Signalling mechanisms of anoikis

Histology and Histopathology

Volumn 19, Issue 3, 2004, Pages 973-983

  Zhan, Mei ^a   Zhao, H ^a   Han, Z C ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Anoikis; bcl 2; Extracellular matrix; Focal adhesion kinase; Integrin; Mitogen activated protein kinase; Phosphoinositide 3 kinase

Indexed keywords

FOCAL ADHESION KINASE; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ANOIKIS; APOPTOSIS; CELL ANCHORAGE; CELL VIABILITY; DEVELOPMENT; EXTRACELLULAR MATRIX; HOMEOSTASIS; HUMAN; NONHUMAN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TISSUE METABOLISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANOIKIS; EXTRACELLULAR MATRIX; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTEGRINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 3042823411     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (109)

1. Almeida E.A., Ilic D., Han O., Hauck C.R., Jin F., Kawakatsu H., Schlaepfer D.D. and Damsky C.H. (2000). Matrix survival signalling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J. Cell. Biol. 149, 741-754.
2. Aoudjit F. and Vuori K. (2001). Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J. Cell Biol. 152, 633-643.
3. Aplin A.E. and Juliano R.L. (1999). Integrin and cytoskeletal regulation of growth factor signalling to the MAP kinase pathway. J. Cell. Sci. 112, 695-706.
4. Aplin A.E., Howe A., Alahari S.K. and Juliano R.L. (1998). Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50, 197-263.
5. Aplin A.E., Howe A.K. and Juliano R.L. (1999). Cell adhesion molecules, signal transduction and cell growth. Curr. Opin. Cell Biol. 11, 737-744.
6. Aplin A.E., Stewart S.A., Assoian R.K. and Juliano R.L. (2001). Integrin-mediated adhesion regulates ERK nuclear translocation and phosphorylation of Elk-1. J. Cell Biol. 153, 273-282.
7. Assoian R.K. and Schwartz M.A. (2001). Coordinate signalling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 11, 48-53.
8. Attwell S., Roskelle C. and Dedhar S. (2000). The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 19, 3811-3815.
9. Bachelder R.E., Ribick M.J., Marchetti A., Falcioni R., Soddu S., Davis K.R. and Mercurio A.M. (1999). p53 inhibits alpha 6 beta 4 integrin survival signalling by promoting the caspase 3-dependent cleavage of AKT/PKB. J. Cell Biol. 147, 1063-1072.
10. Bagrodia S. and Cerione R.A. (1999). Pak to the future. Trends. Cell Biol. 9, 350-355.
11. Bajt M.L., Lawson J.A., Vonderfecht S.L., Gujral J.S. and Jaeschke H. (2000). Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 58, 109-117.
12. Beattie G.M., Leibowitz G., Lopez A.D., Levine F. and Hayek A. (2000). Protection from cell death in cultured human fetal pancreatic cells. Cell. Transplant. 9, 431-438.
13. Bondar V.M. and McConkey D.J. (2002). Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells. Prostate 51, 42-49.
14. Bossy-Wetzel E., Bakifi L. and Yaniv M. (1997). Induction of apoptosis by the transcription factor c-jun. EMBO J. 16, 1695-1709.
15. Boudreau N., Sympson C.J., Werb Z. and Bissell M.J. (1995). Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893.
16. Brooks P.C., Montgomery A.M., Rosenfeld M., Reisfeld R.A., Hu T., Klier G. and Cheresh D.A. (1994). Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
17. Brunet A., Park J., Tran H., Hu L.S., Hemmings B.A. and Greenberg M.E. (2001). Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOX03a). Mol. Cell. Biol. 21, 952-965.
18. Calalb M.B., Polte T.R. and Hanks S.K. (1995). Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases. Mol Cell Biol. 15, 954-963.
19. Cardone M.H., Salvesen G.S., Widmann C., Johnson G. and Frisch S.M. (1997). Regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90, 315-323.
20. Chan P.Y., Kanner S.B., Whitney G. and Aruffo A. (1994). A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylatad at tyrosine residues identical to pp125FAK. J. Biol. Chem. 269, 20567-20574.
