Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4

Neuroscience

Volumn 81, Issue 4, 1997, Pages 1031-1042

  Furuta, A ^a   Martin, L J ^a   Lin, C L G ^a   Dykes Hoberg, M ^a   J D Rothstein, ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocytes; Cerebellum; Dendritic spines; Immunohistochemistry; Purkinje cell; Ultrastructural localization

Indexed keywords

GLUTAMATE RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN STEM; CELLULAR DISTRIBUTION; CEREBELLUM; CORPUS STRIATUM; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NEOCORTEX; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS;

AGED; AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; BRAIN; CARRIER PROTEINS; CEREBELLUM; CHLORIDE CHANNELS; EXCITATORY AMINO ACID TRANSPORTER 3; EXCITATORY AMINO ACID TRANSPORTER 4; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMATES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; MIDDLE AGED; NEURONS; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; SUBCELLULAR FRACTIONS; SYMPORTERS; SYNAPSES;

EID: 0031563761     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00252-2     Document Type: Article

References (30)

1. Arriza J. L., Fairman W. A., Wadiche J. I., Murdoch G. H., Kavanaugh M. P., Amara S. G. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14:1994;5559-5569.
2. Attwell D., Barbour B., Szatkowski M. Nonvesicular release of neurotransmitter. Neuron. 11:1993;401-407.
3. Barbour B., Keller B. U., Llano I., Marty A. Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron. 12:1994;1331-1343.
4. Baude A., Nusser Z., Roberts J. D. B., Mulvihill E., McIlhinney R. A. J., Somogyi P. The metabotropic glutamate receptor (mGluR 1α) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron. 11:1993;771-787.
5. Blackstone C. D., Moss S. J., Martin L. J., Levey A. I., Price D. L., Huganir R. L. Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain. J. Neurochem. 58:1992;1118-1126.
6. Chaudhry F. A., Lehre K. P., van Lookeren Campagne M., Ottersen O. P., Danbolt N. C., Storm-Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron. 15:1995;711-720.
7. Choi D. W., Maulucci-Gedde M., Kriegstein A. R. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7:1987;357-368.
8. Conradt M., Storck T., Stoffel W. Localization of N-glycosylation sites and functional role of the carbohydrate units of GLAST-1, a cloned rat brain L-glutamate/L-aspartate transporter. Eur. J. Biochem. 229:1995;682-687.
9. Duchen L. W. (1992) General pathology of neurons and neuroglia. In Greenfield's Neuropathology (eds Adams J. H. and Duchen L. W.), 5th edn., pp. 1-68. Edward Arnold, London.
10. Eccles C. U., Dykes-Hoberg M., Rothstein J. D. Inhibition of synthesis of EAAC1 glutamate transporter alters γ-aminobutyric acid levels in discrete brain regions. Soc. Neurosci. Abstr. 22:1996;1570.
11. Fairman W. A., Vandenberg R. J., Arriza J. L., Kavanaugh M. P., Amara S. G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 375:1995;599-603.
12. Ginsberg S. D., Martin L. J., Rothstein J. D. Regional deafferentation down-regulates subtypes of glutamate transporter proteins. J. Neurochem. 65:1995;2800-2803.
13. Haugeto Ÿ., Ullensvang K., Levy L. M., Chaudhry F. A., Honoré T., Nielsen M., Lehre K. P., Danbolt N. C. Brain glutamate transporter proteins form homomultimers. J. biol. Chem. 271:1996;27715-27722.
14. Kanai Y., Hediger M. Primary structure and functional characterization of a high affinity glutamate transporter. Nature. 360:1992;467-471.
15. Kanai Y., Smith C. P., Hediger M. A. A new family of neurotransmitter transporters the high-affinity glutamate transporters. Fedn Am. Socs exp. Biol. J. 7:1993;1450-1459.
16. Lehre K. P., Levy L. M., Ottersen O. P., Storm-Mathisen J., Danbolt N. C. Differential expression of two glutamate transporters in rat brain: quantitative and immunocytochemical observations. J. Neurosci. 15:1995;1835-1853.
17. Mann D. M., Stamp J. E., Yates P. O., Bannister C. M. The fine structure of the axonal torpedo in Purkinje cells of the human cerebellum. Neurol. Res. 1:1980;369-378.
18. Martin L. J., Blackstone C. D., Huganir R. L., Price D. L. Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron. 9:1992;259-270.
19. Pines G., Danbolt N. C., Bjoras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., Kanner B. I. Cloning and expression of a rat brain L-glutamate transporter. Nature. 360:1992;464-467.
20. Rosenberg P. A., Amin S., Leitner M. Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture. J. Neurosci. 12:1992;56-61.
21. Rothstein J. D., Martin L. J., Kuncl R. W. Decreased brain and spinal cord glutamate transport in amyotrophic lateral sclerosis. New Engl. J. Med. 326:1992;1464-1468.
22. Rothstein J. D., Jin L., Dykes-Hoberg M., Kuncl R. W. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. natn. Acad. Sci. U.S.A. 90:1993;6591-6595.
23. Rothstein J. D., Martin L., Levey A. I., Dykes-Hoberg M., Jin L., Wu D., Nash N., Kuncl R. W. Localization of neuronal and glial glutamate transporters. Neuron. 13:1994;713-725.
24. Rothstein J. D., van Kammen M., Levey A. I., Martin L. J., Kuncl R. W. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38:1995;73-84.
25. Rothstein J. D., Dykes-Hoberg M., Pardo C. A., Bristol L. A., Jin L., Kuncl R. W., Kanai Y., Hediger M. A., Wang Y., Schielke J. P., Welty D. F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
26. +-dependent glutamate/aspartate transporter from rat brain. Proc. natn. Acad. Sci. U.S.A. 89:1992;10955-10959.
27. Takahashi M., Kovalchuk Y., Attwell D. Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses. J. Neurosci. 15:1995;5693-5702.
28. Taylor C. R., Shi S.-R., Chaiwun B., Young L., Iman S. A., Cote R. J. Strategies for improving the immunohistochemical staining of various intranuclear prognostic markers in formalin-paraffin sections. Human Path. 25:1994;263-270.
29. Wadiche J. I., Amara S. G., Kavanaugh M. P. Ion fluxes associated with excitatory amino acid transport. Neuron. 15:1995;721-728.
30. Yamada K., Watanabe M., Shibata T., Tanaka K., Wada K., Inoue Y. EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. NeuroReport. 7:1996;2013-2017.