메뉴 건너뛰기




Volumn 11, Issue 12, 2005, Pages 546-554

A JAK2 mutation in myeloproliferative disorders: Pathogenesis and therapeutic and scientific prospects

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; JANUS KINASE 2; MESSENGER RNA; NILOTINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 28244496095     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.10.003     Document Type: Review
Times cited : (107)

References (69)
  • 1
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • W. Dameshek Some speculations on the myeloproliferative syndromes Blood 6 1951 372 375
    • (1951) Blood , vol.6 , pp. 372-375
    • Dameshek, W.1
  • 2
    • 2442677685 scopus 로고    scopus 로고
    • The chronic myeloproliferative disorders: Clonality and clinical heterogeneity
    • J.L. Spivak The chronic myeloproliferative disorders: clonality and clinical heterogeneity Semin. Hematol. 41 2, Suppl. 3 2004 1 5
    • (2004) Semin. Hematol. , vol.41 , Issue.2 SUPPL. 3 , pp. 1-5
    • Spivak, J.L.1
  • 3
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • J.W. Vardiman The World Health Organization (WHO) classification of the myeloid neoplasms Blood 100 2002 2292 2302
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1
  • 4
    • 0038717050 scopus 로고    scopus 로고
    • Imatinib mesylate (Gleevec(TM)) reduces phlebotomy requirements in polycythemia vera
    • R.T. Silver Imatinib mesylate (Gleevec(TM)) reduces phlebotomy requirements in polycythemia vera Leukemia 17 2003 1186 1187
    • (2003) Leukemia , vol.17 , pp. 1186-1187
    • Silver, R.T.1
  • 5
    • 20244389579 scopus 로고    scopus 로고
    • Vascular and neoplastic risk in a large cohort of patients with polycythemia vera
    • R. Marchioli Vascular and neoplastic risk in a large cohort of patients with polycythemia vera J. Clin. Oncol. 23 2005 2224 2232
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2224-2232
    • Marchioli, R.1
  • 6
    • 0141574207 scopus 로고    scopus 로고
    • The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis
    • M. Ruggeri The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis Ann. Intern. Med. 139 2003 470 475
    • (2003) Ann. Intern. Med. , vol.139 , pp. 470-475
    • Ruggeri, M.1
  • 7
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • J. Cools A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome N. Engl. J. Med. 348 2003 1201 1214
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1201-1214
    • Cools, J.1
  • 8
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • C. James A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera Nature 434 2005 1144 1148
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1
  • 9
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • R. Kralovics A gain-of-function mutation of JAK2 in myeloproliferative disorders N. Engl. J. Med. 352 2005 1779 1790
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1779-1790
    • Kralovics, R.1
  • 10
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • R.L. Levine Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis Cancer Cell 7 2005 387 397
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1
  • 11
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • E.J. Baxter Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders Lancet 365 2005 1054 1061
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1
  • 12
    • 20744460045 scopus 로고    scopus 로고
    • Identification of an acquired JAK2 mutation in polycythemia vera
    • R. Zhao Identification of an acquired JAK2 mutation in polycythemia vera J. Biol. Chem. 280 2005 22788 22792
    • (2005) J. Biol. Chem. , vol.280 , pp. 22788-22792
    • Zhao, R.1
  • 13
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • R. Ren Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia Nat. Rev. Cancer 5 2005 172 183
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 172-183
    • Ren, R.1
  • 14
    • 1842474941 scopus 로고    scopus 로고
    • The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: Implications for diagnosis, classification, and management
    • J. Gotlib The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management Blood 103 2004 2879 2891
    • (2004) Blood , vol.103 , pp. 2879-2891
    • Gotlib, J.1
  • 15
    • 0346880065 scopus 로고    scopus 로고
    • Clinical, genetic, and therapeutic insights into systemic mast cell disease
    • A. Tefferi, and A. Pardanani Clinical, genetic, and therapeutic insights into systemic mast cell disease Curr. Opin. Hematol. 11 2004 58 64