21. Chaudhary A., King W.G., Mattaliano M.D., Frost J.A., Diaz B., Morrison D.K., Cobb M.H., Marshall M.S. and Brugge J.S. (2000). Phosphatidylinositol 3-kinase regulates Raf 1 through Pak phosphorylation of serine 338. Curr. Biol. 10, 551-554.
22. Chinnaiyan A.M., Orth K., O'Rourke K., Duan H., Poirier G.G. and Dixit V.M. (1996). Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J. Biol. Chem. 271, 4573-4576.
23. Coll M.L., Rosen K., Ladeda V. and Filmus J. (2002). Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells. Oncogene 21, 2908-2913.
24. Coucouvanis E. and Martin G.R. (1995). Signals for death and survival: a two-step mechanism for cavitation in the vertebrate embryo. Cell 83, 279-287.
25. Danilkovitch A., Donley S., Skeel A. and Leonard E.J. (2000). Two independent signalling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Mol. Cell. Biol. 20, 2218-2227.
26. Datta S.R., Brunet A. and Greenberg M.E. (1999). Cellular survival: a play in three Akts. Genes. Dev. 13, 2905-2927.
27. Day M.L., Foster R.G., Day K.C., Zhao X., Humphrey P., Swanson P., Postigo A.A., Zhang S.H. and Dean D.C. (1997). Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway. J. Biol. Chem. 272, 8125-8128.
28. Dedhar S. (2000). Cell-substrate interactions and signalling through ILK. Curr. Opin. Cell. Biol. 12, 250-256.
29. del Pozo M.A., Price L.S., Alderson N.B., Ren X.D. and Schwartz M.A. (2000). Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO. J. 19, 2008-2014.
30. Dolfi F., Garcia-Guzman M., Ojaniemi M., Nakamura H., Matsuda M. and Vuori K. (1998). The adaptor protein Crk connects multiple cellular stimuli to the JNK signalling pathway. Proc. Natl. Acad. Sci. USA 95,15394-15399.
31. Evan G.I. and Vousden K.H. (2001). Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342-348.
32. Farrelly N., Lee Y., Oliver J., Dive C. and Streuli C. (1999). ECM regulates apoptosis in mammary epithelium through a control on insulin signalling. J. Cell Biol. 144, 1337-1348.
33. Flusberg D.A., Numaguchi Y. and Ingber D.E. (2001). Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Mol. Biol. Cell. 12, 3087-3094.
34. Folkman J. and Moscona A. (1978). Role of cell shape in growth control. Nature 273, 345-349.
35. Frisch S.M. and Francis H. (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626.
36. Frisch S.M., Vuori K., Kelaita. D. and Sicks S. (1996a). A role for Jun-N-tarminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135, 1377-1382.
37. Frisch S.M., Vuori K., Ruoslahti E. and Chan-Hui P.Y. (1996b). Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol. 134, 793-799.
38. Frost J.A., Steen H., Shapiro P., Lewis T., Ahn N., Shaw P.E. and Cobb M.H. (1997). Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16, 6426-6438.
39. Fukazawa H., Noguchi K., Murakami Y. and Uehara Y. (2002). Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway. Mol. Cancer. Ther. 1, 303-309.
40. Giancotti F.G. and Ruoslahti E. (1999). Integrin signalling. Science 285, 1028-1035.
41. Gnesutta N., Qu J. and Minden A. (2001). The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J. Biol. Chem. 276, 14414-14419.
42. Gu H., Maeda H., Moon J.J., Lord J.D., Yoakim M., Nelson B.H. and Neel B.G. (2000). New role for Shc in activation of the PI3K/Akt pathway. Mol. Cell. Biol. 20, 7109-7120.
43. Hall P.A., Coates P.J., Ansari B. and Hopwood D. (1994). Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell. Sci. 107, 3569-3577.
44. Heidkamp M.C., Bayer A.L., Kalina J.A., Eble D.M. and Samarel A.M. (2002). GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes. Circ. Res. 90, 1282-1289.
45. Hisano C., Tanaka R., Fujishima H., Ariyama H., Tsuchiya T., Tatsumoto T., Mitsugi K., Nakamura M. and Nakano S. (2003). Suppression of anoikis by v-Src but not by activated c-H-Ras in human gallbladder epithelial cells. Cell Biol. Int. 27, 415-421.
