesteryl ester content in ovariectomized Cynomolgus monkeys. Metabolism. 46:1997;698-705.
7. Kupperman H.S., Meyer H.G., Blatt M.D., Wiesbader H., Filler W. Comparative clinical evaluation of estrogenic preparation by the menopausal and amenorrheal indices. J Clin Endocrinol Metab. 13:1953;688-703.
8. Allain C.C., Poon L.C., Chan C.S.G., Richmond W., Fu P.C. Enzymatic determination of total serum cholesterol. Clin Chem. 20:1974;470-475.
9. Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 19:1973;476-482.
10. Burstein M., Scholnick H.R., Morfin R. Rapid methods for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 11:1970;583-595.
11. Simons L.A., Friedlander Y., Simons J., McCallum J. Lipoprotein(a) is not associated with coronary heart disease in the elderly cross-sectional data from the Dubbo Study . Atherosclerosis. 99:1993;87-95.
12. King R.A., Broadbent J.L., Head R.J. Absorption and excretion of the soy isoflavone genistein in rats. J Nutr. 126:1996;176-182.
13. Sorensen K.E., Celermajer D.S., Spiegelhalter D.J., Georgakopoulos D., Robinson J., Thomas O., Deanfield J.E. Non-invasive measurement of human endothelium dependent arterial responses accuracy and reproducibility . Br Heart J. 74:1995;247-253.
14. Adams M.R., Robinson J., Sorensen K.E., Deanfield J.E., Celermajer D.S. Normal ranges for brachial artery flow-mediated dilation a non-invasive ultrasound test of arterial endothelial function . J Vasc Invest. 2:1996;146-150.
15. Simons L.A., Sullivan D., Simons J., Celermajer D.S. Effects of atorvastatin monotherapy and simvastatin plus cholestyramine on arterial endothelial function in patients with severe primary hypercholesterolaemia. Atherosclerosis. 137:1998;197-203.
16. Anderson T.J., Meredith I.T., Yeung A.C., Frei B., Selwyn A.P., Ganz P. The effect of cholesterol-lowering and anti-oxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med. 332:1995;488-493.
17. Lieberman E.H., Gerhard M.D., Uehata A., Walsh B.W., Selwyn A.P., Ganz P., Yeung A.C., Creager M.A. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med. 121:1994;936-941.
18. Bush D.E., Jones C.E., Bass K.M., Walters G.K., Bruza J.M., Ouyang P. Estrogen replacement reverses endothelial dysfunction in postmenopausal women. Am J Med. 104:1998;552-558.
19. Celermajer D.S., Sorensen K.E., Spiegelhalter D.J., Georgakopoulos D., Robinson J., Deanfield J.E. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 24:1994;471-476.
20. Williams J.K., Honoré E.K., Washburn S.A., Clarkson T.B. Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys. J Am Coll Cardiol. 24:1994;1757-1761.
21. Takase B., Uehata A., Akima T., Nagai T., Nishioka T., Hamabe A., Satomura K., Ohsuzu F., Kurita A. Endothelium-dependent flow-mediated vasodilatation in coronary and brachial arteries in suspected coronary artery disease. Am J Cardiol. 82:1998;1535-1539.
22. Nestel P.J., Yamashita T., Sasahara T., Pomeroy S., Dart A., Komesaroff P., Owen A., Abbey M. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol. 17:1997;3392-3398.
23. Nestel P.J., Pomeroy S. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. (abstr) Proc Nutr Soc Aust. 22:1998;283.
24. Lai N.T., Sullivan D.R., Celermajer D., Howes L., Nestel P. The effects of Promensil on the lipoprotein profiles in patients with hypercholesterolaemia. Proc Nutr Soc Aust. 22:1998;272. (Abstr).
25. Anderson J.W., Johnstone B.M., Cook-Newell M.E. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med. 333:1995;276-282.
26. Hodgson J.M., Puddey I.B., Beilin L.J., Mori T.A., Croft K.D. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations a randomised controlled trial in humans . J Nutr. 128:1998;728-732.
27. Greaves K.A., Parks J.S., Williams J.K., Wagner J.D. Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys. J Nutr. 129:1999;1585-1592.
28. Coward L., Barnes N.C., Setchell K.D.R., Barnes S. The isoflavones genistein and daidzein in soybean foods from American and Asian diets. J Agric Food Chem. 41:1993;1961-1967.