    • (2004) Curr. Opin. Hematol. , vol.11 , pp. 58-64
    • Tefferi, A.1    Pardanani, A.2
  • 16
    • 0033930839 scopus 로고    scopus 로고
    • Towards a molecular understanding of polycythemia rubra vera
    • H.L. Pahl Towards a molecular understanding of polycythemia rubra vera Eur. J. Biochem. 267 2000 3395 3401
    • (2000) Eur. J. Biochem. , vol.267 , pp. 3395-3401
    • Pahl, H.L.1
  • 17
    • 0029825270 scopus 로고    scopus 로고
    • Deletions of chromosome 20q and the pathogenesis of myeloproliferative disorders
    • F.A. Asimakopoulos, and A.R. Green Deletions of chromosome 20q and the pathogenesis of myeloproliferative disorders Br. J. Haematol. 95 1996 219 226
    • (1996) Br. J. Haematol. , vol.95 , pp. 219-226
    • Asimakopoulos, F.A.1    Green, A.R.2
  • 18
    • 10344262019 scopus 로고    scopus 로고
    • Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies
    • A.J. Bench Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies Br. J. Haematol. 127 2004 509 518
    • (2004) Br. J. Haematol. , vol.127 , pp. 509-518
    • Bench, A.J.1
  • 19
    • 0003205281 scopus 로고
    • Familial polycythemia vera: Mode of inheritance, clonality, and genetic analysis of candidate genes and chromosomal regions
    • R. Kralovics Familial polycythemia vera: mode of inheritance, clonality, and genetic analysis of candidate genes and chromosomal regions Blood 94 1994 113a
    • (1994) Blood , vol.94
    • Kralovics, R.1
  • 20
    • 0036191941 scopus 로고    scopus 로고
    • Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera
    • R. Kralovics Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera Exp. Hematol. 30 2002 229 236
    • (2002) Exp. Hematol. , vol.30 , pp. 229-236
    • Kralovics, R.1
  • 21
    • 0036439588 scopus 로고    scopus 로고
    • Exploring polycythaemia vera with fluorescence in situ hybridization: Additional cryptic 9p is the most frequent abnormality detected
    • V. Najfeld Exploring polycythaemia vera with fluorescence in situ hybridization: additional cryptic 9p is the most frequent abnormality detected Br. J. Haematol. 119 2002 558 566
    • (2002) Br. J. Haematol. , vol.119 , pp. 558-566
    • Najfeld, V.1
  • 22
    • 21344472778 scopus 로고    scopus 로고
    • Gain of 9p due to an unbalanced rearrangement der(9;18): A recurrent clonal abnormality in chronic myeloproliferative disorders
    • U. Bacher Gain of 9p due to an unbalanced rearrangement der(9;18): a recurrent clonal abnormality in chronic myeloproliferative disorders Cancer Genet. Cytogenet. 160 2005 179 183
    • (2005) Cancer Genet. Cytogenet. , vol.160 , pp. 179-183
    • Bacher, U.1
  • 23
    • 0041940289 scopus 로고    scopus 로고
    • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders
    • R. Kralovics Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders Blood 102 2003 1869 1871
    • (2003) Blood , vol.102 , pp. 1869-1871
    • Kralovics, R.1
  • 24
    • 0016391236 scopus 로고
    • Letter: Bone-marrow responses in polycythemia vera
    • J.F. Prchal, and A.A. Axelrad Letter: Bone-marrow responses in polycythemia vera N. Engl. J. Med. 290 1974 1382
    • (1974) N. Engl. J. Med. , vol.290 , pp. 1382
    • Prchal, J.F.1    Axelrad, A.A.2
  • 25
    • 0030742530 scopus 로고    scopus 로고
    • Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the Thrombocythemia Vera Study Group
    • J.J. Michiels, and E. Juvonen Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the Thrombocythemia Vera Study Group Semin. Thromb. Hemost. 23 1997 339 347
    • (1997) Semin. Thromb. Hemost. , vol.23 , pp. 339-347
    • Michiels, J.J.1    Juvonen, E.2
  • 26
    • 0141887081 scopus 로고    scopus 로고
    • PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera
    • H.L. Pahl PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera Curr. Hematol. Rep. 2 2003 231 236
    • (2003) Curr. Hematol. Rep. , vol.2 , pp. 231-236
    • Pahl, H.L.1
  • 27
    • 0032913316 scopus 로고    scopus 로고
    • Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L
    • A.L. Taksin Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L Blood 93 1999 125 139
    • (1999) Blood , vol.93 , pp. 125-139
    • Taksin, A.L.1
  • 28
    • 0034669997 scopus 로고    scopus 로고
    • Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia
    • A.A. Axelrad Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia Blood 96 2000 3310 3321
    • (2000) Blood , vol.96 , pp. 3310-3321