46. Howe A.K. and Juliano R.L. (2000). Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat. Cell. Biol. 2, 593-600.
47. Howlett A.R., Bailey N., Damsky C., Petersen O.W. and Bissell M.J. (1995). Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. J. Cell. Sci. 108, 1945-1957.
48. Hungerford J.E., Compton M.T., Matter M.L., Hoffstrom B.G. and Otey C.A. (1996). Inhibition of pp125FAK in cultured fibroblasts results in apoptosis. J. Cell. Biol. 135, 1383-1390.
49. Idogawa M., Adachi M., Minami T., Yasui H. and Imai K. (2003). Overexpression of BAD preferentially augments anoikis. Int. J. Cancer 107, 215-223.
50. Jost M., Huggett T.M., Kari C. and Rodeck U. (2001). Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway. Mol. Biol. Cell. 12, 1519-1527.
51. Khwaja A., Rodriguez-Viciana P., Wennstrom S., Warne P.H. and Downward J. (1997). Matrix adhesion and ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/AKT cellular survival pathway. EMBO J. 16, 2783-2794.
52. King A.J., Sun H., Diaz B., Barnard D., Miao W., Bagrodia S. and Marshall M.S. (1998). The protein kinase Pak3 positively regulates-Raf-1 activity through phosphorylation of serine 338. Nature 396, 180-183.
53. Kiyokawa E., Hashimoto Y., Kurata T., Sugimara H. and Matsuda M. (1998). Evidence that DOCK180 up-regulates signals from the CrkIIp130 (Cas) complex. J. Biol. Chem. 273, 24479-24484.
54. Kuwana T., Smith J.J., Muzio M., Dixit V., Newmeyer D.D. and Kombluth S. (1998). Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J. Biol. Chem. 273, 16589-16594.
55. Le Gall M., Chambard J.C., Breittmayer J.P., Grall D., Pouyssegur J. and Van Obberghen-Schilling E. (2000). The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal. Mol. Biol. Cell. 11, 1103-1112.
56. Lee F., Hagler J., Che Z. and Maniatis T. (1997). Activation of the IkappaB alpha kinase complex by MEKKI1, a kinase of the JNK pathway. Cell 88, 213-222.
57. Liu X.W., Bernardo M.M., Fridman R. and Kim H.R. (2003). Tissue inhibitor of metalloproteinase-1 (TIMP-1) protects human breast epithelial cells against intrinsic apoptotic cell death via the FAK/PI 3-kinase and MAPK signalling pathway. J. Biol. Chem. 278, 40364-40372.
58. Lund L.R., Romer J., Thomasset N., Solberg H., Pyke C., Bissell M.J. Dano K. and Werb Z. (1996). Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122, 181-193.
59. Marco R.A., Diaz-Montero C.M., Wygant J.N., Kleinerman E.S. and McIntyre B.W. (2003). alpha4 integrin increases anoikis of human osteosarcoma cells. J. Cell. Biochem. 88, 1038-1047.
60. Matsunaga T., Takemoto N., Sato T., Takimoto R., Tanaka I., Fujimi A., Akiyama T., Kuroda H., Kawano Y., Kobune M., Kato J., Hirayama Y., Sakamaki S., Kohda K., Miyake K. and Niitsu Y. (2003). Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat. Med. 9, 1158-1165.
61. Matsuzawa S., Takayama S., Froesch B., Zapata J. and Reed J.C. (1998). p53-inducible human homologue of Drosophila Siah inhibits cell growth: suppression by BAG-1. EMBO J. 17, 2736-2747.
62. McFall A., Ulku A., Lambert Q.T., Kusa A., Rogers-Graham K. and Der C.J. (2001). Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol. Cell. Biol. 21, 5488-5499.
63. Meredith J.E. Jr., Fazeli B. and Schwartz M.A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell. 4, 953-961.
64. Montgomery A.M., Reisfeld R.A. and Cheresh D.A. (1994). Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. Natl. Acad. Sci. USA 91, 8856-8860.
65. Morozevich G.E., Kozlova N.I., Chubukina A.N. and Berman A.E. (2003). Role of integrin alphavbeta3 in substrate-dependent apoptosis of human intestinal carcinoma cells. Biochemistry (Mosc) 68, 416-423.
66. O'Brien V., Frisch S.M. and Juliano R.L. (1996). Expression of the integrin alpha 5 subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation. Exp. Cell Res. 224, 208-213.
