Induction of β-Cell Rest by a Kir6.2/SUR1-Selective K ATP-Channel Opener Preserves β-Cell Insulin Stores and Insulin Secretion in Human Islets Cultured at High (11 mM) Glucose

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 2, 2004, Pages 795-805

  Ritzel, Robert A ^a   Hansen, John B ^b   Veldhuis, Johannes D ^c   Butler, Peter C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NOVO NORDISK A S   (Denmark)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 3 (1 METHYLCYCLOPROPYL)AMINO 4H THIENO[3,2 E] 1,2,4 THIADIAZINE 1,1 DIOXIDE; ADENOSINE TRIPHOSPHATE; GLUCAGON; GLUCOSE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; ISOPROTEIN; POTASSIUM CHANNEL STIMULATING AGENT; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CADAVER; CELL ACTIVITY; CELL CULTURE; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; GLUCAGON RELEASE; HUMAN; HUMAN CELL; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORGAN DONOR; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STEREOCHEMISTRY; STIMULATION; STORAGE;

ADENOSINE TRIPHOSPHATE; BICYCLO COMPOUNDS, HETEROCYCLIC; CULTURE TECHNIQUES; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HUMANS; INSULIN; INSULIN ANTAGONISTS; ISLETS OF LANGERHANS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; REST; TIME FACTORS;

EID: 1442327747     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031120     Document Type: Article

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