    • Axelrad, A.A.1
  • 29
    • 0023691494 scopus 로고
    • Megakaryocyte colony formation in chronic myeloid leukemia and myelofibrosis
    • E. Juvonen Megakaryocyte colony formation in chronic myeloid leukemia and myelofibrosis Leuk. Res. 12 1988 751 756
    • (1988) Leuk. Res. , vol.12 , pp. 751-756
    • Juvonen, E.1
  • 30
    • 0030021792 scopus 로고    scopus 로고
    • Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies
    • J.P. Le Couedic Missense mutation of the erythropoietin receptor is a rare event in human erythroid malignancies Blood 87 1996 1502 1511
    • (1996) Blood , vol.87 , pp. 1502-1511
    • Le Couedic, J.P.1
  • 31
    • 0030064060 scopus 로고    scopus 로고
    • Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders
    • Y. Li Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders Br. J. Haematol. 92 1996 60 66
    • (1996) Br. J. Haematol. , vol.92 , pp. 60-66
    • Li, Y.1
  • 32
    • 0017174101 scopus 로고
    • Polycythemia vera: Stem-cell and probable clonal origin of the disease
    • J.W. Adamson Polycythemia vera: stem-cell and probable clonal origin of the disease N. Engl. J. Med. 295 1976 913 916
    • (1976) N. Engl. J. Med. , vol.295 , pp. 913-916
    • Adamson, J.W.1
  • 33
    • 0021956939 scopus 로고
    • Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia
    • W.H. Raskind Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia J. Clin. Invest. 75 1985 1388 1390
    • (1985) J. Clin. Invest. , vol.75 , pp. 1388-1390
    • Raskind, W.H.1
  • 34
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • P.J. Fialkow Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell Blood 58 1981 916 919
    • (1981) Blood , vol.58 , pp. 916-919
    • Fialkow, P.J.1
  • 35
    • 0031019581 scopus 로고    scopus 로고
    • Clonality analysis of hematopoiesis in essential thrombocythemia: Advantages of studying T lymphocytes and platelets
    • N. el-Kassar Clonality analysis of hematopoiesis in essential thrombocythemia: advantages of studying T lymphocytes and platelets Blood 89 1997 128 134
    • (1997) Blood , vol.89 , pp. 128-134
    • El-Kassar, N.1
  • 36
    • 0033555392 scopus 로고    scopus 로고
    • A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications
    • C.N. Harrison A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications Blood 93 1999 417 424
    • (1999) Blood , vol.93 , pp. 417-424
    • Harrison, C.N.1
  • 37
    • 1542615163 scopus 로고    scopus 로고
    • Thrombocytosis
    • A.I. Schafer Thrombocytosis N. Engl. J. Med. 350 2004 1211 1219
    • (2004) N. Engl. J. Med. , vol.350 , pp. 1211-1219
    • Schafer, A.I.1
  • 38
    • 0034656066 scopus 로고    scopus 로고
    • Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera
    • S. Temerinac Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera Blood 95 2000 2569 2576
    • (2000) Blood , vol.95 , pp. 2569-2576
    • Temerinac, S.1
  • 39
    • 0242663394 scopus 로고    scopus 로고
    • Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis
    • S. Klippel Quantification of PRV-1 mRNA distinguishes polycythemia vera from secondary erythrocytosis Blood 102 2003 3569 3574
    • (2003) Blood , vol.102 , pp. 3569-3574
    • Klippel, S.1
  • 40
    • 0037108844 scopus 로고    scopus 로고
    • Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia
    • L. Teofili Overexpression of the polycythemia rubra vera-1 gene in essential thrombocythemia J. Clin. Oncol. 20 2002 4249 4254
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4249-4254
    • Teofili, L.1
  • 41
    • 0038281343 scopus 로고    scopus 로고
    • Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin
    • E. Liu Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin Blood 101 2003 3294 3301
    • (2003) Blood , vol.101 , pp. 3294-3301
    • Liu, E.1
  • 42
    • 4344575870 scopus 로고    scopus 로고
    • CD177: A member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera
    • D.F. Stroncek CD177: a member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera J. Transl. Med. 2 2004 8
    • (2004) J. Transl. Med. , vol.2 , pp. 8
    • Stroncek, D.F.1
  • 43
    • 4544323963 scopus 로고    scopus 로고
    • Clinical significance of neutrophil CD177 mRNA expression in Ph-negative chronic myeloproliferative disorders
    • F. Passamonti Clinical significance of neutrophil CD177 mRNA expression in Ph-negative chronic myeloproliferative disorders Br. J. Haematol. 126 2004 650 656
    • (2004) Br. J. Haematol. , vol.126 , pp. 650-656