67. Oktay M., Wary K.K., Dans M., Birge R.B. and Giancotti F.G. (1999). Integrin mediated activation of focal adhesion kinase is required for signalling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J. Cell. Biol. 145, 1461-1469.
68. Park M.Y., Lee R.H., Lee S.H. and Jung J.S. (1999). Apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells. Nephron 83, 341-351.
69. Persad S., Attwell S., Gray V., Delcommenne M., Troussard A., Sanghera J. and Dedhar S. (2000). Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc. Natl. Acad. Sci. USA 97, 3207-3212.
70. Persad S., Attwell S., Gray V., Mawji N., Deng J.T., Leung D., Yan J., Sanghera J., Walsh M.P. and Dedhar S. (2001). Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276, 27462-27469.
71. Polakowska R.R., Piacentini M., Bartlett R., Goldsmith L.A. and Haake A.R. (1994). Apoptosis in human skin development: morphogenesis, periderm, and stem cells. Dev. Dyn. 199, 176-188.
72. Pullan S., Wilson J., Metcalfe A., Edwards G.M., Goberdhan N., Tilly J., Hickman J.A., Dive C. and Streuli C.H. (1996). Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J. Cell. Sci. 109, 631-642.
73. Re F., Zanetti A., Sironi M., Polentarutti N., Lanfrancone L., Dejana E. and Colotta F. (1994). Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell. Biol. 127, 537-546.
74. Reginato M.J., Mills K.R., Paulus J.K., Lynch D.K., Sgroi D.C., Debnath J., Muthnswamy S.K. and Brugge J.S. (2003). Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat. Cell. Biol. 5, 733-740.
75. Rosen K., Rak J., Leung T., Dean N.M., Kerbel R.S. and Filmus J. (2000). Activated Ras prevents downregulation of Bcl- X (L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells. J. Cell Biol. 149, 447-456.
76. Ruhl M., Sahin E., Johannsen M., Somasundaram R., Manski D., Riecken E.O. and Schuppan D. (1999). Soluble collagen VI drives serum-starved fibroblasts through S phase and prevents apoptosis via down-regulation of Bax. J. Biol. Chem. 274, 34361-34368.
77. Rytomaa M., Lehmann K. and Downward J. (2000). Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene 19, 4461-4468.
78. Rytomaa M., Martins L.M. and Downward J. (1999). Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis. Curr. Biol. 9, 1043-1046.
79. Sakai H., Kobayashi Y., Sakai E., Shibata M. and Kato Y. (2000). Cell adhesion is a prerequisite for osteoclast survival. Biochem. Biophys. Res. Commun. 270, 550-556.
80. Schlaepfer D.D., Hanks S.K., Hunter T. and van der Geer P. (1994). Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
81. Schurmann A., Mooney A.F., Sanders L.C., Sells M.A., Wang H.G., Reed J.C. and Bokoch G.M, (2000). p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol. Cell. Biol. 20, 453-461.
82. Sells M.A., Knaus U.G., Bagrodia S., Ambrose D.M., Bokoch G.M. and Chernoff J. (1997). Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7, 202-210.
83. Seufferlein T., Secki M.J., Schwarz E., Beil M., v Wichert G., Baust H., Luhrs H., Schmid R.M. and Adler G. (2002). Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells. Br. J. Cancer 86, 1188-1196.
84. Sonoda Y., Matsumoto Y., Funakoshi M., Yamamoto D., Hanks S. and Kasahara T. (2000). Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J. Biol. Chem. 275, 16309-16315.
85. Strasser A., Puthalakath H., Bouillry P., Huang D.C., O'Connor L., O'Reilly L.A., Cullen L., Cory S. and Adams J.M. (2000). The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann. NY Acad. Sci. 917, 541-548.
86. Strater J., Wedding U., Barth T.F., Koretz K., Elsing C. and Moller P. (1996). Rapid onset of apoptosis in vitro follows disruption of beta 1-integrin/matrix interactions in human colonic crypt cells. Gastroenterology 110, 1776-1784.
87. Stromblad S., Becker J.C., Yebra M., Brooks P.C. and Cheresh D.A. (1996). Suppression of p53 activity and p21 expression by vascular cell integrin αvβ3 during angiogenesis. J. Clin. Invest. 98, 426-433.
