Abrogation of transforming growth factor-α/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines

Cancer Research

Volumn 61, Issue 15, 2001, Pages 5919-5925

  Song, John I ^a   Lango, Miriam N ^a   Hwang, James D ^a   Drenning, Stephanie D ^a   Zeng, Qing ^a   Grandis, JenniferR ^a   Lamph, William W ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEXAROTENE; EPIDERMAL GROWTH FACTOR RECEPTOR; RETINOIC ACID; RETINOID; RETINOID X RECEPTOR; RETINOL DERIVATIVE; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR ALPHA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOCRINE EFFECT; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; EXPERIMENTAL NEOPLASM; GENE EXPRESSION SYSTEM; HEAD CANCER; HUMAN; HUMAN CELL; MOUSE; NECK CANCER; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION REGULATION;

ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; DNA-BINDING PROTEINS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MICE; MICE, NUDE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TETRAHYDRONAPHTHALENES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035422782     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Head and neck cancer
2. Adjuvant chemotherapy for advanced head and neck squamous carcinoma
3. Randomized trials of induction chemotherapy
4. Overview of combined modality therapies for head and neck cancer
5. Second respiratory and upper digestive tract cancer following oral squamous cell carcinoma: Oral oncology
6. Survival statistics for multiple primaries in head and neck cancer
7. The retinoid signaling pathway: Molecular and genetic analyses
8. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia
9. Retinoids in cancer chemoprevention
10. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells
11. Suppression of retinoic acid receptor-β in premalignant oral lesions and its upregulation by isotretinoin
12. Prevention of second primary tumors with isotretinoin in squamous cell carcinoma of the head and neck
13. Synthetic retinoids in dermatology
14. Vitamin A receptors
15. Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agem and in combination with tamoxifen
16. Chemoprevention of mammary carcinoma by LGD1069 (Targretin): An RXR-selective ligand
17. Beyond Tamoxifen: The retinoid X receptor-selective ligand LGD1069 (Targretin) causes complete regression of mammary carcinoma
18. Initial clinical trial of a selective retinoid X receptor ligand, LGD1069
19. A Phase I study of LGD1069 in adults with advanced cancer
20. Retinoic acid normalizes the increased gene transcription rate of TGF-α and EGFR in head and neck cancer cell lines
21. Quantitative immunohistochemical analysis of transforming growth factor-α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck
22. Asynchronous modulation of transforming growth factor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma
23. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
24. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
25. Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines
26. Stat3 as ah oncogene
27. Determination of intermediate biomarker expression levels by quantitative RT-PCR in cancer patients treated with liarozole
28. A common nuclear signal transduction pathway activated by growth factor and cytokine receptors
29. A unique palindromic element mediates interferon induction of mig gene expression
30. Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer
31. High frequency of the retinoic acid receptor β abnormalities in human lung cancer
32. Role of retinoids in differentiation and carcinogenesis
33. HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis
34. Modulation of growth, differentiation and glycoprotein synthesis by β-all-trans retinoic acid in a multicellular tumor spheroid model for squamous cell carcinoma of the head and neck
35. Inhibition of growth and squamous cell differentiation markers in cultured human head and neck squamous carcinoma cells by β-all-trans retinoic acid
36. Suppression by retinoic acid of epidermal growth factor receptor autophosphorylation and glycosylation in cultured human head and neck squamous cell carcinoma cells
37. 13-cis-Retinoic acid in the treatment of oral leukoplakia
38. Hypervitaminosis A: A paradigm of retinoic acid side effects
39. Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids
40. Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro
41. Effects of retinoid X receptor-selective ligands on proliferation of prostate cancer cells
42. Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines
43. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice
44. Retinoid modulation of biomarkers in oral leukoplakia/dysplasia
45. Transforming growth factor α (TGF-α) expression in dysplastic oral leukoplakia: Modulation by 13-cis retinoic acid
46. Growth inhibition on cultured human gastric cancer cells by 9-cis-retinoic acid with induction of cdk inhibitor Waf1/Cip1/Sdi1/p21 protein
47. STATs: Signal transducers and activators of transcription
48. Regulation of IRF and STAT gene expression by retinoic acid
49. Retinoic acid modulates prolactin receptor expression and prolactin-induced Stat5 activation in breast cells in vitro
50. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
51. Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cells
52. Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention
53. Regulation of RARβ expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: Effect on growth inhibition and apoptosis induction