    • Passamonti, F.1
  • 44
    • 0036376905 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic aspects of essential thrombocythemia
    • D.P. Steensma, and A. Tefferi Cytogenetic and molecular genetic aspects of essential thrombocythemia Acta Haematol. 108 2002 55 65
    • (2002) Acta Haematol. , vol.108 , pp. 55-65
    • Steensma, D.P.1    Tefferi, A.2
  • 45
    • 2642609475 scopus 로고    scopus 로고
    • Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera
    • A.R. Moliterno Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera N. Engl. J. Med. 338 1998 572 580
    • (1998) N. Engl. J. Med. , vol.338 , pp. 572-580
    • Moliterno, A.R.1
  • 46
    • 0032830543 scopus 로고    scopus 로고
    • Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera
    • A.R. Moliterno, and J.L. Spivak Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera Blood 94 1999 2555 2561
    • (1999) Blood , vol.94 , pp. 2555-2561
    • Moliterno, A.R.1    Spivak, J.L.2
  • 47
    • 0037214279 scopus 로고    scopus 로고
    • Role of constitutively activated protein tyrosine kinases in malignant myeloproliferative disorders: An update
    • E. Anastasiadou, and J. Schwaller Role of constitutively activated protein tyrosine kinases in malignant myeloproliferative disorders: an update Curr. Opin. Hematol. 10 2003 40 48
    • (2003) Curr. Opin. Hematol. , vol.10 , pp. 40-48
    • Anastasiadou, E.1    Schwaller, J.2
  • 48
    • 0141455965 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro
    • L. Oehler Imatinib mesylate inhibits autonomous erythropoiesis in patients with polycythemia vera in vitro Blood 102 2003 2240 2242
    • (2003) Blood , vol.102 , pp. 2240-2242
    • Oehler, L.1
  • 49
    • 0032568003 scopus 로고    scopus 로고
    • Expression of Bcl-x in erythroid precursors from patients with polycythemia vera
    • M. Silva Expression of Bcl-x in erythroid precursors from patients with polycythemia vera N. Engl. J. Med. 338 1998 564 571
    • (1998) N. Engl. J. Med. , vol.338 , pp. 564-571
    • Silva, M.1
  • 50
    • 0034982338 scopus 로고    scopus 로고
    • STAT3 is constitutively active in some patients with Polycythemia rubra vera
    • S. Roder STAT3 is constitutively active in some patients with Polycythemia rubra vera Exp. Hematol. 29 2001 694 702
    • (2001) Exp. Hematol. , vol.29 , pp. 694-702
    • Roder, S.1
  • 51
    • 12844271547 scopus 로고    scopus 로고
    • Increased erythropoiesis in polycythemia vera is associated with increased erythroid progenitor proliferation and increased phosphorylation of Akt/PKB
    • C. Dai Increased erythropoiesis in polycythemia vera is associated with increased erythroid progenitor proliferation and increased phosphorylation of Akt/PKB Exp. Hematol. 33 2005 152 158
    • (2005) Exp. Hematol. , vol.33 , pp. 152-158
    • Dai, C.1
  • 52
    • 0035694582 scopus 로고    scopus 로고
    • The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    • L.J. Huang The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor Mol. Cell 8 2001 1327 1338
    • (2001) Mol. Cell , vol.8 , pp. 1327-1338
    • Huang, L.J.1
  • 53
    • 22844438893 scopus 로고    scopus 로고
    • Janus kinases affect thrombopoietin receptor cell surface localization and stability
    • Y. Royer Janus kinases affect thrombopoietin receptor cell surface localization and stability J. Biol. Chem. 280 2005 27251 27261
    • (2005) J. Biol. Chem. , vol.280 , pp. 27251-27261
    • Royer, Y.1
  • 54
    • 0842309105 scopus 로고    scopus 로고
    • Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera
    • V. Ugo Multiple signaling pathways are involved in erythropoietin- independent differentiation of erythroid progenitors in polycythemia vera Exp. Hematol. 32 2004 179 187
    • (2004) Exp. Hematol. , vol.32 , pp. 179-187
    • Ugo, V.1
  • 55
    • 10744224146 scopus 로고    scopus 로고
    • Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: Possible relationship with FKBP51 overexpression
    • E. Komura Spontaneous STAT5 activation induces growth factor independence in idiopathic myelofibrosis: possible relationship with FKBP51 overexpression Exp. Hematol. 31 2003 622 630
    • (2003) Exp. Hematol. , vol.31 , pp. 622-630
    • Komura, E.1
  • 56
    • 25844518265 scopus 로고    scopus 로고
    • The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
    • DOI:10.1182/blood-2005-05-1898
    • Levine, R.L. et al. (2005) The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood DOI:10.1182/blood-2005-05-1898 (www.bloodjournal.org)