88. Stupack D.G., Puente X.S., Boutsaboualoy S., Storgard C.M. and Cheresh D.A. (2001). Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J. Cell Biol. 155, 459-470.
89. Su B. and Karin M. (1996). Mitogen-activated protein kinase cascades and regulation of gene expression. Curt. Opin. Immunol. 8, 402-411.
90. Tamada Y., Takama H., Kitamura T., Yokochi K., Nitta Y., Ikeya T. and Matsumoto Y. (1994). Identification of programmed cell death in normal human skin tissues by using specific labelling of fragmented DNA. Br. J. Dermatol. 131, 521-524.
91. Tang Y., Zhou H., Chen A., Pittman R. and Field J. (2000). The Akt proto-oncogene links Ras to Pak and cell survival signals. J. Biol. Chem. 275, 9106-9109.
92. Tian B., Lessan K., Kahm J., Kleidon J. and Henke C. (2002). beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signalling pathway. J. Biol. Chem. 277, 24667-24675.
93. Tiberio R., Marconi A., Fila C., Fumelli C., Pignatti M., Krajewski S. Giannetti A., Reed J.C. and Pincelli C. (2002). Keratinocytes enriched for stem cells are protected from anoikis via an integrin signalling pathway in a Bcl-2 dependent manner. FEBS Lett. 524, 139-144.
94. Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A. and Davis R.J. (2000). Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288, 870-874.
95. Tran S.E., Holmstrom T.H., Ahonen M., Kahari V.M. and Eriksson J.E. (2001). MAPK/ERK overrides the apoptotic signalling from Fas, TNF, and TRAIL receptors. J. Biol. Chem. 276, 16484-16490.
96. Valentinis B., Morrione A., Peruzzi F., Prisco M., Reiss K. and Baserga R. (1999). Anti-apoptotic signalling of the IGF-1 receptor in fibroblasts following loss of matrix adhesion. Oncogene 18, 1827-1836.
97. Vuori K. and Ruoslahti E. (1994). Association of insulin receptor substrate-1 with integrins. Science 266, 1576-1578.
98. Walsh M.F., Thamilselvan V., Grotelueschen R., Farhana L. and Basson M. (2003). Absence of adhesion triggers differential FAK and SAPKp38 signals in SW620 human colon cancer cells that may inhibit adhesiveness and lead to cell death. Cell. Physiol. Biochem. 13, 135-146.
99. Wang P., Valentijn A.J., Gilmore A.P. and Streuli C.H. (2003). Early events in the anoikis program occur in the absence of caspase activation. J. Biol. Chem. 278, 19917-19925.
100. Wary K.K., Mainiero F., Isakoff S.J., Marcantonio E.E. and Giancotti F.G. (1996). The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87, 733-743.
101. Waskiewicz A.J. and Cooper J.A. (1995). Mitogen end stress response pathways: MAP klnase cascades and phosphatase regulation in mammals and yeast. Curt. Opin. Cell. Biol. 7, 798-805.
102. White D.E., Cardiff R.D., Dedhar S. and Muller W.J. (2001). Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20, 7064-7072.
103. Windham T.C., Parikh N.U., Siwak D.R., Summy J.M., McConkey D.J., Kraker A.J. and Gallick G.E. (2002). Src activation regulates anoikis in human colon tumor cell lines. Oncogene 21, 7797-7807.
104. Xia Z., Dickens M., Raingeaud J., Davis R.J. and Greenberg M.E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
105. Yin X.M. (2000). Signal transduction mediated by Bid, a prodeath Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res. 10, 161-167.
106. Yoshii S., Tanaka M., Otsuki Y., Wang D.Y., Guo R.J., Zhu Y., Takeda R., Hanai H., Kaneko E. and Sugimura H. (1999). alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. Oncogene 18, 5680-5690.
107. Yu J.T., Foster R.G. and Dean D.C. (2001). Transcriptional repression by Rb-E2F and regulation of anchorage-independent survival. Mol. Cell. Biol. 21, 3325-3335.
108. Zeng Q., McCauley L.K. and Wang C.Y. (2002). Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. J. Biol. Chem. 277, 50137-50142.
109. Zhang Z., Vuori K., Reed J.C. and Ruoslahti E. (1995). The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc. Natl. Acad. Sci. USA 92, 6161-6165.