    • (2005) Blood
    • Levine, R.L.1
  • 57
    • 0034012330 scopus 로고    scopus 로고
    • Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
    • P. Saharinen Regulation of the Jak2 tyrosine kinase by its pseudokinase domain Mol. Cell. Biol. 20 2000 3387 3395
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3387-3395
    • Saharinen, P.1
  • 58
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 'atypical' myeloproliferative disorders and the myelodysplastic syndrome
    • D.P. Steensma The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 'atypical' myeloproliferative disorders and the myelodysplastic syndrome Blood 106 2005 1207 1209
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1
  • 59
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • A.V. Jones Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders Blood 106 2005 2162 2168
    • (2005) Blood , vol.106 , pp. 2162-2168
    • Jones, A.V.1
  • 60
    • 85117738363 scopus 로고    scopus 로고
    • JAK2 mutation 1849G >T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome negative CML and megakaryocytic leukemia
    • (in press)
    • Jelinek, J. et al. JAK2 mutation 1849G >T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome negative CML and megakaryocytic leukemia. Blood (in press)
    • Blood
    • Jelinek, J.1
  • 61
    • 25844461158 scopus 로고    scopus 로고
    • The Jak2V617F mutation, PRV-1 overexpression and EEC formation define a similar cohort of MPD patients
    • P.S. Goerttler The Jak2V617F mutation, PRV-1 overexpression and EEC formation define a similar cohort of MPD patients Blood 106 2005 2862 2864
    • (2005) Blood , vol.106 , pp. 2862-2864
    • Goerttler, P.S.1
  • 62
    • 0036216405 scopus 로고    scopus 로고
    • STI571 (Gleevec) as a paradigm for cancer therapy
    • B.J. Druker STI571 (Gleevec) as a paradigm for cancer therapy Trends Mol. Med. 8 4 Suppl 2002 S14 S18
    • (2002) Trends Mol. Med. , vol.8 , Issue.4 SUPPL.
    • Druker, B.J.1
  • 63
    • 1342321787 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) for myeloid malignancies other than CML
    • G.W. Krystal Imatinib mesylate (STI571) for myeloid malignancies other than CML Leuk. Res. 28 Suppl 1 2004 S53 S59
    • (2004) Leuk. Res. , vol.28 , Issue.1 SUPPL.
    • Krystal, G.W.1
  • 64
    • 2342614754 scopus 로고    scopus 로고
    • Beyond chronic myelogenous leukemia: Potential role for imatinib in Philadelphia-negative myeloproliferative disorders
    • J. Cortes, and H. Kantarjian Beyond chronic myelogenous leukemia: potential role for imatinib in Philadelphia-negative myeloproliferative disorders Cancer 100 2004 2064 2078
    • (2004) Cancer , vol.100 , pp. 2064-2078
    • Cortes, J.1    Kantarjian, H.2
  • 65
    • 0033134753 scopus 로고    scopus 로고
    • High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin
    • K. Cohen-Solal High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin Blood 93 1999 2859 2866
    • (1999) Blood , vol.93 , pp. 2859-2866
    • Cohen-Solal, K.1
  • 66
    • 20944437340 scopus 로고    scopus 로고
    • A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis
    • A.M. Vannucchi A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis Blood 105 2005 3493 3501
    • (2005) Blood , vol.105 , pp. 3493-3501
    • Vannucchi, A.M.1
  • 67
    • 0028328265 scopus 로고
    • Identification of a nonsense mutation in the granulocyte-colony- stimulating factor receptor in severe congenital neutropenia
    • F. Dong Identification of a nonsense mutation in the granulocyte-colony- stimulating factor receptor in severe congenital neutropenia Proc. Natl. Acad. Sci. U. S. A. 91 1994 4480 4484
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 4480-4484
    • Dong, F.1
  • 68
    • 19944385935 scopus 로고    scopus 로고
    • MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
    • B.J. Huntly MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors Cancer Cell 6 2004 587 596
    • (2004) Cancer Cell , vol.6 , pp. 587-596
    • Huntly, B.J.1
  • 69
    • 19344362958 scopus 로고    scopus 로고
    • On the molecular origins of the chronic myeloproliferative disorders: It all makes sense
    • K. Kaushansky On the molecular origins of the chronic myeloproliferative disorders: it all makes sense Blood 105 2005 4187 4190
    • (2005) Blood , vol.105 , pp. 4187-4190
    • Kaushansky, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.